Zutt, Markus

[["dc.bibliographiccitation.firstpage","1432"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of the European Academy of Dermatology and Venereology"],["dc.bibliographiccitation.lastpage","1439"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","von Ahsen, Nicolas"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:49:13Z"],["dc.date.available","2018-11-07T08:49:13Z"],["dc.date.issued","2011"],["dc.description.abstract","Background Chronic venous leg ulcers (CVU) cause considerable burden of disease for the patients as well as enormous costs for health care systems. The pathophysiology of CVU is complex and not entirely understood. So far reliable pathogenic and/or prognostic parameters have not been identified. Objectives We studied the role of thrombophilia in patients referred to a University dermatology department for treatment of CVU. Patients and methods A cohort of 310 patients with active chronic venous leg ulcers (CEAP 6) was stratified into two comparably large groups according to the presence or absence of post- thrombotic syndrome (PTS+; PTS-) as determined using duplex scan and/or phlebography. In addition, several thrombophilia parameters were assessed. Results The prevalence of protein S deficiency and factor V Leiden mutation was significantly higher in PTS+ patients compared with the PTS- group. However, patients in both subgroups revealed high prevalences of thrombophilia (antithrombin deficiency, protein C deficiency, protein S deficiency, activated protein C resistance, factor V mutation or elevated homocysteine). Conclusion Based on these data, it is conceivable that thrombophilia contributes to the pathogenesis of CVU, possibly through induction of microcirculatory dysregulations."],["dc.identifier.doi","10.1111/j.1468-3083.2011.04001.x"],["dc.identifier.isi","000297952800011"],["dc.identifier.pmid","21392126"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21406"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0926-9959"],["dc.title","Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0959-8049(02)00534-8"],["dc.bibliographiccitation.firstpage","175"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","183"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Meller, J."],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Funke, M."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2021-06-01T10:50:19Z"],["dc.date.available","2021-06-01T10:50:19Z"],["dc.date.issued","2003"],["dc.description.abstract","To date, there are no reliable criteria to identify those patients with melanoma-infiltrated sentinel lymph nodes (SLNs) of the groin who might benefit from an extended lymphadenectomy, including the pelvic lymph nodes. We hypothesised that there are pelvic lymph nodes that receive lymph directly from the primary tumour, thus being at an increased risk for metastasis. In order to determine the frequency of radioactively labelled pelvic lymph nodes and the kinetics of their appearance, we introduce here a combination of dynamic lymphoscintigraphy, single photon emission computed tomography (SPECT) and image fusion of SPECT and pelvic Computed Tomography (CT)-scans. By dynamic lymphoscintigraphy and intraoperative gamma probe detection, superficially located inguinal SLNs (median 2 nodes) could be identified in all of the 51 patients included in this analysis. The histological search for micrometastases was positive in 16 patients (median Breslow thickness of the primary melanoma 2.5 mm). In 29 patients, SPECT and the image fusion technique were additionally performed. Radioactively labelled pelvic lymph nodes were detected in 20 individuals, 6 of them presenting aberrant pelvic SLNs that, on dynamic lymphoscintigraphy, had appeared simultaneously with the superficial SLN(s). Of the 6 patients in whom radioactive pelvic lymph nodes were excised together with the superficial SLN(s), only one had positive superficial SLNs. In this patient, the aberrant pelvic SLN proved to be tumour-positive. In 9 patients, there was no radiotracer uptake in the pelvic lymph nodes at all. Image fusion of SPECT and pelvic CT-scans is an excellent tool to localise exactly the pelvic tumour-draining nodes. The significance of radioactively labelled pelvic lymph nodes for the probability of pelvic metastases should be analysed further. (C) 2002 Elsevier Science Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0959-8049(02)00534-8"],["dc.identifier.isi","000181789200017"],["dc.identifier.pmid","12509949"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86614"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Dynamic lymphoscintigraphy and image fusion of SPECT and pelvic CT-scans allow mapping of aberrant pelvic sentinel lymph nodes in malignant melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","299"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","302"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T10:38:43Z"],["dc.date.available","2018-11-07T10:38:43Z"],["dc.date.issued","2003"],["dc.description.abstract","The anti-melanoma activity of vindesine as a single or polychemotherapeutic agent has been reported previously in adjuvant and first-line melanoma treatment. In this study, we investigated the usefulness of vindesine monotherapy as salvage therapy in stage IV melanoma patients after failure of other chemotherapies. Thirteen patients with progressive disease were treated with 3 mg/m(2) vindesine every 2 weeks (median age, 61 years). Previous systemic treatment consisted of polychemotherapy or combined chemo-immunotherapy. All 13 patients suffered from visceral metastases (three lung, one liver, one adrenal gland and eight multiple visceral metastases). A median of three vindesine treatments was administered. Despite the various pretreatments, the toxicity of vindesine was mild. In all 13 patients, vindesine treatment was stopped due to disease progression. The median survival after primary tumour diagnosis was 42 months (8-151 months), the survival after entering stage IV was 11 months (3-35 months), and the survival after starting vindesine therapy was 4 months (1-22 months). We conclude that vindesine monotherapy is ineffective in stage IV melanoma patients previously treated with other chemotherapeutic agents."],["dc.identifier.doi","10.1097/00008390-200306000-00012"],["dc.identifier.isi","000183426800012"],["dc.identifier.pmid","12777986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45877"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0960-8931"],["dc.title","Inefficacy of vindesine monotherapy in advanced stage IV malignant melanoma patients previously treated with other chemotherapeutic agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","342"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Der Hautarzt"],["dc.bibliographiccitation.lastpage","347"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Hanssle, H."],["dc.contributor.author","Grafe, A."],["dc.contributor.author","Domhof, S."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T10:39:45Z"],["dc.date.available","2018-11-07T10:39:45Z"],["dc.date.issued","2003"],["dc.description.abstract","Background and Objective. The objective of the study was to evaluate the use of a medical surgical zipper (Medizip(TM)) for wound closure under tension in comparison to conventional cutaneous sutures. The surgical zipper is supposed to reduce wound tension by approximating of the wound edges via epidermal traction. Patients/Methods. This prospective study included patients with a wound diameter of more than 1 cm. 45 patients were treated with the surgical zipper, 38 were randomized into a control group with conventional wound closure. Scars were assessed after 6-18 months focusing on aesthetic and functional aspects. Results. The average length of the scars in both groups was 9 cm, but after a observation time of at least 6 month, there were differences in the width of the scars. The group with the surgical zipper showed significantly thinner scars (2,74 mm versus 4,24 mm, p=0,0008). Only 17% of the Medizip(TM) patients developed unaesthetic rope ladder-like scars versus 65% in the control group. This observation was statistically significant (p<0,0001). Conclusions. Wound stabilization by approximation of the wound edges via surgical zipper results in improved scar formation in wounds with moderate tension. Using the Medizip(TM) in wounds under heavy tension is not recommended because of the possible development of to tension bullae under the zipper."],["dc.identifier.doi","10.1007/s00105-002-0460-7"],["dc.identifier.isi","000182445300006"],["dc.identifier.pmid","12669206"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46127"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0017-8470"],["dc.title","Improved scar formation after using a medical surgical zipper for wound closure under tension"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","22"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical and Experimental Dermatology"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Moussa, I."],["dc.contributor.author","Haas, E."],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T11:19:42Z"],["dc.date.available","2018-11-07T11:19:42Z"],["dc.date.issued","2008"],["dc.description.abstract","We describe the rare Stewart-Bluefarb syndrome in a 15-year-old boy. This syndrome presents as a congenital arteriovenous malformation of the lower leg with multiple arteriovenous shunts accompanied by the benign acroangiodermatitis of Mali (pseudo-Kaposi's sarcoma). The clinical features of this disorder and the treatment options are reviewed."],["dc.identifier.doi","10.1111/j.1365-2230.2007.02541.x"],["dc.identifier.isi","000251809700004"],["dc.identifier.pmid","17927784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55347"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0307-6938"],["dc.title","Acroangiodermatitis Mali resulting from arteriovenous malformation: report of a case of Stewart-Bluefarb syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1166"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of the American Academy of Dermatology"],["dc.bibliographiccitation.lastpage","1169"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Kuster, W. K."],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Hanssle, H."],["dc.contributor.author","Hallermann, Christian"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:34:27Z"],["dc.date.available","2018-11-07T10:34:27Z"],["dc.date.issued","2003"],["dc.description.abstract","We describe a new family with the rare genodermatosis keratosis punctata palmo-plantaris Buschke-Fischer-Brauer (keratoma disseminatum). in all, 3 family members in 3 generations were affected, a pattern consistent with autosomal dominant inheritance. Clinical symptoms started in the third decade with disseminated, small, round, hyperkeratotic papules on the palms and soles. Punctate keratoses coalesced into hyperkeratotic plaques on pressure points. Identification of additional families is necessary to permit definitive genetic classification of this genodermatosis."],["dc.identifier.doi","10.1016/S0190-9622(03)00472-9"],["dc.identifier.isi","000186784800035"],["dc.identifier.pmid","14639410"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44878"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby, Inc"],["dc.relation.issn","0190-9622"],["dc.title","A new family with the rare genodermatosis keratosis punctata palmoplantaris Buschke-Fischer-Brauer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Dermatology"],["dc.bibliographiccitation.lastpage","76"],["dc.bibliographiccitation.volume","207"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Strutz, Frank M."],["dc.contributor.author","Happle, R."],["dc.contributor.author","Habenicht, E. M."],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:42:19Z"],["dc.date.available","2018-11-07T10:42:19Z"],["dc.date.issued","2003"],["dc.description.abstract","The Schimmelpenning-Feuerstein-Mims syndrome (SFM syndrome) is a rare and variable multisystem defect consisting of congenital, extensive linear nevus sebaceus and associated abnormalities in different neuroectodermal organ systems. We present the history of a 52-year-old female patient with disproportionate hyposomia and asymmetric constitution. From birth she suffered from a right-sided, extensive nevus sebaceus following Blaschko's lines extending on the scalp, neck, right arm and trunk. At the age of 5 years, she developed a generalized growth retardation, along with deformations of bones. At the age of 11, hypophosphatemic rickets was diagnosed causing this growth retardation. Moreover, the patient developed a precocious puberty at the age of 9 years. When we saw the patient 40 years after the diagnosis had been made, phosphaturia had returned to normal. Specific therapy of hypophosphatemic rickets is straightforward and efficient in preventing late complications like growth retardation. We suggest to conduct appropriate laboratory tests in early childhood in patients with an extensive systematized sebaceous nevus or with additional signs of growth retardation or skeletal involvement, in order to exclude hypophosphatemic rickets associated with SFM syndrome. Copyright (C) 2003 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000070948"],["dc.identifier.isi","000183981800018"],["dc.identifier.pmid","12835555"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46766"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1018-8665"],["dc.title","Schimmelpenning-Feuerstein-Mims syndrome with hypophosphatemic rickets"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","99"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Dermatologic Surgery"],["dc.bibliographiccitation.lastpage","101"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.date.accessioned","2018-11-07T10:42:19Z"],["dc.date.available","2018-11-07T10:42:19Z"],["dc.date.issued","2003"],["dc.description.abstract","BACKGROUND. Dermabrasion is one approach to the treatment of treating giant melanocytic congenital nevi. Treatment is recommended to reduce the risk of spontaneous malignant transformation of giant nevi into malignant melanomas that usually occur in childhood. OBJECTIVE. To describe the development of a multicentric malignant melanoma in a giant melanocytic congenital nevus after dermabrasion. METHODS. We report about a 46-year-old male patient who developed a multicentric malignant melanoma in a giant melanocytic congenital nevus. The nevus was located on his left shoulder extending to his neck and chest. Previously, dermabrasion of the nevus was performed twice at the ages of 26 and 28. RESULTS. To our knowledge, this is the first report of malignant transformation of a giant nevus into a multicentric malignant melanoma diagnosed 20 years after the procedure of dermabrasion. CONCLUSION. We conclude that a close follow-up of such patients is mandatory."],["dc.identifier.doi","10.1046/j.1524-4725.2003.29007.x"],["dc.identifier.isi","000180389800018"],["dc.identifier.pmid","12534521"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46765"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Inc"],["dc.relation.issn","1076-0512"],["dc.title","Multicentric malignant melanoma in a giant melanocytic congenital nevus 20 years after dermabrasion in adulthood"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","16"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","EUROPEAN JOURNAL OF DERMATOLOGY"],["dc.bibliographiccitation.lastpage","20"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Kuster, W."],["dc.contributor.author","Hennies, Hans Christian"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:42:21Z"],["dc.date.available","2018-11-07T10:42:21Z"],["dc.date.issued","2003"],["dc.description.abstract","We summarize the clinical data of 47 patients with the rare genodermatosis keratosis punctata palmoplantaris Buschke-Fischer-Brauer. The pedigrees of 14 German families were studied. In three families there was only one member affected, two or more affected members were found in the other families. These family pedigrees were consistent with autosomal dominant inheritance. Variable expression of, the disease was noted in members within one family. Over pressure points punctate keratoses coalesced into hyperkeratotic plaques. There was palmoplantar hyperhidrosis in 3 families associated with keratosis. Continuous systemic retinoid treatment can clear symptoms. Future genetic classification on a molecular basis may reveal the existance of more than one entity of this clinically heterogeneous genodermatosis."],["dc.identifier.isi","000181167700004"],["dc.identifier.pmid","12609775"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46774"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Libbey Eurotext Ltd"],["dc.relation.issn","1167-1122"],["dc.title","47 patients in 14 families with the rare genodermatosis keratosis punctata palmoplantaris Buschke-Fischer-Brauer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","423"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Hautarzt"],["dc.bibliographiccitation.lastpage","427"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Hanssle, H."],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T09:52:31Z"],["dc.date.available","2018-11-07T09:52:31Z"],["dc.date.issued","2006"],["dc.description.abstract","Background: Loss of appetite and nausea can reduce the quality of life of patients with malignant melanoma and liver metastases. Often established antiemetic drugs fail to bring relief Tetrahydrocannabinol (THC, Marinol (TM)), which is the active agent of Indian hemp, has been used successfully in this situation for other malignant tumors. Patients and methods: We treated 7 patients with hematogenous metastatic melanoma and liver metastases suffering from extensive loss of appetite and nausea supportively with dronabinol (Marinol (R)). All of these patients had previously received standard antiemetic therapy without adequate relief Dronabinol is a synthetic A-tetrahydrocannabinol. The drug was administered in capsule form. We evaluated the palliative effects of dronabinol with a special patient evaluation form, which was filled out at the beginning of the therapy and again after 4 weeks. Results: The majority of patients described a significant increase in appetite and decrease in nausea. These effects remained for some weeks, but then decreased as metastases progressed and the general condition worsened. All of the patients experienced slight to moderate dizziness, but it was not sufficiently troubling to cause interruption or termination of therapy. Conclusion: Loss of appetite and nausea due to liver metastases of malignant melanoma can be treated in individual cases supportively with Dronabinol."],["dc.identifier.doi","10.1007/s00105-005-1063-x"],["dc.identifier.isi","000237870000011"],["dc.identifier.pmid","16408219"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36145"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0017-8470"],["dc.title","Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]