Zutt, Markus

[["dc.bibliographiccitation.firstpage","1432"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of the European Academy of Dermatology and Venereology"],["dc.bibliographiccitation.lastpage","1439"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","von Ahsen, Nicolas"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:49:13Z"],["dc.date.available","2018-11-07T08:49:13Z"],["dc.date.issued","2011"],["dc.description.abstract","Background Chronic venous leg ulcers (CVU) cause considerable burden of disease for the patients as well as enormous costs for health care systems. The pathophysiology of CVU is complex and not entirely understood. So far reliable pathogenic and/or prognostic parameters have not been identified. Objectives We studied the role of thrombophilia in patients referred to a University dermatology department for treatment of CVU. Patients and methods A cohort of 310 patients with active chronic venous leg ulcers (CEAP 6) was stratified into two comparably large groups according to the presence or absence of post- thrombotic syndrome (PTS+; PTS-) as determined using duplex scan and/or phlebography. In addition, several thrombophilia parameters were assessed. Results The prevalence of protein S deficiency and factor V Leiden mutation was significantly higher in PTS+ patients compared with the PTS- group. However, patients in both subgroups revealed high prevalences of thrombophilia (antithrombin deficiency, protein C deficiency, protein S deficiency, activated protein C resistance, factor V mutation or elevated homocysteine). Conclusion Based on these data, it is conceivable that thrombophilia contributes to the pathogenesis of CVU, possibly through induction of microcirculatory dysregulations."],["dc.identifier.doi","10.1111/j.1468-3083.2011.04001.x"],["dc.identifier.isi","000297952800011"],["dc.identifier.pmid","21392126"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21406"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0926-9959"],["dc.title","Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T08:52:30Z"],["dc.date.available","2018-11-07T08:52:30Z"],["dc.date.issued","2011"],["dc.format.extent","7"],["dc.identifier.isi","000294842800023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22182"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Percutaneous transluminal Angioplasty (PTA) in Ulcus cruris mixtum"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","324"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Dermatology"],["dc.bibliographiccitation.lastpage","328"],["dc.bibliographiccitation.volume","226"],["dc.contributor.author","Kaune, Kjell Matthias"],["dc.contributor.author","Haas, Ellen"],["dc.contributor.author","Jantke, Maren"],["dc.contributor.author","Kramer, Franz-Josef"],["dc.contributor.author","Gruber, Rudolf"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Schön, Michael P."],["dc.date.accessioned","2018-11-07T09:29:38Z"],["dc.date.available","2018-11-07T09:29:38Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Concepts of reconstruction of intraoral structures may often include the transfer of flaps composed of external skin with hairs. Given that intraoral hair growth following myocutaneous flaps can cause discomfort, there is a need for effective treatments to relieve cancer patients of these symptoms. Objective: To describe the successful epilation of hairy intraoral flaps using Nd:YAG laser emitting a wavelength of 1,064 nm. Methods: We performed an interdisciplinary prospective clinical study with 9 patients suffering from intraoral hair growth after plastic reconstruction of a hairy donor site due to cancer. Eight male and one female patients were treated with 1-4 sessions of Nd:YAG laser at 5-15-week intervals. Results: Laser treatment resulted in effective hair reduction in 8/9 patients regardless of flap type. In 5/9 patients a hair clearance of > 90% could be achieved, whereas laser treatment was ineffective in one male with white hair. Patients were very satisfied with the outcome and no side effects could be observed. Conclusion: Nd:YAG laser therapy appears to be a successful therapeutic option for patients suffering from growth of dark hair in the oral cavity after plastic reconstruction using a hairy donor site. (C) 2013 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000350685"],["dc.identifier.isi","000324547600007"],["dc.identifier.pmid","23838394"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10820"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31086"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","S. Karger AG"],["dc.relation.eissn","1421-9832"],["dc.relation.issn","1018-8665"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Successful Nd:YAG Laser Therapy for Hair Removal in the Oral Cavity after Plastic Reconstruction Using Hairy Donor Sites"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Mempel, Martin"],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T08:52:31Z"],["dc.date.available","2018-11-07T08:52:31Z"],["dc.date.issued","2011"],["dc.format.extent","18"],["dc.identifier.isi","000294842800061"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22188"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Lymphocytoma cutis benigna on the Eyebrow"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","184"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","186"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Mousa, Waseem"],["dc.contributor.author","Kues, Kirsten"],["dc.contributor.author","Haas, Ellen"],["dc.contributor.author","Lauerer, Peter"],["dc.contributor.author","Pavlakovic, Helena"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T08:45:30Z"],["dc.date.available","2018-11-07T08:45:30Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1111/j.1610-0387.2009.07266.x"],["dc.identifier.isi","000274923300007"],["dc.identifier.pmid","19788583"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20458"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","1610-0379"],["dc.title","Erfolgreiche Therapie mit Propranolol bei ausgedehntem Sauglings-Hamangiom"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","168"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Wound Repair and Regeneration"],["dc.bibliographiccitation.lastpage","172"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Neumann, Christine"],["dc.contributor.author","von Ahsen, Nico"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:58:36Z"],["dc.date.available","2018-11-07T08:58:36Z"],["dc.date.issued","2011"],["dc.description.abstract","Chronic venous leg ulcers are common and cause considerable burden of disease for affected patients with significant costs for health care systems worldwide. The complex pathophysiology of chronic venous leg ulcers is still not entirely understood. In addition, reliable pathogenic and/or prognostic parameters are not known. Published data suggest that patients with chronic venous leg ulcers reveal congenital or acquired thrombophilia. We examined the serum Lipoprotein (a) [Lp(a)] level, a proatherogenic and prothrombotic risk factor, in patients with chronic venous leg ulcers (n=210, stratified into patients with postthrombotic syndrome or without) and in a healthy control group (n=341). Forty-two percent of all patients, compared with 20% of healthy controls, revealed significantly increased Lp(a) serum concentrations above 0.3 g/L. Furthermore, 49% without postthrombotic syndrome but only 35% with postthrombotic syndrome showed increased Lp(a) levels. The increase of Lp(a) level was significantly different between all three groups (p < 0.001). There was no correlation of Lp(a) levels and CRP values in all groups. Based on these data, it is conceivable that Lp(a) plasma level is a novel pathogenic parameter for chronic venous leg ulcers. Elevated concentrations may contribute to the pathogenesis through induction of thrombogenic microcirculatory dysregulations, impaired extravascular fibrinolysis, or other mechanisms like proinflammatory effects."],["dc.identifier.doi","10.1111/j.1524-475X.2010.00657.x"],["dc.identifier.isi","000287878100225"],["dc.identifier.pmid","21362083"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23682"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1067-1927"],["dc.title","Increased Lipoprotein (a) concentrations in patients with chronic venous leg ulcers: a study on patients with or without postthrombotic syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Lockmann, Anike"],["dc.contributor.author","Groenemeyer, L.-L."],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","von Fintel, H."],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Thoms, Kai Martin"],["dc.date.accessioned","2018-11-07T09:58:42Z"],["dc.date.available","2018-11-07T09:58:42Z"],["dc.date.issued","2015"],["dc.format.extent","97"],["dc.identifier.isi","000360219000277"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37426"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Nd:YAG- and pulsed Colouring Laster-Therapy of 271 infantile Haemangiomas in 149 Children: a retrospective Analysis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","457"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","463"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Krüger, Ullrich"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Padeken, Michael"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Schön, Michael"],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T08:51:33Z"],["dc.date.available","2018-11-07T08:51:33Z"],["dc.date.issued","2011"],["dc.description.abstract","Early detection of melanoma metastases is essential for effective treatment and may be crucial for the prevention of systemic metastases and patient survival. However, data demonstrating the reliability and accuracy of ultrasound examination for the detection of lymph node metastases, in addition to clinical examination, are rare. We have examined 433 melanoma patients with stage-dependent follow-up intervals of 3 to 12 months. One thousand three hundred and thirty-two paired clinical and nonblinded sonographic tests of the locoregional lymph node areas were performed. Lesions suspicious of melanoma metastases were examined histopathologically. Of note, sensitivity [0.9394 (95% confidence interval: 0.7977-0.9926)] and specificity [0.9808 (95% confidence interval: 0.9717-0.9875)] of combined clinical and sonographic investigations were significantly (P < 0.0001) higher than clinical results alone. Significant differences between clinical follow-up and sonographically assisted follow-up were found for American Joint Committee on Cancer 2002 melanoma stages I (P = 0.0389), III P = 0.0101), and IV (P = 0.0016). For stage II melanoma, a trend was detected (P = 0.0821). Lymph node metastases were detected sonographically in 1.73% of clinically metastasis-free investigations (n = 22). Our data suggest that high-frequency sonography should be part of all melanoma follow-up investigations, independent of melanoma type, melanoma stage, or lymph node biopsy status. Melanoma Res 21:457-463 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins."],["dc.identifier.doi","10.1097/CMR.0b013e328348dad3"],["dc.identifier.isi","000294681900012"],["dc.identifier.pmid","21730878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21960"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0960-8931"],["dc.title","Lymph node ultrasound during melanoma follow-up significantly improves metastasis detection compared with clinical examination alone: a study on 433 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","473"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","478"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kaune, Kjell Matthias"],["dc.contributor.author","Lauerer, Peter"],["dc.contributor.author","Kietz, Silke"],["dc.contributor.author","Eich, Christoph B."],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T09:39:25Z"],["dc.date.available","2018-11-07T09:39:25Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Infantile hemangiomas (IH) can cause severe complications like obstruction, ulceration or heart failure. Therefore, in certain difficult-to-treat areas or in absent regression an early and sufficient therapy is required. As systemic treatments like the beta-blocker propranolol or oral corticosteroids can lead to serious side effects in rare cases, effective and well-tolerated local treatment options as an additive or alternative would be desirable. Patients and Methods: In this retrospective interdisciplinary study 38 children with 77 IH were treated with the pulsed dye laser (PDL) (595 nm) and Nd:YAG laser (1 064 nm). The treatment success and the side effects were evaluated on the basis of objective parameters like sonographically proven depth extend as well as subjectively by the parents of the children. Results: All 77 treated IH responded to the therapy, of which 52.8 % had healed after the end of treatment and 47.2 % showed only a minimum residual. The success of treatment was assessed by the parents in 92.6 % as very good or good. As the main side effect in 45.9 % a transient blistering occurred. Conclusions: The combination therapy with PDL and Nd:YAG laser represents an effective local therapy against IH with minimal side effects."],["dc.identifier.doi","10.1111/ddg.12354"],["dc.identifier.isi","000337590600005"],["dc.identifier.pmid","24825388"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33276"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Combination therapy of infantile hemangiomas with pulsed dye laser and Nd:YAG laser is effective and safe"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","830"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","EUROPEAN JOURNAL OF DERMATOLOGY"],["dc.bibliographiccitation.lastpage","836"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Ayad, Nadia"],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T09:17:43Z"],["dc.date.available","2018-11-07T09:17:43Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: D-dimer analysis and clinical probability scoring (Wells-score) show a high sensitivity and negative predictive value for the exclusion of deep vein thrombosis (DVT). Objective: To identify the diagnostic performance of D-dimer testing and Wells-score in hospitalized patients with dermatologic conditions. Methods: In this retrospective cohort study, 109 examinations in 102 patients were performed by Wells-score, Tina-quant (R) D-dimer testing and whole-leg duplex ultrasonography or phlebography. Results: DVT was confirmed in 14 patients. The Wells-score alone allowed no discrimination of DVT and non-DVT patients. D-dimer testing identified all cases of DVT (100% sensitivity). Only 16 patients showed D-dimers within normal limits and none was diagnosed with DVT (100% negative predictive value). A high rate of false-positive D-dimer results (72%) led to a low specificity (17%). The number needed-to-test to exclude one DVT was 6.8. Based on multivariate statistical analysis, increased D-dimer levels were significantly associated with the dermatologic main diagnosis (p = 0.008), age (p = 0.001) and with the presence of DVT (p = 0.011). The highest D-dimer values were found in non-DVT patients with metastasized or systemic malignancies (median 2.48 mg/L) or inflammatory skin conditions (e.g. generalized psoriasis, median 2.22 mg/L). Conclusions: Wells-score and D-Dimer testing were of limited diagnostic value because of many false-positive results. Required imaging procedures were reduced by only 16 cases (15%). Therefore, we suggest directly investigating hospitalized dermatologic patients with suspected DVT and skin diseases associated with high D-Dimer levels, by whole-leg compression ultrasonography."],["dc.identifier.doi","10.1684/ejd.2013.2188"],["dc.identifier.isi","000331460000012"],["dc.identifier.pmid","24192389"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28233"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Libbey Eurotext Ltd"],["dc.relation.issn","1952-4013"],["dc.relation.issn","1167-1122"],["dc.title","Limited diagnostic value of Wells-score and D-dimer testing in hospitalized dermatologic patients with symptoms of deep vein thrombosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]