Zutt, Markus

[["dc.bibliographiccitation.firstpage","1432"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of the European Academy of Dermatology and Venereology"],["dc.bibliographiccitation.lastpage","1439"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","von Ahsen, Nicolas"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:49:13Z"],["dc.date.available","2018-11-07T08:49:13Z"],["dc.date.issued","2011"],["dc.description.abstract","Background Chronic venous leg ulcers (CVU) cause considerable burden of disease for the patients as well as enormous costs for health care systems. The pathophysiology of CVU is complex and not entirely understood. So far reliable pathogenic and/or prognostic parameters have not been identified. Objectives We studied the role of thrombophilia in patients referred to a University dermatology department for treatment of CVU. Patients and methods A cohort of 310 patients with active chronic venous leg ulcers (CEAP 6) was stratified into two comparably large groups according to the presence or absence of post- thrombotic syndrome (PTS+; PTS-) as determined using duplex scan and/or phlebography. In addition, several thrombophilia parameters were assessed. Results The prevalence of protein S deficiency and factor V Leiden mutation was significantly higher in PTS+ patients compared with the PTS- group. However, patients in both subgroups revealed high prevalences of thrombophilia (antithrombin deficiency, protein C deficiency, protein S deficiency, activated protein C resistance, factor V mutation or elevated homocysteine). Conclusion Based on these data, it is conceivable that thrombophilia contributes to the pathogenesis of CVU, possibly through induction of microcirculatory dysregulations."],["dc.identifier.doi","10.1111/j.1468-3083.2011.04001.x"],["dc.identifier.isi","000297952800011"],["dc.identifier.pmid","21392126"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21406"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0926-9959"],["dc.title","Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T08:52:30Z"],["dc.date.available","2018-11-07T08:52:30Z"],["dc.date.issued","2011"],["dc.format.extent","7"],["dc.identifier.isi","000294842800023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22182"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Percutaneous transluminal Angioplasty (PTA) in Ulcus cruris mixtum"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0959-8049(02)00534-8"],["dc.bibliographiccitation.firstpage","175"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","183"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Meller, J."],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Funke, M."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2021-06-01T10:50:19Z"],["dc.date.available","2021-06-01T10:50:19Z"],["dc.date.issued","2003"],["dc.description.abstract","To date, there are no reliable criteria to identify those patients with melanoma-infiltrated sentinel lymph nodes (SLNs) of the groin who might benefit from an extended lymphadenectomy, including the pelvic lymph nodes. We hypothesised that there are pelvic lymph nodes that receive lymph directly from the primary tumour, thus being at an increased risk for metastasis. In order to determine the frequency of radioactively labelled pelvic lymph nodes and the kinetics of their appearance, we introduce here a combination of dynamic lymphoscintigraphy, single photon emission computed tomography (SPECT) and image fusion of SPECT and pelvic Computed Tomography (CT)-scans. By dynamic lymphoscintigraphy and intraoperative gamma probe detection, superficially located inguinal SLNs (median 2 nodes) could be identified in all of the 51 patients included in this analysis. The histological search for micrometastases was positive in 16 patients (median Breslow thickness of the primary melanoma 2.5 mm). In 29 patients, SPECT and the image fusion technique were additionally performed. Radioactively labelled pelvic lymph nodes were detected in 20 individuals, 6 of them presenting aberrant pelvic SLNs that, on dynamic lymphoscintigraphy, had appeared simultaneously with the superficial SLN(s). Of the 6 patients in whom radioactive pelvic lymph nodes were excised together with the superficial SLN(s), only one had positive superficial SLNs. In this patient, the aberrant pelvic SLN proved to be tumour-positive. In 9 patients, there was no radiotracer uptake in the pelvic lymph nodes at all. Image fusion of SPECT and pelvic CT-scans is an excellent tool to localise exactly the pelvic tumour-draining nodes. The significance of radioactively labelled pelvic lymph nodes for the probability of pelvic metastases should be analysed further. (C) 2002 Elsevier Science Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0959-8049(02)00534-8"],["dc.identifier.isi","000181789200017"],["dc.identifier.pmid","12509949"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86614"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Dynamic lymphoscintigraphy and image fusion of SPECT and pelvic CT-scans allow mapping of aberrant pelvic sentinel lymph nodes in malignant melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Mempel, Martin"],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T08:52:31Z"],["dc.date.available","2018-11-07T08:52:31Z"],["dc.date.issued","2011"],["dc.format.extent","18"],["dc.identifier.isi","000294842800061"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22188"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Lymphocytoma cutis benigna on the Eyebrow"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","184"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","186"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Mousa, Waseem"],["dc.contributor.author","Kues, Kirsten"],["dc.contributor.author","Haas, Ellen"],["dc.contributor.author","Lauerer, Peter"],["dc.contributor.author","Pavlakovic, Helena"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T08:45:30Z"],["dc.date.available","2018-11-07T08:45:30Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1111/j.1610-0387.2009.07266.x"],["dc.identifier.isi","000274923300007"],["dc.identifier.pmid","19788583"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20458"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","1610-0379"],["dc.title","Erfolgreiche Therapie mit Propranolol bei ausgedehntem Sauglings-Hamangiom"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","299"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","302"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T10:38:43Z"],["dc.date.available","2018-11-07T10:38:43Z"],["dc.date.issued","2003"],["dc.description.abstract","The anti-melanoma activity of vindesine as a single or polychemotherapeutic agent has been reported previously in adjuvant and first-line melanoma treatment. In this study, we investigated the usefulness of vindesine monotherapy as salvage therapy in stage IV melanoma patients after failure of other chemotherapies. Thirteen patients with progressive disease were treated with 3 mg/m(2) vindesine every 2 weeks (median age, 61 years). Previous systemic treatment consisted of polychemotherapy or combined chemo-immunotherapy. All 13 patients suffered from visceral metastases (three lung, one liver, one adrenal gland and eight multiple visceral metastases). A median of three vindesine treatments was administered. Despite the various pretreatments, the toxicity of vindesine was mild. In all 13 patients, vindesine treatment was stopped due to disease progression. The median survival after primary tumour diagnosis was 42 months (8-151 months), the survival after entering stage IV was 11 months (3-35 months), and the survival after starting vindesine therapy was 4 months (1-22 months). We conclude that vindesine monotherapy is ineffective in stage IV melanoma patients previously treated with other chemotherapeutic agents."],["dc.identifier.doi","10.1097/00008390-200306000-00012"],["dc.identifier.isi","000183426800012"],["dc.identifier.pmid","12777986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45877"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0960-8931"],["dc.title","Inefficacy of vindesine monotherapy in advanced stage IV malignant melanoma patients previously treated with other chemotherapeutic agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","168"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Wound Repair and Regeneration"],["dc.bibliographiccitation.lastpage","172"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Neumann, Christine"],["dc.contributor.author","von Ahsen, Nico"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:58:36Z"],["dc.date.available","2018-11-07T08:58:36Z"],["dc.date.issued","2011"],["dc.description.abstract","Chronic venous leg ulcers are common and cause considerable burden of disease for affected patients with significant costs for health care systems worldwide. The complex pathophysiology of chronic venous leg ulcers is still not entirely understood. In addition, reliable pathogenic and/or prognostic parameters are not known. Published data suggest that patients with chronic venous leg ulcers reveal congenital or acquired thrombophilia. We examined the serum Lipoprotein (a) [Lp(a)] level, a proatherogenic and prothrombotic risk factor, in patients with chronic venous leg ulcers (n=210, stratified into patients with postthrombotic syndrome or without) and in a healthy control group (n=341). Forty-two percent of all patients, compared with 20% of healthy controls, revealed significantly increased Lp(a) serum concentrations above 0.3 g/L. Furthermore, 49% without postthrombotic syndrome but only 35% with postthrombotic syndrome showed increased Lp(a) levels. The increase of Lp(a) level was significantly different between all three groups (p < 0.001). There was no correlation of Lp(a) levels and CRP values in all groups. Based on these data, it is conceivable that Lp(a) plasma level is a novel pathogenic parameter for chronic venous leg ulcers. Elevated concentrations may contribute to the pathogenesis through induction of thrombogenic microcirculatory dysregulations, impaired extravascular fibrinolysis, or other mechanisms like proinflammatory effects."],["dc.identifier.doi","10.1111/j.1524-475X.2010.00657.x"],["dc.identifier.isi","000287878100225"],["dc.identifier.pmid","21362083"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23682"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1067-1927"],["dc.title","Increased Lipoprotein (a) concentrations in patients with chronic venous leg ulcers: a study on patients with or without postthrombotic syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","244"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Clinical and Experimental Dermatology"],["dc.bibliographiccitation.lastpage","246"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Wolf, C."],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T10:49:10Z"],["dc.date.available","2018-11-07T10:49:10Z"],["dc.date.issued","2004"],["dc.description.abstract","Pityriasis rubra pilaris (PRP) is a rare papulosquamous skin disease of unknown aetiology that has been categorized into five clinical types based on age at onset, cutaneous features and prognosis. We present a patient with chronic exanthematic type II atypical adult PRP, whose skin status was significantly improved with monthly extracorporeal photochemotherapy (ECP). Various therapeutic regimens including narrow-band UV-B, bath PUVA therapy, systemic fumaric acid esters and systemic cyclosporin had failed. Oral retinoids could not be administered due to a type IIa hyperlipoproteinemia with profound hepatic steatosis and elevated liver transaminases. The observed clinical benefit may encourage future clinical studies analysing the effectiveness of ECP in otherwise unresponsive cases of type II PRP."],["dc.identifier.doi","10.1111/j.1365-2230.2004.01468.x"],["dc.identifier.isi","000221125900006"],["dc.identifier.pmid","15115502"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48365"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Ltd"],["dc.relation.issn","0307-6938"],["dc.title","Extracorporeal photochemotherapy for the treatment of exanthematic pityriasis rubra pilaris"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","342"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Der Hautarzt"],["dc.bibliographiccitation.lastpage","347"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Hanssle, H."],["dc.contributor.author","Grafe, A."],["dc.contributor.author","Domhof, S."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T10:39:45Z"],["dc.date.available","2018-11-07T10:39:45Z"],["dc.date.issued","2003"],["dc.description.abstract","Background and Objective. The objective of the study was to evaluate the use of a medical surgical zipper (Medizip(TM)) for wound closure under tension in comparison to conventional cutaneous sutures. The surgical zipper is supposed to reduce wound tension by approximating of the wound edges via epidermal traction. Patients/Methods. This prospective study included patients with a wound diameter of more than 1 cm. 45 patients were treated with the surgical zipper, 38 were randomized into a control group with conventional wound closure. Scars were assessed after 6-18 months focusing on aesthetic and functional aspects. Results. The average length of the scars in both groups was 9 cm, but after a observation time of at least 6 month, there were differences in the width of the scars. The group with the surgical zipper showed significantly thinner scars (2,74 mm versus 4,24 mm, p=0,0008). Only 17% of the Medizip(TM) patients developed unaesthetic rope ladder-like scars versus 65% in the control group. This observation was statistically significant (p<0,0001). Conclusions. Wound stabilization by approximation of the wound edges via surgical zipper results in improved scar formation in wounds with moderate tension. Using the Medizip(TM) in wounds under heavy tension is not recommended because of the possible development of to tension bullae under the zipper."],["dc.identifier.doi","10.1007/s00105-002-0460-7"],["dc.identifier.isi","000182445300006"],["dc.identifier.pmid","12669206"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46127"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0017-8470"],["dc.title","Improved scar formation after using a medical surgical zipper for wound closure under tension"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","566"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","568"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Stahl, Maren"],["dc.contributor.author","Meyer, Cora"],["dc.contributor.author","Haas, Ellen"],["dc.contributor.author","Glaenz, Thomas"],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T11:13:33Z"],["dc.date.available","2018-11-07T11:13:33Z"],["dc.date.issued","2008"],["dc.description.abstract","While treating a 63-year-old woman with leg ulcerations, we observed an unusual phenomenon. A wound debridement was planned to remove adherent necrotic material. After topical anesthesia with a lidocaine-prilocaine mixture ( EMLA cream) a hemorrhagic, livid margin area developed around the ulcer 90 minutes after application. The area turned necrotic over days and the center was debrided. A more detailed history revealed that similar necrosis had occurred previously when EMLA cream had been employed. We interpreted the current event, as well as the past episodes, as a pathological reaction of the small cutaneous blood vessels to EMLA cream. The history also revealed an overlap connective tissue disease with microvascular impairment. After exposure to the topical anesthetics, the pre-damaged cutaneous blood vessels presumably produced a critical ischemia with subsequent necrosis. Based on this case, we recommend careful use of EMLA cream with frequent monitoring for necrosis when treating patients with a known disorder of microcirculation."],["dc.identifier.doi","10.1111/j.1610-0387.2007.06532.x"],["dc.identifier.isi","000256969100007"],["dc.identifier.pmid","17941883"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53925"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0379"],["dc.title","Leg ulcer progression caused by topical anesthesia with EMLA (TM) cream"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]