Bramlage, Carsten

[["dc.bibliographiccitation.firstpage","A100"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","MEDIZINISCHE KLINIK"],["dc.bibliographiccitation.lastpage","A101"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Scheel, A."],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Grone, H. J."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T09:59:01Z"],["dc.date.available","2018-11-07T09:59:01Z"],["dc.date.issued","2006"],["dc.identifier.isi","000237562000323"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37491"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.issn","0723-5003"],["dc.title","Effective therapy of a hepatitis-C-associated immunocomplex nephritis by means of cryoprecipitate apheresis and interferon-alpha"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S8"],["dc.bibliographiccitation.issue","46"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","S9"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Bevandaf, J."],["dc.contributor.author","Maatouk, I."],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Lauterberg, Christina"],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T10:52:57Z"],["dc.date.available","2018-11-07T10:52:57Z"],["dc.date.issued","2007"],["dc.identifier.isi","000251423500025"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49234"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.issn","0012-0472"],["dc.title","BMP-5 is expressed in renal interstitial fibroblasts and has TGF-beta neutralizing effect in vitro"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","401"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Scandinavian Journal of Rheumatology"],["dc.bibliographiccitation.lastpage","409"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Kaps, C."],["dc.contributor.author","Ungethuem, U."],["dc.contributor.author","Bramlage, Peter"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Wessels, Johannes Theodor"],["dc.contributor.author","Krenn, V."],["dc.contributor.author","Pruss, Axel"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Strutz, Frank M."],["dc.contributor.author","Burmester, Gerd-Ruediger"],["dc.contributor.author","Haeupl, T."],["dc.date.accessioned","2018-11-07T11:20:44Z"],["dc.date.available","2018-11-07T11:20:44Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective: Growth differentiation factor-5 (GDF-5), a member of the transforming growth factor (TGF)-beta family, is involved in joint development during embryogenesis and has the potential to regenerate cartilage in adult animals. As progression of chronic joint diseases is influenced by cytokines of the synovial tissue, we examined the expression and effects of GDF-5 in this tissue. Methods: Microarray experiments were investigated for differential expression of GDF-5 in synovial tissues, synovial fibroblasts, and peripheral blood cells. GDF-5 expression was validated by semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR), immunohistochemistry, double immunofluorescence, and in situ hybridization in synovial tissue of normal donors (ND) and patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Effects of inflammation and therapy were investigated in RA and OA fibroblasts after stimulation with interleukin (IL)-1 beta, tumour necrosis factor (TNF)-alpha, methotrexate (MTX), and prednisolone. The influence of GDF-5 on macophages was studied by chemotaxis assay. Results: Microarray analysis and immunostaining revealed expression predominantly in synovial fibroblasts. Compared to patients without immunomodulating drugs, expression of GDF-5 was decreased significantly in patients receiving glucocorticoids and/or disease-modifying antirheumatic drugs (DMARDs) (p=0.007), but did not differ between the total group of ND, OA, and RA. Stimulation with prednisolone and TNF alpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1 beta revealed minor or no relevant change. GDF-5 also reduced cell migration of macrophages (p<0.001). Conclusion: GDF-5 is expressed in synovial fibroblasts and may counteract macrophage infiltration. Its modulation by inflammation and therapy suggests that glucocorticoids play a conflicting role by suppressing not only inflammation but also putative mechanisms of repair."],["dc.identifier.doi","10.1080/03009740802120010"],["dc.identifier.isi","000262270200001"],["dc.identifier.pmid","18830904"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55613"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis As"],["dc.relation.issn","0300-9742"],["dc.title","Modulatory effects of inflammation and therapy on GDF-5 expression in rheumatoid arthritis synovium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Hypertension"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Amann, Kerstin"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T11:14:45Z"],["dc.date.available","2018-11-07T11:14:45Z"],["dc.date.issued","2008"],["dc.format.extent","S154"],["dc.identifier.isi","000257197001070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54209"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","18th Scientific Meeting of the European-Society-of-Hypertension/22nd Scientific Meeting of the International-Society-of-Hypertension"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0263-6352"],["dc.title","The prenatal exposure of dexamethason in marmoset monkeys does not result in hypertension"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","MEDIZINISCHE KLINIK"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Werner, C."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T09:58:58Z"],["dc.date.available","2018-11-07T09:58:58Z"],["dc.date.issued","2006"],["dc.format.extent","A100"],["dc.identifier.isi","000237562000321"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37479"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.issn","0723-5003"],["dc.title","Prenatal programming of arterial hypertonia in common marmosets (EUPEAH): Study design and first results"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","44"],["dc.bibliographiccitation.journal","Nephrology Dialysis Transplantation"],["dc.bibliographiccitation.lastpage","45"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Bramlage, Carsten"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Werner, Carola"],["dc.contributor.author","Mueller, Gerhard Anton"],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T09:38:34Z"],["dc.date.available","2018-11-07T09:38:34Z"],["dc.date.issued","2006"],["dc.identifier.isi","000239919000119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33091"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","43rd ERA-EDTA Congress"],["dc.relation.eventlocation","Glasgow, SCOTLAND"],["dc.relation.issn","0931-0509"],["dc.title","Programming of arterial hypertension by prenatal dexamethason exposure in utero in marmoset monkeys (EUPEAH)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","684"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Nephrology Dialysis Transplantation"],["dc.bibliographiccitation.lastpage","698"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Mueller, Gerhard-Anton"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Patschan, Daniel"],["dc.contributor.author","Schmid, Holger"],["dc.contributor.author","Cohen, Clemens D."],["dc.contributor.author","Koschnick, Stefan"],["dc.contributor.author","Vasko, Radovan"],["dc.contributor.author","Bramlage, Carsten"],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T08:45:39Z"],["dc.date.available","2018-11-07T08:45:39Z"],["dc.date.issued","2010"],["dc.description.abstract","Methods. Functional data were analysed in folic acid nephropathy (FAN) at different time points (up to day 142 after induction). Immunostaining for CX3C-L, CD3, S100A4, collagen type I, fibronectin, alpha-smooth muscle actin, Tamm-horsfall protein, aquaporin 1 and 2 as well as quantitative real-time PCR (qRT-PCR) for CX3C-L, CX3C-R and fibroblast-specific protein 1 (FSP-1) were performed. Additionally, regulatory mechanisms and functional activity of CX3C-L in murine proximal and distal tubular epithelial cells as well as in fibroblasts were investigated. Results. CX3C-L/GAPDH ratio was upregulated in FAN 3.4-fold at day 7 further increasing up to 7.1-fold at day 106. The expression of mRNA CX3C-L correlated well with CX3C-R (R-2 = 0.96), the number of infiltrating CD3+ cells (R-2 = 0.60) and the degree of tubulointerstitial fibrosis (R-2 = 0.56) and moderately with FSP-1 (R-2 = 0.33). Interleukin-1 beta, tumour necrosis factor-alpha, transforming growth factor-beta as well as the reactive oxygen species (ROS) H2O2 were identified by qRT-PCR as inductors of CX3C-L/fractalkine (FKN) in tubular epithelial cells. Functionally, CX3C-L/FKN chemoattracts peripheral blood mononuclear cells, activates several aspects of fibrogenesis and induces the mitogen-activated protein kinases in renal fibroblasts. Conclusions. In FAN, there is a good correlation between the expression of CX3C-L with markers of interstitial inflammation and fibrosis which may result from upregulation by pro-inflammatory and pro-fibrotic cytokines as well as by ROS in tubular epithelial cells. The FKN system may promote renal inflammation and renal fibrogenesis."],["dc.description.sponsorship","Georg-August-University"],["dc.identifier.doi","10.1093/ndt/gfp602"],["dc.identifier.isi","000274987800011"],["dc.identifier.pmid","19934081"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20497"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0931-0509"],["dc.title","Role of CX3C-chemokine CX3C-L/fractalkine expression in a model of slowly progressive renal failure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Experimental and Clinical Endocrinology & Diabetes"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Strutz, Frank M."],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","Fuchs, E."],["dc.date.accessioned","2018-11-07T10:58:58Z"],["dc.date.available","2018-11-07T10:58:58Z"],["dc.date.issued","2007"],["dc.format.extent","548"],["dc.identifier.isi","000250144000040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50589"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh"],["dc.publisher.place","Stuttgart"],["dc.relation.issn","0947-7349"],["dc.title","Predictive value of maternal bodyweight, postnatal weight gain and prenatal clexamethasone overexposure for the development of obesity in adult marmoset monkeys"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S27"],["dc.bibliographiccitation.issue","46"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","S28"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Neuhoff, R."],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Grone, E."],["dc.contributor.author","Strutz, Frank M."],["dc.contributor.author","Koiolek, M."],["dc.contributor.author","Mueller, Gerhard A."],["dc.date.accessioned","2018-11-07T10:52:59Z"],["dc.date.available","2018-11-07T10:52:59Z"],["dc.date.issued","2007"],["dc.identifier.isi","000251423500086"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49245"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.issn","0012-0472"],["dc.title","Progressive renal failure for spontaneous occurring cholesterol crystal embolisms"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","647"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Nephrology"],["dc.bibliographiccitation.lastpage","655"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Tampe, Bjoern"],["dc.contributor.author","Bevanda, Jelena"],["dc.contributor.author","Maatouk, Imad"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Lange, Katharina"],["dc.contributor.author","Ahrens, Katharina"],["dc.contributor.author","Schmid, Holger"],["dc.contributor.author","Cohen, Clemens D."],["dc.contributor.author","Bramlage, Peter"],["dc.contributor.author","Kretzler, Matthias"],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T08:51:58Z"],["dc.date.available","2018-11-07T08:51:58Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Bone morphogenetic protein-5 (BMP-5) has been shown to be essential for nephrogenesis. Its role in adult kidney and in patients with hypertensive nephrosclerosis is still unknown. Methods: BMP-5 expression was evaluated by immunostaining and real-time PCR in tissue samples from normal and nephrosclerotic human kidneys. The impact of transforming growth factor-beta (TGF-beta), tumor necrosis factor-alpha (TNF-alpha) and angiotensin-II (AT-II) on expression of BMP-5 and its receptors was quantified in proximal tubular cells (HK-2). Functional characteristics of BMP-5 were evaluated by testing its influence on TGF-beta-induced epithelial-to-mesenchymal transition (EMT), TNF-alpha-induced apoptosis of HK-2 cells and inflammatory cell infiltration. Results: BMP-5 expression was localized in tubular epithelial cells and significantly decreased in nephrosclerotic kidneys. Stimulation of HK-2 cells with TGF-beta, TNF-alpha and AT-II resulted in a significant decreased expression of BMP-5 and its receptors. BMP-5 attenuated TGF-beta-induced EMT, TNF-alpha-induced apoptosis and migration of mononuclear cells. Conclusions: BMP-5 is expressed in the tubuli of adult kidneys. Its decreased expression in nephrosclerosis along with its regenerative capabilities in HK-2 cells may point to a protective role in hypertensive nephrosclerosis."],["dc.identifier.doi","10.5301/JN.2011.6330"],["dc.identifier.isi","000296976000016"],["dc.identifier.pmid","21319131"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22061"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wichtig Editore"],["dc.relation.issn","1121-8428"],["dc.title","The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]