Tirilomis, Theodor

[["dc.bibliographiccitation.firstpage","E308"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The Heart Surgery Forum"],["dc.bibliographiccitation.lastpage","E309"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.date.accessioned","2021-06-01T10:48:26Z"],["dc.date.available","2021-06-01T10:48:26Z"],["dc.date.issued","2009"],["dc.description.abstract","The case of a newborn with malignant tachyarrhythmia after heart surgery treated with cardiac extracorporeal membrane oxygenation (ECMO) is presented. After emergency surgery for a large right atrial tumor, the newborn developed supraventricular and ventricular arrhythmias. Despite antiarrhythmic medication, tachyarrhythmia remained, and low cardiac output syndrome developed progressively. Mechanical circulatory support was started, and soon thereafter sinus rhythm recovered. Four days after implantation, mechanical circulatory support was terminated, and the ECMO device was explanted. At discharge from the hospital, the baby had had stable sinus rhythm without any antiarrhythmic medication."],["dc.identifier.doi","10.1532/HSF98.20091058"],["dc.identifier.isi","000271489400015"],["dc.identifier.pmid","20077633"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85936"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Forum Multimedia Publishing, Llc"],["dc.relation.eissn","1522-6662"],["dc.relation.issn","1098-3511"],["dc.title","Mechanical Circulatory Support for Low Cardiac Output Syndrome Due to Tachyarrhythmia after Cardiac Surgery in a Newborn"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E40"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","E43"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Malliarou, Stella"],["dc.contributor.author","Bensch, Marc"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T09:30:27Z"],["dc.date.available","2018-11-07T09:30:27Z"],["dc.date.issued","2013"],["dc.description.abstract","Although the mechanisms of neurological disorders after cardiac surgery in neonates are still not fully understood, alterations in blood flow after cardiopulmonary bypass (CPB) may lead to cerebral injury. The aim of the study was the analysis of flow changes in the carotid artery of neonatal piglets after CPB. Ten neonatal piglets (younger than 7 days) were connected to the CPB and further management underwent three steps: (i) cooling to 32 degrees C core temperature within 30?min; (ii) cardiac arrest under cardioplegic myocardial protection for 90?min; and (iii) rewarming to 37 degrees C after cross-clamp release (60?min of reperfusion). In summary, piglets were separated from CPB after a total duration time of 180?min. The blood flow was measured in the left carotid artery by an ultrasonic flow probe before CPB (baseline), immediately after CPB, 30?min, and 60?min after CPB. Additionally, the pulsatility index and the resistance index were calculated and compared. Finally, the relation of the carotid artery flow data with the corresponding pressure data at each time point was compared. After termination of CPB, the carotid artery mean flow was reduced from 28.34?+/-?13.79?mL/min at baseline to 20.91?+/-?10.61?mL/min and remained reduced 30 and 60?min after CPB termination (19.71?+/-?11.11 and 17.64?+/-?15.31?mL/min, respectively). Both the pulsatility and the resistance index were reduced immediately after CPB termination and increased thereafter. Nevertheless, values did not reach statistical significance. In conclusion, the carotid Doppler flow immediately after CPB and mild hypothermia in neonatal piglets was lower than before CPB due to reduced vascular resistance. Additionally, the pressureflow relation revealed that immediately after CPB, a higher pressure is required to obtain adequate flow."],["dc.identifier.doi","10.1111/aor.12012"],["dc.identifier.isi","000313706400013"],["dc.identifier.pmid","23305586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31309"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","8th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Istanbul, TURKEY"],["dc.relation.issn","1525-1594"],["dc.relation.issn","0160-564X"],["dc.title","Carotid Doppler Flow After Cardiopulmonary Bypass and Mild Hypothermia in Neonatal Piglets"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","57"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Bireta, Christian"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Mokashi, Suyog A."],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Friedrich, Martin"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T08:40:27Z"],["dc.date.available","2018-11-07T08:40:27Z"],["dc.date.issued","2010"],["dc.description.abstract","We present a case of a 77-year old female who had undergone a coronary artery bypass grafting with an aortic valve replacement and developed three month later a Methicillin-Resistant Staphylococcus aureus (MRSA) sternal wound infection which was successful treated with Daptomycin combined with vacuum-assisted closure (VAC)."],["dc.identifier.doi","10.1186/1749-8090-5-57"],["dc.identifier.isi","000282338800001"],["dc.identifier.pmid","20691034"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19234"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.title","Daptomycin as a possible new treatment option for surgical management of Methicillin-Resistant Staphylococcus aureus sternal wound infection after cardiac surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1103"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","1104"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Friedrich, Martin"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Tempes, Tasso"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T08:50:09Z"],["dc.date.available","2018-11-07T08:50:09Z"],["dc.date.issued","2011"],["dc.description.abstract","Renal failure after open heart surgery is a serious complication even in the pediatric population. The aim of the present study was to analyze morphological changes after cardiopulmonary bypass (CPB) surgery in a neonatal piglet model. The kidneys of newborn piglets sacrificed 6 h after CPB were examined (CPB; n = 4) regarding tubular dilatation, vacuole formation, leukocytic infiltration, epithelial destruction, and interstitial edema. Thereafter, the findings were compared with the morphology of normal (untreated) neonatal piglet kidneys (control; n = 4). All changes but the interstitial edema were statistically significant if compared with the normal renal tissue: tubular dilatation (CPB vs. control P < 0.05), vacuole formation (CPB vs. control P < 0.05), leukocytic infiltration (CPB vs. control P < 0.05), and epithelial destruction (CPB vs. control P < 0.001). In conclusion, CPB induces significant changes in the morphology of the neonatal piglet kidneys."],["dc.identifier.doi","10.1111/j.1525-1594.2011.01364.x"],["dc.identifier.isi","000297201200017"],["dc.identifier.pmid","21973032"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21631"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0160-564X"],["dc.title","Cardiopulmonary Bypass and Its Direct Effects on Neonatal Piglet Kidney Morphology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","92"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","96"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.date.accessioned","2018-11-07T09:30:26Z"],["dc.date.available","2018-11-07T09:30:26Z"],["dc.date.issued","2013"],["dc.description.abstract","Irrespective of previous procedure in congenital aortic stenosis, aortic surgery later in life may be indicated. The aim of the present study was the analysis of indications, risks, and outcomes of aortic surgery after previous aortic valve procedure. The data of patients who underwent aortic surgery after previous treatment of congenital aortic stenosis in a 10-year period (from 2000 to 2009) were retrospectively analyzed. Thirty-two patients (23 male and 9 female) underwent redo aortic surgery. The mean age at surgery was 13.5 +/- 11.3 years. Seventeen patients had undergone initial aortic balloon valvuloplasty (BVP) and 15 patients open commissurotomy (COM). Nine cases had undergone the primary procedure at neonatal age and two patients had undergone cardiac surgery before the initial aortic valve procedure. Seven of the patients with previous COM (43.8%) had undergone concomitant surgery along with initial commissurotomy. A reintervention within the first year after the primary procedure was performed in seven patients (seven after BVP and none after COM; P?

[["dc.bibliographiccitation.firstpage","E85"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","E90"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Coskun, Sinan Tolga"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.date.accessioned","2018-11-07T08:45:10Z"],["dc.date.available","2018-11-07T08:45:10Z"],["dc.date.issued","2010"],["dc.description.abstract","The optimal treatment of congenital aortic valve lesions is a controversial issue. This study was performed to evaluate the outcome after surgical treatment of aortic valve lesions in congenital aortic valve disease. Between the years of 2000 and 2008, 61 patients (mean age: 12.6 +/- 9.6 years, range: 1 day to 40 years) underwent aortic valve surgery for congenital aortic valve disease. Twenty-four patients had undergone previous cardiovascular operations. Indications for surgery were aortic regurgitation in 14.7% (n = 9), aortic stenoses in 26.2% (n = 16), and mixed disease in 59.1% (n = 36). The Ross procedure was performed in 37.7% (n = 23), aortic valve replacement with biological or mechanical prostheses in 29.5% (n = 18). Concomitant procedures were performed in 91.8% (n = 56) due to associated congenital cardiac defects. The overall mortality rate was 5%. Six patients needed reoperation. Implantation of permanent pacemakers occurred in six patients for permanent atrioventricular block. At the latest clinical evaluation, all survivors are in New York Heart Association class I-II and are living normal lives. Aortic valve surgeries in patients with congenital heart disease have had low mortality and morbidity rates in our series. Surgical technique as well as timing should be tailored for each patient. Aortic valve replacement should be delayed until the implantation of an adult-sized prosthesis is possible."],["dc.identifier.doi","10.1111/j.1525-1594.2009.00958.x"],["dc.identifier.isi","000275725900004"],["dc.identifier.pmid","20447039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20370"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","5th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Dallas, TX"],["dc.relation.issn","0160-564X"],["dc.title","Aortic Valve Surgery in Congenital Heart Disease: A Single-Center Experience"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","101"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","105"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Liakopoulos, Oliver Joannis"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Bensch, Marc"],["dc.contributor.author","Steinke, Katja"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T09:15:52Z"],["dc.date.available","2018-11-07T09:15:52Z"],["dc.date.issued","2012"],["dc.description.abstract","Cooling before circulatory arrest or ischemic arrest has been reported to influence myocardial performance in isolated neonatal hearts. The aim of the present study was to analyze indices of myocardial contractility and relaxation in an in vivo neonatal model after deep hypothermic circulatory arrest (DHCA). DHCA (18 degrees C; DHCA group; n = 8) or mild hypothermic cardiopulmonary bypass ([MH-CPB] 32 degrees C; MH-CPB group; n = 10) was applied in newborn piglets. After reperfusion (60 and 120 min), left ventricular dP/dt(max) increased in DHCA and MH-CPB, while -dP/dt(max) decreased slightly in DHCA and increased in MH-CPB. Nevertheless, the differences between the two groups did not reach statistical significance. In conclusion, left ventricular contractility remained stable after reperfusion following DHCA, to some degree at the expense of the diastolic function."],["dc.identifier.doi","10.1111/j.1525-1594.2011.01242.x"],["dc.identifier.isi","000299205500015"],["dc.identifier.pmid","21790676"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27803"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0160-564X"],["dc.title","Myocardial Contractility and Relaxation After Deep Hypothermic Circulatory Arrest in a Neonatal Piglet Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","915"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","921"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.date.accessioned","2018-11-07T11:22:22Z"],["dc.date.available","2018-11-07T11:22:22Z"],["dc.date.issued","2009"],["dc.description.abstract","Due to improved outcome after surgery for congenital heart defects, children, adolescents, and grown-ups with congenital heart defects become an increasing population. In order to evaluate operative risk and early outcome after mechanical aortic valve replacement (AVR) in this population, we reviewed patients who underwent previous repair of congenital heart defects. Between July 2002 and November 2008, 15 (10 male and 5 female) consecutive patients (mean age 14.5 +/- 10.5 years) underwent mechanical AVR. Hemodynamic indications for AVR were aortic stenosis in four (27%), aortic insufficiency in eight (53%), and mixed disease in three (20%) after previous repair of congenital heart defects. All patients had undergone one or more previous cardiovascular operations due to any congenital heart disease. Concomitant cardiac procedures were performed in all of them. In addition to AVR, in two patients, a mitral valve exchange was performed. One patient received a right ventricle-pulmonary artery conduit replacement as concomitant procedure. The mean size of implanted valves was 23 mm (range 17-29 mm). There were neither early deaths nor late mortality until December 2008. Reoperations were necessary in five (33%) and included implantation of a permanent pacemaker due to complete atrioventricular block in two (15%), mitral valve replacement with a mechanical prosthesis due to moderate to severe mitral regurgitation in one (7%), aortocoronary bypass grafting due to stenosis of a coronary artery in one (7%), and in one (7%), a redo subaortic stenosis resection was performed because of a secondary subaortic stenosis. At the latest clinical evaluation, all patients were in good clinical condition without a pathological increased gradient across the aortic valve prosthesis or paravalvular leakage in echocardiography. Mechanical AVR has excellent results in patients after previous repair of congenital heart defects in childhood, even in combination with complex concomitant procedures. Previous operations do not significantly affect postoperative outcome."],["dc.identifier.doi","10.1111/j.1525-1594.2009.00886.x"],["dc.identifier.isi","000272127800007"],["dc.identifier.pmid","19817736"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55984"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0160-564X"],["dc.title","Mechanical Aortic Valve Replacement in Children and Adolescents After Previous Repair of Congenital Heart Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","947"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","952"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Coskun, Sinan Tolga"],["dc.contributor.author","Ortmann, Philipp"],["dc.contributor.author","Vorkamp, Tobias"],["dc.contributor.author","Heidrich, Florian"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Heuer, J. F."],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Chen, Frederick Yen-Ching"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:22:23Z"],["dc.date.available","2018-11-07T11:22:23Z"],["dc.date.issued","2009"],["dc.description.abstract","Although a large variety of animal models for acute ischemia and acute heart failure exist, valuable models for studies on the effect of ventricular assist devices in chronic heart failure are scarce. We established a stable and reproducible animal model of chronic heart failure in sheep and aimed to investigate the hemodynamic changes of this animal model of chronic heart failure in sheep. In five sheep (n = 5, 77 +/- 2 kg), chronic heart failure was induced under flouroscopic guidance by multiple sequential microembolization through bolus injection of polysterol microspheres (90 mu m, n = 25.000) into the left main coronary artery. Coronary microembolization (CME) was repeated up to three times in 2 to 3-week intervals until animals started to develop stable signs of heart failure. During each operation, hemodynamic monitoring was performed through implantation of central venous catheter (central venous pressure [CVP]), arterial pressure line (mean arterial pressure [MAP]), implantation of a right heart catheter {Swan-Ganz catheter (mean pulmonary arterial pressure [PAPmean])}, pulmonary capillary wedge pressure (PCWP), and cardiac output [CO]) as well as pre- and postoperative clinical investigations. All animals were followed for 3 months after first microembolization and then sacrificed for histological examination. All animals developed clinical signs of heart failure as indicated by increased heart rate (HR) at rest (68 +/- 4 bpm [base] to 93 +/- 5 bpm [3 mo] [P < 0.05]), increased respiratory rate (RR) at rest (28 +/- 5 [base] to 38 +/- 7 [3 mo] [P < 0.05]), and increased body weight 77 +/- 2 kg to 81 +/- 2 kg (P < 0.05) due to pleural effusion, peripheral edema, and ascites. Hemodynamic signs of heart failure were revealed as indicated by increase of HR, RR, CVP, PAP, and PCWP as well as a decrease of CO, stroke volume, and MAP 3 months after the first CME. Multiple sequential intracoronary microembolization can effectively induce myocardial dysfunction with clinical and hemodynamic signs of chronic ischemic cardiomyopathy. The present model may be suitable in experimental work on heart failure and left ventricular assist devices, for example, for studying the impact of mechanical unloading, mechanisms of recovery, and reverse remodeling."],["dc.identifier.doi","10.1111/j.1525-1594.2009.00921.x"],["dc.identifier.isi","000272127800012"],["dc.identifier.pmid","19817734"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55985"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0160-564X"],["dc.title","Hemodynamic Changes in a Model of Chronic Heart Failure Induced by Multiple Sequential Coronary Microembolization in Sheep"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","98"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Liakopoulos, Oliver Joannis"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Bensch, Marc"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T08:37:06Z"],["dc.date.available","2018-11-07T08:37:06Z"],["dc.date.issued","2010"],["dc.description.abstract","Background: Hemodynamic function may be depressed in the early postoperative stages after cardiac surgery. The aim of this study was the analysis of the myocardial contractility in neonates after cardiopulmonary bypass (CPB) and mild hypothermia. Methods: Three indices of left ventricular myocardial contractile function (dP/dt, (dP/dt)/P, and wall thickening) were studied up to 6 hours after CPB in neonatal piglets (CPB group; n = 4). The contractility data were analysed and then compared to the data of newborn piglets who also underwent median thoracotomy and instrumentation for the same time intervals but without CPB (non-CPB group; n = 3). Results: Left ventricular dP/dt(max) and (dP/dt(max))/P remained stable in CPB group, while dP/dt(max) decreased in non-CPB group 5 hours postoperatively (1761 +/- 205 mmHg/s at baseline vs. 1170 +/- 205 mmHg/s after 5 h; p < 0.05). However, with regard to dP/dt(max) and (dP/dt(max))/P there were no statistically significant differences between the two groups. Comparably, although myocardial thickening decreased in the non-CPB group the differences between the two groups were not statistically significant. Conclusions: The myocardial contractile function in survived neonatal piglets remained stable 6 hours after cardiopulmonary bypass and mild hypothermia probably due to regional hypercontractility."],["dc.identifier.doi","10.1186/1749-8090-5-98"],["dc.identifier.isi","000284615700001"],["dc.identifier.pmid","21044329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18453"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.title","Myocardial contractile function in survived neonatal piglets after cardiopulmonary bypass"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]