Tirilomis, Theodor

[["dc.bibliographiccitation.artnumber","112"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Bireta, Christian"],["dc.contributor.author","Friedrich, Martin"],["dc.contributor.author","Rajaruthnam, Direndra"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T08:51:42Z"],["dc.date.available","2018-11-07T08:51:42Z"],["dc.date.issued","2011"],["dc.description.abstract","The reported incidence of deep sternal wound infection (DSWI) after cardiac surgery is 0.4-5% with Staphylococcus aureus being the most common pathogen isolated from infected wound sternotomies and bacteraemic blood cultures. This infection is associated with a higher morbidity and mortality than other known aetiologies. Little is reported about the optimal antibiotic management. The aim of the study is to quantify the application of daptomycin treatment of DSWI due to gram-positive organisms post cardiac surgery. We performed an observational analysis in 23 cases of post sternotomy DSWI with gram-positive organisms February 2009 and September 2010. When the wound appeared viable and the microbiological cultures were negative, the technique of chest closure was individualised to the patient. The incidence of DSWI was 1.46%. The mean dose of daptomycin application was 4.4 +/- 0.9 mg/kg/d and the average duration of the daptomycin application was 14.47 +/- 7.33 days. In 89% of the patients VAC therapy was used. The duration from daptomycin application to sternal closure was 18 +/- 13.9 days. The parameters of infection including, fibrinogen (p = 0.03), white blood cell count (p = 0.001) and C-reactive protein (p = 0.0001) were significantly reduced after daptomycin application. We had no mortality and wound healing was successfully achieved in all patients. Treatment of DSWI due to gram-positive organisms with a daptomycin-containing antibiotic regimen is safe, effective and promotes immediate improvement of local wound conditions. Based on these observations, daptomycin may offer a new treatment option for expediting surgical management of DSWI after cardiac surgery."],["dc.identifier.doi","10.1186/1749-8090-6-112"],["dc.identifier.isi","000295483400002"],["dc.identifier.pmid","21929771"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6983"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21999"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Treatment of gram-positive deep sternal wound infections in cardiac surgery -experiences with daptomycin-"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","12"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Bireta, Christian"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schotola, Hanna"],["dc.contributor.author","Trethowan, Brian"],["dc.contributor.author","Friedrich, Martin"],["dc.contributor.author","El-Mehsen, Mohamed"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Tirilomis, Theodor"],["dc.date.accessioned","2018-11-07T08:59:19Z"],["dc.date.available","2018-11-07T08:59:19Z"],["dc.date.issued","2011"],["dc.description.abstract","We report a case of a female patient who was operated at the third relapse of an atrial myxoma caused by Carney complex. The difficult operation was performed without any complications despite extensive adhesions caused by the previous operations. The further inpatient course went without complications and the patient was discharged to the consecutive treatment on the 9th postoperative day. The echocardiographic finding postoperative showed no abnormalities."],["dc.identifier.doi","10.1186/1749-8090-6-12"],["dc.identifier.fs","577749"],["dc.identifier.isi","000287353500001"],["dc.identifier.pmid","21291531"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5887"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23862"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 2.0"],["dc.rights.access","openAccess"],["dc.rights.holder","Bireta et al.; licensee BioMed Central Ltd."],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.subject.ddc","610"],["dc.title","Carney-Complex: Multiple resections of recurrent cardiac myxoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","52"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Ortmann, Philipp"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Friedrich, Martin"],["dc.contributor.author","Sossalla, Samuel Tobias"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Mokashi, Suyog A."],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Baryalei, Mersa Mohammed"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:24:13Z"],["dc.date.available","2018-11-07T11:24:13Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Despite the existence of controversial debates on the efficiency of coronary endarterectomy (CE), it is still used as an adjunct to coronary artery bypass grafting (CABG). This is particularly true in patients with endstage coronary artery disease. Given the improvements in cardiac surgery and postoperative care, as well as the rising number of elderly patient with numerous co-morbidities, re-evaluating the pros and cons of this technique is needed. Methods: Patient demographic information, operative details and outcome data of 104 patients with diffuse calcified coronary artery disease were retrospectively analyzed with respect to functional capacity (NYHA), angina pectoris (CCS) and mortality. Actuarial survival was reported using a Kaplan-Meyer analysis. Results: Between August 2001 and March 2005, 104 patients underwent coronary artery bypass grafting (CABG) with adjunctive coronary endarterectomy (CE) in the Department of Thoracic-, Cardiac-and Vascular Surgery, University of Goettingen. Four patients were lost during follow-up. Data were gained from 88 male and 12 female patients; mean age was 65.5 +/- 9 years. A total of 396 vessels were bypassed (4 +/- 0.9 vessels per patient). In 98% left internal thoracic artery (LITA) was used as arterial bypass graft and a total of 114 vessels were endarterectomized. CE was performed on right coronary artery (RCA) (n = 55), on left anterior descending artery (LAD) (n = 52) and circumflex artery (RCX) (n = 7). Ninety-five patients suffered from 3-vessel-disease, 3 from 2-vessel- and 2 from 1-vessel-disease. Closed technique was used in 18%, open technique in 79% and in 3% a combination of both. The most frequent endarterectomized localization was right coronary artery (RCA = 55%). Despite the severity of endstage atherosclerosis, hospital mortality was only 5% (n = 5). During follow-up (24.5 +/- 13.4 months), which is 96% complete (4 patients were lost caused by unknown address) 8 patients died (cardiac failure: 3; stroke: 1; cancer: 1; unknown reasons: 3). NYHA-classification significantly improved after CABG with CE from 2.2 +/- 0.9 preoperative to 1.7 +/- 0.9 postoperative. CCS also changed from 2.4 +/- 1.0 to 1.5 +/- 0.8 Conclusion: Early results of coronary endarterectomy are acceptable with respect to mortality, NYHA & CCS. This technique offers a valuable surgical option for patients with endstage coronary artery disease in whom complete revascularization otherwise can not be obtained. Careful patient selection will be necessary to assure the long-term benefit of this procedure."],["dc.identifier.doi","10.1186/1749-8090-4-52"],["dc.identifier.isi","000270928300001"],["dc.identifier.pmid","19772645"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5786"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56353"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Early results of coronary artery bypass grafting with coronary endarterectomy for severe coronary artery disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]