Harnisch, Lars-Olav

[["dc.bibliographiccitation.firstpage","15"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Respiratory Care"],["dc.bibliographiccitation.lastpage","22"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Zippel, Carsten"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2018-11-07T10:21:44Z"],["dc.date.available","2018-11-07T10:21:44Z"],["dc.date.issued","2016"],["dc.description.abstract","BACKGROUND: During noninvasive ventilation (NIV) of COPD patients, delayed off-cycling of pressure support can cause patient ventilator mismatch and NIV failure. This systematic experimental study analyzes the effects of varying cycling criteria on patient-ventilator interaction. METHODS: A lung simulator with COPD settings was connected to an ICU ventilator via helmet or face mask. Cycling was varied between 10 and 70% of peak inspiratory flow at different breathing frequencies (15 and 30 breaths/min) and pressure support levels (5 and 15 cm H2O) using the ventilator's invasive and NIV mode with and without an applied leakage. RESULTS: Low cycling criteria led to severe expiratory cycle latency. Augmenting off-cycling reduced expiratory cycle latency (P < .001), decreased intrinsic PEEP, and avoided non-supported breaths. Setting cycling to 50% of peak inspiratory flow achieved best synchronization. Overall, using the helmet interface increased expiratory cycle latency in almost all settings (P < .001). Augmenting cycling from 10 to 40% progressively decreased expiratory pressure load (P < .001). NIV mode decreased expiratory cycle latency compared with the invasive mode (P < .001). CONCLUSION: Augmenting the cycling criterion above the default setting (20-30% peak inspiratory flow) improved patient ventilator synchrony in a simulated COPD model. This suggests that an individual approach to cycling should be considered, since interface, level of pressure support, breathing frequency, and leakage influence patient-ventilator interaction and thus need to be considered."],["dc.identifier.doi","10.4187/respcare.04141"],["dc.identifier.isi","000367062300005"],["dc.identifier.pmid","26556898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42144"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Daedalus Enterprises Inc"],["dc.relation.issn","1943-3654"],["dc.relation.issn","0020-1324"],["dc.title","Patient-Ventilator Interaction During Noninvasive Ventilation in Simulated COPD"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","743"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","MINERVA ANESTESIOLOGICA"],["dc.bibliographiccitation.lastpage","750"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","Zippel, Carsten"],["dc.contributor.author","Hermann, Peter"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Moerer, Onnen"],["dc.date.accessioned","2018-11-07T10:11:48Z"],["dc.date.available","2018-11-07T10:11:48Z"],["dc.date.issued","2016"],["dc.description.abstract","BACKGROUND: Patient-ventilator asynchrony that prolongs weaning and increases morbidity and mortality is common during invasive ventilation of patients with chronic obstructive pulmonary disease (COPD). In this context, the inspiratory cycling criteria (iCC) of the ventilator during assisted pressure support (PS) ventilation is a poorly acknowledged key factor. We investigated the changes of flow and pressure parameters that resulted from varying the iCC in a simulated COPD lung model. METHODS: A lung simulator was connected to an ICU ventilator through an endotracheal tube. We studied iCC settings from 10% to 70% at different respiratory rates (RR) (15 and 30 bpm) and pressure support (PS) (5 and 15 cmH(2)O) settings and registered asynchrony-index, double-triggering, expiratory trigger latency (TLEXP), intrinsic PEEP (PEEPi), expiratory pressure time product (PTPEXP) and tidal volume. RESULTS: At iCC <= 20%, asynchrony occurred in 50% of all recordings in high RR/high PS. At a low RR, double triggering occurred at high iCC settings. It appeared at 50% iCC with low PS and at 60% iCC with high PS. TLEXP was positive at iCC 10% to 30% but decreased with increasing iCC (P< 0.001). At low RR/high PS settings, PEEPi decreased at iCC <= 40% but increased at iCC >= 50%. High RR/low PS constantly reduced PTPEXP up to 60% iCC. Changes in iCC strongly influenced the resulting tidal volume. CONCLUSIONS: Non-adapted ventilator iCC can cause patient-ventilator asynchrony. The success of assisted invasive ventilation and weaning relies on meticulous adjustments."],["dc.description.sponsorship","Faron Pharm."],["dc.identifier.isi","000386888700006"],["dc.identifier.pmid","26630027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40114"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Edizioni Minerva Medica"],["dc.relation.issn","1827-1596"],["dc.relation.issn","0375-9393"],["dc.title","Adjusting ventilator off-cycling in invasively ventilated COPD patients needs comprehensive adjustments"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e66"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Anesthesia & Analgesia"],["dc.bibliographiccitation.lastpage","e67"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","von der Brelie, Christian"],["dc.contributor.author","Meissner, Konrad"],["dc.date.accessioned","2021-12-01T09:22:31Z"],["dc.date.available","2021-12-01T09:22:31Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1213/ANE.0000000000005757"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94418"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.issn","0003-2999"],["dc.title","Management of Severe Traumatic Brain Injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","0"],["dc.bibliographiccitation.journal","Clinical Chemistry and Laboratory Medicine (CCLM)"],["dc.bibliographiccitation.volume","0"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","Mihaylov, Diana"],["dc.contributor.author","Bein, Thomas"],["dc.contributor.author","Apfelbacher, Christian"],["dc.contributor.author","Kiehntopf, Michael"],["dc.contributor.author","Bauer, Michael"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2022-04-01T10:01:58Z"],["dc.date.available","2022-04-01T10:01:58Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Objectives Cholestasis and elevated serum bile 1 acid levels are common in critically ill patients. This study aims to define the specific pattern of bile acids associated with acute respiratory distress syndrome (ARDS) and the changes in pattern over time. Methods Prospective observational study. Serum samples of 70 ARDS patients were analyzed for primary bile acids (cholic acid, chenodeoxycholic acid) and secondary bile acids (deoxycholic acid, litocholic acid, and ursodeoxycholic acid) as well as their glycine and taurine glycation products. Results Primary bile acid levels increased from day zero to day five by almost 50% (p<0.05). This change bases on a statistically significant increase in all primary bile acids between day 0 and day 5 (cholic acid [CA] p=0.001, taurocholic acid [TCA] p=0.004, glycocholic acid [GCA] p<0.001, chenodeoxycholic acid [CDCA] p=0.036, taurochenodeoxycholic acid [TCDCA] p<0.001, glycochenodeoxycholic acid [GCDCA] p<0.001). Secondary bile acids showed predominantly decreased levels on day 0 compared to the control group and remained stable throughout the study period; the differences between day zero and day five were not statistically significant. Non-survivors exhibited significantly higher levels of TCDCA on day 5 (p<0.05) than survivors. This value was also independently associated with survival in a logistic regression model with an odds ratio of 2.24 (95% CI 0.53–9.46). Conclusions The individual bile acid profile of this ARDS patient cohort is unique compared to other disease states. The combination of changes in individual bile acids reflects a shift toward the acidic pathway of bile acid synthesis. Our results support the concept of ARDS-specific plasma levels of bile acids in a specific pattern as an adaptive response mechanism."],["dc.identifier.doi","10.1515/cclm-2021-1176"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105790"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1437-4331"],["dc.relation.issn","1434-6621"],["dc.title","Determination of individual bile acids in acute respiratory distress syndrome reveals a specific pattern of primary and secondary bile acids and a shift to the acidic pathway as an adaptive response to the critical condition"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Internal and Emergency Medicine"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","Mihaylov, Diana"],["dc.contributor.author","Bein, Thomas"],["dc.contributor.author","Apfelbacher, Christian"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2022-12-01T08:31:56Z"],["dc.date.available","2022-12-01T08:31:56Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1007/s11739-022-03152-0"],["dc.identifier.pii","3152"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118313"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","1970-9366"],["dc.relation.issn","1828-0447"],["dc.rights.uri","https://www.springer.com/tdm"],["dc.title","A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","68"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Artificial Organs"],["dc.bibliographiccitation.lastpage","76"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","Barwing, Jürgen"],["dc.contributor.author","Heise, Daniel"],["dc.contributor.author","Heuer, Jan Florian"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2020-12-10T14:11:08Z"],["dc.date.available","2020-12-10T14:11:08Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s10047-018-1068-8"],["dc.identifier.eissn","1619-0904"],["dc.identifier.issn","1434-7229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70977"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Minimal-flow ECCO2R in patients needing CRRT does not facilitate lung-protective ventilation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","365"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Artificial Organs"],["dc.bibliographiccitation.lastpage","370"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Harnisch, L. O."],["dc.contributor.author","Moerer, O."],["dc.date.accessioned","2020-12-10T14:11:08Z"],["dc.date.available","2020-12-10T14:11:08Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s10047-017-0983-4"],["dc.identifier.eissn","1619-0904"],["dc.identifier.issn","1434-7229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70975"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Sequential use of extracorporeal devices to avoid mechanical ventilation in a patient with complicated pulmonary fibrosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2348"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Thoracic Disease"],["dc.bibliographiccitation.lastpage","2352"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.date.accessioned","2018-11-07T10:09:10Z"],["dc.date.available","2018-11-07T10:09:10Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.21037/jtd.2016.08.43"],["dc.identifier.isi","000385615400078"],["dc.identifier.pmid","27746973"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39607"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pioneer Bioscience Publ Co"],["dc.relation.issn","2077-6624"],["dc.relation.issn","2072-1439"],["dc.title","Non-invasive mechanical ventilation in hypoxemic respiratory failure: Just a matter of the interface?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Clinical Biochemistry"],["dc.contributor.author","Schnabel, Claudia"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","Walter, Dominic"],["dc.contributor.author","Blaurock-Möller, Nancy"],["dc.contributor.author","Bauer, Michael"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Kiehntopf, Michael"],["dc.date.accessioned","2022-11-01T10:17:46Z"],["dc.date.available","2022-11-01T10:17:46Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.clinbiochem.2022.10.005"],["dc.identifier.pii","S0009912022002296"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116900"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-605"],["dc.relation.issn","0009-9120"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Association of the C-terminal 42-peptide fragment of alpha-1 antitrypsin with the severity of ARDS: A pilot study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]