Dresbach, Thomas

[["dc.bibliographiccitation.issue","143"],["dc.bibliographiccitation.journal","Journal of Visualized Experiments"],["dc.contributor.author","Wallrafen, Rebecca"],["dc.contributor.author","Dresbach, Thomas"],["dc.contributor.author","Viotti, Julio S."],["dc.date.accessioned","2020-12-10T18:47:30Z"],["dc.date.available","2020-12-10T18:47:30Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.3791/58940"],["dc.identifier.eissn","1940-087X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78785"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","136"],["dc.bibliographiccitation.journal","Journal of Visualized Experiments"],["dc.contributor.author","Riemann, Donatus"],["dc.contributor.author","Petkova, Andoniya"],["dc.contributor.author","Dresbach, Thomas"],["dc.contributor.author","Wallrafen, Rebecca"],["dc.date.accessioned","2020-12-10T18:47:29Z"],["dc.date.available","2020-12-10T18:47:29Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3791/58043"],["dc.identifier.eissn","1940-087X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78783"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","15791"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Riemann, Donatus"],["dc.contributor.author","Wallrafen, Rebecca"],["dc.contributor.author","Dresbach, Thomas"],["dc.date.accessioned","2018-10-10T08:59:42Z"],["dc.date.available","2018-10-10T08:59:42Z"],["dc.date.issued","2017-11-17"],["dc.description.abstract","Mutations in the human homolog of the Drosophila gene Rogdi cause Kohlschütter-Tönz syndrome. This disorder is characterised by amelogenesis imperfecta, as well as severe neurological symptoms including epilepsy and psychomotor delay. However, little is known about the protein encoded by Rogdi, and hence the pathogenic mechanisms underlying Kohlschütter-Tönz syndrome have remained elusive. Using immunofluorescence of rat cultured hippocampal neurons and brain sections we find that Rogdi is enriched at synaptic sites. In addition, recombinant GFP-Rogdi expressed in cultured neurons was efficiently targeted to presynaptic sites, where it colocalised with the presynaptic scaffolding protein Bassoon and the synaptic vesicle markers Synaptophysin, Synapsin-1, VAMP2/Synaptobrevin and Mover. Our data indicate that GFP-Rogdi harbours efficient signals for presynaptic targeting, and that Rogdi is a presynaptic protein. Thus, the neurological symptoms associated with Kohlschütter-Tönz syndrome may arise from presynaptic dysfunction."],["dc.fs.pkfprnr","69207"],["dc.identifier.doi","10.1038/s41598-017-16004-1"],["dc.identifier.fs","633270"],["dc.identifier.pmid","29150638"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14859"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15926"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","2045-2322"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","58"],["dc.bibliographiccitation.journal","Frontiers in Neuroanatomy"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Wallrafen, Rebecca"],["dc.contributor.author","Dresbach, Thomas"],["dc.date.accessioned","2019-07-09T11:45:42Z"],["dc.date.available","2019-07-09T11:45:42Z"],["dc.date.issued","2018"],["dc.description.abstract","The assembly and function of presynaptic nerve terminals relies on evolutionarily conserved proteins. A small number of presynaptic proteins occurs only in vertebrates. These proteins may add specialized functions to certain synapses, thus increasing synaptic heterogeneity. Here, we show that the vertebrate-specific synaptic vesicle (SV) protein mover is differentially distributed in the forebrain and cerebellum of the adult mouse. Using a quantitative immunofluorescence approach, we compare the expression of mover to the expression of the general SV marker synaptophysin in 16 brain areas. We find that mover is particularly abundant in the septal nuclei (SNu), ventral pallidum (VPa), amygdala and hippocampus. Within the hippocampus, mover is predominantly associated with excitatory synapses. Its levels are low in layers that receive afferent input from the entorhinal cortex, and high in layers harboring intrahippocampal circuits. In contrast, mover levels are high in all nuclei of the amygdala, and mover is associated with inhibitory synapses in the medioposterior amygdala. Our data reveal a striking heterogeneity in the abundance of mover on three levels, i.e., between brain areas, within individual brain areas and between synapse types. This distribution suggests a role for mover in providing specialization to subsets of synapses, thereby contributing to the functional diversity of brain areas."],["dc.identifier.doi","10.3389/fnana.2018.00058"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15291"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59291"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]