Kretschmer, Lutz

[["dc.bibliographiccitation.firstpage","1107"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","British Journal of Dermatology"],["dc.bibliographiccitation.lastpage","1109"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Krone, Bernd"],["dc.contributor.author","Beckmann, I."],["dc.contributor.author","Ritter, K."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:56:30Z"],["dc.date.available","2018-11-07T08:56:30Z"],["dc.date.issued","2011"],["dc.description.abstract","P>Background Infantile haemangioma (IH) is a tumour of the microvasculature composed predominantly of proliferating endothelial cells. It expresses markers associated with endothelial, haematopoietic and mesenchymal lineages. We have previously shown that the cells forming the capillary endothelium of proliferating IH express cell surface markers and transcriptions factors consistent with it being a haemogenic endothelium. Objectives We wished to determine whether the expression of transcription factors associated with the erythroid lineage was of physiological relevance and sufficient for IH tissue cultured in vitro to undergo erythropoiesis. Methods Immunohistochemical staining of paraffin-embedded sections of proliferating IHs was undertaken and expression of the embryonically associated haemoglobin zeta (HBZ) chain and the erythropoietin receptor (EPO-R) was determined. Relative expression of mRNA encoding these proteins was determined by quantitative reverse transcription-polymerase chain reaction using snap-frozen biopsy samples. Differentiation towards erythrocytes was investigated using freshly resected tissue cultured as explants in Matrigel. Results The endothelium of the microvessels, but not the pericyte layer, was strongly immunoreactive for the EPO-R and the embryonically associated HBZ chain. Abundant expression of transcripts encoding these proteins was also detected, corroborating the immunohistochemical staining. When tissue was grown in culture the cells emanating from IH explants were able to generate enucleated erythrocytes in vitro. The erythrocytes were immunoreactive for the erythrocyte-specific marker glycophorin A. Conclusions The microvessels in IH are a functional haemogenic endothelium that expresses the embryonically associated HBZ chain and is able to form erythrocytes in vitro. IH thus represents a possible extramedullary site for tumour-associated primitive erythropoiesis."],["dc.identifier.doi","10.1111/j.1365-2133.2010.10188.x"],["dc.identifier.isi","000289898200028"],["dc.identifier.pmid","21166659"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23170"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0007-0963"],["dc.title","Successful treatment of classic kaposi sarcoma with low-dose intramuscular immunoglobulins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E21"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Clinical Lymphoma & Myeloma"],["dc.bibliographiccitation.lastpage","E24"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Bertsch, Hans P."],["dc.contributor.author","Kaune, Kjell M."],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2021-06-01T10:48:52Z"],["dc.date.available","2021-06-01T10:48:52Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.3816/CLM.2009.n.079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86081"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","1557-9190"],["dc.title","Low-Dose Gemcitabine Efficacious in Three Patients With Tumor-Stage Mycosis Fungoides"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1435"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","International Journal of Cancer"],["dc.bibliographiccitation.lastpage","1442"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Starz, Hans"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Satzger, Imke"],["dc.contributor.author","Voelker, Bernward"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Bader, Claudia"],["dc.contributor.author","Siedlecki, Katharina"],["dc.contributor.author","Kapp, Alexander"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Gutzmer, Ralf"],["dc.date.accessioned","2018-11-07T08:51:44Z"],["dc.date.available","2018-11-07T08:51:44Z"],["dc.date.issued","2011"],["dc.description.abstract","In our study, we investigated the impact of the constitutional factor age on the clinical courses of melanoma patients with sentinel lymph node (SLN) biopsy. Descriptive statistics, Kaplan-Meier estimates, logistic regression analysis and the Cox proportional hazards model were used to study a population of 2,268 consecutive patients from three German melanoma centers. Younger age was significantly related to less advanced primary tumors. Nevertheless, patients younger than 40 years of age had a twofold risk of being SLN-positive (p < 0.000001). Of the young patients with primary melanomas with a thickness of 0.76 mm to 1.0 mm, 19.7% were SLN-positive. Using multivariate analysis, younger age, increasing Breslow thickness, ulceration and male sex were significantly related to a higher probability of SLN-metastasis. During follow-up, older patients displayed a significantly increased risk of in-transit recurrences (p = 0.000002) and lymph node recurrences (p = 0.0004). With respect to melanoma specific overall survival the patient's age was highly significant in the multivariate analysis. The unfavorable effect of being older was significant in the subgroups with positive and negative SLNs. Age remained also significant for the survival after the onset of distant metastases (p = 0.002). In conclusion, the patient's age is a strong and independent predictor of melanoma-specific survival in patients with localized melanomas, in patients with positive SLNs and after the onset of distant metastases. Younger patients have a better prognosis despite their higher probability of SLN metastasis. Older patients are less frequently SLN-positive but have a higher risk of loco-regional recurrence."],["dc.identifier.doi","10.1002/ijc.25747"],["dc.identifier.isi","000293245800019"],["dc.identifier.pmid","21064111"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22008"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0020-7136"],["dc.title","Age as a key factor influencing metastasizing patterns and disease-specific survival after sentinel lymph node biopsy for cutaneous melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Krone, Bernd"],["dc.contributor.author","Beckmann, I."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:39:47Z"],["dc.date.available","2018-11-07T08:39:47Z"],["dc.date.issued","2010"],["dc.format.extent","758"],["dc.identifier.isi","000281219100079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19082"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Succesful Treatment of a classic Kaposi's Sarcoma with low-dose intramuscular Immunoglobulin"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","158"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","164"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Gutzmer, Ralf"],["dc.contributor.author","Satzger, Imke"],["dc.contributor.author","Starz, Hans"],["dc.contributor.author","Bader, Christina"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Kapp, Alexander"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T09:42:15Z"],["dc.date.available","2018-11-07T09:42:15Z"],["dc.date.issued","2014"],["dc.description.abstract","Head or neck location of primary cutaneous melanomas has been described as an adverse prognostic factor, but this has to be reassessed after the introduction of sentinel lymph node (SLN) excision (SLNE). Descriptive statistics, Kaplan-Meier estimates and Cox proportional hazard models were used to study retrospectively a population of 2302 consecutive melanoma patients from three German melanoma centres undergoing SLNE. Approximately 10% of the patients (N=237) had a primary melanoma located at the head or neck (HNM). In both the SLN-positive and SLN-negative subpopulation, patients with HNM were significantly older, more frequently men and had thicker primaries compared with patients with tumours in other locations. The proportion of positive SLNs was lower in HNM compared with other locations of the primary (20 vs. 26%, P=0.048). The false-negative rate was higher in HNM (17.5 vs. 8.4%, P=0.05). In patients with HNM, the SLN status was a significant factor for recurrence-free survival but not for overall survival. SLN-negative HNM patients had a significantly worse overall survival than the SLN negatives with primaries at other sites, whereas the prognosis of the SLN-positive patients was similar in both groups. The prevalence of lymph node metastases after SLNE is lower in patients with HNM compared with other melanoma locations. As a result, the prognostic information provided by the SLN for HNM seems less important. Decision making for SLNE in HNM should be carefully balanced considering the potential morbidity of the procedure."],["dc.identifier.doi","10.1097/CMR.0000000000000042"],["dc.identifier.isi","000332601400009"],["dc.identifier.pmid","24346168"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33915"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1473-5636"],["dc.relation.issn","0960-8931"],["dc.title","Lower prevalence of lymphatic metastasis and poorer survival of the sentinel node-negative patients limit the prognostic value of sentinel node biopsy for head or neck melanomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","531"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","538"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Beckmann, I."],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T11:19:01Z"],["dc.date.available","2018-11-07T11:19:01Z"],["dc.date.issued","2005"],["dc.description.abstract","With regard to malignant melanoma, the impact of lymph node surgery on the development of loco-regional cutaneous metastases (LCM) has not yet been adequately addressed. However, this aspect is of interest, since sentinel lymphonodectomy (SLNE) has been suspected of causing LCM by inducing entrapment of melanoma cells. We analysed 244 patients with SLNE and compared the data with 199 patients treated with delayed lymph node dissection (DLND) for clinically palpable metastases. Analysis of both groups commenced at the time of excision of the primary tumour, using the Kaplan-Meier method. LCM that appeared as a first recurrence, as well as the overall probability of developing LCM, were recorded. For sentinel-negative patients with a primary melanoma > 1 mm thick, the 5-year probability of developing LCM as a first recurrence was 6.9 +/- 0.02% (standard error of the mean (SEM)). The probability was 17.6 +/- 0.03% in the DLND group. Comparing the two node-positive subgroups, the probability of developing LCM as a first recurrence was significantly higher in patients with positive SLNE (27.3 +/- 0.05%, P = 0.03). However, the 5-year overall probability of developing LCM did not differ significantly in the node-positive groups (33.3% in the DLND group vs. 33.7% in patients with positive sentinel lymph nodes (SLNs)). Since early excision of lymphatic metastases by SLNE avoids nodal recurrences, thereby prolonging the recurrence-free interval, the chance of LCM to manifest as a first recurrence should inevitably increase. However, the overall in-transit probability is not increased after SLNE. (c) 2004 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejca.2004.11.019"],["dc.identifier.isi","000227937800017"],["dc.identifier.pmid","15737557"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55170"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Sentinel lymphonodectomy does not increase the risk of loco-regional cutaneous metastases of malignant melanomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Cancer"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:55:04Z"],["dc.date.available","2018-11-07T08:55:04Z"],["dc.date.issued","2011"],["dc.format.extent","2821"],["dc.identifier.doi","10.1002/cncr.25785"],["dc.identifier.isi","000291450100031"],["dc.identifier.pmid","21264822"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22819"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0008-543X"],["dc.title","Assessment of Capsular Melanoma Cell Deposits in Sentinel Lymph Nodes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Thoms, K-M"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:57:22Z"],["dc.date.available","2018-11-07T08:57:22Z"],["dc.date.issued","2011"],["dc.format.extent","155"],["dc.identifier.isi","000288955200544"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23381"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Submammary of Giant Condylomata"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","457"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","463"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Krüger, Ullrich"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Padeken, Michael"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Schön, Michael"],["dc.contributor.author","Zutt, Markus"],["dc.date.accessioned","2018-11-07T08:51:33Z"],["dc.date.available","2018-11-07T08:51:33Z"],["dc.date.issued","2011"],["dc.description.abstract","Early detection of melanoma metastases is essential for effective treatment and may be crucial for the prevention of systemic metastases and patient survival. However, data demonstrating the reliability and accuracy of ultrasound examination for the detection of lymph node metastases, in addition to clinical examination, are rare. We have examined 433 melanoma patients with stage-dependent follow-up intervals of 3 to 12 months. One thousand three hundred and thirty-two paired clinical and nonblinded sonographic tests of the locoregional lymph node areas were performed. Lesions suspicious of melanoma metastases were examined histopathologically. Of note, sensitivity [0.9394 (95% confidence interval: 0.7977-0.9926)] and specificity [0.9808 (95% confidence interval: 0.9717-0.9875)] of combined clinical and sonographic investigations were significantly (P < 0.0001) higher than clinical results alone. Significant differences between clinical follow-up and sonographically assisted follow-up were found for American Joint Committee on Cancer 2002 melanoma stages I (P = 0.0389), III P = 0.0101), and IV (P = 0.0016). For stage II melanoma, a trend was detected (P = 0.0821). Lymph node metastases were detected sonographically in 1.73% of clinically metastasis-free investigations (n = 22). Our data suggest that high-frequency sonography should be part of all melanoma follow-up investigations, independent of melanoma type, melanoma stage, or lymph node biopsy status. Melanoma Res 21:457-463 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins."],["dc.identifier.doi","10.1097/CMR.0b013e328348dad3"],["dc.identifier.isi","000294681900012"],["dc.identifier.pmid","21730878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21960"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0960-8931"],["dc.title","Lymph node ultrasound during melanoma follow-up significantly improves metastasis detection compared with clinical examination alone: a study on 433 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2252"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Annals of Surgical Oncology"],["dc.bibliographiccitation.lastpage","2258"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Tronnier, Michael"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T09:38:39Z"],["dc.date.available","2018-11-07T09:38:39Z"],["dc.date.issued","2014"],["dc.description.abstract","Sentinel lymph node (SLN) biopsy (SLNB) for pT1 melanomas is not generally recognized as a clinical standard. We studied the value of SLNB for pT1 melanoma patients having at least one additional risk factor. Among 931 patients with SLNB, 210 had pT1 melanomas. All of the latter showed at least one of the following risk factors: ulceration (4 %) Clark level IV (44 %), nodular growth pattern (11 %), mitoses (59 %), regression (38 %) or age a parts per thousand currency sign40 years (27 %). In this selected pT1 population, we observed a surprisingly high SLN positivity rate of 18 %. The melanoma-specific overall survival significantly depended on SLN status. Compared with Clark IV, a lower invasion level (Clark II/III) was associated with a higher proportion of positive SLNs (25 vs. 10 %; p < 0.01). There was a trend towards a higher SLN positivity rate in younger patients (p = 0.06). Breslow, ulceration, mitoses, nodular growth pattern, and sex did not reach significance. Regression was significantly more frequently found in very thin melanomas (a parts per thousand currency sign0.75 mm) and tended to be significant in this subgroup (p = 0.075). SLNB improves prognostic stratification in patients with thin melanomas having an additional risk factor. Clark level IV most likely does not belong to these risk factors. The impact of regression deserves further consideration. Our data suggest that SLNB should be offered to patients with thin melanomas, if ulceration, nodular growth pattern, mitoses, or regression are present, or if the patient is younger than 40 years of age."],["dc.identifier.doi","10.1245/s10434-014-3641-6"],["dc.identifier.isi","000337063400023"],["dc.identifier.pmid","24652352"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33111"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1534-4681"],["dc.relation.issn","1068-9265"],["dc.title","Sentinel Node Biopsy Improves Prognostic Stratification in Patients with Thin (pT1) Melanomas and an Additional Risk Factor"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]