Kretschmer, Lutz

[["dc.bibliographiccitation.firstpage","1432"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of the European Academy of Dermatology and Venereology"],["dc.bibliographiccitation.lastpage","1439"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","von Ahsen, Nicolas"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:49:13Z"],["dc.date.available","2018-11-07T08:49:13Z"],["dc.date.issued","2011"],["dc.description.abstract","Background Chronic venous leg ulcers (CVU) cause considerable burden of disease for the patients as well as enormous costs for health care systems. The pathophysiology of CVU is complex and not entirely understood. So far reliable pathogenic and/or prognostic parameters have not been identified. Objectives We studied the role of thrombophilia in patients referred to a University dermatology department for treatment of CVU. Patients and methods A cohort of 310 patients with active chronic venous leg ulcers (CEAP 6) was stratified into two comparably large groups according to the presence or absence of post- thrombotic syndrome (PTS+; PTS-) as determined using duplex scan and/or phlebography. In addition, several thrombophilia parameters were assessed. Results The prevalence of protein S deficiency and factor V Leiden mutation was significantly higher in PTS+ patients compared with the PTS- group. However, patients in both subgroups revealed high prevalences of thrombophilia (antithrombin deficiency, protein C deficiency, protein S deficiency, activated protein C resistance, factor V mutation or elevated homocysteine). Conclusion Based on these data, it is conceivable that thrombophilia contributes to the pathogenesis of CVU, possibly through induction of microcirculatory dysregulations."],["dc.identifier.doi","10.1111/j.1468-3083.2011.04001.x"],["dc.identifier.isi","000297952800011"],["dc.identifier.pmid","21392126"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21406"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0926-9959"],["dc.title","Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:30:37Z"],["dc.date.available","2018-11-07T10:30:37Z"],["dc.date.issued","2002"],["dc.format.extent","2208"],["dc.identifier.isi","000175154900034"],["dc.identifier.pmid","11956283"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43906"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0732-183X"],["dc.title","Sentinel-node technique will change the design of clinical trials in malignant melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0959-8049(02)00534-8"],["dc.bibliographiccitation.firstpage","175"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","183"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Meller, J."],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Funke, M."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2021-06-01T10:50:19Z"],["dc.date.available","2021-06-01T10:50:19Z"],["dc.date.issued","2003"],["dc.description.abstract","To date, there are no reliable criteria to identify those patients with melanoma-infiltrated sentinel lymph nodes (SLNs) of the groin who might benefit from an extended lymphadenectomy, including the pelvic lymph nodes. We hypothesised that there are pelvic lymph nodes that receive lymph directly from the primary tumour, thus being at an increased risk for metastasis. In order to determine the frequency of radioactively labelled pelvic lymph nodes and the kinetics of their appearance, we introduce here a combination of dynamic lymphoscintigraphy, single photon emission computed tomography (SPECT) and image fusion of SPECT and pelvic Computed Tomography (CT)-scans. By dynamic lymphoscintigraphy and intraoperative gamma probe detection, superficially located inguinal SLNs (median 2 nodes) could be identified in all of the 51 patients included in this analysis. The histological search for micrometastases was positive in 16 patients (median Breslow thickness of the primary melanoma 2.5 mm). In 29 patients, SPECT and the image fusion technique were additionally performed. Radioactively labelled pelvic lymph nodes were detected in 20 individuals, 6 of them presenting aberrant pelvic SLNs that, on dynamic lymphoscintigraphy, had appeared simultaneously with the superficial SLN(s). Of the 6 patients in whom radioactive pelvic lymph nodes were excised together with the superficial SLN(s), only one had positive superficial SLNs. In this patient, the aberrant pelvic SLN proved to be tumour-positive. In 9 patients, there was no radiotracer uptake in the pelvic lymph nodes at all. Image fusion of SPECT and pelvic CT-scans is an excellent tool to localise exactly the pelvic tumour-draining nodes. The significance of radioactively labelled pelvic lymph nodes for the probability of pelvic metastases should be analysed further. (C) 2002 Elsevier Science Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0959-8049(02)00534-8"],["dc.identifier.isi","000181789200017"],["dc.identifier.pmid","12509949"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86614"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Dynamic lymphoscintigraphy and image fusion of SPECT and pelvic CT-scans allow mapping of aberrant pelvic sentinel lymph nodes in malignant melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","299"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","302"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T10:38:43Z"],["dc.date.available","2018-11-07T10:38:43Z"],["dc.date.issued","2003"],["dc.description.abstract","The anti-melanoma activity of vindesine as a single or polychemotherapeutic agent has been reported previously in adjuvant and first-line melanoma treatment. In this study, we investigated the usefulness of vindesine monotherapy as salvage therapy in stage IV melanoma patients after failure of other chemotherapies. Thirteen patients with progressive disease were treated with 3 mg/m(2) vindesine every 2 weeks (median age, 61 years). Previous systemic treatment consisted of polychemotherapy or combined chemo-immunotherapy. All 13 patients suffered from visceral metastases (three lung, one liver, one adrenal gland and eight multiple visceral metastases). A median of three vindesine treatments was administered. Despite the various pretreatments, the toxicity of vindesine was mild. In all 13 patients, vindesine treatment was stopped due to disease progression. The median survival after primary tumour diagnosis was 42 months (8-151 months), the survival after entering stage IV was 11 months (3-35 months), and the survival after starting vindesine therapy was 4 months (1-22 months). We conclude that vindesine monotherapy is ineffective in stage IV melanoma patients previously treated with other chemotherapeutic agents."],["dc.identifier.doi","10.1097/00008390-200306000-00012"],["dc.identifier.isi","000183426800012"],["dc.identifier.pmid","12777986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45877"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0960-8931"],["dc.title","Inefficacy of vindesine monotherapy in advanced stage IV malignant melanoma patients previously treated with other chemotherapeutic agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","499"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","504"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Preusser, K. P."],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:07:43Z"],["dc.date.available","2018-11-07T10:07:43Z"],["dc.date.issued","2002"],["dc.description.abstract","In patients with lymph node metastasis of malignant melanoma, the incidence of additional locoregional cutaneous metastases has not been well documented. More importantly, the prognostic impact of locoregional cutaneous metastases appearing prior to therapeutic lymphadenectomy is unclear. Using Kaplan-Meier estimations and a Cox proportional hazards model, we addressed these questions in 224 patients with palpable lymph node metastases to the axilla or the groin. The 10 year overall probability to develop regional cutaneous metastasis, calculated from primary tumour excision, was 38.7%. Using univariate and multivariate analysis, Breslow thickness was a significant risk factor of in-transit disease in node-positive patients. In 24 patients (10.7%) locoregional cutaneous metastases had appeared before therapeutic lymphadenectomy, but this was not associated with a survival disadvantage. In conclusion, locoregional cutaneous metastases amenable to surgical excision do not significantly influence the survival prognosis after therapeutic lymphadenectomy. In the subpopulation of patients with lymph node metastasis, Breslow thickness predicts the probability of additional locoregional cutaneous metastasis. (C) 2002 Lippincott Williams Wilkins."],["dc.identifier.doi","10.1097/00008390-200209000-00012"],["dc.identifier.isi","000178645900012"],["dc.identifier.pmid","12394192"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39333"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0960-8931"],["dc.title","Locoregional cutaneous metastasis in patients with therapeutic lymph node dissection for malignant melanoma: risk factors and prognostic impact"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","342"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Der Hautarzt"],["dc.bibliographiccitation.lastpage","347"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Hanssle, H."],["dc.contributor.author","Grafe, A."],["dc.contributor.author","Domhof, S."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T10:39:45Z"],["dc.date.available","2018-11-07T10:39:45Z"],["dc.date.issued","2003"],["dc.description.abstract","Background and Objective. The objective of the study was to evaluate the use of a medical surgical zipper (Medizip(TM)) for wound closure under tension in comparison to conventional cutaneous sutures. The surgical zipper is supposed to reduce wound tension by approximating of the wound edges via epidermal traction. Patients/Methods. This prospective study included patients with a wound diameter of more than 1 cm. 45 patients were treated with the surgical zipper, 38 were randomized into a control group with conventional wound closure. Scars were assessed after 6-18 months focusing on aesthetic and functional aspects. Results. The average length of the scars in both groups was 9 cm, but after a observation time of at least 6 month, there were differences in the width of the scars. The group with the surgical zipper showed significantly thinner scars (2,74 mm versus 4,24 mm, p=0,0008). Only 17% of the Medizip(TM) patients developed unaesthetic rope ladder-like scars versus 65% in the control group. This observation was statistically significant (p<0,0001). Conclusions. Wound stabilization by approximation of the wound edges via surgical zipper results in improved scar formation in wounds with moderate tension. Using the Medizip(TM) in wounds under heavy tension is not recommended because of the possible development of to tension bullae under the zipper."],["dc.identifier.doi","10.1007/s00105-002-0460-7"],["dc.identifier.isi","000182445300006"],["dc.identifier.pmid","12669206"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46127"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0017-8470"],["dc.title","Improved scar formation after using a medical surgical zipper for wound closure under tension"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","531"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","538"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Beckmann, I."],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T11:19:01Z"],["dc.date.available","2018-11-07T11:19:01Z"],["dc.date.issued","2005"],["dc.description.abstract","With regard to malignant melanoma, the impact of lymph node surgery on the development of loco-regional cutaneous metastases (LCM) has not yet been adequately addressed. However, this aspect is of interest, since sentinel lymphonodectomy (SLNE) has been suspected of causing LCM by inducing entrapment of melanoma cells. We analysed 244 patients with SLNE and compared the data with 199 patients treated with delayed lymph node dissection (DLND) for clinically palpable metastases. Analysis of both groups commenced at the time of excision of the primary tumour, using the Kaplan-Meier method. LCM that appeared as a first recurrence, as well as the overall probability of developing LCM, were recorded. For sentinel-negative patients with a primary melanoma > 1 mm thick, the 5-year probability of developing LCM as a first recurrence was 6.9 +/- 0.02% (standard error of the mean (SEM)). The probability was 17.6 +/- 0.03% in the DLND group. Comparing the two node-positive subgroups, the probability of developing LCM as a first recurrence was significantly higher in patients with positive SLNE (27.3 +/- 0.05%, P = 0.03). However, the 5-year overall probability of developing LCM did not differ significantly in the node-positive groups (33.3% in the DLND group vs. 33.7% in patients with positive sentinel lymph nodes (SLNs)). Since early excision of lymphatic metastases by SLNE avoids nodal recurrences, thereby prolonging the recurrence-free interval, the chance of LCM to manifest as a first recurrence should inevitably increase. However, the overall in-transit probability is not increased after SLNE. (c) 2004 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejca.2004.11.019"],["dc.identifier.isi","000227937800017"],["dc.identifier.pmid","15737557"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55170"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Sentinel lymphonodectomy does not increase the risk of loco-regional cutaneous metastases of malignant melanomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Oncologica"],["dc.bibliographiccitation.lastpage","78"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Preusser, K. P."],["dc.contributor.author","Marsch, W. C."],["dc.date.accessioned","2018-11-07T09:27:38Z"],["dc.date.available","2018-11-07T09:27:38Z"],["dc.date.issued","2001"],["dc.description.abstract","The present study addresses the question whether an extended ilioinguinal dissection as compared to an only superficial inguinal dissection improves survival and/or local tumour control after the appearance of palpable melanoma metastases to the groin. We retrospectively analysed the data of 104 patients with 69 ilioinguinal and 35 superficial inguinal dissections (median follow up 127 months). Prognostic factors of survival and groin recurrence were assessed using Kaplan-Meier estimation and Cox proportional hazards model. By multifactorial analysis, metastatic involvement of two lymph nodes or less was associated with a significantly better survival rate than involvement of >2 or pelvic nodes (p = 0.0002). After radical ilioinguinal dissection, patients with extremity-located primaries had a better prognosis than patients with truncal primaries (p = 0.03). Tumour infiltration of the ilio-obturator compartment was found to be an independent factor of poor prognosis (p = 0.0009). The probability of recurrence in the dissected groin paralleled the number of positive nodes and significantly increased if intransits were observed (p = 0.0002). The extent of surgery, Breslow thickness, epidermal ulceration, sex, age and adjuvant chemotherapy neither significantly influenced survival nor local control rates. In summary; when metastatic inguinal nodes become palpable, the presence of pelvic metastases indicates systemic disease. After therapeutic groin dissection, local recurrence and survival depend rather on regional tumour burden than on the extent of surgery."],["dc.identifier.isi","000167594600012"],["dc.identifier.pmid","11321665"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30585"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis As"],["dc.relation.issn","0284-186X"],["dc.title","Superficial inguinal and radical ilioinguinal lymph node dissection in patients with palpable melanoma metastases to the groin - An analysis of survival and local recurrence"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1166"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of the American Academy of Dermatology"],["dc.bibliographiccitation.lastpage","1169"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Kuster, W. K."],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Hanssle, H."],["dc.contributor.author","Hallermann, Christian"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:34:27Z"],["dc.date.available","2018-11-07T10:34:27Z"],["dc.date.issued","2003"],["dc.description.abstract","We describe a new family with the rare genodermatosis keratosis punctata palmo-plantaris Buschke-Fischer-Brauer (keratoma disseminatum). in all, 3 family members in 3 generations were affected, a pattern consistent with autosomal dominant inheritance. Clinical symptoms started in the third decade with disseminated, small, round, hyperkeratotic papules on the palms and soles. Punctate keratoses coalesced into hyperkeratotic plaques on pressure points. Identification of additional families is necessary to permit definitive genetic classification of this genodermatosis."],["dc.identifier.doi","10.1016/S0190-9622(03)00472-9"],["dc.identifier.isi","000186784800035"],["dc.identifier.pmid","14639410"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44878"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby, Inc"],["dc.relation.issn","0190-9622"],["dc.title","A new family with the rare genodermatosis keratosis punctata palmoplantaris Buschke-Fischer-Brauer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Dermatology"],["dc.bibliographiccitation.lastpage","76"],["dc.bibliographiccitation.volume","207"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Strutz, Frank M."],["dc.contributor.author","Happle, R."],["dc.contributor.author","Habenicht, E. M."],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:42:19Z"],["dc.date.available","2018-11-07T10:42:19Z"],["dc.date.issued","2003"],["dc.description.abstract","The Schimmelpenning-Feuerstein-Mims syndrome (SFM syndrome) is a rare and variable multisystem defect consisting of congenital, extensive linear nevus sebaceus and associated abnormalities in different neuroectodermal organ systems. We present the history of a 52-year-old female patient with disproportionate hyposomia and asymmetric constitution. From birth she suffered from a right-sided, extensive nevus sebaceus following Blaschko's lines extending on the scalp, neck, right arm and trunk. At the age of 5 years, she developed a generalized growth retardation, along with deformations of bones. At the age of 11, hypophosphatemic rickets was diagnosed causing this growth retardation. Moreover, the patient developed a precocious puberty at the age of 9 years. When we saw the patient 40 years after the diagnosis had been made, phosphaturia had returned to normal. Specific therapy of hypophosphatemic rickets is straightforward and efficient in preventing late complications like growth retardation. We suggest to conduct appropriate laboratory tests in early childhood in patients with an extensive systematized sebaceous nevus or with additional signs of growth retardation or skeletal involvement, in order to exclude hypophosphatemic rickets associated with SFM syndrome. Copyright (C) 2003 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000070948"],["dc.identifier.isi","000183981800018"],["dc.identifier.pmid","12835555"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46766"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1018-8665"],["dc.title","Schimmelpenning-Feuerstein-Mims syndrome with hypophosphatemic rickets"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]