Popeneciu, Ionel Valentin

[["dc.bibliographiccitation.firstpage","585"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Biomedicines"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Hahn, Oliver"],["dc.contributor.author","Heining, Franziska M."],["dc.contributor.author","Janzen, Jörn"],["dc.contributor.author","Becker, Johanna C. R."],["dc.contributor.author","Bertlich, Marina"],["dc.contributor.author","Thelen, Paul"],["dc.contributor.author","Mansour, Josef J."],["dc.contributor.author","Duensing, Stefan"],["dc.contributor.author","Pahernik, Sascha"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Popeneciu, Ionel V."],["dc.date.accessioned","2021-04-14T08:28:05Z"],["dc.date.available","2021-04-14T08:28:05Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/biomedicines8120585"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17692"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82497"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2227-9059"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Modulating the Heat Sensitivity of Prostate Cancer Cell Lines In Vitro: A New Impact for Focal Therapies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","493"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Prostate"],["dc.bibliographiccitation.lastpage","501"],["dc.bibliographiccitation.volume","82"],["dc.contributor.affiliation","Uhlig, Annemarie; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Bremmer, Felix; 2\r\nDepartment of Pathology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Mut, Tuna Till; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Ahyai, Sascha; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Reichert, Mathias; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Leitsmann, Marianne; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Trojan, Lutz; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Popeneciu, Ionel‐Valentin; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Mut, Tuna Till"],["dc.contributor.author","Ahyai, Sascha"],["dc.contributor.author","Reichert, Mathias"],["dc.contributor.author","Leitsmann, Marianne"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Popeneciu, Ionel‐Valentin"],["dc.date.accessioned","2022-02-01T10:31:29Z"],["dc.date.available","2022-02-01T10:31:29Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-20T23:34:50Z"],["dc.description.abstract","Abstract Background The aim of our study was to evaluate the impact of prostate biopsy technique (transrectal ultrasound (US)—prostate biopsy (PBx) versus multiparametric magnetic resonance imaging (mpMRI) targeted prostate biopsy (MRI‐PBx) on intraoperative nerve‐sparing and the rate of secondary neurovascular‐bundle resection (SNR) in patients undergoing robot‐assisted laparoscopic radical prostatectomy (RARP). A real‐time investigation with a frozen‐section examination (NeuroSAFE) microscopically excluded or confirmed prostate cancer invasion of the nerve structures resulting in preservation of the neurovascular bundle or SNR. Additionally, we analyzed risk factors related to SNR, such as longer operation time and postoperative complications. Methods The total study cohort was stratified according to non‐nerve‐sparing versus nerve‐sparing RARP. Patients with nerve‐sparing approach were then stratified according to biopsy technique (PBx vs. MRI‐PBx). Further, we compared PBx versus MRI‐PBx according to SNR rate. Results We included a total of 470 consecutive patients, who underwent RARP for PCa at our institution between January 2016 and December 2019. Patients with a preoperative MRI‐PBx had a 2.12‐fold higher chance of successful nerve‐sparing (without SNR) compared to patients with PBx (p < 0.01). Patients with preoperative MRI‐PBx required 73% less intraoperative SNR compared to patients with PBx (p < 0.0001). Prior MRI‐PBx is thus a predictor for successful nerve‐sparing RARP approach. Conclusion Preoperative MRI‐PBx led to better oncological outcomes and less SNR. Young patients with good erectile function could benefit from a preoperative MRI‐PBx before nerve‐sparing RARP."],["dc.identifier.doi","10.1002/pros.24295"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98873"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1097-0045"],["dc.relation.issn","0270-4137"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Impact of mpMRI targeted biopsy on intraoperative nerve‐sparing (NeuroSAFE) during robot‐assisted laparoscopic radical prostatectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]