Falkai, Peter Gaston

[["dc.bibliographiccitation.firstpage","126"],["dc.bibliographiccitation.journal","Brain Research"],["dc.bibliographiccitation.lastpage","134"],["dc.bibliographiccitation.volume","1301"],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Erdmann, Andrea"],["dc.contributor.author","Bernstein, Hans-Gert"],["dc.contributor.author","Breunig, Barbara"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Petroianu, Georg A."],["dc.contributor.author","von Wilmsdorff, Martina"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Honer, William G."],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T11:22:01Z"],["dc.date.available","2018-11-07T11:22:01Z"],["dc.date.issued","2009"],["dc.description.abstract","There is evidence for migrational disturbances in the entorhinal cortex (ERC) in schizophrenia that supports a neurodevelopmental origin of the disorder. Since impaired myelin basic protein (MBP) gene expression during the migration phase could lead to abnormalities in final laminar position, we performed layer specific measurements of MBP expression in the ERC and hypothesised that migrational disturbances of pre-alpha-cell clusters relate to decreased MBP expression. Paraffin embedded sections of the left entorhinal cortex of 16 schizophrenia patients and 10 control subjects were stained for MBP using routine immunohistochemistry. on each section representative regions of interest were scanned to attain optimal quality images of the gray matter. Results were correlated to previous published disturbed dispersion of pre-alpha-cell clusters in adjacent brain sections. Mean MBP stain-intensity was significantly reduced in schizophrenia patients. Absolute MBP stain-intensity was significantly reduced in layers III and IV in patients. A significant correlation of MBP stain-intensity with the distance of the deep pole of the pre-alpha-cell cluster from the gray white matter junction was observed in the ERC of schizophrenia patients. The present data provide evidence for reduced MBP expression in the ERC in schizophrenia, which implies deficits in axonal myelination and disturbed connectivity. MBP gene is expressed in oligodendrocytes and neuronal populations during embryonic development, which are important in establishing the structure of the cerebral cortex. Correlation between reduced MBP as a sign of down-regulated MBP gene expression and disorganization of pre-alpha-cell clusters supports a neurodevelopmental origin of pathological processes in schizophrenia. (C) 2009 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.brainres.2009.09.007"],["dc.identifier.isi","000272100200014"],["dc.identifier.pmid","19747901"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55908"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0006-8993"],["dc.title","Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Schizophrenia Bulletin"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Schmitt, A."],["dc.contributor.author","Schulenberg, Wiebke"],["dc.contributor.author","Bernstein, Hans-Gert"],["dc.contributor.author","Bogerts, Bernhard"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T08:32:32Z"],["dc.date.available","2018-11-07T08:32:32Z"],["dc.date.issued","2009"],["dc.format.extent","229"],["dc.identifier.isi","000263964700659"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17359"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","12th International Congress on Schizophrenia Research"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","0586-7614"],["dc.title","DECREASED GYRIFICATION-INDEX (GI) IN THE CEREBELLAR VERMIS OF SCHIZOPHRENIA PATIENTS AND AN ANIMAL MODEL OF SCHIZOPHRENIA"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","201"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The World Journal of Biological Psychiatry"],["dc.bibliographiccitation.lastpage","215"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Leonardi-Essmann, Fernando"],["dc.contributor.author","Durrenberger, Pascal F."],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Spanagel, Rainer"],["dc.contributor.author","Arzberger, Thomas"],["dc.contributor.author","Kretzschmar, Hans A."],["dc.contributor.author","Herrera-Marschitz, Mario"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Reynolds, Richard"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gebicke-Haerter, Peter J."],["dc.date.accessioned","2018-11-07T08:57:28Z"],["dc.date.available","2018-11-07T08:57:28Z"],["dc.date.issued","2011"],["dc.description.abstract","Objectives. The role of neuroinflammation in schizophrenia has been an issue for long time. There are reports supporting the hypothesis of ongoing inflammation and others denying it. This may be partly ascribed to the origin of the materials (CSF, blood, brain tissue) or to the genes selected for the respective studies. Moreover, in some locations, inflammatory genes may be up-regulated, others may be down-regulated. Methods. Genome-wide microarrays have been used for expression profiling in post-mortem brains of schizophrenia patients. Array data have been analyzed by gene set enrichment analysis (GSEA) and further confirmed with selected genes by real-time PCR. Results. In Brodman Area 22 of left superior temporal cortex, at least 70 genes (19%) out of 369 down-regulated genes (P < 0.05) belonged to the immune system. 23 from those 70 genes were randomly selected for real-time PCR. Six reached significance level at P < 0.05. Conclusions. The present data support a brain-specific view of the role immune-modulatory genes may play in the left superior temporal cortex in schizophrenia, because immune functions in the patients are not disturbed. In keeping with comparable, previous studies supporting the notion that schizophrenia is a disease of the synapse, we hypothesize that dysregulation of immune-related genes modifies synaptic functions and stability in this region."],["dc.identifier.doi","10.3109/15622975.2010.530690"],["dc.identifier.isi","000289439200004"],["dc.identifier.pmid","21091092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23409"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1562-2975"],["dc.title","Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients: a genome-wide microarray study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","35"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","39"],["dc.bibliographiccitation.volume","258"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T11:09:24Z"],["dc.date.available","2018-11-07T11:09:24Z"],["dc.date.issued","2008"],["dc.description.abstract","To a large extend schizophrenia has been shown to be heritable, with neuregulin-1 (NRG1) one of the candidate genes considered to play a role in the pathophysiology of the disorder. While several polymorphisms within this gene have been reported to be associated with schizophrenia, the impact of NRG1 risk genotypes on disturbed brain function and symptoms of the disease is unknown and might be elucidated using post-mortem studies. Neuregulins are signalling proteins and the NRG1 family encodes at least 15 different splice variants, classified into four isoforms. They play an important role in cell differentiation, migration, myelination and proliferation of oligodendrocytes and neurons. Dysfunction in these processes may be related to neurodevelopmental disturbances in schizophrenia. NRG1 isoforms are differentially expressed in relevant brain regions of schizophrenia patients such as the prefrontal cortex and hippocampus and may contribute to pathophysiological processes. Different NRG1 genotypes have been shown to influence gene expression of isoforms and the risk-associated variants are in primarily noncoding and promoter regions, probably operating by altering gene expression or splicing. In addition, NRG1 regulates the expression of the nicotinic acetylcholine receptor, and expression of the 7-aminobutyric acid (GABA(A)) and N-methyl-D-aspartate receptor in the brain. However, the contribution of NRG1 risk genotypes to expression of isoforms and cognitive or psychotic symptoms in patients remain to be investigated in prospective post-mortem studies."],["dc.identifier.doi","10.1007/s00406-008-5019-x"],["dc.identifier.isi","000262752900007"],["dc.identifier.pmid","18985292"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53001"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0940-1334"],["dc.title","Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1726"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Neural Transmission"],["dc.bibliographiccitation.lastpage","1727"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Schmitt, A."],["dc.contributor.author","Schulenberg, Wiebke"],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Bernstein, Hans-Gert"],["dc.contributor.author","Bogerts, Bernhard"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T11:08:39Z"],["dc.date.available","2018-11-07T11:08:39Z"],["dc.date.issued","2008"],["dc.identifier.isi","000261180300056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52834"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.conference","BrainNet Europe 2nd International Conference on Human Brain Tissue Research"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0300-9564"],["dc.title","Decreased gyrification-index (GI) in the cerebellar vermis of schizophrenia patients and an animal model of schizophrenia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Schmitt, A."],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T10:57:24Z"],["dc.date.available","2018-11-07T10:57:24Z"],["dc.date.issued","2007"],["dc.format.extent","314"],["dc.identifier.isi","000253318800829"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50237"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0028-2804"],["dc.title","Functional significance of NRG-1 for the pathophysiology of the schizophrenia in human post-mortem trials"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","243"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The World Journal of Biological Psychiatry"],["dc.bibliographiccitation.lastpage","250"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Wirths, Oliver"],["dc.contributor.author","Bauer, Manfred"],["dc.contributor.author","Sommer, Clemens"],["dc.contributor.author","Rueb, Udo"],["dc.contributor.author","Skowronek, Markus H."],["dc.contributor.author","Treutlein, Jens"],["dc.contributor.author","Petroianu, Georg A."],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T08:45:49Z"],["dc.date.available","2018-11-07T08:45:49Z"],["dc.date.issued","2010"],["dc.description.abstract","One important risk gene in schizophrenia is neuregulin-1 (NRG1), which is expressed in different isoforms in the brain. To determine if alterations of NRG1 are present in schizophrenia, we measured gene expression of NRG1 and its main isoforms as well as the impact of genetic variation of NRG1 in an exploratory study examining three brain regions instead of only one as published so far. In all, we examined post-mortem samples from 11 schizophrenia patients and eight normal subjects. We investigated gene expression of total NRG1 and isoforms I, II and III by real-time PCR in the prefrontal cortex (Brodmann areas 9 and 10) and right hippocampal tissue. For the genetic study, we genotyped the NRG1 polymorphism SNP8NRG221533, which is within the core haplotype of the original publication. Compared to controls, gene expression of the NRG1 isoform I was decreased and isoform II increased in the prefrontal cortex (BA10) of schizophrenia patients. There were no statistically significant differences between individuals carrying at least one C allele of SNP8NRG221533 compared to individuals homozygous for the Tallele. The decreased expression of NRG1 isoform I and overexpression of isoform II may be related to deficits in receptor function as well as abnormal migration and myelination. However, our study sample was small and results of this exploratory study should be verified in a larger sample."],["dc.description.sponsorship","European Commission [LSHM-CT-2004-503039]"],["dc.identifier.doi","10.3109/15622970802022376"],["dc.identifier.isi","000284143000009"],["dc.identifier.pmid","20218788"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20539"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis Ltd"],["dc.relation.issn","1562-2975"],["dc.title","Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","255"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinics (São Paulo)"],["dc.bibliographiccitation.lastpage","266"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Bauer, Manfred"],["dc.contributor.author","Heinsen, Helmut"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2021-06-01T10:48:28Z"],["dc.date.available","2021-06-01T10:48:28Z"],["dc.date.issued","2008"],["dc.description.abstract","It is widely accepted that neurobiological abnon-nalities underlie the symptoms of psychiatric disorders such as schizophrenia and unipolar or bipolar affective disorders. New molecular methods, computer-assisted quantification techniques and neurobiological investigation methods that can be applied to the human brain are all used inpost-mortem investigations of psychiatric disorders. The following article describes modem quantitative methods and recent post-mortem findings in schizophrenia and affective disorders. Using our brain bank as an example, necessary considerations of modem brain banking are addressed such as ethical considerations, clinical work-up, preparation techniques and the organization of a brain bank, the value of modem brain banking for investigations of psychiatric disorders is summarized."],["dc.identifier.doi","10.1590/S1807-59322008000200015"],["dc.identifier.isi","000255101600015"],["dc.identifier.pmid","18438581"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85950"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hospital Clinicas, Univ Sao Paulo"],["dc.relation.eissn","1807-5932"],["dc.relation.issn","1807-5932"],["dc.title","Is brain banking of psychiatric cases valuable for neurobiological research?"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Neural Transmission"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Bergmann, Andreas"],["dc.contributor.author","Schmitt, A."],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Ovary, I."],["dc.contributor.author","Majtenyi, K."],["dc.contributor.author","Havas, L."],["dc.contributor.author","Kovacs, G."],["dc.contributor.author","Honer, William G."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T11:08:39Z"],["dc.date.available","2018-11-07T11:08:39Z"],["dc.date.issued","2008"],["dc.format.extent","1726"],["dc.identifier.isi","000261180300055"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52833"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.conference","BrainNet Europe 2nd International Conference on Human Brain Tissue Research"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0300-9564"],["dc.title","Migrational disturbances and layer specific reduction of myelin basic protein expression in the entorhinal cortex in schizophrenia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Schizophrenia Bulletin"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Zink, M."],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Treutlein, Jens"],["dc.contributor.author","Schulze, T."],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Henn, Fritz A."],["dc.date.accessioned","2018-11-07T08:32:31Z"],["dc.date.available","2018-11-07T08:32:31Z"],["dc.date.issued","2009"],["dc.format.extent","228"],["dc.identifier.isi","000263964700656"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17355"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","12th International Congress on Schizophrenia Research"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","0586-7614"],["dc.title","THE RELATIONSHIP BETWEEN GENE EXPRESSION OF NMDA RECEPTOR SUBUNITS AND A NEUREGULIN-1 SNP IN THE CEREBELLUM OF SCHIZOPHRENIA PATIENTS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]