Sommer, Martin

[["dc.bibliographiccitation.artnumber","e0202634"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Whillier, Alexander"],["dc.contributor.author","Hommel, Sina"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Wolff von Gudenberg, Alexander"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2019-07-09T11:46:08Z"],["dc.date.available","2019-07-09T11:46:08Z"],["dc.date.issued","2018"],["dc.description.abstract","OBJECTIVES: Persistent developmental stuttering is a speech fluency disorder defined by its symptoms, where the underlying neurophysiological causes remain uncertain. This study examined the underlying neurophysiological mechanisms of the speech planning process, using facilitation in the motor cortex during speech preparation as an analogue. METHODS: transcranial magnetic stimulation (TMS) pulses induced motor evoked potentials (MEPs), which were recorded from the tongue. Eighteen adults who stutter (AWS) and 17 adults who do not stutter (ANS) completed three experiments, which involved reading a German prefix+verb utterance from a screen. Each experiment involved 120 trials with three distinct levels of speech production: immediate speech, delayed speech without pacing and delayed speech with predefined pacing. TMS was applied shortly before speech onset. Trial MEPs were normalised to average non-speech MEPs. MEP amplitude, MEP facilitation ratio (amplitude: pre-speech offset) and group difference were the outcomes of interest analysed by multiple regression, as well as speech reaction time analysed by correlation. RESULTS: MEP values were 11·1%-23·4% lower in AWS than ANS (by standardised Beta), across all three experiments. MEP facilitation ratio slopes were also 4·9%-18·3% flatter in AWS than ANS across all three experiments. Reaction times for AWS were only significantly slower than for ANS in immediate speech and predefined pacing experiments. No stuttering was detected during the trials. The group difference in immediate speech was 100% and 101% greater than the other two experiments respectively. DISCUSSION: While performance of both ANS and AWS worsens under disturbed speech conditions, greater disturbance conditions affected controls worse than AWS. Future research and therapy in stuttering should focus on non-disturbed speech."],["dc.identifier.doi","10.1371/journal.pone.0202634"],["dc.identifier.pmid","30303960"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15398"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59381"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15696 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Adults who stutter lack the specialised pre-speech facilitation found in non-stutterers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","945"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","954"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Jung, Kristina"],["dc.contributor.author","Rothkegel, Holger"],["dc.contributor.author","Pollok, Bettina"],["dc.contributor.author","von Gudenberg, Alexander Wolff"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2018-11-07T08:53:01Z"],["dc.date.available","2018-11-07T08:53:01Z"],["dc.date.issued","2011"],["dc.description.abstract","Introduction: In adults who do not stutter (AWNS), the control of hand movement timing is assumed to be lateralized to the left dorsolateral premotor cortex (PMd). In adults who stutter (AWS), the network of speech motor control is abnormally shifted to the right hemisphere. Motor impairments in AWS are not restricted to speech, but extend to non-speech orofacial and finger movements. We here investigated the lateralization of finger movement timing control in AWS. Methods: We explored PMd function in 14 right-handed AWS and 15 age matched AWNS. In separate sessions, they received subthreshold repetitive transcranial magnetic stimulation (rTMS) for 20 min at 1 Hz over the left or right PMd, respectively. Pre- and post-stimulation participants were instructed to synchronize their index finger taps of either hand with an isochronous sequence of clicks presented binaurally via earphones. Synchronization accuracy was measured to quantify the effect of the PMd stimulation. Results: In AWNS inhibition of left PMd affected synchronization accuracy of the left hand. Conversely, in AWS TMS over the right PMd increased the asynchrony of the left hand. Conclusions: The present data indicate an altered functional connectivity in AWS in which the right PMd seems to be important for the control of timed non-speech movements. Moreover, the laterality-shift suggests a compensatory role of the right PMd to successfully perform paced finger tapping. (C) 2010 Elsevier Srl. All rights reserved."],["dc.identifier.doi","10.1016/j.cortex.2010.06.007"],["dc.identifier.isi","000293155300005"],["dc.identifier.pmid","20822768"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22305"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Masson"],["dc.relation.issn","0010-9452"],["dc.title","Right-shift for non-speech motor processing in adults who stutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","712"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","725"],["dc.bibliographiccitation.volume","138"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Hoang, T. N. Linh"],["dc.contributor.author","Neef, Andreas"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2018-11-07T10:00:13Z"],["dc.date.available","2018-11-07T10:00:13Z"],["dc.date.issued","2015"],["dc.description.abstract","The precise excitability regulation of neuronal circuits in the primary motor cortex is central to the successful and fluent production of speech. Our question was whether the involuntary execution of undesirable movements, e.g. stuttering, is linked to an insufficient excitability tuning of neural populations in the orofacial region of the primary motor cortex. We determined the speech-related time course of excitability modulation in the left and right primary motor tongue representation. Thirteen fluent speakers (four females, nine males; aged 23-44) and 13 adults who stutter (four females, nine males, aged 21-55) were asked to build verbs with the verbal prefix 'auf'. Single-pulse transcranial magnetic stimulation was applied over the primary motor cortex during the transition phase between a fixed labiodental articulatory configuration and immediately following articulatory configurations, at different latencies after transition onset. Bilateral electromyography was recorded from self-adhesive electrodes placed on the surface of the tongue. Off-line, we extracted the motor evoked potential amplitudes and normalized these amplitudes to the individual baseline excitability during the fixed configuration. Fluent speakers demonstrated a prominent left hemisphere increase of motor cortex excitability in the transition phase (P = 0.009). In contrast, the excitability of the right primary motor tongue representation was unchanged. Interestingly, adults afflicted with stuttering revealed a lack of left-hemisphere facilitation. Moreover, the magnitude of facilitation was negatively correlated with stuttering frequency. Although orofacial midline muscles are bilaterally innervated from corticobulbar projections of both hemispheres, our results indicate that speech motor plans are controlled primarily in the left primary speech motor cortex. This speech motor planning-related asymmetry towards the left orofacial motor cortex is missing in stuttering. Moreover, a negative correlation between the amount of facilitation and stuttering severity suggests that we discovered a main physiological principle of fluent speech production and its role in stuttering."],["dc.identifier.doi","10.1093/brain/awu390"],["dc.identifier.isi","000351510700026"],["dc.identifier.pmid","25595146"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37754"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1460-2156"],["dc.relation.issn","0006-8950"],["dc.title","Speech dynamics are coded in the left motor cortex in fluent speakers but not in adults who stutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","84"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","96"],["dc.bibliographiccitation.volume","138"],["dc.contributor.author","Korzeczek, Alexandra"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Steinmann, Iris"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2022-05-02T08:09:50Z"],["dc.date.available","2022-05-02T08:09:50Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.clinph.2022.03.010"],["dc.identifier.pii","S1388245722002139"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107480"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.issn","1388-2457"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Stuttering severity relates to frontotemporal low-beta synchronization during pre-speech preparation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","769"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","773"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Sommer, Martin"],["dc.contributor.author","Knappmeyer, Kathrin"],["dc.contributor.author","Hunter, Evke Jane"],["dc.contributor.author","Gudenberg, Alexander Wolffvon"],["dc.contributor.author","Neef, Nicole"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T08:30:46Z"],["dc.date.available","2018-11-07T08:30:46Z"],["dc.date.issued","2009"],["dc.description.abstract","Imaging studies suggest a right hemispheric (pre)motor overactivity in patients with persistent developmental stuttering (PDS). The interhemispheric inhibition (IHI) studied with transcranial magnetic stimulation is an established measure of the interplay between right and left motor areas. We assessed IHI in 15 young Male adults with PDS and 15 age-matched fluent-speaking subjects. We additionally studied the ipsilateral silent period (iSP) duration. We found no significant between-group difference for IHI or tor iSP duration. We conclude that the interplay between the primary motor cortices is normal in patients with PDS. The abnormal right motor and premotor activity observed in functional imaging studies on PDS are not likely to reflect altered primary motor cortex excitability, hot are likely, to have a different origin. (C) 2009 Movement Disorder Society"],["dc.identifier.doi","10.1002/mds.22383"],["dc.identifier.isi","000265625400022"],["dc.identifier.pmid","19224611"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16972"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0885-3185"],["dc.title","Normal Interhemispheric Inhibition in Persistent Developmental Stuttering"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Human Neuroscience"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Wolff von Gudenberg, Alexander"],["dc.contributor.author","Baehr, Mathias"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2021-04-14T08:27:59Z"],["dc.date.available","2021-04-14T08:27:59Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3389/fnhum.2021.639269"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82466"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1662-5161"],["dc.rights","CC BY 4.0"],["dc.title","Enlarged Area of Mesencephalic Iron Deposits in Adults Who Stutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Human Neuroscience"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Busan, Pierpaolo"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Rogić Vidaković, Maja"],["dc.contributor.author","Battaglini, Piero Paolo"],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2022-04-01T10:03:16Z"],["dc.date.available","2022-04-01T10:03:16Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.3389/fnhum.2021.833870"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106127"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1662-5161"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Editorial: The Neurophysiology of Developmental Stuttering: Unraveling the Mysteries of Fluency"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","165"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Brain Structure & Function"],["dc.bibliographiccitation.lastpage","182"],["dc.bibliographiccitation.volume","223"],["dc.contributor.author","Metzger, F. Luise"],["dc.contributor.author","Auer, Tibor"],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Sommer, Martin"],["dc.contributor.author","Neef, Nicole E."],["dc.date.accessioned","2018-10-10T10:27:29Z"],["dc.date.available","2018-10-10T10:27:29Z"],["dc.date.issued","2018"],["dc.description.abstract","Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performed a response anticipation paradigm in the MRI scanner. The preparation of a manual Go/No-Go response reliably produced activity in the basal ganglia and thalamus and particularly in the substantia nigra. Strikingly, in adults who stutter, substantia nigra activity correlated positively with stuttering severity. Furthermore, functional connectivity analyses yielded altered task-related network formations in adults who stutter compared to fluent speakers. Specifically, in adults who stutter, the globus pallidus and the thalamus showed increased network synchronization with the inferior frontal gyrus. This implies dynamic shifts in the response preparation-related network organization through the basal ganglia in the context of a non-speech motor task in stuttering. Here we discuss current findings in the traditional framework of how D1 and D2 receptor activity shapes focused movement selection, thereby suggesting a disproportional involvement of the direct and the indirect pathway in stuttering."],["dc.identifier.doi","10.1007/s00429-017-1476-1"],["dc.identifier.pmid","28741037"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15068"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15941"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1863-2661"],["dc.relation.issn","1863-2653"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","191"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Brain: A Journal of Neurology"],["dc.bibliographiccitation.lastpage","204"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Neef, Nicole E"],["dc.contributor.author","Anwander, Alfred"],["dc.contributor.author","Bütfering, Christoph"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Friederici, Angela D"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2020-12-10T18:17:54Z"],["dc.date.available","2020-12-10T18:17:54Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1093/brain/awx316"],["dc.identifier.eissn","1460-2156"],["dc.identifier.issn","0006-8950"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75083"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Structural connectivity of right frontal hyperactive areas scales with stuttering severity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","I"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","II"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Jung, Kristina"],["dc.contributor.author","Rothkegel, Holger"],["dc.contributor.author","Pollok, Bettina"],["dc.contributor.author","von Gudenberg, Alexander Wolff"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2018-11-07T08:50:12Z"],["dc.date.available","2018-11-07T08:50:12Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1016/j.cortex.2011.08.009"],["dc.identifier.isi","000296930600023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21644"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Masson"],["dc.relation.issn","0010-9452"],["dc.title","Right-shift for non-speech motor processing in adults who stutter (vol 47, pg 945, 2011)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]