Ducho, Christian

[["dc.bibliographiccitation.firstpage","2503"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Synlett"],["dc.bibliographiccitation.lastpage","2507"],["dc.contributor.author","Spork, Anatol P."],["dc.contributor.author","Koppermann, Stefan"],["dc.contributor.author","Ducho, Christian"],["dc.date.accessioned","2018-11-07T11:24:15Z"],["dc.date.available","2018-11-07T11:24:15Z"],["dc.date.issued","2009"],["dc.description.abstract","Nucleoside antibiotics represent a promising class of natural products for the development of novel antibacterial agents, with particular respect to structurally simplified analogues maintaining biological activity. There are established truncated 5'-epi-derivatives of muraymycin nucleoside antibiotics with reported antibacterial properties, but the lengthy preparation Of Such compounds is a major hurdle in more detailed structure-activity relationship (SAR) studies. A concise, improved synthesis of truncated 5'-epi-muraymycins based on a previously reported approach using sulfur ylide chemistry is reported here. The highly convergent nature of this strategy will allow the efficient synthesis of novel muraymycin analogues for thorough SAR investigations."],["dc.identifier.doi","10.1055/s-0029-1217742"],["dc.identifier.isi","000270593200026"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56360"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0936-5214"],["dc.title","Improved Convergent Synthesis of 5 '-epi-Analogues of Muraymycin Nucleoside Antibiotics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2868"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Molecules"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Spork, Anatol"],["dc.contributor.author","Koppermann, Stefan"],["dc.contributor.author","Schier (née Wohnig), Stephanie"],["dc.contributor.author","Linder, Ruth"],["dc.contributor.author","Ducho, Christian"],["dc.date.accessioned","2020-12-10T18:47:16Z"],["dc.date.available","2020-12-10T18:47:16Z"],["dc.date.issued","2018"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.3390/molecules23112868"],["dc.identifier.eissn","1420-3049"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78702"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","MDPI"],["dc.relation.eissn","1420-3049"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Analogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core Structures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","763"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Tetrahedron Asymmetry"],["dc.bibliographiccitation.lastpage","766"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Spork, Anatol P."],["dc.contributor.author","Koppermann, Stefan"],["dc.contributor.author","Dittrich, Birger"],["dc.contributor.author","Herbst-Irmer, Regine"],["dc.contributor.author","Ducho, Christian"],["dc.date.accessioned","2018-11-07T08:43:59Z"],["dc.date.available","2018-11-07T08:43:59Z"],["dc.date.issued","2010"],["dc.description.abstract","The reaction of protected uridine 5'-aldehydes with sulfur ylides has been reinvestigated Further transformation of the resulting epoxide product provided a compound of which a single crystal for X-ray diffraction was obtained. As a consequence from the elucidated structure, the stereochemical configuration of the epoxide furnished by the sulfur ylide reaction was revised. Based on these results, an efficient synthesis of the core structure of the naturally occurring muraymycin and caprazamycin nucleoside antibiotics was developed. (C) 2010 Elsevier Ltd. All rights reserved"],["dc.identifier.doi","10.1016/j.tetasy.2010.03.037"],["dc.identifier.isi","000279493400001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20106"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0957-4166"],["dc.title","Efficient synthesis of the core structure of muraymycin and caprazamycin nucleoside antibiotics based on a stereochemically revised sulfur ylide reaction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","17813"],["dc.bibliographiccitation.issue","49"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","17819"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Wohnig, Stephanie"],["dc.contributor.author","Anatol, P. Spork A."],["dc.contributor.author","Koppermann, Stefan"],["dc.contributor.author","Mieskes, Gottfried"],["dc.contributor.author","Gisch, Nicolas"],["dc.contributor.author","Jahn, Reinhard"],["dc.contributor.author","Ducho, Christian"],["dc.date.accessioned","2018-11-07T10:04:38Z"],["dc.date.available","2018-11-07T10:04:38Z"],["dc.date.issued","2016"],["dc.description.abstract","The membrane protein translocase I (MraY) is a key enzyme in bacterial peptidoglycan biosynthesis. It is therefore frequently discussed as a target for the development of novel antibiotics. The screening of compound libraries for the identification of MraY inhibitors is enabled by an established fluorescence-based MraY assay. However, this assay requires a dansylated derivative of the bacterial biosynthetic intermediate Park's nucleotide as the MraY substrate. Isolation of Park's nucleotide from bacteria and subsequent dansylation only furnishes limited amounts of this substrate, thus hampering the high-throughput screening for MraY inhibitors. Accordingly, the efficient provision of dansylated Park's nucleotide is a major bottleneck in the exploration of this promising drug target. In this work, we present the first total synthesis of dansylated Park's nucleotide, affording an unprecedented amount of the target compound for high-throughput MraY assays."],["dc.identifier.doi","10.1002/chem.201604279"],["dc.identifier.isi","000388471700040"],["dc.identifier.pmid","27791327"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38739"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1521-3765"],["dc.relation.issn","0947-6539"],["dc.title","Total Synthesis of Dansylated Park's Nucleotide for High-Throughput MraY Assays"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]