Knauf, Yvonne

[["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.journal","Virus Research"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","204"],["dc.contributor.author","Plotzki, Elena"],["dc.contributor.author","Buerck, Lelia Wolf-van"],["dc.contributor.author","Knauf, Yvonne"],["dc.contributor.author","Becker, Tamara"],["dc.contributor.author","Maetz-Rensing, Kerstin"],["dc.contributor.author","Schuster, Marion"],["dc.contributor.author","Baehr, Andrea"],["dc.contributor.author","Klymiuk, Nikolai"],["dc.contributor.author","Wolf, Eckhard"],["dc.contributor.author","Seissler, Jochen"],["dc.contributor.author","Denner, Joachim"],["dc.date.accessioned","2022-10-06T13:33:28Z"],["dc.date.available","2022-10-06T13:33:28Z"],["dc.date.issued","2015"],["dc.description.sponsorship"," https://doi.org/10.13039/100007798 German Research Foundation"],["dc.identifier.doi","10.1016/j.virusres.2015.04.016"],["dc.identifier.pii","S0168170215001677"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115639"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0168-1702"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Virus safety of islet cell transplantation from transgenic pigs to marmosets"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","349"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Complementary medicine research"],["dc.bibliographiccitation.lastpage","357"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Biegel, Ulrike"],["dc.contributor.author","Stratmann, Nina"],["dc.contributor.author","Knauf, Yvonne"],["dc.contributor.author","Ruess, Katja"],["dc.contributor.author","Reif, Marcus"],["dc.contributor.author","Wehrend, Axel"],["dc.date.accessioned","2020-12-10T18:37:49Z"],["dc.date.available","2020-12-10T18:37:49Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1159/000485228"],["dc.identifier.eissn","2504-2106"],["dc.identifier.issn","2504-2092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77102"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Postoperative adjuvante Therapie mit einem Mistelextrakt (Viscum album ssp. album) bei Hündinnen mit Mammatumoren"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11745"],["dc.bibliographiccitation.issue","44"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences"],["dc.bibliographiccitation.lastpage","11750"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Ludwig, Barbara"],["dc.contributor.author","Ludwig, Stefan"],["dc.contributor.author","Steffen, Anja"],["dc.contributor.author","Knauf, Yvonne"],["dc.contributor.author","Zimerman, Baruch"],["dc.contributor.author","Heinke, Sophie"],["dc.contributor.author","Lehmann, Susann"],["dc.contributor.author","Schubert, Undine"],["dc.contributor.author","Schmid, Janine"],["dc.contributor.author","Bleyer, Martina"],["dc.contributor.author","Bornstein, Stefan R."],["dc.date.accessioned","2022-10-06T13:34:32Z"],["dc.date.available","2022-10-06T13:34:32Z"],["dc.date.issued","2017"],["dc.description.abstract","Significance\n Diabetes mellitus type 1 is an autoimmune disease that results in irreversible destruction of insulin-producing beta cells. Substantial advances have been made in beta cell replacement therapies during the last decades. However, lack of eligible donor organs and the need for chronic immunosuppression to prevent rejection critically limit widespread application of these strategies. In this manuscript, we present an experimental study using a bioartificial pancreas device for the transplantation of xenogeneic islet without affecting the immune system in nonhuman primates. We could demonstrate stable graft function and adequate glucose-regulated insulin secretion without the need for immunosuppressive medication. This strategy opens up new avenues for more widespread and safe application of various cell-based therapies."],["dc.description.abstract","Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions."],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship"," Bundesministerium für Bildung und Forschung http://dx.doi.org/10.13039/501100002347"],["dc.identifier.doi","10.1073/pnas.1708420114"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115933"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1091-6490"],["dc.relation.issn","0027-8424"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","http://www.pnas.org/site/aboutpnas/licenses.xhtml"],["dc.title","Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","579"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","American Journal of Primatology"],["dc.bibliographiccitation.lastpage","594"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Nga Nguyen, Nga Nguyen"],["dc.contributor.author","Fashing, Peter J."],["dc.contributor.author","Boyd, Derek A."],["dc.contributor.author","Barry, Tyler S."],["dc.contributor.author","Burke, Ryan J."],["dc.contributor.author","Goodale, C. Barret"],["dc.contributor.author","Jones, Sorrel C. Z."],["dc.contributor.author","Kerby, Jeffrey T."],["dc.contributor.author","Kellogg, Bryce S."],["dc.contributor.author","Lee, Laura M."],["dc.contributor.author","Miller, Carrie M."],["dc.contributor.author","Nurmi, Niina O."],["dc.contributor.author","Ramsay, Malcolm S."],["dc.contributor.author","Reynolds, Jason D."],["dc.contributor.author","Stewart, Kathrine M."],["dc.contributor.author","Turner, Taylor J."],["dc.contributor.author","Venkataraman, Vivek V."],["dc.contributor.author","Knauf, Yvonne"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Knauf, Sascha"],["dc.date.accessioned","2018-11-07T09:58:03Z"],["dc.date.available","2018-11-07T09:58:03Z"],["dc.date.issued","2015"],["dc.description.abstract","Parasitism is expected to impact host morbidity or mortality, although the fitness costs of parasitism have rarely been quantified for wildlife hosts. Tapeworms in the genus Taenia exploit a variety of vertebrates, including livestock, humans, and geladas (Theropithecus gelada), monkeys endemic to the alpine grasslands of Ethiopia. Despite Taenia's adverse societal and economic impacts, we know little about the prevalence of disease associated with Taenia infection in wildlife or the impacts of this disease on host health, mortality and reproduction. We monitored geladas at Guassa, Ethiopia over a continuous 61/2 year period for external evidence (cysts or coenuri) of Taenia-associated disease (coenurosis) and evaluated the impact of coenurosis on host survival and reproduction. We also identified (through genetic and histological analyses) the tapeworms causing coenurosis in wild geladas at Guassa as Taenia serialis. Nearly 1/3 of adult geladas at Guassa possessed 1 coenurus at some point in the study. Coenurosis adversely impacted gelada survival and reproduction at Guassa and this impact spanned two generations: adults with coenuri suffered higher mortality than members of their sex without coenuri and offspring of females with coenuri also suffered higher mortality. Coenurosis also negatively affected adult reproduction, lengthening interbirth intervals and reducing the likelihood that males successfully assumed reproductive control over units of females. Our study provides the first empirical evidence that coenurosis increases mortality and reduces fertility in wild nonhuman primate hosts. Our research highlights the value of longitudinal monitoring of individually recognized animals in natural populations for advancing knowledge of parasite-host evolutionary dynamics and offering clues to the etiology and control of infectious disease. Am. J. Primatol. 77:579-594, 2015. (c) 2015 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/ajp.22379"],["dc.identifier.isi","000353030300010"],["dc.identifier.pmid","25716944"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37292"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1098-2345"],["dc.relation.issn","0275-2565"],["dc.title","Fitness Impacts of Tapeworm Parasitism on Wild Gelada Monkeys at Guassa, Ethiopia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]