Kramann, Nadine

[["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Kramann, N."],["dc.contributor.author","Menken, Lena"],["dc.contributor.author","Hayardeny, Liat"],["dc.contributor.author","Hanisch, U-K"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Wegner, C."],["dc.date.accessioned","2018-11-07T09:35:28Z"],["dc.date.available","2018-11-07T09:35:28Z"],["dc.date.issued","2014"],["dc.format.extent","382"],["dc.identifier.isi","000354441300878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32389"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.conference","Joint ACTRIMS-ECTRIMS Meeting"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1477-0970"],["dc.relation.issn","1352-4585"],["dc.title","Laquinimod treatment prevents cuprizone-induced demyelination independent of Toll-like receptor signaling via MyD88 and TRIF"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","88"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cardiovascular Research"],["dc.bibliographiccitation.lastpage","96"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Kramann, Nadine"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Seidler, Tim"],["dc.date.accessioned","2017-09-07T11:46:22Z"],["dc.date.available","2017-09-07T11:46:22Z"],["dc.date.issued","2014"],["dc.description.abstract","Aim Activation of the kinase RAF and its downstream targets leads to cardiomyocyte hypertrophy. It has been hypothesized that B-RAF might be the main activator of MEK in various cell types. Therefore, the aim of this study was to investigate the role of B-RAF and its modulating factors in cardiomyocyte hypertrophy. Methods and results Neonatal rat cardiomyocytes were pre-treated with and without the specific B-RAF inhibitor SB590885 and then stimulated with phenylephrine to induce hypertrophy. Inhibition of B-RAF completely impeded the hypertrophic response and led to a significant reduction of MEK1/2 phosphorylation. By applying a eukaryotic cDNA expression screen, based on a dual-luciferase reporter assay for B-RAF activity measurement, we identified RCN1 as a new negative modulator of B-RAF activity. Adenovirus-mediated overexpression of reticulocalbin 1 (RCN1) completely impeded phenylephrine-induced hypertrophy and led to significantly reduced MEK1/2 phosphorylation. Conversely, adenoviral knockdown of RCN1 with a specific synthetic miRNA induced cardiomyocyte hypertrophy and significantly increased MEK1/2 phosphorylation. Conclusions In summary, our results show that the inhibition of B-RAF abolishes cardiomyocyte hypertrophy and we identified RCN1 as novel negative modulator of cardiomyocyte hypertrophy by inhibition of the mitogen-activated protein kinase signalling cascade. Our results show that B-RAF kinase activity is essential for cardiac hypertrophy and RCN1, its newly identified negative regulator, abolishes hypertrophic response of cardiomyocytes in vitro."],["dc.identifier.doi","10.1093/cvr/cvu024"],["dc.identifier.gro","3142156"],["dc.identifier.isi","000334105600012"],["dc.identifier.pmid","24492844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/5155"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Oxford Univ Press"],["dc.relation.eissn","1755-3245"],["dc.relation.issn","0008-6363"],["dc.title","B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.volume","105"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Schmidt, Albrecht"],["dc.contributor.author","Kurz, Kathrin"],["dc.contributor.author","Knoell, Ralph"],["dc.contributor.author","Kramann, Nadine"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T11:24:12Z"],["dc.date.available","2018-11-07T11:24:12Z"],["dc.date.issued","2009"],["dc.format.extent","E15"],["dc.identifier.isi","000270150800039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56352"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","Basic Cardiovascular Sciences Conference 2009"],["dc.relation.eventlocation","Lake Las Vegas, Henderson, NV"],["dc.relation.issn","0009-7330"],["dc.title","Impedes Mitogenic Signal Propagation (IMP) Is Essential for Embryonic Heart and Brain Development and Controls Cardiac Performance via MAPK Signaling in Vivo"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.volume","253"],["dc.contributor.author","Kramann, Nadine"],["dc.contributor.author","Pfoertner, Ramona"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Wegner, Christiane"],["dc.date.accessioned","2018-11-07T09:02:17Z"],["dc.date.available","2018-11-07T09:02:17Z"],["dc.date.issued","2012"],["dc.format.extent","172"],["dc.identifier.isi","000312764800462"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24647"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","11th International Congress of Neuroimmunology (ISNI)"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","0165-5728"],["dc.title","Laquinimod reduces astrocytic NF kappa B activation in vitro and in vivo"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Pfoertner, Ramona"],["dc.contributor.author","Kramann, N."],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Wegner, C."],["dc.date.accessioned","2018-11-07T09:05:36Z"],["dc.date.available","2018-11-07T09:05:36Z"],["dc.date.issued","2012"],["dc.format.extent","215"],["dc.identifier.isi","000328702201080"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25361"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.conference","28th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis"],["dc.relation.eventlocation","Lyon, FRANCE"],["dc.relation.issn","1477-0970"],["dc.relation.issn","1352-4585"],["dc.title","Laquinimod treatment reduces cuprizone-induced pathology in a dose-dependent manner"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Kramann, N."],["dc.contributor.author","Pfoertner, Ramona"],["dc.contributor.author","Hanisch, U.-K."],["dc.contributor.author","Hagemeier, Karin"],["dc.contributor.author","Kuhlmann, T."],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Wegner, C."],["dc.date.accessioned","2018-11-07T09:23:23Z"],["dc.date.available","2018-11-07T09:23:23Z"],["dc.date.issued","2013"],["dc.format.extent","S62"],["dc.identifier.isi","000320408400191"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29564"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","11th European Meeting on Glial Cell Function in Health and Disease"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0894-1491"],["dc.title","LAQUINIMOD REDUCES ASTROCYTIC BUT NOT MICROGLIAL NFKB ACTIVATION IN VITRO AND IN VIVO"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e233"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neurology - Neuroimmunology Neuroinflammation"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Kramann, Nadine"],["dc.contributor.author","Menken, Lena"],["dc.contributor.author","Hayardeny, Liat"],["dc.contributor.author","Hanisch, Uwe-Karsten"],["dc.contributor.author","Brück, Wolfgang"],["dc.date.accessioned","2020-12-10T18:41:41Z"],["dc.date.available","2020-12-10T18:41:41Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1212/NXI.0000000000000233"],["dc.identifier.eissn","2332-7812"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77647"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]