Thumm, Michael

[["dc.bibliographiccitation.firstpage","965"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","The Journal of Cell Biology"],["dc.bibliographiccitation.lastpage","973"],["dc.bibliographiccitation.volume","190"],["dc.contributor.author","Krick, Roswitha"],["dc.contributor.author","Bremer, Sebastian"],["dc.contributor.author","Welter, Evelyn"],["dc.contributor.author","Schlotterhose, Petra"],["dc.contributor.author","Muehe, Yvonne"],["dc.contributor.author","Eskelinen, Eeva-Liisa"],["dc.contributor.author","Thumm, Michael"],["dc.date.accessioned","2018-11-07T08:39:07Z"],["dc.date.available","2018-11-07T08:39:07Z"],["dc.date.issued","2010"],["dc.description.abstract","The molecular details of the biogenesis of double-membraned autophagosomes are poorly understood. We identify the Saccharomyces cerevisiae AAA-adenosine triphosphatase Cdc48 and its substrate-recruiting cofactor Shp1/Ubx1 as novel components needed for autophagosome biogenesis. In mammals, the Cdc48 homologue p97/VCP and the Shp1 homologue p47 mediate Golgi reassembly by extracting an unknown mono-ubiquitinated fusion regulator from a complex. We find no requirement of ubiquitination or the proteasome system for autophagosome biogenesis but detect interaction of Shp1 with the ubiquitin-fold autophagy protein Atg8. Atg8 coupled to phosphatidylethanolamine ( PE) is crucial for autophagosome elongation and, in vitro, mediates tethering and hemifusion. Interaction with Shp1 requires an FK motif within the N-terminal non-ubiquitin-like Atg8 domain. Based on our data, we speculate that autophagosome formation, in contrast to Golgi reassembly, requires a complex in which Atg8 functionally substitutes ubiquitin. This, for the first time, would give a rationale for use of the ubiquitin-like Atg8 during macroautophagy and would explain why Atg8-PE delipidation is necessary for efficient macroautophagy."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.1083/jcb.201002075"],["dc.identifier.isi","000282604600005"],["dc.identifier.pmid","20855502"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6296"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18915"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Rockefeller Univ Press"],["dc.relation.issn","0021-9525"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1273"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Autophagy"],["dc.bibliographiccitation.lastpage","1294"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Klionsky, Daniel J."],["dc.contributor.author","Baehrecke, Eric H."],["dc.contributor.author","Brumell, John H."],["dc.contributor.author","Chu, Charleen T."],["dc.contributor.author","Codogno, Patrice"],["dc.contributor.author","Cuervo, Ana Maria"],["dc.contributor.author","Debnath, Jayanta"],["dc.contributor.author","Deretic, Vojo"],["dc.contributor.author","Elazar, Zvulun"],["dc.contributor.author","Eskelinen, Eeva-Liisa"],["dc.contributor.author","Finkbeiner, Steven"],["dc.contributor.author","Fueyo-Margareto, Juan"],["dc.contributor.author","Gewirtz, David A."],["dc.contributor.author","Jaattela, Marja"],["dc.contributor.author","Kroemer, Guido"],["dc.contributor.author","Levine, Beth"],["dc.contributor.author","Melia, Thomas J."],["dc.contributor.author","Mizushima, Noboru"],["dc.contributor.author","Rubinsztein, David C."],["dc.contributor.author","Simonsen, Anne"],["dc.contributor.author","Thorburn, Andrew"],["dc.contributor.author","Thumm, Michael"],["dc.contributor.author","Tooze, Sharon A."],["dc.date.accessioned","2018-11-07T08:50:15Z"],["dc.date.available","2018-11-07T08:50:15Z"],["dc.date.issued","2011"],["dc.description.abstract","The study of autophagy is rapidly expanding, and our knowledge of the molecular mechanism and its connections to a wide range of physiological processes has increased substantially in the past decade. The vocabulary associated with autophagy has grown concomitantly. In fact, it is difficult for readers-even those who work in the field-to keep up with the ever-expanding terminology associated with the various autophagy-related processes. Accordingly, we have developed a comprehensive glossary of autophagy-related terms that is meant to provide a quick reference for researchers who need a brief reminder of the regulatory effects of transcription factors and chemical agents that induce or inhibit autophagy, the function of the autophagy-related proteins, and the roles of accessory components and structures that are associated with autophagy."],["dc.identifier.doi","10.4161/auto.7.11.17661"],["dc.identifier.isi","000296588300002"],["dc.identifier.pmid","21997368"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21656"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis Inc"],["dc.relation.issn","1554-8635"],["dc.relation.issn","1554-8627"],["dc.title","A comprehensive glossary of autophagy-related molecules and processes (2(nd) edition)"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Autophagy"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Thumm, Michael"],["dc.contributor.author","Bremer, Sebastian"],["dc.contributor.author","Welter, Evelyn"],["dc.contributor.author","Eskelinen, Eeva-Liisa"],["dc.contributor.author","Krick, Roswitha"],["dc.date.accessioned","2018-11-07T11:25:41Z"],["dc.date.available","2018-11-07T11:25:41Z"],["dc.date.issued","2009"],["dc.format.extent","897"],["dc.identifier.isi","000269021700039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56684"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.publisher.place","Austin"],["dc.relation.issn","1554-8627"],["dc.title","Molecular mechanism of micronucleophagy (piecemeal microautophagy of the nucleus, PMN) in S. cerevisiae"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","270"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Autophagy"],["dc.bibliographiccitation.lastpage","272"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Krick, Roswitha"],["dc.contributor.author","Muhe, Yvonne"],["dc.contributor.author","Prick, Tanja"],["dc.contributor.author","Bredschneider, Monika"],["dc.contributor.author","Bremer, Sebastian"],["dc.contributor.author","Wenzel, Dirk"],["dc.contributor.author","Eskelinen, Eeva-Liisa"],["dc.contributor.author","Thumm, Michael"],["dc.date.accessioned","2018-11-07T08:32:42Z"],["dc.date.available","2018-11-07T08:32:42Z"],["dc.date.issued","2009"],["dc.description.abstract","Nucleus-vacuole (NV) junctions are formed in Saccharomyces cerevisiae through interactions between Vac8 in the vacuole membrane and Nvj1 in the perinuclear ER. Upon starvation, vesicles containing part of the nucleus emanate from these contact sites and finally pinch off into invaginations of the vacuole. Due to its morphological similarity to microautophagy this process had been termed \"piecemeal microautophagy of the nucleus\" (PMN). We recently discovered that a number of ATG genes required for macroautophagy and micropexophagy are also required for PMN and accordingly named it micronucleophagy. Therefore, PMN represents a novel model system to investigate the functions of the highly conserved but poorly understood core autophagic apparatus. We here extend the morphological analysis of PMN using immunogold and freeze fracture electron microscopy."],["dc.identifier.doi","10.1091/mbc.E08-04-0363"],["dc.identifier.isi","000263723900027"],["dc.identifier.pmid","19182523"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17400"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.relation.issn","1554-8627"],["dc.title","Piecemeal microautophagy of the nucleus Genetic and morphological traits"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","250"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Autophagy"],["dc.bibliographiccitation.lastpage","251"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Krick, Roswitha"],["dc.contributor.author","Bremer, Sebastian"],["dc.contributor.author","Welter, Evelyn"],["dc.contributor.author","Eskelinen, Eeva-Liisa"],["dc.contributor.author","Thumm, Michael"],["dc.date.accessioned","2018-11-07T08:59:37Z"],["dc.date.available","2018-11-07T08:59:37Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.4161/auto.7.2.14383"],["dc.identifier.isi","000286802800018"],["dc.identifier.pmid","21150310"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23943"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.relation.issn","1554-8627"],["dc.title","Cheating on ubiquitin with Atg8"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]