Schaap, Iwan A. T.

[["dc.bibliographiccitation.artnumber","7523"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Butkevich, Eugenia"],["dc.contributor.author","Bodensiek, Kai"],["dc.contributor.author","Fakhri, Nikta"],["dc.contributor.author","von Roden, Kerstin"],["dc.contributor.author","Schaap, Iwan A. T."],["dc.contributor.author","Majoul, Irina"],["dc.contributor.author","Schmidt, Christoph"],["dc.contributor.author","Klopfenstein, Dieter R."],["dc.date.accessioned","2017-09-07T11:43:42Z"],["dc.date.available","2017-09-07T11:43:42Z"],["dc.date.issued","2015"],["dc.description.abstract","Actin filament organization and stability in the sarcomeres of muscle cells are critical for force generation. Here we identify and functionally characterize a Caenorhabditis elegans drebrin-like protein DBN-1 as a novel constituent of the muscle contraction machinery. In vitro, DBN-1 exhibits actin filament binding and bundling activity. In vivo, DBN-1 is expressed in body wall muscles of C. elegans. During the muscle contraction cycle, DBN-1 alternates location between myosin- and actin-rich regions of the sarcomere. In contracted muscle, DBN-1 is accumulated at I-bands where it likely regulates proper spacing of alpha-actinin and tropomyosin and protects actin filaments from the interaction with ADF/cofilin. DBN-1 loss of function results in the partial depolymerization of F-actin during muscle contraction. Taken together, our data show that DBN-1 organizes the muscle contractile apparatus maintaining the spatial relationship between actin-binding proteins such as alpha-actinin, tropomyosin and ADF/cofilin and possibly strengthening actin filaments by bundling."],["dc.identifier.doi","10.1038/ncomms8523"],["dc.identifier.gro","3141869"],["dc.identifier.isi","000358851600001"],["dc.identifier.pmid","26146072"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16945"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1978"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2041-1723"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]