Mandad, Sunit

[["dc.bibliographiccitation.firstpage","3333"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Nature Protocols"],["dc.bibliographiccitation.lastpage","3365"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Alevra, Mihai"],["dc.contributor.author","Mandad, Sunit"],["dc.contributor.author","Ischebeck, Till"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Rizzoli, Silvio O."],["dc.contributor.author","Fornasiero, Eugenio F."],["dc.date.accessioned","2020-12-10T18:10:05Z"],["dc.date.available","2020-12-10T18:10:05Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1038/s41596-019-0222-y"],["dc.identifier.pmid","31685960"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73844"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/110"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/80"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | A03: Dynamische Analyse der Remodellierung der extrazellulären Matrix (ECM) als Mechanismus der Synapsenorganisation und Plastizität"],["dc.relation.workinggroup","RG Rizzoli (Quantitative Synaptology in Space and Time)"],["dc.relation.workinggroup","RG Urlaub (Bioanalytische Massenspektrometrie)"],["dc.title","A mass spectrometry workflow for measuring protein turnover rates in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","eabn4437"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Science Advances"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Kluever, Verena"],["dc.contributor.author","Russo, Belisa"],["dc.contributor.author","Mandad, Sunit"],["dc.contributor.author","Kumar, Nisha Hemandhar"],["dc.contributor.author","Alevra, Mihai"],["dc.contributor.author","Ori, Alessandro"],["dc.contributor.author","Rizzoli, Silvio O."],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Fornasiero, Eugenio F."],["dc.date.accessioned","2022-06-01T09:39:33Z"],["dc.date.available","2022-06-01T09:39:33Z"],["dc.date.issued","2022"],["dc.description.abstract","Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the molecular mechanisms rendering the aged brain particularly susceptible to neurodegeneration remain unclear. Here, we aim to determine the link between physiological aging and NDDs by exploring protein turnover using metabolic labeling and quantitative pulse-SILAC proteomics. By comparing protein lifetimes between physiologically aged and young adult mice, we found that in aged brains protein lifetimes are increased by ~20% and that aging affects distinct pathways linked to NDDs. Specifically, a set of neuroprotective proteins are longer-lived in aged brains, while some mitochondrial proteins linked to neurodegeneration are shorter-lived. Strikingly, we observed a previously unknown alteration in proteostasis that correlates to parsimonious turnover of proteins with high biosynthetic costs, revealing an overall metabolic adaptation that preludes neurodegeneration. Our findings suggest that future therapeutic paradigms, aimed at addressing these metabolic adaptations, might be able to delay NDD onset."],["dc.description.abstract","Physiological brain aging affects protein turnover, altering the stability of proteins linked to neurodegenerative diseases."],["dc.identifier.doi","10.1126/sciadv.abn4437"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108506"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","2375-2548"],["dc.title","Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The EMBO Journal"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Mariappan, Aruljothi"],["dc.contributor.author","Soni, Komal"],["dc.contributor.author","Schorpp, Kenji"],["dc.contributor.author","Zhao, Fan"],["dc.contributor.author","Minakar, Amin"],["dc.contributor.author","Zheng, Xiangdong"],["dc.contributor.author","Mandad, Sunit"],["dc.contributor.author","Macheleidt, Iris"],["dc.contributor.author","Ramani, Anand"],["dc.contributor.author","Kubelka, Tomáš"],["dc.contributor.author","Dawidowski, Maciej"],["dc.contributor.author","Golfmann, Kristina"],["dc.contributor.author","Wason, Arpit"],["dc.contributor.author","Yang, Chunhua"],["dc.contributor.author","Simons, Judith"],["dc.contributor.author","Schmalz, Hans‐Günther"],["dc.contributor.author","Hyman, Anthony A"],["dc.contributor.author","Aneja, Ritu"],["dc.contributor.author","Ullrich, Roland"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Odenthal, Margarete"],["dc.contributor.author","Büttner, Reinhardt"],["dc.contributor.author","Li, Haitao"],["dc.contributor.author","Sattler, Michael"],["dc.contributor.author","Hadian, Kamyar"],["dc.contributor.author","Gopalakrishnan, Jay"],["dc.date.accessioned","2020-12-10T18:42:37Z"],["dc.date.available","2020-12-10T18:42:37Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.15252/embj.201899876"],["dc.identifier.eissn","1460-2075"],["dc.identifier.issn","0261-4189"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78027"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Inhibition of CPAP –tubulin interaction prevents proliferation of centrosome‐amplified cancer cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3618"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.lastpage","3630.e6"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Ramani, Anand"],["dc.contributor.author","Mariappan, Aruljothi"],["dc.contributor.author","Gottardo, Marco"],["dc.contributor.author","Mandad, Sunit"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Avidor-Reiss, Tomer"],["dc.contributor.author","Riparbelli, Maria"],["dc.contributor.author","Callaini, Giuliano"],["dc.contributor.author","Debec, Alain"],["dc.contributor.author","Feederle, Regina"],["dc.contributor.author","Gopalakrishnan, Jay"],["dc.date.accessioned","2020-12-10T14:23:01Z"],["dc.date.available","2020-12-10T14:23:01Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.celrep.2018.11.102"],["dc.identifier.issn","2211-1247"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71805"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Plk1/Polo Phosphorylates Sas-4 at the Onset of Mitosis for an Efficient Recruitment of Pericentriolar Material to Centrosomes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","eaam7816"],["dc.bibliographiccitation.issue","419"],["dc.bibliographiccitation.journal","Science Translational Medicine"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Fard, Maryam K."],["dc.contributor.author","van der Meer, Franziska"],["dc.contributor.author","Sánchez, Paula"],["dc.contributor.author","Cantuti-Castelvetri, Ludovico"],["dc.contributor.author","Mandad, Sunit"],["dc.contributor.author","Jäkel, Sarah"],["dc.contributor.author","Fornasiero, Eugenio F."],["dc.contributor.author","Schmitt, Sebastian"],["dc.contributor.author","Ehrlich, Marc"],["dc.contributor.author","Starost, Laura"],["dc.contributor.author","Kuhlmann, Tanja"],["dc.contributor.author","Sergiou, Christina"],["dc.contributor.author","Schultz, Verena"],["dc.contributor.author","Wrzos, Claudia"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Dimou, Leda"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Simons, Mikael"],["dc.date.accessioned","2020-12-10T18:36:46Z"],["dc.date.available","2020-12-10T18:36:46Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1126/scitranslmed.aam7816"],["dc.identifier.eissn","1946-6242"],["dc.identifier.issn","1946-6234"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76735"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1023"],["dc.bibliographiccitation.issue","6187"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.lastpage","1028"],["dc.bibliographiccitation.volume","344"],["dc.contributor.author","Wilhelm, Benjamin G."],["dc.contributor.author","Mandad, Sunit"],["dc.contributor.author","Truckenbrodt, Sven"],["dc.contributor.author","Kroehnert, Katharina"],["dc.contributor.author","Schaefer, Christina"],["dc.contributor.author","Rammner, Burkhard"],["dc.contributor.author","Koo, Seong Joo"],["dc.contributor.author","Classen, Gala A."],["dc.contributor.author","Krauss, Michael"],["dc.contributor.author","Haucke, Volker"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Rizzoli, S. O."],["dc.date.accessioned","2017-09-07T11:46:14Z"],["dc.date.available","2017-09-07T11:46:14Z"],["dc.date.issued","2014"],["dc.description.abstract","Synaptic vesicle recycling has long served as a model for the general mechanisms of cellular trafficking. We used an integrative approach, combining quantitative immunoblotting and mass spectrometry to determine protein numbers; electron microscopy to measure organelle numbers, sizes, and positions; and super-resolution fluorescence microscopy to localize the proteins. Using these data, we generated a three-dimensional model of an \"average\" synapse, displaying 300,000 proteins in atomic detail. The copy numbers of proteins involved in the same step of synaptic vesicle recycling correlated closely. In contrast, copy numbers varied over more than three orders of magnitude between steps, from about 150 copies for the endosomal fusion proteins to more than 20,000 for the exocytotic ones."],["dc.identifier.doi","10.1126/science.1252884"],["dc.identifier.gro","3142118"],["dc.identifier.isi","000336495800044"],["dc.identifier.pmid","24876496"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4744"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1095-9203"],["dc.relation.issn","0036-8075"],["dc.title","Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1151"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Nature Neuroscience"],["dc.bibliographiccitation.lastpage","1162"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Helm, Martin S."],["dc.contributor.author","Dankovich, Tal M."],["dc.contributor.author","Mandad, Sunit"],["dc.contributor.author","Rammner, Burkhard"],["dc.contributor.author","Jähne, Sebastian"],["dc.contributor.author","Salimi, Vanessa"],["dc.contributor.author","Koerbs, Christina"],["dc.contributor.author","Leibrandt, Richard"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Rizzoli, Silvio O."],["dc.date.accessioned","2021-08-12T07:44:59Z"],["dc.date.available","2021-08-12T07:44:59Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1038/s41593-021-00874-w"],["dc.identifier.pii","874"],["dc.identifier.pmid","34168338"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88345"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/312"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/148"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/125"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P09: Proteinsortierung in der Synapse: Prinzipien und molekulare Organisation"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | A03: Dynamische Analyse der Remodellierung der extrazellulären Matrix (ECM) als Mechanismus der Synapsenorganisation und Plastizität"],["dc.relation","SFB 1286 | A08: Die Rolle post-translational modifizierter Proteine in der synaptischen Übertragung"],["dc.relation.eissn","1546-1726"],["dc.relation.issn","1097-6256"],["dc.relation.workinggroup","RG Rizzoli (Quantitative Synaptology in Space and Time)"],["dc.relation.workinggroup","RG Urlaub (Bioanalytische Massenspektrometrie)"],["dc.title","A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]