Schnieder, Marlena

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2018-01-08T17:09:39Z"],["dc.date.available","2018-01-08T17:09:39Z"],["dc.date.issued","2017"],["dc.description.abstract","Identification of patients requiring decompressive hemicraniectomy (DH) after endovascular therapy (EVT) is crucial as clinical signs are not reliable and early DH has been shown to improve clinical outcome. The aim of our study was to identify imaging-based scores to predict the risk for space occupying ischemic stroke and DH."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1371/journal.pone.0173737"],["dc.identifier.pmid","28282456"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14394"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11572"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Early computed tomography-based scores to predict decompressive hemicraniectomy after endovascular therapy in acute ischemic stroke"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","338"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Fischer-Wedi, Charlotte V."],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Kortleben, Mai-Linh"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2021-04-14T08:29:40Z"],["dc.date.available","2021-04-14T08:29:40Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3390/jcm10020338"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82962"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","2077-0383"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","The Retrobulbar Spot Sign and Prominent Middle Limiting Membrane as Prognostic Markers in Non-Arteritic Retinal Artery Occlusion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2171"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Kirsch, Mareike"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Riedel, Christian Heiner"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Brehm, Alex"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","von Arnim, Christine A. F."],["dc.date.accessioned","2021-07-05T15:00:47Z"],["dc.date.available","2021-07-05T15:00:47Z"],["dc.date.issued","2021"],["dc.description.abstract","Frailty is associated with an increased risk of adverse health-care outcomes in elderly patients. The Hospital Frailty Risk Score (HFRS) has been developed and proven to be capable of identifying patients which are at high risk of adverse outcomes. We aimed to investigate whether frail patients also face adverse outcomes after experiencing an endovascular treated large vessel occlusion stroke (LVOS). In this retrospective observational cohort study, we analyzed patients ≥ 65 years that were admitted during 2015–2019 with LVOS and endovascular treatment. Primary outcomes were mortality and the modified Rankin Scale (mRS) after three months. Regression models were used to determine the impact of frailty. A total of 318 patients were included in the cohort. The median HFRS was 1.6 (IQR 4.8). A total of 238 (75.1%) patients fulfilled the criteria for a low-frailty risk with a HFRS < 5.72 (22.7%) for moderate-frailty risk with an HFRS from 5–15 and 7 (2.2%) patients for a high-frailty risk. Multivariate regression analyses revealed that the HFRS was associated with an increased mortality after 90 days (CI (95%) 1.001 to 1.236; OR 1.112) and a worse mRS (CI (95%) 1.004 to 1.270; OR 1.129). We identified frailty as an impact factor on functional outcome and mortality in patients undergoing thrombectomy in LVOS."],["dc.description.abstract","Frailty is associated with an increased risk of adverse health-care outcomes in elderly patients. The Hospital Frailty Risk Score (HFRS) has been developed and proven to be capable of identifying patients which are at high risk of adverse outcomes. We aimed to investigate whether frail patients also face adverse outcomes after experiencing an endovascular treated large vessel occlusion stroke (LVOS). In this retrospective observational cohort study, we analyzed patients ≥ 65 years that were admitted during 2015–2019 with LVOS and endovascular treatment. Primary outcomes were mortality and the modified Rankin Scale (mRS) after three months. Regression models were used to determine the impact of frailty. A total of 318 patients were included in the cohort. The median HFRS was 1.6 (IQR 4.8). A total of 238 (75.1%) patients fulfilled the criteria for a low-frailty risk with a HFRS < 5.72 (22.7%) for moderate-frailty risk with an HFRS from 5–15 and 7 (2.2%) patients for a high-frailty risk. Multivariate regression analyses revealed that the HFRS was associated with an increased mortality after 90 days (CI (95%) 1.001 to 1.236; OR 1.112) and a worse mRS (CI (95%) 1.004 to 1.270; OR 1.129). We identified frailty as an impact factor on functional outcome and mortality in patients undergoing thrombectomy in LVOS."],["dc.identifier.doi","10.3390/jcm10102171"],["dc.identifier.pii","jcm10102171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87901"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.publisher","MDPI"],["dc.relation.eissn","2077-0383"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2185"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Hesse, Amélie Carolina"],["dc.contributor.author","Brehm, Alex"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Papageorgiou, Ismini"],["dc.contributor.author","Liebeskind, David S."],["dc.contributor.author","Goyal, Mayank"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2020-12-10T18:47:12Z"],["dc.date.available","2020-12-10T18:47:12Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.3390/jcm8122185"],["dc.identifier.eissn","2077-0383"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78678"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2077-0383"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","One-Stop Management of 230 Consecutive Acute Stroke Patients: Report of Procedural Times and Clinical Outcome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","29"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurological Research and Practice"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Ettelt, Philipp"],["dc.contributor.author","Maier, Ilko L"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2020-08-02T03:48:09Z"],["dc.date.accessioned","2021-10-27T13:22:18Z"],["dc.date.available","2020-08-02T03:48:09Z"],["dc.date.available","2021-10-27T13:22:18Z"],["dc.date.issued","2020"],["dc.date.updated","2020-08-02T03:48:09Z"],["dc.description.abstract","Abstract Background The targeted use of endovascular therapy (EVT), with or without intravenous thrombolysis (IVT) in acute large cerebral vessel occlusion stroke (LVOS) has been proven to be superior compared to IVT alone. Despite favorable functional outcome, many patients complain about cognitive decline after EVT. If IVT in addition to EVT has positive effects on cognitive function is unclear. Methods We analyzed data from the German Stroke Registry (GSR, an open, multicenter and prospective observational study) and compared cognitive function 90 days after index ischemic stroke using MoCA in patients with independent (mRS ≤ 2 pts) and excellent (mRS = 0 pts) functional outcome receiving combined EVT and IVT (EVT + IVT) vs. EVT alone (EVT-IVT). Results Of the 2636 GSR patients, we included 166 patients with mRS ≤ 2 at 90 days in our analysis. Of these, 103 patients (62%) received EVT + IVT, 63 patients (38%) were treated with EVT alone. There was no difference in reperfusion status between groups (mTICI ≥ 2b in both groups at 95%, p = 0.65). Median MoCA score in the EVT + IVT group was 20 pts. (18–25 IQR) vs. 18 pts. (16–21 IQR) in the EVT-IVT group (p = 0.014). There were more patients with cognitive impairment (defined as MoCA < 26 pts) in the EVT-IVT group (54 patients (86%)) compared to the EVT + IVT group (78 patients (76%)). EVT + IVT was associated with a higher MoCA score at 90 days (mRS ≤ 2: p = 0.033, B = 2.39; mRS = 0: p = 0.021, B = 4.38). Conclusions In Patients with good functional outcome after LVOS, rates of cognitive impairment are lower with combined EVT and IVT compared to EVT alone. Trial registration ClinicalTrials.gov Identifier: NCT03356392 ."],["dc.identifier.doi","10.1186/s42466-020-00079-9"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17491"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92082"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Bridging therapy is associated with improved cognitive function after large vessel occlusion stroke – an analysis of the German Stroke Registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0216258"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Brehm, Alex"],["dc.contributor.author","Hesse, Amelie"],["dc.contributor.author","McTaggart, Ryan"],["dc.contributor.author","Goyal, Mayank"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Maus, Volker"],["dc.date.accessioned","2019-07-09T11:51:31Z"],["dc.date.available","2019-07-09T11:51:31Z"],["dc.date.issued","2019"],["dc.description.abstract","INTRODUCTION: The \"Stent retriever Assisted Vacuum-locked Extraction\" (SAVE) technique is a promising embolectomy method for intracranial large vessel occlusion (LVO). We report our experience using a modified SAVE (mSAVE) approach for clot reduction prior to embolectomy in acute ischemic stroke patients with large clots. MATERIALS AND METHODS: We retrospectively analyzed 20 consecutive patients undergoing mSAVE in our center due to intracranial LVO. Angiographic data (including first-pass and overall complete reperfusion, defined as an expanded Thrombolysis in Cerebral Infarction (eTICI) score of 3, rate of successful reperfusion (eTICI ≥2c), number of passes, time from groin puncture to reperfusion) and clinical data (favorable outcome at 90 days, defined as modified Rankin Scale (mRS) ≤2) were assessed. RESULTS: First-pass and overall eTICI 3 reperfusion was reached in 13/20 (65%) and 14/20 (70%), respectively. The rate of successful reperfusion (eTICI ≥2c) after one pass was 85% and on final angiogram 90% with an average number of 1.1 ± 0.3 attempts. Eight out of 11 (73%) ICA occlusions were reperfused successfully and 5 (46%) completely after a single pass. Median groin to reperfusion time was 33 minutes (IQR 25-46). A favorable clinical outcome was achieved in 9/20 (45%) patients at discharge and after 90 days, respectively. CONCLUSION: Clot reduction followed by embolectomy (mSAVE) is feasible and may be an important tool in the treatment of large clots."],["dc.identifier.doi","10.1371/journal.pone.0216258"],["dc.identifier.pmid","31071109"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16142"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59962"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Clot reduction prior to embolectomy: mSAVE as a first-line technique for large clots"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0196174"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Becker, Johannes C."],["dc.contributor.author","Leyhe, Johanna Rosemarie"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2019-07-09T11:45:41Z"],["dc.date.available","2019-07-09T11:45:41Z"],["dc.date.issued","2018"],["dc.description.abstract","BACKGROUND: Stroke-induced immunodepression is a well characterized complication of acute ischemic stroke. In experimental studies beta-blocker therapy reversed stroke-induced immunodepression, reduced infection rates and mortality. Recent, heterogeneous studies in stroke patients could not provide evidence of a protective effect of beta-blocker therapy. Aim of this study is to investigate the potential preventive effect of beta-blockers in subgroups of patients at high risk for stroke-induced immunodepression. METHODS: Data from a prospectively derived registry of major stroke patients receiving endovascular therapy between 2011-2017 in a tertiary stroke center (University Medical Center Göttingen. Germany) was used. The effect of beta-blocker therapy on pneumonia, urinary tract infection, sepsis and mortality was assessed using multivariate logistic regression analysis. RESULTS: Three hundred six patients with a mean age of 72 ± 13 years and a median NIHSS of 16 (IQR 10.75-20) were included. 158 patients (51.6%) had pre-stroke- and continued beta-blocker therapy. Beta-blocker therapy did not reduce the incidence of pneumonia (OR 0.78, 95% CI 0.31-1.92, p = 0.584), urinary tract infections (OR 1.51, 0.88-2.60, p = 0.135), sepsis (OR 0.57, 0.18-1.80, p = 0.334) or mortality (OR 0.59, 0.16-2.17, p = 0.429). Strokes involving the insula and anterio-medial cortex increased the risk for pneumonia (OR 4.55, 2.41-8.56, p<0.001) and sepsis (OR 4.13, 1.81-9.43, p = 0.001), while right hemispheric strokes increased the risk for pneumonia (OR 1.60, 0.92-2.77, p = 0.096). There was a non-significantly increased risk for urinary tract infections in patients with beta-blocker therapy and insula/anterio-medial cortex strokes (OR 3.12, 95% CI 0.88-11.05, p = 0.077) with no effect of beta-blocker therapy on pneumonia, sepsis or mortality in both subgroups. CONCLUSIONS: In major ischemic stroke patients, beta-blocker therapy did not lower post-stroke infection rates and was associated with urinary tract infections in a subgroup with insula/anterio-medial strokes."],["dc.identifier.doi","10.1371/journal.pone.0196174"],["dc.identifier.pmid","29694433"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15285"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59286"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.subject.mesh","Adrenergic beta-Antagonists"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Aged, 80 and over"],["dc.subject.mesh","Death"],["dc.subject.mesh","Female"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Incidence"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Pneumonia"],["dc.subject.mesh","Prospective Studies"],["dc.subject.mesh","Registries"],["dc.subject.mesh","Sepsis"],["dc.subject.mesh","Stroke"],["dc.subject.mesh","Tertiary Care Centers"],["dc.subject.mesh","Urinary Tract Infections"],["dc.title","Influence of beta-blocker therapy on the risk of infections and death in patients at high risk for stroke induced immunodepression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","118"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Chebbok, Mohammed"],["dc.contributor.author","Didié, Michael"],["dc.contributor.author","Wolf, Frieder"],["dc.contributor.author","Badr, Mostafa"],["dc.contributor.author","Allam, Ibrahim"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Schroeter, Marco R."],["dc.date.accessioned","2021-04-14T08:28:09Z"],["dc.date.accessioned","2022-08-18T12:34:55Z"],["dc.date.available","2021-04-14T08:28:09Z"],["dc.date.available","2022-08-18T12:34:55Z"],["dc.date.issued","2021-03-17"],["dc.date.updated","2022-07-29T12:07:15Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Echocardiography is one of the main diagnostic tools for the diagnostic workup of stroke and is already well integrated into the clinical workup. However, the value of transthoracic vs. transesophageal echocardiography (TTE/TEE) in stroke patients is still a matter of debate. Aim of this study was to characterize relevant findings of TTE and TEE in the management of stroke patients and to correlate them with subsequent clinical decisions and therapies.\r\n \r\n \r\n Methods\r\n We evaluated n = 107 patients admitted with an ischemic stroke or transient ischemic attack to our stroke unit of our university medical center. They underwent TTE and TEE examination by different blinded investigators.\r\n \r\n \r\n Results\r\n Major cardiac risk factors were found in 8 of 98 (8.2%) patients and minor cardiac risk factors for stroke were found in 108 cases. We found a change in therapeutic regime after TTE or TEE in 22 (22.5%) cases, in 5 (5%) cases TEE leads to the change of therapeutic regime, in 4 (4%) TTE and in 13 cases (13.3%) TTE and TEE lead to the same change in therapeutic regime. The major therapy change was the indication to close a patent foramen ovale (PFO) in 9 (9.2%) patients with TTE and in 10 (10.2%) patients with TEE (p = 1.000).\r\n \r\n \r\n Conclusion\r\n Major finding with clinical impact on therapy change is the detection of PFO. But for the detection of PFO, TTE is non inferior to TEE, implicating that TTE serves as a good screening tool for detection of PFO, especially in young age patients.\r\n \r\n \r\n Trial registration\r\n The trial was registered and approved prior to inclusion by our local ethics committee (1/3/17)."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Neurology. 2021 Mar 17;21(1):118"],["dc.identifier.doi","10.1186/s12883-021-02136-5"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17746"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82515"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112935"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Stroke"],["dc.subject","Echocardiography"],["dc.subject","Patent foramen ovale"],["dc.subject","Cardio-embolic stroke"],["dc.title","Comparing the diagnostic value of Echocardiography In Stroke (CEIS) – results of a prospective observatory cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]