Meyer-Marcotty, Philipp

[["dc.bibliographiccitation.artnumber","8940"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Dieks, Jana-K."],["dc.contributor.author","Jünemann, Laura"],["dc.contributor.author","Hensel, Kai O."],["dc.contributor.author","Bergmann, Charlotte"],["dc.contributor.author","Schmidt, Stefan"],["dc.contributor.author","Quast, Anja"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.contributor.author","Santander, Petra"],["dc.date.accessioned","2022-06-01T09:39:11Z"],["dc.date.available","2022-06-01T09:39:11Z"],["dc.date.issued","2022"],["dc.description.abstract","Head development is a surrogate for brain development in infants and is related to neurocognitive outcome. There is only limited knowledge on early extra-uterine head shape and size assessment in very preterm infants. Here, 26 very preterm infants with a mean gestational age of 29.1 ± 2.2 weeks and a mean birth weight of 1273.8 ± 427.7 g underwent serial stereophotogrammetric 3D head imaging in weekly intervals from birth to term-equivalent age. The main outcome was the longitudinal assessment of the ‘physiological’ preterm head development with cephalometric size (head circumference, cranial volume) and shape parameters (cranial index, cranial vault asymmetry index) according to chronological and postmenstrual age (PMA). Potential clinical risk factors for the development of an abnormal low cranial index (dolichocephaly) were analysed. In serial measurements of 26 infants, the estimated head volume (95% confidence interval) increased from 244 (226–263) cm 3 at 28 weeks PMA to 705 (688–721) cm 3 at 40 weeks PMA. Moderate or severe dolichocephaly occurred in 21/26 infants (80.8%). Cranial index decreased over time (72.4%; 70.7–74 95% confidence interval). Brachycephaly and plagiocephaly were uncommon. No risk factors for severe dolichocephaly were identified. Our study shows that early detection of head shape and size anomalies utilizing 3D stereophotogrammetry is feasible and safe even in very preterm infants < 1500 g and/or < 32 weeks. 3D stereophotogrammetry could be used for timely identification of infants at risk for head shape anomalies. No specific risk factors for head shape anomalies were identified, especially not mode and duration of respiratory support."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1038/s41598-022-12887-x"],["dc.identifier.pii","12887"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108408"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Stereophotogrammetry can feasibly assess ‘physiological’ longitudinal three-dimensional head development of very preterm infants from birth to term"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0167033"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Subramanian, Hariharan"],["dc.contributor.author","Doering, Frank"],["dc.contributor.author","Kollert, Sina"],["dc.contributor.author","Rukoyatkina, Natalia"],["dc.contributor.author","Sturm, Julia"],["dc.contributor.author","Gambaryan, Stepan"],["dc.contributor.author","Stellzig-Eisenhauer, Angelika"],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.contributor.author","Eigenthaler, Martin"],["dc.contributor.author","Wischmeyer, Erhard"],["dc.date.accessioned","2018-11-07T10:05:38Z"],["dc.date.available","2018-11-07T10:05:38Z"],["dc.date.issued","2016"],["dc.description.abstract","Aim Primary failure of tooth eruption (PFE) is causally linked to heterozygous mutations of the parathyroid hormone receptor (PTH1R) gene. The mutants described so far lead to exchange of amino acids or truncation of the protein that may result in structural changes of the expressed PTH1R. However, functional effects of these mutations have not been investigated yet. Materials and Methods In HEK293 cells, PTH1R wild type was co-transfected with selected PTH1R mutants identified in patients with PFE. The effects on activation of PTH-regulated intracellular signaling pathways were analyzed by ELISA and Western immunoblotting. Differential effects of wild type and mutated PTH1R on TRESK ion channel regulation were analyzed by electrophysiological recordings in Xenopus laevis oocytes. Results In HEK293 cells, activation of PTH1R wild type increases cAMP and in response activates cAMP-stimulated protein kinase as detected by phosphorylation of the vasodilator stimulated phosphoprotein (VASP). In contrast, the PTH1R mutants are functionally inactive and mutant PTH1R/Gly452Glu has a dominant negative effect on the signaling of PTH1R wild type. Confocal imaging revealed that wild type PTH1R is expressed on the cell surface, whereas PTH1R/Gly452Glu mutant is mostly retained inside the cell. Furthermore, in contrast to wild type PTH1R which substantially augmented K+ currents of TRESK channels, coupling of mutated PTH1R to TRESK channels was completely abolished. Conclusions PTH1R mutations affect intracellular PTH-regulated signaling in vitro. In patients with primary failure of tooth eruption defective signaling of PTH1R mutations is suggested to occur in dento-alveolar cells and thus may lead to impaired tooth movement."],["dc.identifier.doi","10.1371/journal.pone.0167033"],["dc.identifier.isi","000389474000030"],["dc.identifier.pmid","27898723"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13946"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38938"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","PTH1R Mutants Found in Patients with Primary Failure of Tooth Eruption Disrupt G-Protein Signaling"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Head & Face Medicine"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Quast, Anja"],["dc.contributor.author","Olbrisch, Carolin"],["dc.contributor.author","Rose, Marius"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.date.accessioned","2021-04-14T08:32:08Z"],["dc.date.available","2021-04-14T08:32:08Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1186/s13005-020-00245-z"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17690"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83821"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1746-160X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Comprehensive 3D analysis of condylar morphology in adults with different skeletal patterns – a cross-sectional study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","15"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Head & Face Medicine"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Klenke, Daniela"],["dc.contributor.author","Quast, Anja"],["dc.contributor.author","Prelog, Martina"],["dc.contributor.author","Holl-Wieden, Annette"],["dc.contributor.author","Riekert, Maximilian"],["dc.contributor.author","Stellzig-Eisenhauer, Angelika"],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.date.accessioned","2019-07-09T11:45:54Z"],["dc.date.available","2019-07-09T11:45:54Z"],["dc.date.issued","2018"],["dc.description.abstract","Abstract Background Juvenile idiopathic arthritis (JIA) is often accompanied by pathomorphological changes to the temporomandibular joint (TMJ). By analyzing orthodontical orthopantomograms of JIA patients the aims of the study were a) classification of condyle changes, b) quantification of bony asymmetries of condylar destruction and c) detection of relationships between disease duration and TMJ-involvement. Patients/Methods 46 caucasian JIA-patients (28 female; 18 male; < 16.0 years) were enrolled, each joint (n = 92) was morphologically assessed by means of orthopantomogram, quantitatively analysed and compared with duration of general disease. Condyle morphology was assessed using the Billiau scale for severity of destruction [1]. The quantitative analysis was based on ratios of condyle, ramus and mandible height. Results Patients were divided into groups (Group I – slightly affected, n = 36; Billiau severity 0–2; condyle findings: X-ray normal, condyle erosions, condylar flattening; Group II – severely affected, N = 10; Billiau severity 3–4; condyle findings: condylar flattenings and erosions, unilateral/bilateral complete loss of condyles), based on morphological analysis of condylar destruction. Duration of disease was significantly longer in Group II (8.9 ± 5.2 years) than in Group I (4.6 ± 4.7 years). Asymmetries of condyle, ramus and mandible height, quantitatively analysed by contralateral comparison, were significantly more marked in patients of Group II than of Group I. Conclusions Orthopantomogram imaging can be used in orthodontics clinical routine to detect TMJ-pathologies and is an important reference for monitoring progression of JIA. Classification into severe and slightly affected TMJ is possible by analysis of condylar pathomorphology. An association between degree of destruction, extent of lower jaw asymmetry and disease duration is suggested by the results."],["dc.identifier.doi","10.1186/s13005-018-0173-5"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15337"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59330"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15405 but duplicate"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","TMJ pathomorphology in patients with JIA-radiographic parameters for early diagnosis-"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","27"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Head & Face Medicine"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Quast, Anja"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Kahlmeier, Timon"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.date.accessioned","2021-11-25T11:13:00Z"],["dc.date.available","2021-11-25T11:13:00Z"],["dc.date.issued","2021-07-13"],["dc.date.updated","2021-11-19T12:47:38Z"],["dc.description.abstract","Abstract Background Virtual surgery planning (VSP) is believed to reduce inaccuracies in maxillary positioning compared to conventional surgery planning (CSP) due to the elimination of face-bow transfer and laboratory steps. However, there is still a lack of comparative studies for the accuracy of splint-based maxillary positioning in CSP versus VSP. Therefore, the objective of this retrospective, observational study was to compare if splints produced by VSP and CSP reach postoperative outcomes within clinically acceptable limits. Methods The planned and actual postoperative results of 52 patients (VSP: n = 26; CSP: n = 26) with a mean age of 24.4 ± 6.2 years were investigated by three-dimensional (3D) alignment with planning software. The conventional treatment plan was digitized, so that the evaluation of both methods was performed in the same manner using the same coordinate system. Inaccuracies were measured by sagittal, vertical and transversal deviations of the upper central incisors and the inclination of the maxillary occlusal plane between the planned and achieved maxillary positions. Results Both methods demonstrated significant differences between the planned and actual outcome. The highest inaccuracies were observed in vertical impaction and midline correction. No significant differences between CSP and VSP were observed in any dimension. Errors in vertical and sagittal dimension intensified each other. Conclusions In conclusion, splint-based surgeries reached similar results regardless of the applied planning method and splint production."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","Head & Face Medicine. 2021 Jul 13;17(1):27"],["dc.identifier.doi","10.1186/s13005-021-00279-x"],["dc.identifier.pii","279"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93539"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1746-160X"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Orthognathic surgery"],["dc.subject","Orthodontic-surgical treatment"],["dc.subject","Osteotomy"],["dc.subject","BSSO"],["dc.subject","Le Fort I"],["dc.subject","Accuracy"],["dc.subject","Maxillary positioning"],["dc.title","Predictability of maxillary positioning: a 3D comparison of virtual and conventional orthognathic surgery planning"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","21155"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Quast, Anja"],["dc.contributor.author","Hubbert, Johanna"],["dc.contributor.author","Juenemann, Laura"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Hensel, Kai O."],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.contributor.author","Dieks, Jana-Katharina"],["dc.date.accessioned","2021-12-01T09:23:10Z"],["dc.date.available","2021-12-01T09:23:10Z"],["dc.date.issued","2021"],["dc.description.abstract","The development of head shape and volume may reflect neurodevelopmental outcome and therefore is of paramount importance in neonatal care. Here, we compare head morphology in 25 very preterm infants with a birth weight of below 1500 g and / or a gestational age (GA) before 32 completed weeks to 25 term infants with a GA of 37–42 weeks at term equivalent age (TEA) and identify possible risk factors for non-synostotic head shape deformities. For three-dimensional head assessments, a portable stereophotogrammetric device was used. The most common and distinct head shape deformity in preterm infants was dolichocephaly. Severity of dolichocephaly correlated with GA and body weight at TEA but not with other factors such as neonatal morbidity, sex or total duration of respiratory support. Head circumference (HC) and cranial volume (CV) were not significantly different between the preterm and term infant group. Digitally measured HC and the CV significantly correlated even in infants with head shape deformities. Our study shows that stereophotogrammetric head assessment is feasible in all preterm and term infants and provides valuable information on volumetry and comprehensive head shape characteristics. In a small sample of preterm infants, body weight at TEA was identified as a specific risk factor for the development of dolichocephaly."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1038/s41598-021-00680-1"],["dc.identifier.pii","680"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94581"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.title","Stereophotogrammetric head shape assessment in neonates is feasible and can identify distinct differences between term-born and very preterm infants at term equivalent age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]