Poustka, Luise

[["dc.bibliographiccitation.firstpage","435"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JAMA Psychiatry"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Luo, Qiang"],["dc.contributor.author","Chen, Qiang"],["dc.contributor.author","Wang, Wenjia"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Jia, Tianye"],["dc.contributor.author","Macare, Christine"],["dc.contributor.author","Robert, Gabriel H."],["dc.contributor.author","Cui, Jing"],["dc.contributor.author","Guedj, Mickaël"],["dc.contributor.author","Palaniyappan, Lena"],["dc.contributor.author","Kherif, Ferath"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Paillère-Martinot, Marie-Laure"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Fröhner, Juliane H."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Callicott, Joseph H."],["dc.contributor.author","Mattay, Venkata S."],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Dartigues, Jean-François"],["dc.contributor.author","Tzourio, Christophe"],["dc.contributor.author","Crivello, Fabrice"],["dc.contributor.author","Berman, Karen F."],["dc.contributor.author","Li, Fei"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Weinberger, Daniel R."],["dc.contributor.author","Murray, Robin M."],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Feng, Jianfeng"],["dc.date.accessioned","2019-07-09T11:51:24Z"],["dc.date.available","2019-07-09T11:51:24Z"],["dc.date.issued","2019"],["dc.description.abstract","Importance: Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective: To identify genetic variants associated with adolescent brain structure and explore psychopathologic relevance of such associations. Design, Setting, and Participants: Voxelwise genome-wide association study in a cohort of healthy adolescents aged 14 years and validation of the findings using 4 independent samples across the life span with allele-specific expression analysis of top hits. Group comparison of the identified gene-brain association among patients with schizophrenia, unaffected siblings, and healthy control individuals. This was a population-based, multicenter study combined with a clinical sample that included participants from the IMAGEN cohort, Saguenay Youth Study, Three-City Study, and Lieber Institute for Brain Development sample cohorts and UK biobank who were assessed for both brain imaging and genetic sequencing. Clinical samples included patients with schizophrenia and unaffected siblings of patients from the Lieber Institute for Brain Development study. Data were analyzed between October 2015 and April 2018. Main Outcomes and Measures: Gray matter volume was assessed by neuroimaging and genetic variants were genotyped by Illumina BeadChip. Results: The discovery sample included 1721 adolescents (873 girls [50.7%]), with a mean (SD) age of 14.44 (0.41) years. The replication samples consisted of 8690 healthy adults (4497 women [51.8%]) from 4 independent studies across the life span. A nonsynonymous genetic variant (minor T allele of rs13107325 in SLC39A8, a gene implicated in schizophrenia) was associated with greater gray matter volume of the putamen (variance explained of 4.21% in the left hemisphere; 8.66; 95% CI, 6.59-10.81; P = 5.35 × 10-18; and 4.44% in the right hemisphere; t = 8.90; 95% CI, 6.75-11.19; P = 6.80 × 10-19) and also with a lower gene expression of SLC39A8 specifically in the putamen (t127 = -3.87; P = 1.70 × 10-4). The identified association was validated in samples across the life span but was significantly weakened in both patients with schizophrenia (z = -3.05; P = .002; n = 157) and unaffected siblings (z = -2.08; P = .04; n = 149). Conclusions and Relevance: Our results show that a missense mutation in gene SLC39A8 is associated with larger gray matter volume in the putamen and that this association is significantly weakened in schizophrenia. These results may suggest a role for aberrant ion transport in the etiology of psychosis and provide a target for preemptive developmental interventions aimed at restoring the functional effect of this mutation."],["dc.identifier.doi","10.1001/jamapsychiatry.2018.4126"],["dc.identifier.pmid","30649180"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16122"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59943"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/720270/EU//HBP SGA1"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/695313/EU//STRATIFY"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602450/EU//IMAGEMEND"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/603016/EU//MATRICS"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Genetics"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Millenet, Sabina K."],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Heintz, Stefan"],["dc.contributor.author","Bach, Christiane"],["dc.contributor.author","Frank, Josef"],["dc.contributor.author","Vollstädt-Klein, Sabine"],["dc.contributor.author","Bokde, Arun"],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin B."],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Fröhner, Juliane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Lemaire, Herve"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Martinot, Marie-Laure P."],["dc.contributor.author","Papadoulos, Dimitri O."],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Rob"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Hohmann, Sarah"],["dc.date.accessioned","2020-12-10T18:44:23Z"],["dc.date.available","2020-12-10T18:44:23Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3389/fgene.2018.00284"],["dc.identifier.eissn","1664-8021"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15711"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78431"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Kühn, Simone"],["dc.contributor.author","Mascharek, Anna"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bodke, Arun"],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Desrivieres, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Grigis, Antoine"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny A"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Papadopoulos Orfanos, Dimitri"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Millenet, Sabina"],["dc.contributor.author","Fröhner, Juliane H"],["dc.contributor.author","Smolka, Michael N"],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Lindenberger, Ulman"],["dc.contributor.author","Gallinat, Jürgen"],["dc.date.accessioned","2020-12-10T18:48:07Z"],["dc.date.available","2020-12-10T18:48:07Z"],["dc.date.issued","2019"],["dc.description.abstract","Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acquired at three measurement occasions across five years. Based on a two-part latent growth curve model, we conducted whole-brain analyses on structural MRI data at age 14, predicting change in alcohol use score over time. Higher grey-matter volumes in the caudate nucleus and the left cerebellum at age 14 years were predictive of stronger increase in alcohol use score over 5 years. The study is the first to demonstrate the feasibility of running separate voxel-wise structural equation models thereby opening new avenues for data analysis in brain imaging."],["dc.identifier.doi","10.7554/eLife.44056"],["dc.identifier.eissn","2050-084X"],["dc.identifier.pmid","31262402"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16292"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/79024"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2050-084X"],["dc.relation.issn","2050-084X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0216152"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Albaugh, Matthew D."],["dc.contributor.author","Hudziak, James. J."],["dc.contributor.author","Orr, Catherine"],["dc.contributor.author","Spechler, Philip A."],["dc.contributor.author","Chaarani, Bader"],["dc.contributor.author","Mackey, Scott"],["dc.contributor.author","Lepage, Claude"],["dc.contributor.author","Fonov, Vladimir"],["dc.contributor.author","Rioux, Pierre"],["dc.contributor.author","Evans, Alan C."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Grigis, Antoine"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Martinot, Marie-Laure Paillère"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Millenet, Sabina"],["dc.contributor.author","Fröhner, Juliane H."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Potter, Alexandra S."],["dc.contributor.author","Garavan, Hugh"],["dc.date.accessioned","2019-07-09T11:51:17Z"],["dc.date.available","2019-07-09T11:51:17Z"],["dc.date.issued","2019"],["dc.description.abstract","In structural neuroimaging studies, reduced cerebral cortical thickness in orbital and ventromedial prefrontal regions is frequently interpreted as reflecting an impaired ability to downregulate neuronal activity in the amygdalae. Unfortunately, little research has been conducted in order to test this conjecture. We examine the extent to which amygdalar reactivity is associated with cortical thickness in a population-based sample of adolescents. Data were obtained from the IMAGEN study, which includes 2,223 adolescents. While undergoing functional neuroimaging, participants passively viewed video clips of a face that started from a neutral expression and progressively turned angry, or, instead, turned to a second neutral expression. Left and right amygdala ROIs were used to extract mean BOLD signal change for the angry minus neutral face contrast for all subjects. T1-weighted images were processed through the CIVET pipeline (version 2.1.0). In variable-centered analyses, local cortical thickness was regressed against amygdalar reactivity using first and second-order linear models. In a follow-up person-centered analysis, we defined a \"high reactive\" group of participants based on mean amygdalar BOLD signal change for the angry minus neutral face contrast. Between-group differences in cortical thickness were examined (\"high reactive\" versus all other participants). A significant association was revealed between the continuous measure of amygdalar reactivity and bilateral ventromedial prefrontal cortical thickness in a second-order linear model (p < 0.05, corrected). The \"high reactive\" group, in comparison to all other participants, possessed reduced cortical thickness in bilateral orbital and ventromedial prefrontal cortices, bilateral anterior temporal cortices, left caudal middle temporal gyrus, and the left inferior and middle frontal gyri (p < 0.05, corrected). Results are consistent with non-human primate studies, and provide empirical support for an association between reduced prefrontal cortical thickness and amygdalar reactivity. Future research will likely benefit from investigating the degree to which psychopathology qualifies relations between prefrontal cortical structure and amygdalar reactivity."],["dc.identifier.doi","10.1371/journal.pone.0216152"],["dc.identifier.pmid","31048888"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16093"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59915"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/695313/EU//STRATIFY"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602450/EU//IMAGEMEND"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/603016/EU//MATRICS"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Amygdalar reactivity is associated with prefrontal cortical thickness in a large population-based sample of adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Translational Psychiatry"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Velthorst, Eva"],["dc.contributor.author","Froudist-Walsh, Sean"],["dc.contributor.author","Stahl, Eli"],["dc.contributor.author","Ruderfer, Douglas"],["dc.contributor.author","Ivanov, Ilyan"],["dc.contributor.author","Buxbaum, Joseph"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Dipl-Psych, Uli Bromberg"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Marie-Laure Paillère"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Hohmann, Sarah"],["dc.contributor.author","Fröhner, Juliane H."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Reichenberg, Abraham"],["dc.date.accessioned","2020-12-10T18:09:39Z"],["dc.date.available","2020-12-10T18:09:39Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1038/s41398-018-0229-0"],["dc.identifier.eissn","2158-3188"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73719"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1736"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","1751"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Müller, Christian P"],["dc.contributor.author","Chu, Congying"],["dc.contributor.author","Qin, Liya"],["dc.contributor.author","Liu, Chunyu"],["dc.contributor.author","Xu, Bing"],["dc.contributor.author","Gao, He"],["dc.contributor.author","Ruggeri, Barbara"],["dc.contributor.author","Hieber, Saskia"],["dc.contributor.author","Schneider, Julia"],["dc.contributor.author","Jia, Tianye"],["dc.contributor.author","Tay, Nicole"],["dc.contributor.author","Akira, Shizuo"],["dc.contributor.author","Satoh, Takashi"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L W"],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Martinot, Marie-Laure Paillère"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Lemaitre, Herve"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Papadopoulos Orfanos, Dimitri"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Millenet, Sabina"],["dc.contributor.author","Fröhner, Juliane H"],["dc.contributor.author","Smolka, Michael N"],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Bakalkin, Georgy"],["dc.contributor.author","Liu, Yun"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Elliott, Paul"],["dc.contributor.author","Eulenburg, Volker"],["dc.contributor.author","Levy, Daniel"],["dc.contributor.author","Crews, Fulton"],["dc.contributor.author","Schumann, Gunter"],["dc.date.accessioned","2020-12-10T18:18:38Z"],["dc.date.available","2020-12-10T18:18:38Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1093/cercor/bhy341"],["dc.identifier.eissn","1460-2199"],["dc.identifier.issn","1047-3211"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16501"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75091"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3020"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","3033"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Bayard, Frida"],["dc.contributor.author","Nymberg Thunell, Charlotte"],["dc.contributor.author","Abé, Christoph"],["dc.contributor.author","Almeida, Rita"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barker, Gareth"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Martinot, Marie-Laure Paillère"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Conrod, Patricia"],["dc.contributor.author","Stringaris, Argyris"],["dc.contributor.author","Struve, Maren"],["dc.contributor.author","Penttilä, Jani"],["dc.contributor.author","Kappel, Viola"],["dc.contributor.author","Grimmer, Yvonne"],["dc.contributor.author","Fadai, Tahmine"],["dc.contributor.author","van Noort, Betteke"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Vetter, Nora C."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Petrovic, Predrag"],["dc.date.accessioned","2021-04-14T08:31:51Z"],["dc.date.available","2021-04-14T08:31:51Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1038/s41380-018-0202-6"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15578"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83733"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1476-5578"],["dc.relation.issn","1359-4184"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Distinct brain structure and behavior related to ADHD and conduct disorder traits"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","101804"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Ruan, Hongtao"],["dc.contributor.author","Zhou, Yunyi"],["dc.contributor.author","Luo, Qiang"],["dc.contributor.author","Robert, Gabriel H."],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Liu, ZhaoWen"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L.W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Martinot, Marie-Laure Paillère"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Hohmann, Sarah"],["dc.contributor.author","Fröhner, Juliane H."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Li, Fei"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Feng, Jianfeng"],["dc.date.accessioned","2019-07-09T11:51:49Z"],["dc.date.available","2019-07-09T11:51:49Z"],["dc.date.issued","2019"],["dc.description.abstract","Adolescent binge drinking has been associated with higher risks for the development of many health problems throughout the lifespan. Adolescents undergo multiple changes that involve the co-development processes of brain, personality and behavior; therefore, certain behavior, such as alcohol consumption, can have disruptive effects on both brain development and personality maturation. However, these effects remain unclear due to the scarcity of longitudinal studies. In the current study, we used multivariate approaches to explore discriminative features in brain functional architecture, personality traits, and genetic variants in 19-year-old individuals (n = 212). Taking advantage of a longitudinal design, we selected features that were more drastically altered in drinkers with an earlier onset of binge drinking. With the selected features, we trained a hierarchical model of support vector machines using a training sample (n = 139). Using an independent sample (n = 73), we tested the model and achieved a classification accuracy of 71.2%. We demonstrated longitudinally that after the onset of binge drinking the developmental trajectory of improvement in impulsivity slowed down. This study identified the disrupting effects of adolescent binge drinking on the developmental trajectories of both brain and personality."],["dc.identifier.doi","10.1016/j.nicl.2019.101804"],["dc.identifier.pmid","30991616"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16200"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60018"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/695313/EU//STRATIFY"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602450/EU//IMAGEMEND"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/115300/EU//EU-AIMS"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/321580/EU//ERANID"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/610691/EU//BRIDGET"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]