Poustka, Luise

[["dc.bibliographiccitation.firstpage","489"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Public Health"],["dc.bibliographiccitation.lastpage","495"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Parchetka, Caroline"],["dc.contributor.author","Strache, Nicole"],["dc.contributor.author","Raffaelli, Bianca"],["dc.contributor.author","Gemmeke, Isabel"],["dc.contributor.author","Weiß, Katharina"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Buechel, Christian"],["dc.contributor.author","Conrod, Patricia"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Lemaitre, Herve"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Mennigen, Eva"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Paillère Martinot, Marie-Laure"],["dc.contributor.author","Papadopoulos, Dimitri"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Jurk, Sarah"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Vetter, Nora C."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Gallinat, Juergen"],["dc.date.accessioned","2018-06-04T09:18:35Z"],["dc.date.available","2018-06-04T09:18:35Z"],["dc.date.issued","2016"],["dc.description.abstract","Purpose The onset of substance use mostly occurs during adolescence. The aim of the present study is to investigate the relevance of personality on the basis of the NEO-Five-Factor Inventory (NEO-FFI) to future experiences with tobacco, alcohol and cannabis. Methods The test data were derived from the baseline assessment and first follow-up of the IMAGEN study, a European multicenter and multidisciplinary research project on adolescent mental health. In the present study 1004 participants were tested. The characterization of personality was conducted with the NEO-FFI at the age of 14 (T1). The data on substance use were collected with the European School Survey Project on Alcohol and Other Drugs (ESPAD) questionnaire at the age of 16 (T2). For the statistical analysis, t-tests and univariate analyses of variance were performed. Results The scores of Conscientiousness at T1 were significantly lower for adolescents with tobacco, alcohol and cannabis experiences at T2. We found lower scores of Agreeableness at T1 in participants with tobacco and cannabis use at T2. Extraversion at T1 was significantly higher for adolescents with smoking experiences at T2. No significant associations between Neuroticism or Openness and future substance use were observed. Conclusion Low scores of Conscientiousness and Agreeableness seem to have the greatest value for a prediction of later experiences with substance use. As the present study is the first one to examine the predictive value of the NEO-FFI for future substance use in an adolescent sample, further studies are necessary to enable a better applicability in a clinical context."],["dc.identifier.doi","10.1007/s10389-016-0747-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/14854"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Predictive utility of the NEO-FFI for later substance experiences among 16-year-old adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","O'Leary-Barrett, M."],["dc.contributor.author","Pihl, Robert O."],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Mann, Karl"],["dc.contributor.author","Paillere-Martinot, Marie-Laure"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Robbins, Trevor W."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Strohle, Andreas"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Conrod, Patricia J."],["dc.date.accessioned","2017-09-07T11:52:11Z"],["dc.date.available","2017-09-07T11:52:11Z"],["dc.date.issued","2015"],["dc.description.abstract","OBJECTIVE: To investigate the role of personality factors and attentional biases towards emotional faces, in establishing concurrent and prospective risk for mental disorder diagnosis in adolescence.; METHOD: Data were obtained as part of the IMAGEN study, conducted across 8 European sites, with a community sample of 2257 adolescents. At 14 years, participants completed an emotional variant of the dot-probe task, as well two personality measures, namely the Substance Use Risk Profile Scale and the revised NEO Personality Inventory. At 14 and 16 years, participants and their parents were interviewed to determine symptoms of mental disorders.; RESULTS: Personality traits were general and specific risk indicators for mental disorders at 14 years. Increased specificity was obtained when investigating the likelihood of mental disorders over a 2-year period, with the Substance Use Risk Profile Scale showing incremental validity over the NEO Personality Inventory. Attentional biases to emotional faces did not characterise or predict mental disorders examined in the current sample.; DISCUSSION: Personality traits can indicate concurrent and prospective risk for mental disorders in a community youth sample, and identify at-risk youth beyond the impact of baseline symptoms. This study does not support the hypothesis that attentional biases mediate the relationship between personality and psychopathology in a community sample. Task and sample characteristics that contribute to differing results among studies are discussed."],["dc.identifier.doi","10.1371/journal.pone.0128271"],["dc.identifier.gro","3151225"],["dc.identifier.pmid","26046352"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8005"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1932-6203"],["dc.title","Personality, Attentional Biases towards Emotional Faces and Symptoms of Mental Disorders in an Adolescent Sample"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","435"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JAMA Psychiatry"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Luo, Qiang"],["dc.contributor.author","Chen, Qiang"],["dc.contributor.author","Wang, Wenjia"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Jia, Tianye"],["dc.contributor.author","Macare, Christine"],["dc.contributor.author","Robert, Gabriel H."],["dc.contributor.author","Cui, Jing"],["dc.contributor.author","Guedj, Mickaël"],["dc.contributor.author","Palaniyappan, Lena"],["dc.contributor.author","Kherif, Ferath"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Paillère-Martinot, Marie-Laure"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Fröhner, Juliane H."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Callicott, Joseph H."],["dc.contributor.author","Mattay, Venkata S."],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Dartigues, Jean-François"],["dc.contributor.author","Tzourio, Christophe"],["dc.contributor.author","Crivello, Fabrice"],["dc.contributor.author","Berman, Karen F."],["dc.contributor.author","Li, Fei"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Weinberger, Daniel R."],["dc.contributor.author","Murray, Robin M."],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Feng, Jianfeng"],["dc.date.accessioned","2019-07-09T11:51:24Z"],["dc.date.available","2019-07-09T11:51:24Z"],["dc.date.issued","2019"],["dc.description.abstract","Importance: Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective: To identify genetic variants associated with adolescent brain structure and explore psychopathologic relevance of such associations. Design, Setting, and Participants: Voxelwise genome-wide association study in a cohort of healthy adolescents aged 14 years and validation of the findings using 4 independent samples across the life span with allele-specific expression analysis of top hits. Group comparison of the identified gene-brain association among patients with schizophrenia, unaffected siblings, and healthy control individuals. This was a population-based, multicenter study combined with a clinical sample that included participants from the IMAGEN cohort, Saguenay Youth Study, Three-City Study, and Lieber Institute for Brain Development sample cohorts and UK biobank who were assessed for both brain imaging and genetic sequencing. Clinical samples included patients with schizophrenia and unaffected siblings of patients from the Lieber Institute for Brain Development study. Data were analyzed between October 2015 and April 2018. Main Outcomes and Measures: Gray matter volume was assessed by neuroimaging and genetic variants were genotyped by Illumina BeadChip. Results: The discovery sample included 1721 adolescents (873 girls [50.7%]), with a mean (SD) age of 14.44 (0.41) years. The replication samples consisted of 8690 healthy adults (4497 women [51.8%]) from 4 independent studies across the life span. A nonsynonymous genetic variant (minor T allele of rs13107325 in SLC39A8, a gene implicated in schizophrenia) was associated with greater gray matter volume of the putamen (variance explained of 4.21% in the left hemisphere; 8.66; 95% CI, 6.59-10.81; P = 5.35 × 10-18; and 4.44% in the right hemisphere; t = 8.90; 95% CI, 6.75-11.19; P = 6.80 × 10-19) and also with a lower gene expression of SLC39A8 specifically in the putamen (t127 = -3.87; P = 1.70 × 10-4). The identified association was validated in samples across the life span but was significantly weakened in both patients with schizophrenia (z = -3.05; P = .002; n = 157) and unaffected siblings (z = -2.08; P = .04; n = 149). Conclusions and Relevance: Our results show that a missense mutation in gene SLC39A8 is associated with larger gray matter volume in the putamen and that this association is significantly weakened in schizophrenia. These results may suggest a role for aberrant ion transport in the etiology of psychosis and provide a target for preemptive developmental interventions aimed at restoring the functional effect of this mutation."],["dc.identifier.doi","10.1001/jamapsychiatry.2018.4126"],["dc.identifier.pmid","30649180"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16122"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59943"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/720270/EU//HBP SGA1"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/695313/EU//STRATIFY"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602450/EU//IMAGEMEND"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/603016/EU//MATRICS"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","660"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Biological psychiatry"],["dc.bibliographiccitation.lastpage","668"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Albaugh, Matthew D."],["dc.contributor.author","Orr, Catherine"],["dc.contributor.author","Chaarani, Bader"],["dc.contributor.author","Althoff, Robert R."],["dc.contributor.author","Allgaier, Nicholas"],["dc.contributor.author","D'Alberto, N."],["dc.contributor.author","Hudson, Kelsey E."],["dc.contributor.author","Mackey, Scott"],["dc.contributor.author","Spechler, Philip A."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Brühl, Rüdiger"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Cattrell, Anna"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Desrivieres, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Goodman, Robert"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Grimmer, Yvonne"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Kappel, Viola"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Paillere Martinot, Marie-Laure"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Penttila, Jani"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Struve, Maren"],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Potter, Alexandra S."],["dc.date.accessioned","2017-09-07T11:52:08Z"],["dc.date.available","2017-09-07T11:52:08Z"],["dc.date.issued","2017"],["dc.description.abstract","BACKGROUND: Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices. Few studies have examined the relationship between ADHD symptomatology and brain structure in population-based samples. We investigated the relationship between dimensional measures of ADHD symptomatology, brain structure, and reaction time variability-an index of lapses in attention. We also tested for associations between brain structural correlates of ADHD symptomatology and maps of dopaminergic gene expression.; METHODS: Psychopathology and imaging data were available for 1538 youths. Parent ratings of ADHD symptoms were obtained using the Development and Well-Being Assessment and the Strengths and Difficulties Questionnaire (SDQ). Self-reports of ADHD symptoms were assessed using the youth version of the SDQ. Reaction time variability was available in a subset of participants. For each measure, whole-brain voxelwise regressions with gray matter volume were calculated.; RESULTS: Parent ratings of ADHD symptoms (Development and Well-Being Assessment and SDQ), adolescent self-reports of ADHD symptoms on the SDQ, and reaction time variability were each negatively associated with gray matter volume in an overlapping region of the ventromedial prefrontal cortex. Maps of DRD1 and DRD2 gene expression were associated with brain structural correlates of ADHD symptomatology.; CONCLUSIONS: This is the first study to reveal relationships between ventromedial prefrontal cortex structure and multi-informant measures of ADHD symptoms in a large population-based sample of adolescents. Our results indicate that ventromedial prefrontal cortex structure is a biomarker for ADHD symptomatology. These findings extend previous research implicating the default mode network and dopaminergic dysfunction in ADHD. Copyright 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.biopsych.2017.01.003"],["dc.identifier.gro","3151189"],["dc.identifier.pmid","28237458"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7966"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1873-2402"],["dc.subject","Attention-deficit/hyperactivity disorder; Inattention; Multi-informant; Neuroimaging; Reaction time variability; Ventromedial prefrontal cortex"],["dc.title","Inattention and Reaction Time Variability Are Linked to Ventromedial Prefrontal Volume in Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Genetics"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Millenet, Sabina K."],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Heintz, Stefan"],["dc.contributor.author","Bach, Christiane"],["dc.contributor.author","Frank, Josef"],["dc.contributor.author","Vollstädt-Klein, Sabine"],["dc.contributor.author","Bokde, Arun"],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin B."],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Fröhner, Juliane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Lemaire, Herve"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Martinot, Marie-Laure P."],["dc.contributor.author","Papadoulos, Dimitri O."],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Rob"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Hohmann, Sarah"],["dc.date.accessioned","2020-12-10T18:44:23Z"],["dc.date.available","2020-12-10T18:44:23Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3389/fgene.2018.00284"],["dc.identifier.eissn","1664-8021"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15711"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78431"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","JAMA psychiatry"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Lancaster, Thomas M."],["dc.contributor.author","Linden, David E."],["dc.contributor.author","Tansey, Katherine E."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Cattrell, Anna"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Paillere Martinot, Marie-Laure"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Lemaitre, Herve"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Vetter, Nora C."],["dc.contributor.author","Jurk, Sarah"],["dc.contributor.author","Mennigen, Eva"],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.date.accessioned","2017-09-07T11:46:24Z"],["dc.date.available","2017-09-07T11:46:24Z"],["dc.date.issued","2016"],["dc.description.abstract","IMPORTANCE: Psychotic disorders are characterized by attenuated activity in the brain's valuation system in key reward processing areas, such as the ventral striatum (VS), as measured with functional magnetic resonance imaging.; OBJECTIVE: To examine whether common risk variants for psychosis are associated with individual variation in the VS.; DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study of a large cohort of adolescents from the IMAGEN study (a European multicenter study of reinforcement sensitivity in adolescents) was performed from March 1, 2008, through December 31, 2011. Data analysis was conducted from October 1, 2015, to January 9, 2016. Polygenic risk profile scores (RPSs) for psychosis were generated for 1841 healthy adolescents. Sample size and characteristics varied across regression analyses, depending on mutual information available (N=1524-1836).; MAIN OUTCOMES AND MEASURES: Reward-related brain function was assessed with blood oxygen level dependency (BOLD) in the VS using the monetary incentive delay (MID) task, distinguishing reward anticipation and receipt. Behavioral impulsivity, IQ, MID task performance, and VS BOLD were regressed against psychosis RPS at 4 progressive P thresholds (P < .01, P < .05, P < .10, and P < .50 for RPS models 1-4, respectively).; RESULTS: In a sample of 1841 healthy adolescents (mean age, 14.5 years; 906 boys and 935 girls), we replicated an association between increasing psychosis RPS and reduced IQ (matrix reasoning: corrected P = .003 for RPS model 2, 0.4% variance explained), supporting the validity of the psychosis RPS models. We also found a nominally significant association between increased psychosis RPS and reduced MID task performance (uncorrected P =.03 for RPS model 4, 0.2% variance explained). Our main finding was a positive association between psychosis RPS and VS BOLD during reward anticipation at all 4 psychosis RPS models and for 2 P thresholds for reward receipt (RPS models 1 and 3), correcting for the familywise error rate (0.8%-1.9% variance explained).; CONCLUSIONS AND RELEVANCE: These findings support an association between psychosis RPS and VS BOLD in adolescents. Genetic risk for psychosis may shape an individual's response to rewarding stimuli."],["dc.identifier.doi","10.1001/jamapsychiatry.2016.1135"],["dc.identifier.gro","3151922"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8757"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","2168-6238"],["dc.title","Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1092"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of the American Academy of Child and Adolescent Psychiatry"],["dc.bibliographiccitation.lastpage","1103"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Spechler, Philip A."],["dc.contributor.author","Chaarani, Bader"],["dc.contributor.author","Orr, Catherine"],["dc.contributor.author","Mackey, Scott"],["dc.contributor.author","Higgins, Stephen T."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L.W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Fröhner, Juliane H."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Althoff, Robert R."],["dc.contributor.author","Barker, Gareth"],["dc.contributor.author","Paillère Martinot, Marie-Laure"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Lemaitre, Herve"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Vetter, Nora C."],["dc.contributor.author","Jurk, Sarah"],["dc.contributor.author","Mennigen, Eva"],["dc.date.accessioned","2020-12-10T14:24:42Z"],["dc.date.available","2020-12-10T14:24:42Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.jaac.2019.01.021"],["dc.identifier.issn","0890-8567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72329"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","566"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","The American journal of psychiatry"],["dc.bibliographiccitation.lastpage","575"],["dc.bibliographiccitation.volume","174"],["dc.contributor.author","Bourque, Josiane"],["dc.contributor.author","Spechler, Philip A."],["dc.contributor.author","Potvin, Stephane"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Desrivieres, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Paillere-Martinot, Marie-Laure"],["dc.contributor.author","McEwen, Sarah C."],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Vetter, Nora C."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Conrod, Patricia J."],["dc.date.accessioned","2017-09-07T11:52:07Z"],["dc.date.available","2017-09-07T11:52:07Z"],["dc.date.issued","2017"],["dc.description.abstract","OBJECTIVE: This study investigated the neural correlates of psychotic-like experiences in youths during tasks involving inhibitory control, reward anticipation, and emotion processing. A secondary aim was to test whether these neurofunctional correlates of risk were predictive of psychotic symptoms 2 years later.; METHOD: Functional imaging responses to three paradigms-the stop-signal, monetary incentive delay, and faces tasks-were collected in youths at age 14, as part of the IMAGEN study. At baseline, youths from London and Dublin sites were assessed on psychotic-like experiences, and those reporting significant experiences were compared with matched control subjects. Significant brain activity differences between the groups were used to predict, with cross-validation, the presence of psychotic symptoms in the context of mood fluctuation at age 16, assessed in the full sample. These prediction analyses were conducted with the London-Dublin subsample (N=246) and the full sample (N=1,196).; RESULTS: Relative to control subjects, youths reporting psychotic-like experiences showed increased hippocampus/amygdala activity during processing of neutral faces and reduced dorsolateral prefrontal activity during failed inhibition. The most prominent regional difference for classifying 16-year-olds with mood fluctuation and psychotic symptoms relative to the control groups (those with mood fluctuations but no psychotic symptoms and those with no mood symptoms) was hyperactivation of the hippocampus/amygdala, when controlling for baseline psychotic-like experiences and cannabis use.; CONCLUSIONS: The results stress the importance of the limbic network's increased response to neutral facial stimuli as a marker of the extended psychosis phenotype. These findings might help to guide early intervention strategies for at-risk youths."],["dc.identifier.doi","10.1176/appi.ajp.2017.16080897"],["dc.identifier.gro","3151181"],["dc.identifier.pmid","28320226"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7957"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1535-7228"],["dc.title","Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","The European journal of neuroscience"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Heinrich, Angela"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Lourdusamy, Anbarasu"],["dc.contributor.author","Tzschoppe, Jelka"],["dc.contributor.author","Meier, Sandra"],["dc.contributor.author","Vollstadt-Klein, Sabine"],["dc.contributor.author","Fauth-Buhler, Mira"],["dc.contributor.author","Steiner, Sabina"],["dc.contributor.author","Bach, Christiane"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barker, Gareth J."],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Loth, Eva"],["dc.contributor.author","Mann, Karl"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Lawrence, Claire"],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Strohle, Andreas"],["dc.contributor.author","Struve, Maren"],["dc.contributor.author","Witt, Stephanie H."],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Rietschel, Marcella"],["dc.date.accessioned","2017-09-07T11:52:44Z"],["dc.date.available","2017-09-07T11:52:44Z"],["dc.date.issued","2013"],["dc.description.abstract","Recently, genome-wide association between schizophrenia and an intronic variant in AMBRA1 (rs11819869) was reported. Additionally, in a reverse genetic approach in adult healthy subjects, risk allele carriers showed a higher medial prefrontal cortex blood oxygen level-dependent (BOLD) response during a flanker task examining motor inhibition as an aspect of impulsivity. To test whether this finding can be expanded to further aspects of impulsivity, we analysed the effects of the rs11819869 genotype on impulsivity-related traits on a behavioral, temperament and neural level in a large sample of healthy adolescents. We consider this reverse genetic approach specifically suited for use in a healthy adolescent sample, as these individuals comprise those who will eventually develop mental disorders in which impulsivity is implicated. Healthy adolescents from the IMAGEN study were included in the neuropsychological analysis (n=848) and a functional magnetic resonance imaging (fMRI) task (n=512). Various aspects of impulsivity were assessed using the Temperament and Character Inventory-Revised, the Substance Use Risk Profile Scale, the Cambridge Cognition Neuropsychological Test Automated Battery, and the Stop Signal Task (SST) in the fMRI paradigm. On a behavioral level, increased delay aversion was observed in risk allele carriers. Furthermore, risk allele carriers showed a higher BOLD response in an orbito-frontal target region during the SST, which declined to trend status after Family Wise Error correction. Our findings support the hypothesis that the schizophrenia-related risk variant of rs11819869 is involved in various aspects of impulsivity, and that this involvement occurs on a behavioral as well as an imaging genetics level. 2013 Federation of European Neuroscience Societies and Blackwell Publishing Ltd."],["dc.identifier.doi","10.1111/ejn.12201"],["dc.identifier.gro","3151243"],["dc.identifier.pmid","23551272"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8026"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1460-9568"],["dc.title","From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The American journal of psychiatry"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Cattrell, Anna"],["dc.contributor.author","Jia, Tianye"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barker, Gareth J."],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Brühl, Rüdiger"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Desrivieres, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Paillere Martinot, Marie-Laure"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Papadopoulos-Orfanos, Dimitri"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Vetter, Nora C."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Glennon, Jeffrey C."],["dc.contributor.author","Buitelaar, Jan K."],["dc.contributor.author","Happe, Francesca"],["dc.contributor.author","Loth, Eva"],["dc.contributor.author","Barker, Edward D."],["dc.contributor.author","Schumann, Gunter"],["dc.date.accessioned","2017-09-07T11:46:19Z"],["dc.date.available","2017-09-07T11:46:19Z"],["dc.date.issued","2017"],["dc.description.abstract","OBJECTIVE: The authors sought to explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships.; METHOD: Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains and functional MRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions. Exploratory functional connectivity and whole brain multiple regression approaches were used to analyze how the symptoms and psychosocial stress relate to other brain regions.; RESULTS: In response to the social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symptoms who had also experienced a greater number of stressful life events showed hyperactivity of the amygdala and several regions across the brain. This effect was not observed with emotional symptoms. A cluster in the midcingulate was found to be common to both conduct problems and hyperactivity symptoms. Exploratory functional connectivity analyses suggested that amygdala-precuneus connectivity is associated with hyperactivity/inattention symptoms.; CONCLUSIONS: The results link hyperactive amygdala responses and regions critical for top-down emotional processing with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights the importance of studying how psychosocial stress affects functional brain responses to social-emotional stimuli, particularly in adolescents with externalizing symptoms."],["dc.identifier.doi","10.1176/appi.ajp.2017.16040464"],["dc.identifier.gro","3151901"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8734"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1535-7228"],["dc.title","Psychosocial Stress and Brain Function in Adolescent Psychopathology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]