Weber-Krüger, Mark

[["dc.bibliographiccitation.firstpage","3643"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","3645"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Lahno, Rosine"],["dc.contributor.author","Seegers, Jochen"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, Rolf"],["dc.date.accessioned","2017-09-07T11:43:17Z"],["dc.date.available","2017-09-07T11:43:17Z"],["dc.date.issued","2011"],["dc.description.abstract","Background and Purpose-We assessed whether echocardiography can predict paroxysmal atrial fibrillation (PAF) in patients with cerebral ischemia presenting in sinus rhythm. Methods-Within the prospective Find-AF cohort, 193 consecutive patients with cerebral ischemia and sinus rhythm on presentation had evaluation of echocardiographic parameters of left atrial size and function. PAF was diagnosed by 7-day Holter monitoring. Results-In 26 patients with PAF, late diastolic Doppler (A') and tissue Doppler (a') velocities were lower whereas left atrial diameter, left atrial volume index (LAVI), LAVI/A, and LAVI/a' were larger (P < 0.05 for all) than they were in 167 patients without PAF. In multivariate models A, a', LAVI/A, and LAVI/a' predicted the presence of PAF. Area under the receiver operating characteristic curve to diagnose PAF was highest for LAVI/a' (0.813 [0.738; 0.889]). A previously suggested cut-off of LAVI/a' < 2.3 had 92% sensitivity, 55.8% specificity, and 98% negative predictive value for PAF. Conclusions-LAVI/a' < 2.3 can effectively rule out PAF in patients with cerebral ischemia. (Stroke. 2011; 42: 3643-3645.)"],["dc.identifier.doi","10.1161/STROKEAHA.111.632836"],["dc.identifier.gro","3142621"],["dc.identifier.isi","000297941500066"],["dc.identifier.pmid","21998056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0039-2499"],["dc.title","Transthoracic Echocardiography to Rule Out Paroxysmal Atrial Fibrillation as a Cause of Stroke or Transient Ischemic Attack"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","438"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","American Heart Journal"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","168"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Hamann, Gerhard F."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T09:34:27Z"],["dc.date.available","2018-11-07T09:34:27Z"],["dc.date.issued","2014"],["dc.description.abstract","Background Detecting paroxysmal atrial fibrillation (AF) in patients with ischemic strokes presenting in sinus rhythm is challenging because episodes are often short, occur randomly, and are frequently asymptomatic. If AF is detected, recurrent thromboembolism can be prevented efficiently by oral anticoagulation. Numerous uncontrolled studies using various electrocardiogram (ECG) devices have established that prolonged ECG monitoring increases the yield of AF detection, but most established procedures are time-consuming and costly. The few randomized trials are mostly limited to cryptogenic strokes. The optimal method, duration, and patient selection remain unclear. Repeated prolonged continuous Holter ECG monitoring to detect paroxysmal AF within an unspecific stroke population may prove to be a widely applicable, effective secondary prevention strategy. Study Design Find-AF(RANDOMISED) is a randomized and controlled prospective multicenter trial. Four hundred patients 60 years or older with manifest (symptoms >= 24 hours or acute computed tomography/magnetic resonance imaging lesion) and acute (symptoms <= 7 days) ischemic strokes will be included at 4 certified stroke centers in Germany. Those with previously diagnosed AF/flutter, indications/contraindications for oral anticoagulation, or obvious causative blood vessel pathologies will be excluded. Patients will be randomized 1:1 to either enhanced and prolonged Holter ECG monitoring (10 days at baseline and after 3 and 6 months) or standard of care (>= 24-hour continuous ECG monitoring, according to current stroke guidelines). All patients will be followed up for at least 12 months. Outcomes The primary end point is newly detected AF (>= 30 seconds) after 6 months, confirmed by an independent adjudication committee. We plan to complete recruitment in autumn 2014. First results can be expected by spring 2016."],["dc.description.sponsorship","Boehringer Ingelheim; Pfizer; Medtronic"],["dc.identifier.doi","10.1016/j.ahj.2014.06.018"],["dc.identifier.isi","000343096900008"],["dc.identifier.pmid","25262252"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32171"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","1097-5330"],["dc.relation.issn","0002-8703"],["dc.title","Finding atrial fibrillation in stroke patients: Randomized evaluation of enhanced and prolonged Holter monitoring-Find-AF(RANDOMISED) -rationale and design"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, Frank T."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T08:49:44Z"],["dc.date.available","2018-11-07T08:49:44Z"],["dc.date.issued","2011"],["dc.identifier.isi","000299738705335"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21533"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","High-Sensitivity Troponin T Improves Cardiovascular Risk Prediction in Patients With Cerebral Ischemia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Messerschmid, Anna"],["dc.contributor.author","Heuschmann, Peter U."],["dc.contributor.author","Behnke, Nico"],["dc.contributor.author","Schulte, Anna"],["dc.contributor.author","Juerries, Falko"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Hamann, Gerhard F."],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T10:19:02Z"],["dc.date.available","2018-11-07T10:19:02Z"],["dc.date.issued","2016"],["dc.description.sponsorship","Boehringer Ingelheim"],["dc.identifier.isi","000399956101165"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41577"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","American-Heart-Association/American-Stroke-Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium"],["dc.relation.eventlocation","Los Angeles, CA"],["dc.relation.issn","1524-4628"],["dc.relation.issn","0039-2499"],["dc.title","Atrial Fibrillation and Flutter as a Cause of Stroke in an Unspecific Stroke Population. Stroke Subtypes in the Findaf Randomised Study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Lahno, Rosine C."],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.date.accessioned","2018-11-07T08:36:41Z"],["dc.date.available","2018-11-07T08:36:41Z"],["dc.date.issued","2010"],["dc.identifier.isi","000208231603210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","Nt-probnp for the Diagnosis of Paroxysmal Atrial Fibrillation in Patients With Ischemic Stroke - The Prospective Find-af Trial"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, F."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T08:53:53Z"],["dc.date.available","2018-11-07T08:53:53Z"],["dc.date.issued","2011"],["dc.format.extent","322"],["dc.identifier.isi","000208702703028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22536"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Routine echocardiography to rule out paroxysmal atrial fibrillation in patients with cerebral ischemia presenting in sinus rhythm in the Find-AF trial"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Schulte, Anna"],["dc.contributor.author","Juerries, Falko"],["dc.contributor.author","Messerschmid, Anna"],["dc.contributor.author","Behnke, Nico"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T10:19:02Z"],["dc.date.available","2018-11-07T10:19:02Z"],["dc.date.issued","2016"],["dc.description.sponsorship","Boehringer Ingelheim"],["dc.identifier.isi","000399956101183"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41578"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","American-Heart-Association/American-Stroke-Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium"],["dc.relation.eventlocation","Los Angeles, CA"],["dc.relation.issn","1524-4628"],["dc.relation.issn","0039-2499"],["dc.title","Are Baseline Characteristics of Stroke Patients Included Into an Observational Study Similar to Patients Included Into a Randomised Controlled Trial?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2884"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","2888"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Lahno, Rosine"],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, Rolf"],["dc.date.accessioned","2017-09-07T11:45:14Z"],["dc.date.available","2017-09-07T11:45:14Z"],["dc.date.issued","2010"],["dc.description.abstract","Background and Purpose-Diagnosis of paroxysmal atrial fibrillation is difficult but highly relevant in patients presenting with cerebral ischemia yet free from atrial fibrillation on admission. Early initiation and prolongation of continuous Holter monitoring may improve diagnostic yield compared with the standard of care including a 24-hour Holter recording. Methods-In the observational Find-AF trial (ISRCTN 46104198), consecutive patients presenting with symptoms of cerebral ischemia were included. Patients free from atrial fibrillation at presentation received 7-day Holter monitoring. Results-Two hundred eighty-one patients were prospectively included. Forty-four (15.7%) had atrial fibrillation documented by routine electrocardiogram on admission. All remaining patients received Holter monitors at a median of 5.5 hours after presentation. In those 224 patients who received Holter monitors but had no previously known paroxysmal atrial fibrillation, the detection rate with early and prolonged (7 days) Holter monitoring (12.5%) was significantly higher than for any 24-hour (mean of 7 intervals: 4.8%, P=0.015) or any 48-hour monitoring interval (mean of 6 intervals: 6.4%, P=0.023). Of those 28 patients with new atrial fibrillation on Holter monitoring, 15 (6.7%) had been discharged without therapeutic anticoagulation after routine clinical care (ie, with data from 24-hour Holter monitoring only). Detection rates were 43.8% or 6.3% for short supraventricular runs of >= 10 beats or prolonged episodes (>5 hours) of atrial fibrillation, respectively. Diagnostic yield appeared to be only slightly and not significantly increased during the first 3 days after the index event. Conclusions-Prolongation of Holter monitoring in patients with symptoms of cerebral ischemic events increases the rate of detection of paroxysmal atrial fibrillation up to Day 7, leading to a relevant change in therapy in a substantial number of patients. Early initiation of monitoring does not appear to be crucial. Hence, prolonged Holter monitoring (>= 7 days) should be considered for all patients with unexplained cerebral ischemia. (Stroke. 2010;41:2884-2888.)"],["dc.identifier.doi","10.1161/STROKEAHA.110.591958"],["dc.identifier.gro","3142825"],["dc.identifier.isi","000284685600033"],["dc.identifier.pmid","20966415"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/272"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0039-2499"],["dc.title","Enhanced Detection of Paroxysmal Atrial Fibrillation by Early and Prolonged Continuous Holter Monitoring in Patients With Cerebral Ischemia Presenting in Sinus Rhythm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","21"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Groeschel, S."],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Edelmann, F."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Groeschel, Klaus"],["dc.date.accessioned","2018-11-07T09:47:11Z"],["dc.date.available","2018-11-07T09:47:11Z"],["dc.date.issued","2014"],["dc.description.abstract","Background and purposeDetection of paroxysmal atrial fibrillation (pAF) after an ischaemic cerebrovascular event is of imminent interest, because oral anticoagulation as a highly effective secondary preventive treatment is available. Whereas permanent atrial fibrillation (AF) can be detected during routine electrocardiogram (ECG), longer detection duration will detect more pAF but might be resource consuming. The current study tried to identify clinical predictors for pAF detected during long-term Holter ECG and clinical follow-up. MethodsPatients with acute ischaemic stroke were prospectively investigated with an intensified algorithm to detect pAF (7-day Holter ECG, follow-up investigations after 90days and 1year). ResultsTwo hundred and eighty-one patients were included, 44 of whom had to be excluded since they presented with permanent AF and another 13 patients had to be excluded due to other causes leaving 224 patients (mean age 68.5years, 58.5% male). Twenty-nine (12.9%) patients could be identified to have pAF during prolonged Holter monitoring, an additional 13 (5.8%) after follow-up investigations. Multivariate analysis identified advanced age [odds ratio (OR) 1.05, 95% confidence interval (CI) 1.01-1.08] as well as clinical symptoms >24h (OR 5.17, 95% CI 1.73-15.48) and a history of coronary artery disease (OR 3.14, 95% CI 1.35-7.28) to be predictive for the detection of pAF. ConclusionsIn acute stroke patients with advanced age, history of coronary artery disease and clinical symptoms >24h, a prolonged Holter ECG monitoring and follow-up is warranted to identify pAF. This could increase the detection rate of patients requiring anticoagulation and may be able to reduce the risk of recurrent stroke in the case of successful anticoagulation of these patients."],["dc.identifier.doi","10.1111/ene.12198"],["dc.identifier.isi","000327943000009"],["dc.identifier.pmid","23711185"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35051"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1468-1331"],["dc.relation.issn","1351-5101"],["dc.title","Clinical predictors to identify paroxysmal atrial fibrillation after ischaemic stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Groeschel, Klaus"],["dc.date.accessioned","2018-11-07T09:20:07Z"],["dc.date.available","2018-11-07T09:20:07Z"],["dc.date.issued","2013"],["dc.format.extent","E111"],["dc.identifier.doi","10.1161/STROKEAHA.113.002203"],["dc.identifier.isi","000329982500008"],["dc.identifier.pmid","23943220"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28801"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1524-4628"],["dc.relation.issn","0039-2499"],["dc.title","Letter by Wachter et al Regarding Article, \"Occult Atrial Fibrillation in Cryptogenic Stroke: Detection by 7-Day Electrocardiogram Versus Implantable Cardiac Monitors\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]