Weber-Krüger, Mark

[["dc.bibliographiccitation.firstpage","3643"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","3645"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Lahno, Rosine"],["dc.contributor.author","Seegers, Jochen"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, Rolf"],["dc.date.accessioned","2017-09-07T11:43:17Z"],["dc.date.available","2017-09-07T11:43:17Z"],["dc.date.issued","2011"],["dc.description.abstract","Background and Purpose-We assessed whether echocardiography can predict paroxysmal atrial fibrillation (PAF) in patients with cerebral ischemia presenting in sinus rhythm. Methods-Within the prospective Find-AF cohort, 193 consecutive patients with cerebral ischemia and sinus rhythm on presentation had evaluation of echocardiographic parameters of left atrial size and function. PAF was diagnosed by 7-day Holter monitoring. Results-In 26 patients with PAF, late diastolic Doppler (A') and tissue Doppler (a') velocities were lower whereas left atrial diameter, left atrial volume index (LAVI), LAVI/A, and LAVI/a' were larger (P < 0.05 for all) than they were in 167 patients without PAF. In multivariate models A, a', LAVI/A, and LAVI/a' predicted the presence of PAF. Area under the receiver operating characteristic curve to diagnose PAF was highest for LAVI/a' (0.813 [0.738; 0.889]). A previously suggested cut-off of LAVI/a' < 2.3 had 92% sensitivity, 55.8% specificity, and 98% negative predictive value for PAF. Conclusions-LAVI/a' < 2.3 can effectively rule out PAF in patients with cerebral ischemia. (Stroke. 2011; 42: 3643-3645.)"],["dc.identifier.doi","10.1161/STROKEAHA.111.632836"],["dc.identifier.gro","3142621"],["dc.identifier.isi","000297941500066"],["dc.identifier.pmid","21998056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0039-2499"],["dc.title","Transthoracic Echocardiography to Rule Out Paroxysmal Atrial Fibrillation as a Cause of Stroke or Transient Ischemic Attack"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","438"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","American Heart Journal"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","168"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Hamann, Gerhard F."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T09:34:27Z"],["dc.date.available","2018-11-07T09:34:27Z"],["dc.date.issued","2014"],["dc.description.abstract","Background Detecting paroxysmal atrial fibrillation (AF) in patients with ischemic strokes presenting in sinus rhythm is challenging because episodes are often short, occur randomly, and are frequently asymptomatic. If AF is detected, recurrent thromboembolism can be prevented efficiently by oral anticoagulation. Numerous uncontrolled studies using various electrocardiogram (ECG) devices have established that prolonged ECG monitoring increases the yield of AF detection, but most established procedures are time-consuming and costly. The few randomized trials are mostly limited to cryptogenic strokes. The optimal method, duration, and patient selection remain unclear. Repeated prolonged continuous Holter ECG monitoring to detect paroxysmal AF within an unspecific stroke population may prove to be a widely applicable, effective secondary prevention strategy. Study Design Find-AF(RANDOMISED) is a randomized and controlled prospective multicenter trial. Four hundred patients 60 years or older with manifest (symptoms >= 24 hours or acute computed tomography/magnetic resonance imaging lesion) and acute (symptoms <= 7 days) ischemic strokes will be included at 4 certified stroke centers in Germany. Those with previously diagnosed AF/flutter, indications/contraindications for oral anticoagulation, or obvious causative blood vessel pathologies will be excluded. Patients will be randomized 1:1 to either enhanced and prolonged Holter ECG monitoring (10 days at baseline and after 3 and 6 months) or standard of care (>= 24-hour continuous ECG monitoring, according to current stroke guidelines). All patients will be followed up for at least 12 months. Outcomes The primary end point is newly detected AF (>= 30 seconds) after 6 months, confirmed by an independent adjudication committee. We plan to complete recruitment in autumn 2014. First results can be expected by spring 2016."],["dc.description.sponsorship","Boehringer Ingelheim; Pfizer; Medtronic"],["dc.identifier.doi","10.1016/j.ahj.2014.06.018"],["dc.identifier.isi","000343096900008"],["dc.identifier.pmid","25262252"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32171"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","1097-5330"],["dc.relation.issn","0002-8703"],["dc.title","Finding atrial fibrillation in stroke patients: Randomized evaluation of enhanced and prolonged Holter monitoring-Find-AF(RANDOMISED) -rationale and design"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e34351"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Lahno, Rosine"],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Goerlitz, Anke"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.date.accessioned","2017-09-07T11:48:54Z"],["dc.date.available","2017-09-07T11:48:54Z"],["dc.date.issued","2012"],["dc.description.abstract","Background and Purpose: Diagnosis of paroxysmal atrial fibrillation (AF) can be challenging, but it is highly relevant in patients presenting with sinus rhythm and acute cerebral ischemia. We aimed to evaluate prospectively whether natriuretic peptide levels and kinetics identify patients with paroxysmal AF. Methods: Patients with acute cerebral ischemia were included into the prospective observational Find-AF study. N-terminal pro brain-type natriuretic peptide (NT-proBNP), brain-type natriuretic peptide (BNP) and N-terminal pro atrial-type natriuretic peptide (NT-proANP) plasma levels were measured on admission, after 6 and 24 hours. Patients free from AF at presentation received 7 day Holter monitoring. We prospectively hypothesized that patients presenting in sinus rhythm with NT-proBNP>median were more likely to have paroxysmal AF than patients with NT-proBNPmedian (239 pg/ml), 17.9% had paroxysmal AF in contrast to 7.4% with NT-proBNP<239 pg/ml (p = 0.025). The ratio of early (0 h) to late (24 h) plasma levels of NT-proBNP showed no difference between both groups. For the detection of paroxysmal atrial fibrillation, BNP, NT-proBNP and NT-proANP at admission had an area under the curve in ROC analysis of 0.747 (0.663-0.831), 0.638 (0.531-0.744) and 0.663 (0.566-0.761), respectively. In multivariate analysis, BNP was the only biomarker to be independently predictive for paroxysmal atrial fibrillation. Conclusions: BNP is independently predictive of paroxysmal AF detected by prolonged ECG monitoring in patients with cerebral ischemia and may be used to effectively select patients for prolonged Holter monitoring."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2012"],["dc.identifier.doi","10.1371/journal.pone.0034351"],["dc.identifier.gro","3142549"],["dc.identifier.isi","000305336600027"],["dc.identifier.pmid","22509292"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7572"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8912"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Natriuretic Peptides for the Detection of Paroxysmal Atrial Fibrillation in Patients with Cerebral Ischemia - the Find-AF Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e67602"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Lahno, Rosine"],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Niehaus, Cord-Friedrich"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.date.accessioned","2017-09-07T11:47:40Z"],["dc.date.available","2017-09-07T11:47:40Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Detecting paroxysmal atrial fibrillation (PAF) in patients with cerebral ischemia is challenging. Frequent premature atrial complexes (PAC/h) and the longest supraventricular run on 24-h-Holter (SV-run(24 h)), summarised as excessive supraventricular ectopic activity (ESVEA), may help selecting patients for extended ECG-monitoring, especially in combination with echocardiographic marker LAVI/a' (left atrial volume index/late diastolic tissue Doppler velocity). Methods: Retrospective analysis from the prospective monocentric observational trial Find-AF (ISRCTN-46104198). Patients with acute stroke or TIA were enrolled at the University Hospital Gottingen, Germany. Those with sinus rhythm at presentation received 7-day Holter-monitoring. ESVEA was quantified in one 24-hour interval free from PAF. Echocardiographic parameters were assessed prospectively. Results: PAF was detected in 23/208 patients (11.1%). The median was 4 [IQR 1; 22] for PAC/h and 5 [IQR 0; 9] for SV-run(24 h). PAF was more prevalent in patients with ESVEA: 19.6% vs. 2.8% for PAC/h >4 vs. <= 4 (p<0.001); 17.0% vs. 4.9% for SV-run(24) (h) >5 vs. <= 5 beats (p = 0.003). Patients with PAF showed more supraventricular ectopic activity: 29 PAC/h [IQR 9; 143] vs. 4 PAC/h [1; 14] and longest SV-run(24) (h) = 10 [5; 21] vs. 0 [0; 8] beats (both p<0.001). Both markers discriminated between the PAF- and the Non-PAF-group (area under receiver-operator-characteristics-curve 0.763 [95% CI 0.667; 0.858] and 0.716 [0.600; 0.832]). In multivariate analyses log(PAC/h) and log(SV-run(24 h)) were independently indicative of PAF. In Patients with PAC/h <= 4 and normal LAVI/a' PAF was excluded, whereas those with PAC/h>4 and abnormal LAVI/a' showed high PAF-rates. Conclusions: ESVEA discriminated PAF from non-PAF beyond clinical factors including LAVI/a' in patients with cerebral ischemia. Normal LAVI/a'+PAC/h <= 4 ruled out PAF, while prevalence was high in those with abnormal LAVI/a'+PAC/h >4."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2013"],["dc.identifier.doi","10.1371/journal.pone.0067602"],["dc.identifier.gro","3142337"],["dc.identifier.isi","000321148400112"],["dc.identifier.pmid","23840747"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9133"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7164"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/3.0"],["dc.title","Excessive Supraventricular Ectopic Activity Is Indicative of Paroxysmal Atrial Fibrillation in Patients with Cerebral Ischemia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, Frank T."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T08:49:44Z"],["dc.date.available","2018-11-07T08:49:44Z"],["dc.date.issued","2011"],["dc.identifier.isi","000299738705335"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21533"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","High-Sensitivity Troponin T Improves Cardiovascular Risk Prediction in Patients With Cerebral Ischemia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Messerschmid, Anna"],["dc.contributor.author","Heuschmann, Peter U."],["dc.contributor.author","Behnke, Nico"],["dc.contributor.author","Schulte, Anna"],["dc.contributor.author","Juerries, Falko"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Hamann, Gerhard F."],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T10:19:02Z"],["dc.date.available","2018-11-07T10:19:02Z"],["dc.date.issued","2016"],["dc.description.sponsorship","Boehringer Ingelheim"],["dc.identifier.isi","000399956101165"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41577"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","American-Heart-Association/American-Stroke-Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium"],["dc.relation.eventlocation","Los Angeles, CA"],["dc.relation.issn","1524-4628"],["dc.relation.issn","0039-2499"],["dc.title","Atrial Fibrillation and Flutter as a Cause of Stroke in an Unspecific Stroke Population. Stroke Subtypes in the Findaf Randomised Study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Lahno, Rosine C."],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.date.accessioned","2018-11-07T08:36:41Z"],["dc.date.available","2018-11-07T08:36:41Z"],["dc.date.issued","2010"],["dc.identifier.isi","000208231603210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","Nt-probnp for the Diagnosis of Paroxysmal Atrial Fibrillation in Patients With Ischemic Stroke - The Prospective Find-af Trial"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1574"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1579"],["dc.bibliographiccitation.volume","259"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Schnaudigel, Sonja"],["dc.contributor.author","Edelmann, Frank T."],["dc.contributor.author","Niehaus, Cord-Friedrich"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Lahno, Rosine C."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T09:07:49Z"],["dc.date.available","2018-11-07T09:07:49Z"],["dc.date.issued","2012"],["dc.description.abstract","Blood biomarkers may improve the performance in predicting early stroke outcome beyond well-established clinical factors. We investigated the value of growth-differentiation factor-15 (GDF-15) to predict functional outcome after 90 days in a prospectively collected patient cohort with symptoms of acute ischemic stroke. Two hundred eighty-one patients with symptoms of acute ischemic stroke were prospectively investigated. Serial blood samples for GDF-15 analysis were obtained after the admission of the patient, after 6 and 24 h. Primary outcome was the dichotomized modified ranking scale (MRS) 90 days after the initial clinical event. Within the final study population (264 patients, mean age 70.3 +/- A 12.7 years, 55.3% male), National Institutes of Health Stroke Scale (NIH-SS) [odds ratio (OR) 1.269, 95% confidence interval (CI) 1.141-1.412, p < 0.001] and initial GDF-15 levels (OR 1.029, 95% CI 1.007-1.053, p = 0.011) were independently associated with a MRS a parts per thousand yen 2 after day 90 after multiple regression analysis. Growth-differentiation factor-15 levels increase with higher NIH-SS-tertiles (p = 0.005). Receiver-operator characteristic curves demonstrated a discriminatory accuracy to predict unfavourable stroke outcome of 0.629 (95% CI 0.558-0.699), 0.753 (95% CI 0.693-812) and 0.774 (95% CI 0.717-0.832) for GDF-15, NIH-SS and the combination of these variables. The additional use of GDF-15 to NIH-SS ameliorates the model with a net reclassification index of 0.044 (p = 0.541) and integrated discrimination improvement of 0.034 (p = 0.443). Growth-differentiation factor-15 as an acute stroke biomarker independently predicts unfavourable functional 90 day stroke outcome. Discriminatory value in addition to NIH-SS is only modestly distinct."],["dc.identifier.doi","10.1007/s00415-011-6379-0"],["dc.identifier.isi","000307267300007"],["dc.identifier.pmid","22231869"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8099"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25886"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Growth-differentiation factor-15 and functional outcome after acute ischemic stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2042"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","2045"],["dc.bibliographiccitation.volume","260"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Groeschel, Klaus"],["dc.date.accessioned","2017-09-07T11:47:38Z"],["dc.date.available","2017-09-07T11:47:38Z"],["dc.date.issued","2013"],["dc.description.abstract","Diagnosis of paroxysmal atrial fibrillation (AF) in stroke patients is challenging, but highly clinically relevant. The percentage of stroke patients with permanent AF increases with age, but limited data are available for the age-dependent yield of paroxysmal AF by Holter monitoring. Patients with acute cerebral ischemia were included into the prospective observational Find-AF study. Patients free from AF at presentation received 7 day Holter monitoring. We calculated the percentage of otherwise undetected paroxysmal AF and the number needed to screen for age groups under 60 years, and in 5 year clusters from the age of 60 up to 85 and older. 272 patients were included, 43 (15.8 %) had AF at admission, 33 patients with paroxysmal AF were identified by 7 day Holter (n = 29) or medical history (n = 4).The yield of 7 day Holter ECG clearly increased with older age (p = 0.004): < 60 years: 5 %, 60-64 years: 5 %, 65-69 years: 7 %, 70-74 years: 11 %, 75-79 years: 13 %, 80-84 years: 25 %, a parts per thousand yen85 years: 39 %. The number needed to screen (NNS) to find one patient with paroxysmal AF decreased with age: a parts per thousand currency sign60 years: 18, 60-64 years: 20, 65-69 years: 14, 70-74 years: 9, 75-79 years: 8, 80-84 years: 4, a parts per thousand yen85 years: 3, respectively. In patients < 65 years, all AF cases were detected by Holter ECG. The percentage of paroxysmal AF in stroke patients increases with age. The 7 day Holter ECG is most efficient in elderly patients."],["dc.identifier.doi","10.1007/s00415-013-6935-x"],["dc.identifier.gro","3142313"],["dc.identifier.isi","000322783000012"],["dc.identifier.pmid","23632947"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10309"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/6898"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, F."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T08:53:53Z"],["dc.date.available","2018-11-07T08:53:53Z"],["dc.date.issued","2011"],["dc.format.extent","322"],["dc.identifier.isi","000208702703028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22536"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Routine echocardiography to rule out paroxysmal atrial fibrillation in patients with cerebral ischemia presenting in sinus rhythm in the Find-AF trial"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]