Weber-Krüger, Mark

[["dc.bibliographiccitation.firstpage","282"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Lancet. Neurology"],["dc.bibliographiccitation.lastpage","290"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Gröschel, Klaus"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Hamann, Gerhard F"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Schulte, Anna"],["dc.contributor.author","Jürries, Falko"],["dc.contributor.author","Messerschmid, Anna"],["dc.contributor.author","Behnke, Nico"],["dc.contributor.author","Gröschel, Sonja"],["dc.contributor.author","Uphaus, Timo"],["dc.contributor.author","Grings, Anne"],["dc.contributor.author","Ibis, Tugba"],["dc.contributor.author","Klimpe, Sven"],["dc.contributor.author","Wagner-Heck, Michaela"],["dc.contributor.author","Arnold, Magdalena"],["dc.contributor.author","Protsenko, Evgeny"],["dc.contributor.author","Heuschmann, Peter U"],["dc.contributor.author","Conen, David"],["dc.contributor.author","Weber-Krüger, Mark"],["dc.date.accessioned","2020-12-10T15:22:02Z"],["dc.date.available","2020-12-10T15:22:02Z"],["dc.date.issued","2017"],["dc.description.abstract","Background Atrial fibrillation is a major risk factor for recurrent ischaemic stroke, but often remains undiagnosed in patients who have had an acute ischaemic stroke. Enhanced and prolonged Holter-electrocardiogram-monitoring might increase detection of atrial fibrillation. We therefore investigated whether enhanced and prolonged rhythm monitoring was better for detection of atrial fibrillation than standard care procedures in patients with acute ischaemic stroke. Methods Find-AF(RANDOMISED) is an open-label randomised study done at four centres in Germany. We recruited patients with acute ischaemic stroke (symptoms for 7 days or less) aged 60 years or older presenting with sinus rhythm and without history of atrial fibrillation. Patients were included irrespective of the suspected cause of stroke, unless they had a severe ipsilateral carotid or intracranial artery stenosis, which were the exclusion criteria. We used a computer-generated allocation sequence to randomly assign patients in a 1: 1 ratio with permuted block sizes of 2, 4, 6, and 8, stratified by centre, to enhanced and prolonged monitoring (ie, 10-day Holter-electrocardiogram [ECG]-monitoring at baseline, and at 3 months and 6 months of follow-up) or standard care procedures (ie, at least 24 h of rhythm monitoring). Participants and study physicians were not masked to group assignment, but the expert committees that adjudicated endpoints were. The primary endpoint was the occurrence of atrial fibrillation or atrial flutter (30 sec or longer) within 6 months after randomisation and before stroke recurrence. Because Holter ECG is a widely used procedure and not known to harm patients, we chose not to assess safety in detail. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT01855035. Findings Between May 8, 2013, and Aug 31, 2014, we recruited 398 patients. 200 patients were randomly assigned to the enhanced and prolonged monitoring group and 198 to the standard care group. After 6 months, we detected atrial fibrillation in 14% of 200 patients in the enhanced and prolonged monitoring group (27 patients) versus 5% in the control group (nine of 198 patients, absolute difference 9.0%; 95% CI 3.4-14.5, p=0.002; number needed to screen 11). Interpretation Enhanced and prolonged monitoring initiated early in patients with acute ischaemic stroke aged 60 years or older was better than standard care for the detection of atrial fibrillation. These findings support the consideration of all patients aged 60 years or older with stroke for prolonged monitoring if the detection of atrial fibrillation would result in a change in medical management (eg, initiation of anticoagulation)."],["dc.identifier.doi","10.1016/S1474-4422(17)30002-9"],["dc.identifier.isi","000396336600017"],["dc.identifier.issn","1474-4422"],["dc.identifier.pmid","28187920"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73251"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1474-4465"],["dc.relation.issn","1474-4422"],["dc.title","Holter-electrocardiogram-monitoring in patients with acute ischaemic stroke (Find-AF RANDOMISED ): an open-label randomised controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","438"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","American Heart Journal"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","168"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Hamann, Gerhard F."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T09:34:27Z"],["dc.date.available","2018-11-07T09:34:27Z"],["dc.date.issued","2014"],["dc.description.abstract","Background Detecting paroxysmal atrial fibrillation (AF) in patients with ischemic strokes presenting in sinus rhythm is challenging because episodes are often short, occur randomly, and are frequently asymptomatic. If AF is detected, recurrent thromboembolism can be prevented efficiently by oral anticoagulation. Numerous uncontrolled studies using various electrocardiogram (ECG) devices have established that prolonged ECG monitoring increases the yield of AF detection, but most established procedures are time-consuming and costly. The few randomized trials are mostly limited to cryptogenic strokes. The optimal method, duration, and patient selection remain unclear. Repeated prolonged continuous Holter ECG monitoring to detect paroxysmal AF within an unspecific stroke population may prove to be a widely applicable, effective secondary prevention strategy. Study Design Find-AF(RANDOMISED) is a randomized and controlled prospective multicenter trial. Four hundred patients 60 years or older with manifest (symptoms >= 24 hours or acute computed tomography/magnetic resonance imaging lesion) and acute (symptoms <= 7 days) ischemic strokes will be included at 4 certified stroke centers in Germany. Those with previously diagnosed AF/flutter, indications/contraindications for oral anticoagulation, or obvious causative blood vessel pathologies will be excluded. Patients will be randomized 1:1 to either enhanced and prolonged Holter ECG monitoring (10 days at baseline and after 3 and 6 months) or standard of care (>= 24-hour continuous ECG monitoring, according to current stroke guidelines). All patients will be followed up for at least 12 months. Outcomes The primary end point is newly detected AF (>= 30 seconds) after 6 months, confirmed by an independent adjudication committee. We plan to complete recruitment in autumn 2014. First results can be expected by spring 2016."],["dc.description.sponsorship","Boehringer Ingelheim; Pfizer; Medtronic"],["dc.identifier.doi","10.1016/j.ahj.2014.06.018"],["dc.identifier.isi","000343096900008"],["dc.identifier.pmid","25262252"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32171"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","1097-5330"],["dc.relation.issn","0002-8703"],["dc.title","Finding atrial fibrillation in stroke patients: Randomized evaluation of enhanced and prolonged Holter monitoring-Find-AF(RANDOMISED) -rationale and design"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, Frank T."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T08:49:44Z"],["dc.date.available","2018-11-07T08:49:44Z"],["dc.date.issued","2011"],["dc.identifier.isi","000299738705335"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21533"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","High-Sensitivity Troponin T Improves Cardiovascular Risk Prediction in Patients With Cerebral Ischemia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1545"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","1552"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Weber-Krüger, Mark"],["dc.contributor.author","Lutz, Constanze"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Witzenhausen, Janin"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Gröschel, Klaus"],["dc.contributor.author","Wachter, Rolf"],["dc.date.accessioned","2021-06-01T10:48:11Z"],["dc.date.available","2021-06-01T10:48:11Z"],["dc.date.issued","2017"],["dc.description.abstract","Objective: Prolonged ECG monitoring after stroke frequently reveals short paroxysmal atrial fibrillation (pAF) and supraventricular (SV) runs. The minimal duration of atrial fibrillation (AF) required to induce cardioembolism, the relevance of SV runs, and whether short pAF results from cerebral damage itself are currently being debated. We aimed to study the relevance of SV runs and short pAF detected by prolonged Holter ECG after cerebral ischemia during long-term follow-up. Methods: Analysis is from the prospective Find-AF trial ( ISRCTN46104198 ). We included patients with acute cerebral ischemia. Those without AF on admission received 7-day Holter ECG monitoring. We differentiated patients with AF on admission (AF-adm), with pAF (>30 seconds), with SV runs (>5 beats but <30 seconds in a 24-hour ECG interval), and without SV runs (controls). During follow-up, those with baseline pAF received another 7-day Holter ECG to examine AF persistence. Results: A total of 254 of 281 initially included patients were analyzed (mean age 70.0 years, 45.3% female). Forty-three (16.9%) had AF-adm. A total of 211 received 7-day Holter ECG monitoring: 27 (12.8%) had pAF, 67 (31.8%) had SV runs, and 117 (55.5%) were controls. During a mean 3.7 years of follow-up, the SV runs group had more recurrent strokes ( p = 0.04) and showed numerically more novel AF (12% vs 5%, p = 0.09) than the controls. Seventy-five percent of the patients with manifest pAF detected after cerebral ischemia still had AF during follow-up (50% paroxysmal, 50% persisting/permanent). Conclusions: Patients with cerebral ischemia and SV runs had more recurrent strokes and numerically more novel AF during follow-up and could benefit from further prolonged ECG monitoring. pAF detected after stroke is not a temporal phenomenon."],["dc.identifier.doi","10.1212/WNL.0000000000004487"],["dc.identifier.gro","3142329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85851"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","final"],["dc.relation.eissn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","Relevance of supraventricular runs detected after cerebral ischemia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","98"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Stroke"],["dc.bibliographiccitation.lastpage","107"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Weber-Krüger, Mark"],["dc.contributor.author","Hamann, Gerhard F."],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Gröschel, Sonja"],["dc.contributor.author","Uphaus, Timo"],["dc.contributor.author","Gröschel, Klaus"],["dc.contributor.authorgroup","on Behalf of the Find-AFRANDOMISED Investigators and Coordinators"],["dc.date.accessioned","2022-05-02T08:09:39Z"],["dc.date.available","2022-05-02T08:09:39Z"],["dc.date.issued","2022"],["dc.description.abstract","Background and Purpose Prolonged electrocardiography (ECG)-monitoring in stroke patients improves the detection of paroxysmal atrial fibrillation (pAF). However, most randomized studies only had short follow-up. We aimed to provide 3-year follow-up data for AF detection and stroke recurrence risk.Methods We randomized 402 patients aged ≥60 years with acute ischemic strokes without AF to either enhanced and prolonged monitoring (EPM; 3×10-day Holter-ECG-monitoring) or standard-of-care (≥24 hours ECG-monitoring). The endpoint of the current analysis was AF within 36 months analyzed by intention to treat. Long-term follow-up was performed for 36 months.Results Two hundred and seventy-four patients (80%) participated in the extended follow-up (median duration of follow-up was 36 months [interquartile range, 12 to 36]). During the first 6 months, more AF was documented in the EPM arm compared to the control arm (13.5% vs. 5.1%; 95% confidence interval, 2.9% to 14.4%; P=0.004). During months 6 to 36, AF was less detected in the EPM intervention arm than in the control arm (2.0% vs. 7.3%; 95% confidence interval, 0.7% to 9.9%; P=0.028). Overall, the detection rate of AF within 36 months was numerically higher within the EPM group (15.0% vs. 11.1%, P=0.30). Numerically less patients in the EPM arm had recurrent ischemic strokes (5.5% vs. 9.1%, P=0.18), transient ischemic attacks (3.0% vs. 4.5%, P=0.44) or died (4.5% vs. 6.6%, P=0.37).Conclusions Enhanced and prolonged ECG monitoring increased AF detection during the first six months, but there was significantly more clinical AF during months 6 to 36 observed in the usual-care arm. This suggests that EPM leads to an earlier detection of clinically relevant AF."],["dc.description.abstract","Background and Purpose Prolonged electrocardiography (ECG)-monitoring in stroke patients improves the detection of paroxysmal atrial fibrillation (pAF). However, most randomized studies only had short follow-up. We aimed to provide 3-year follow-up data for AF detection and stroke recurrence risk.Methods We randomized 402 patients aged ≥60 years with acute ischemic strokes without AF to either enhanced and prolonged monitoring (EPM; 3×10-day Holter-ECG-monitoring) or standard-of-care (≥24 hours ECG-monitoring). The endpoint of the current analysis was AF within 36 months analyzed by intention to treat. Long-term follow-up was performed for 36 months.Results Two hundred and seventy-four patients (80%) participated in the extended follow-up (median duration of follow-up was 36 months [interquartile range, 12 to 36]). During the first 6 months, more AF was documented in the EPM arm compared to the control arm (13.5% vs. 5.1%; 95% confidence interval, 2.9% to 14.4%; P=0.004). During months 6 to 36, AF was less detected in the EPM intervention arm than in the control arm (2.0% vs. 7.3%; 95% confidence interval, 0.7% to 9.9%; P=0.028). Overall, the detection rate of AF within 36 months was numerically higher within the EPM group (15.0% vs. 11.1%, P=0.30). Numerically less patients in the EPM arm had recurrent ischemic strokes (5.5% vs. 9.1%, P=0.18), transient ischemic attacks (3.0% vs. 4.5%, P=0.44) or died (4.5% vs. 6.6%, P=0.37).Conclusions Enhanced and prolonged ECG monitoring increased AF detection during the first six months, but there was significantly more clinical AF during months 6 to 36 observed in the usual-care arm. This suggests that EPM leads to an earlier detection of clinically relevant AF."],["dc.identifier.doi","10.5853/jos.2021.01207"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107431"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.eissn","2287-6405"],["dc.relation.issn","2287-6391"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/4.0/"],["dc.title","Long-Term Follow-up of Enhanced Holter-Electrocardiography Monitoring in Acute Ischemic Stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, F."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T08:53:53Z"],["dc.date.available","2018-11-07T08:53:53Z"],["dc.date.issued","2011"],["dc.format.extent","322"],["dc.identifier.isi","000208702703028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22536"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Routine echocardiography to rule out paroxysmal atrial fibrillation in patients with cerebral ischemia presenting in sinus rhythm in the Find-AF trial"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Witzenhausen, J."],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Groschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T09:53:35Z"],["dc.date.available","2018-11-07T09:53:35Z"],["dc.date.issued","2015"],["dc.format.extent","911"],["dc.identifier.isi","000361205106225"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36356"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","Congress of the European-Society-of-Cardiology (ESC)"],["dc.relation.eventlocation","London, ENGLAND"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Stroke severity in relation to duration of atrial fibrillation and supraventricular runs in patients with cerebral ischemia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2884"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","2888"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Lahno, Rosine"],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, Rolf"],["dc.date.accessioned","2017-09-07T11:45:14Z"],["dc.date.available","2017-09-07T11:45:14Z"],["dc.date.issued","2010"],["dc.description.abstract","Background and Purpose-Diagnosis of paroxysmal atrial fibrillation is difficult but highly relevant in patients presenting with cerebral ischemia yet free from atrial fibrillation on admission. Early initiation and prolongation of continuous Holter monitoring may improve diagnostic yield compared with the standard of care including a 24-hour Holter recording. Methods-In the observational Find-AF trial (ISRCTN 46104198), consecutive patients presenting with symptoms of cerebral ischemia were included. Patients free from atrial fibrillation at presentation received 7-day Holter monitoring. Results-Two hundred eighty-one patients were prospectively included. Forty-four (15.7%) had atrial fibrillation documented by routine electrocardiogram on admission. All remaining patients received Holter monitors at a median of 5.5 hours after presentation. In those 224 patients who received Holter monitors but had no previously known paroxysmal atrial fibrillation, the detection rate with early and prolonged (7 days) Holter monitoring (12.5%) was significantly higher than for any 24-hour (mean of 7 intervals: 4.8%, P=0.015) or any 48-hour monitoring interval (mean of 6 intervals: 6.4%, P=0.023). Of those 28 patients with new atrial fibrillation on Holter monitoring, 15 (6.7%) had been discharged without therapeutic anticoagulation after routine clinical care (ie, with data from 24-hour Holter monitoring only). Detection rates were 43.8% or 6.3% for short supraventricular runs of >= 10 beats or prolonged episodes (>5 hours) of atrial fibrillation, respectively. Diagnostic yield appeared to be only slightly and not significantly increased during the first 3 days after the index event. Conclusions-Prolongation of Holter monitoring in patients with symptoms of cerebral ischemic events increases the rate of detection of paroxysmal atrial fibrillation up to Day 7, leading to a relevant change in therapy in a substantial number of patients. Early initiation of monitoring does not appear to be crucial. Hence, prolonged Holter monitoring (>= 7 days) should be considered for all patients with unexplained cerebral ischemia. (Stroke. 2010;41:2884-2888.)"],["dc.identifier.doi","10.1161/STROKEAHA.110.591958"],["dc.identifier.gro","3142825"],["dc.identifier.isi","000284685600033"],["dc.identifier.pmid","20966415"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/272"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0039-2499"],["dc.title","Enhanced Detection of Paroxysmal Atrial Fibrillation by Early and Prolonged Continuous Holter Monitoring in Patients With Cerebral Ischemia Presenting in Sinus Rhythm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","21"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Groeschel, S."],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Edelmann, F."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Groeschel, Klaus"],["dc.date.accessioned","2018-11-07T09:47:11Z"],["dc.date.available","2018-11-07T09:47:11Z"],["dc.date.issued","2014"],["dc.description.abstract","Background and purposeDetection of paroxysmal atrial fibrillation (pAF) after an ischaemic cerebrovascular event is of imminent interest, because oral anticoagulation as a highly effective secondary preventive treatment is available. Whereas permanent atrial fibrillation (AF) can be detected during routine electrocardiogram (ECG), longer detection duration will detect more pAF but might be resource consuming. The current study tried to identify clinical predictors for pAF detected during long-term Holter ECG and clinical follow-up. MethodsPatients with acute ischaemic stroke were prospectively investigated with an intensified algorithm to detect pAF (7-day Holter ECG, follow-up investigations after 90days and 1year). ResultsTwo hundred and eighty-one patients were included, 44 of whom had to be excluded since they presented with permanent AF and another 13 patients had to be excluded due to other causes leaving 224 patients (mean age 68.5years, 58.5% male). Twenty-nine (12.9%) patients could be identified to have pAF during prolonged Holter monitoring, an additional 13 (5.8%) after follow-up investigations. Multivariate analysis identified advanced age [odds ratio (OR) 1.05, 95% confidence interval (CI) 1.01-1.08] as well as clinical symptoms >24h (OR 5.17, 95% CI 1.73-15.48) and a history of coronary artery disease (OR 3.14, 95% CI 1.35-7.28) to be predictive for the detection of pAF. ConclusionsIn acute stroke patients with advanced age, history of coronary artery disease and clinical symptoms >24h, a prolonged Holter ECG monitoring and follow-up is warranted to identify pAF. This could increase the detection rate of patients requiring anticoagulation and may be able to reduce the risk of recurrent stroke in the case of successful anticoagulation of these patients."],["dc.identifier.doi","10.1111/ene.12198"],["dc.identifier.isi","000327943000009"],["dc.identifier.pmid","23711185"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35051"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1468-1331"],["dc.relation.issn","1351-5101"],["dc.title","Clinical predictors to identify paroxysmal atrial fibrillation after ischaemic stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","401"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Weber-Krüger, Mark"],["dc.contributor.author","Gröschel, Sonja"],["dc.contributor.author","Uphaus, Timo"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Hamann, Gerhard F."],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Gröschel, Klaus"],["dc.contributor.author","Wachter, Rolf"],["dc.date.accessioned","2020-12-10T18:38:10Z"],["dc.date.available","2020-12-10T18:38:10Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1161/STROKEAHA.119.026496"],["dc.identifier.eissn","1524-4628"],["dc.identifier.issn","0039-2499"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77202"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Brain Natriuretic Peptide and Discovery of Atrial Fibrillation After Stroke"],["dc.title.alternative","A Subanalysis of the Find-AF\r\n RANDOMISED\r\n Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]