Weber-Krüger, Mark

[["dc.bibliographiccitation.firstpage","3643"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","3645"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Haase, Beatrice"],["dc.contributor.author","Lahno, Rosine"],["dc.contributor.author","Seegers, Jochen"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, Rolf"],["dc.date.accessioned","2017-09-07T11:43:17Z"],["dc.date.available","2017-09-07T11:43:17Z"],["dc.date.issued","2011"],["dc.description.abstract","Background and Purpose-We assessed whether echocardiography can predict paroxysmal atrial fibrillation (PAF) in patients with cerebral ischemia presenting in sinus rhythm. Methods-Within the prospective Find-AF cohort, 193 consecutive patients with cerebral ischemia and sinus rhythm on presentation had evaluation of echocardiographic parameters of left atrial size and function. PAF was diagnosed by 7-day Holter monitoring. Results-In 26 patients with PAF, late diastolic Doppler (A') and tissue Doppler (a') velocities were lower whereas left atrial diameter, left atrial volume index (LAVI), LAVI/A, and LAVI/a' were larger (P < 0.05 for all) than they were in 167 patients without PAF. In multivariate models A, a', LAVI/A, and LAVI/a' predicted the presence of PAF. Area under the receiver operating characteristic curve to diagnose PAF was highest for LAVI/a' (0.813 [0.738; 0.889]). A previously suggested cut-off of LAVI/a' < 2.3 had 92% sensitivity, 55.8% specificity, and 98% negative predictive value for PAF. Conclusions-LAVI/a' < 2.3 can effectively rule out PAF in patients with cerebral ischemia. (Stroke. 2011; 42: 3643-3645.)"],["dc.identifier.doi","10.1161/STROKEAHA.111.632836"],["dc.identifier.gro","3142621"],["dc.identifier.isi","000297941500066"],["dc.identifier.pmid","21998056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0039-2499"],["dc.title","Transthoracic Echocardiography to Rule Out Paroxysmal Atrial Fibrillation as a Cause of Stroke or Transient Ischemic Attack"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1859"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Current Medical Research and Opinion"],["dc.bibliographiccitation.lastpage","1866"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Diekmann, Sandra"],["dc.contributor.author","Hörster, Laura"],["dc.contributor.author","Evers, Silvia"],["dc.contributor.author","Hiligsmann, Mickaël"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Gröschel, Klaus"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Hamann, Gerhard F."],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Weber-Krüger, Mark"],["dc.contributor.author","Wasem, Jürgen"],["dc.contributor.author","Neumann, Anja"],["dc.date.accessioned","2020-12-10T18:14:50Z"],["dc.date.available","2020-12-10T18:14:50Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1080/03007995.2019.1646000"],["dc.identifier.eissn","1473-4877"],["dc.identifier.issn","0300-7995"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74635"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Economic evaluation of prolonged and enhanced ECG Holter monitoring in acute ischemic stroke patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","282"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Lancet. Neurology"],["dc.bibliographiccitation.lastpage","290"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Gröschel, Klaus"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Hamann, Gerhard F"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Schulte, Anna"],["dc.contributor.author","Jürries, Falko"],["dc.contributor.author","Messerschmid, Anna"],["dc.contributor.author","Behnke, Nico"],["dc.contributor.author","Gröschel, Sonja"],["dc.contributor.author","Uphaus, Timo"],["dc.contributor.author","Grings, Anne"],["dc.contributor.author","Ibis, Tugba"],["dc.contributor.author","Klimpe, Sven"],["dc.contributor.author","Wagner-Heck, Michaela"],["dc.contributor.author","Arnold, Magdalena"],["dc.contributor.author","Protsenko, Evgeny"],["dc.contributor.author","Heuschmann, Peter U"],["dc.contributor.author","Conen, David"],["dc.contributor.author","Weber-Krüger, Mark"],["dc.date.accessioned","2020-12-10T15:22:02Z"],["dc.date.available","2020-12-10T15:22:02Z"],["dc.date.issued","2017"],["dc.description.abstract","Background Atrial fibrillation is a major risk factor for recurrent ischaemic stroke, but often remains undiagnosed in patients who have had an acute ischaemic stroke. Enhanced and prolonged Holter-electrocardiogram-monitoring might increase detection of atrial fibrillation. We therefore investigated whether enhanced and prolonged rhythm monitoring was better for detection of atrial fibrillation than standard care procedures in patients with acute ischaemic stroke. Methods Find-AF(RANDOMISED) is an open-label randomised study done at four centres in Germany. We recruited patients with acute ischaemic stroke (symptoms for 7 days or less) aged 60 years or older presenting with sinus rhythm and without history of atrial fibrillation. Patients were included irrespective of the suspected cause of stroke, unless they had a severe ipsilateral carotid or intracranial artery stenosis, which were the exclusion criteria. We used a computer-generated allocation sequence to randomly assign patients in a 1: 1 ratio with permuted block sizes of 2, 4, 6, and 8, stratified by centre, to enhanced and prolonged monitoring (ie, 10-day Holter-electrocardiogram [ECG]-monitoring at baseline, and at 3 months and 6 months of follow-up) or standard care procedures (ie, at least 24 h of rhythm monitoring). Participants and study physicians were not masked to group assignment, but the expert committees that adjudicated endpoints were. The primary endpoint was the occurrence of atrial fibrillation or atrial flutter (30 sec or longer) within 6 months after randomisation and before stroke recurrence. Because Holter ECG is a widely used procedure and not known to harm patients, we chose not to assess safety in detail. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT01855035. Findings Between May 8, 2013, and Aug 31, 2014, we recruited 398 patients. 200 patients were randomly assigned to the enhanced and prolonged monitoring group and 198 to the standard care group. After 6 months, we detected atrial fibrillation in 14% of 200 patients in the enhanced and prolonged monitoring group (27 patients) versus 5% in the control group (nine of 198 patients, absolute difference 9.0%; 95% CI 3.4-14.5, p=0.002; number needed to screen 11). Interpretation Enhanced and prolonged monitoring initiated early in patients with acute ischaemic stroke aged 60 years or older was better than standard care for the detection of atrial fibrillation. These findings support the consideration of all patients aged 60 years or older with stroke for prolonged monitoring if the detection of atrial fibrillation would result in a change in medical management (eg, initiation of anticoagulation)."],["dc.identifier.doi","10.1016/S1474-4422(17)30002-9"],["dc.identifier.isi","000396336600017"],["dc.identifier.issn","1474-4422"],["dc.identifier.pmid","28187920"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73251"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1474-4465"],["dc.relation.issn","1474-4422"],["dc.title","Holter-electrocardiogram-monitoring in patients with acute ischaemic stroke (Find-AF RANDOMISED ): an open-label randomised controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","424"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Heart Rhythm"],["dc.bibliographiccitation.lastpage","432"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Backhaus, Sören J."],["dc.contributor.author","Weber-Krüger, Mark"],["dc.contributor.author","Bauer, Lukas"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Lüthje, Lars"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Bergau, Leonard"],["dc.date.accessioned","2020-12-10T14:24:26Z"],["dc.date.available","2020-12-10T14:24:26Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.hrthm.2018.09.016"],["dc.identifier.issn","1547-5271"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72245"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Reverse left ventricular structural remodeling after catheter ablation of atrial fibrillation in patients with preserved left ventricular function: Insights from cardiovascular magnetic resonance native T1 mapping"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","438"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","American Heart Journal"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","168"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Kermer, Pawel"],["dc.contributor.author","Hamann, Gerhard F."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T09:34:27Z"],["dc.date.available","2018-11-07T09:34:27Z"],["dc.date.issued","2014"],["dc.description.abstract","Background Detecting paroxysmal atrial fibrillation (AF) in patients with ischemic strokes presenting in sinus rhythm is challenging because episodes are often short, occur randomly, and are frequently asymptomatic. If AF is detected, recurrent thromboembolism can be prevented efficiently by oral anticoagulation. Numerous uncontrolled studies using various electrocardiogram (ECG) devices have established that prolonged ECG monitoring increases the yield of AF detection, but most established procedures are time-consuming and costly. The few randomized trials are mostly limited to cryptogenic strokes. The optimal method, duration, and patient selection remain unclear. Repeated prolonged continuous Holter ECG monitoring to detect paroxysmal AF within an unspecific stroke population may prove to be a widely applicable, effective secondary prevention strategy. Study Design Find-AF(RANDOMISED) is a randomized and controlled prospective multicenter trial. Four hundred patients 60 years or older with manifest (symptoms >= 24 hours or acute computed tomography/magnetic resonance imaging lesion) and acute (symptoms <= 7 days) ischemic strokes will be included at 4 certified stroke centers in Germany. Those with previously diagnosed AF/flutter, indications/contraindications for oral anticoagulation, or obvious causative blood vessel pathologies will be excluded. Patients will be randomized 1:1 to either enhanced and prolonged Holter ECG monitoring (10 days at baseline and after 3 and 6 months) or standard of care (>= 24-hour continuous ECG monitoring, according to current stroke guidelines). All patients will be followed up for at least 12 months. Outcomes The primary end point is newly detected AF (>= 30 seconds) after 6 months, confirmed by an independent adjudication committee. We plan to complete recruitment in autumn 2014. First results can be expected by spring 2016."],["dc.description.sponsorship","Boehringer Ingelheim; Pfizer; Medtronic"],["dc.identifier.doi","10.1016/j.ahj.2014.06.018"],["dc.identifier.isi","000343096900008"],["dc.identifier.pmid","25262252"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32171"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","1097-5330"],["dc.relation.issn","0002-8703"],["dc.title","Finding atrial fibrillation in stroke patients: Randomized evaluation of enhanced and prolonged Holter monitoring-Find-AF(RANDOMISED) -rationale and design"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","990"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.lastpage","994"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Uphaus, T."],["dc.contributor.author","Grings, A."],["dc.contributor.author","Gröschel, S."],["dc.contributor.author","Müller, A."],["dc.contributor.author","Weber-Krüger, M."],["dc.contributor.author","Wachter, R."],["dc.contributor.author","Gröschel, K."],["dc.date.accessioned","2020-12-10T18:28:34Z"],["dc.date.available","2020-12-10T18:28:34Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1111/ene.13326"],["dc.identifier.issn","1351-5101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76363"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Automatic detection of paroxysmal atrial fibrillation in patients with ischaemic stroke: better than routine diagnostic workup?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Immig, Kerstin"],["dc.contributor.author","Gericke, Martin"],["dc.contributor.author","Menzel, Franziska"],["dc.contributor.author","Merz, Felicitas"],["dc.contributor.author","Krueger, M."],["dc.contributor.author","Schiefenhoevel, Fridtjof"],["dc.contributor.author","Hanisch, Uwe-Karsten"],["dc.contributor.author","Biber, K."],["dc.contributor.author","Bechmann, Ingo"],["dc.date.accessioned","2018-11-07T09:54:18Z"],["dc.date.available","2018-11-07T09:54:18Z"],["dc.date.issued","2015"],["dc.format.extent","E334"],["dc.identifier.isi","000356386700567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36508"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","12th European Meeting on Glial Cell Function in Health and Disease"],["dc.relation.eventlocation","Bilbao, SPAIN"],["dc.relation.issn","1098-1136"],["dc.relation.issn","0894-1491"],["dc.title","CD11c-positive cells from brain, spleen, lung, and liver exhibit site-specific immune phenotypes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3077"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","3084"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Uphaus, Timo"],["dc.contributor.author","Bittner, Stefan"],["dc.contributor.author","Gröschel, Sonja"],["dc.contributor.author","Steffen, Falk"],["dc.contributor.author","Muthuraman, Muthuraman"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Weber-Krüger, Mark"],["dc.contributor.author","Zipp, Frauke"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Gröschel, Klaus"],["dc.date.accessioned","2020-12-10T18:38:09Z"],["dc.date.available","2020-12-10T18:38:09Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1161/STROKEAHA.119.026410"],["dc.identifier.eissn","1524-4628"],["dc.identifier.issn","0039-2499"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77201"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","NfL (Neurofilament Light Chain) Levels as a Predictive Marker for Long-Term Outcome After Ischemic Stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Edelmann, Frank T."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Wohlfahrt, Janin"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T08:49:44Z"],["dc.date.available","2018-11-07T08:49:44Z"],["dc.date.issued","2011"],["dc.identifier.isi","000299738705335"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21533"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","High-Sensitivity Troponin T Improves Cardiovascular Risk Prediction in Patients With Cerebral Ischemia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1545"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","1552"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Weber-Krüger, Mark"],["dc.contributor.author","Lutz, Constanze"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Witzenhausen, Janin"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Gröschel, Klaus"],["dc.contributor.author","Wachter, Rolf"],["dc.date.accessioned","2021-06-01T10:48:11Z"],["dc.date.available","2021-06-01T10:48:11Z"],["dc.date.issued","2017"],["dc.description.abstract","Objective: Prolonged ECG monitoring after stroke frequently reveals short paroxysmal atrial fibrillation (pAF) and supraventricular (SV) runs. The minimal duration of atrial fibrillation (AF) required to induce cardioembolism, the relevance of SV runs, and whether short pAF results from cerebral damage itself are currently being debated. We aimed to study the relevance of SV runs and short pAF detected by prolonged Holter ECG after cerebral ischemia during long-term follow-up. Methods: Analysis is from the prospective Find-AF trial ( ISRCTN46104198 ). We included patients with acute cerebral ischemia. Those without AF on admission received 7-day Holter ECG monitoring. We differentiated patients with AF on admission (AF-adm), with pAF (>30 seconds), with SV runs (>5 beats but <30 seconds in a 24-hour ECG interval), and without SV runs (controls). During follow-up, those with baseline pAF received another 7-day Holter ECG to examine AF persistence. Results: A total of 254 of 281 initially included patients were analyzed (mean age 70.0 years, 45.3% female). Forty-three (16.9%) had AF-adm. A total of 211 received 7-day Holter ECG monitoring: 27 (12.8%) had pAF, 67 (31.8%) had SV runs, and 117 (55.5%) were controls. During a mean 3.7 years of follow-up, the SV runs group had more recurrent strokes ( p = 0.04) and showed numerically more novel AF (12% vs 5%, p = 0.09) than the controls. Seventy-five percent of the patients with manifest pAF detected after cerebral ischemia still had AF during follow-up (50% paroxysmal, 50% persisting/permanent). Conclusions: Patients with cerebral ischemia and SV runs had more recurrent strokes and numerically more novel AF during follow-up and could benefit from further prolonged ECG monitoring. pAF detected after stroke is not a temporal phenomenon."],["dc.identifier.doi","10.1212/WNL.0000000000004487"],["dc.identifier.gro","3142329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85851"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","final"],["dc.relation.eissn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","Relevance of supraventricular runs detected after cerebral ischemia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]