Wick, Barbara

[["dc.bibliographiccitation.firstpage","1226"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","1234"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Mollenhauer, B."],["dc.contributor.author","Trautmann, E."],["dc.contributor.author","Sixel-Doring, F."],["dc.contributor.author","Wicke, T."],["dc.contributor.author","Ebentheuer, J."],["dc.contributor.author","Schaumburg, M."],["dc.contributor.author","Lang, E."],["dc.contributor.author","Focke, N. K."],["dc.contributor.author","Kumar, K. R."],["dc.contributor.author","Trenkwalder, C."],["dc.contributor.authorgroup","On behalf of the DeNoPa Study Group"],["dc.date.accessioned","2021-06-01T10:48:12Z"],["dc.date.available","2021-06-01T10:48:12Z"],["dc.date.issued","2013"],["dc.description.abstract","Objective: To determine nonmotor signs (NMS) and evaluate the utility of several diagnostic tools in patients with de novo Parkinson disease (PD). Methods: This is a large single-center study of the DeNoPa cohort, including frequency-matched healthy controls. This study covers motor signs, NMS, and a combination of diagnostic tests including olfactory testing, transcranial sonography of substantia nigra (TCS), and polysomnography (PSG). We report the frequency and characteristics of NMS and the outcomes of nonmotor tests at the time of diagnosis. Results: Cross-sectional analyses of baseline investigations identified significant differences in the NMS Questionnaire (NMSQuest) and the Scopa-AUT Gastrointestinal score in 159 drug-naive PD patients vs 110 controls. In addition, patients with PD showed reduced olfactory function, hyperechogenicity on TCS, and higher frequency of REM sleep behavior disorder (RBD). In exploring predictive markers, we found that the combination of several investigations, i.e., the NMSQuest, Scopa-AUT Gastrointestinal score, and Smell Identification Test reached an area under the receiver operating characteristic curve (AUC) of 0.913 (95% confidence interval [CI] 0.878-0.948). With the addition of serum cholesterol and mean heart rate values, the AUC value reached 0.919 (95% CI 886-0.953); when TCS and PSG were added, the AUC increased to 0.963 (95% CI 0.943-0.982). Conclusions: We show feasibility and utility of standardized data acquisition in a large, single-center cohort of patients with de novo PD and matched healthy controls. The baseline results from our prospective investigations reached a value of >0.9 sensitivity and specificity for biological markers when we added routine laboratory investigations and quantified nonmotor features including sleep."],["dc.identifier.doi","10.1212/WNL.0b013e3182a6cbd5"],["dc.identifier.isi","000330768200012"],["dc.identifier.pmid","23997153"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85857"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.eissn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","195"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Plant and Soil"],["dc.bibliographiccitation.lastpage","205"],["dc.bibliographiccitation.volume","252"],["dc.contributor.author","Tiessen, Holm"],["dc.contributor.author","Menezes, RSC"],["dc.contributor.author","Salcedo, I. H."],["dc.contributor.author","Wick, B."],["dc.date.accessioned","2018-11-07T10:39:27Z"],["dc.date.available","2018-11-07T10:39:27Z"],["dc.date.issued","2003"],["dc.description.abstract","Planted silvo-pastoral systems are formed by sparing selected native trees when land is cleared for pasture establishment, or by planting selected species - often known agroforestry species - into the establishing pasture. Isolated trees within pastures and savannas are often associated with 'resource islands', characterized by higher fertility and organic matter levels under the tree canopies. We here examine the processes underlying the differences in fertility and organic matter in a buffel grass ( Cenchrus ciliaris L.) pasture that contained two tree species (Ziziphus joazeiro Mart., Spondias tuberosa Arruda Cam.) preserved from the native thorn forest and a planted agroforestry species (Prospois juliflora Swartz D. C). The objective is to distinguish effects of soil variability from those induced by the presence of trees or the planting of pasture. The delta(13)C signatures of the original ( largely C3) vegetation, the preserved and planted trees, and the planted C4 grass were used to distinguish the provenance of organic matter in the top soil (0 - 15 cm). This allowed the conclusion that all trees maintained C3 derived C at the original thorn forest level, while lower levels under pasture were due to mineralisation of organic matter. The net rates of forest-derived C loss under pasture varied with soil type amounting to between 25 and 50% in 13 years after pasture establishment. Only on Alfisol, C inputs from the pasture compensated for the C3-C losses. Analysis of organic and inorganic P fractions indicated Z. joazeiro and P. juliflora enriched the soil under their canopy with P, whereas S. tuberosa had no positive effect on fertility. A combination of ANOVA and spatial analysis and mapping was used to show vegetation effects."],["dc.identifier.doi","10.1023/A:1024762501920"],["dc.identifier.isi","000184191800002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46048"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Kluwer Academic Publ"],["dc.relation.issn","0032-079X"],["dc.title","Organic matter transformations and soil fertility in a treed pasture in semiarid NE Brazil"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","947"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Soil Biology and Biochemistry"],["dc.bibliographiccitation.lastpage","954"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Potthoff, M."],["dc.contributor.author","Loftfield, N."],["dc.contributor.author","Buegger, F."],["dc.contributor.author","Wick, B."],["dc.contributor.author","John, Bettina"],["dc.contributor.author","Joergensen, Rainer Georg"],["dc.contributor.author","Flessa, H."],["dc.date.accessioned","2018-11-07T10:38:09Z"],["dc.date.available","2018-11-07T10:38:09Z"],["dc.date.issued","2003"],["dc.description.abstract","The determination of the isotopic composition of the microbial biomass C in soil is an important tool to study soil microbial ecology and the decomposition and microbial immobilization of soil organic C. We discuss advantages and disadvantages of different methods to determine C-13/C-12 in soil microbial biomass and propose a new procedure that is based on the UV-catalyzed liquid oxidation of fumigated and non-fumigated soil extracts combined with trapping of the released CO2 in liquid nitrogen and subsequent determination of delta(13)CO(2)-C by a gas chromatograph connected with an isotope ratio mass spectrometer (IRMS). This method was evaluated using test solutions with known isotopic composition and soil extracts. Additionally, the method was compared with an off-line sample preparation technique combined with isotope analysis by a dual-inlet IRMS and an on-line analysis using an elemental analyser connected with an IRMS. All methods applied obtained comparable results and there were no significant differences between the delta(13)C values measured. The off-line preparation procedure had the highest precision but it was also the most labour-intensive. The choice of the most suitable method depends mainly on the number of samples that have to be analysed, the salt concentration of the extracts and the differences of delta(13)C that have to be detected. The application of this method with liquid oxidation and subsequent GC-IRMS analysis showed that microbial biomass C of a grassland soil was C-13-enriched by 2parts per thousand delta(13)C(PDB) compared with the total soil organic C. The addition of maize straw resulted in a rapid immobilization of maize C in the microbial biomass. (C) 2003 Elsevier Science Ltd. All fights reserved."],["dc.identifier.doi","10.1016/S0038-0717(03)00151-2"],["dc.identifier.isi","000184125500008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45743"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0038-0717"],["dc.title","The determination of delta C-13 in soil microbial biomass using fumigation-extraction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","59"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Plant and Soil"],["dc.bibliographiccitation.lastpage","70"],["dc.bibliographiccitation.volume","222"],["dc.contributor.author","Wick, B."],["dc.contributor.author","Tiessen, Holm"],["dc.contributor.author","Menezes, RSC"],["dc.date.accessioned","2018-11-07T11:14:32Z"],["dc.date.available","2018-11-07T11:14:32Z"],["dc.date.issued","2000"],["dc.description.abstract","The presence of trees in grasslands frequently results in resource islands of higher soil quality. Therefore, some native trees are often preserved or agroforestry species are interplanted when land is cleared for pasture. We evaluated soil quality changes associated with the conversion of a native thorn forest (caatinga) into silvo-pastoral systems in semiarid NE Brazil. Soil nutrients, organic matter, microbial biomass and soil enzymes under native caatinga, the canopy of two preserved native (Ziziphus joazeiro and Spondias tuberosa) and one introduced tree species (Prosopis juliflora), and under a planted pasture of Cenchrus ciliaris were compared. The two preserved tree species maintained high nutrient and organic matter contents and high biological activity levels not only relative to the grass but also relative to the native caatinga. The non-deciduous Z. joazeiro was more effective than the deciduous S. tuberosa, and enriched surface soils by 100 mg P kg(-1). The complete replacement of natural caatinga with C. ciliaris pasture or a C. ciliaris-P. juliflora silvopastoral system had, after 14 years, decreased microbial biomass C and N contents, and ss-glucosidase activity, but did not affect soil nutrient or organic matter status. The biological activity under the trees of the tree-grass association was greater than under grass alone, although P. juliflora did not maintain higher nutrient or organic matter levels. The search for indigenous alternatives to the main agroforestry species may provide viable alternatives for improved land management and the conservation of biodiversity. Microbiological and biochemical parameters responded more readily to changes in land management than chemical fertility indices. They are important indices for the impact of vegetation changes and its associated land quality changes."],["dc.identifier.doi","10.1023/A:1004756416281"],["dc.identifier.isi","000088041000006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54143"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Kluwer Academic Publ"],["dc.relation.issn","0032-079X"],["dc.title","Land quality changes following the conversion of the natural vegetation into silvo-pastoral systems in semi-arid NE Brazil"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","155"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biology and Fertility of Soils"],["dc.bibliographiccitation.lastpage","167"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Wick, B."],["dc.contributor.author","Kuhne, R. F."],["dc.contributor.author","Vielhauer, K."],["dc.contributor.author","Vlek, Paul L. G."],["dc.date.accessioned","2018-11-07T10:30:03Z"],["dc.date.available","2018-11-07T10:30:03Z"],["dc.date.issued","2002"],["dc.description.abstract","We evaluated the temporal variation of microbial biomass C, beta-glucosidase, acid phosphomonoesterase (acP), alkaline phosphomonoesterase (alP), and protease activity over 18 consecutive months. The likely causes for the seasonal variability at a non-degraded and a degraded site in south-western Nigeria were identified. Microbial biomass, alP, and beta-glucosidase activity were sensitive indicators of soil quality changes over time. Microbial biomass C correlated significantly with soil moisture conditions and soil organic matter-related parameters. AlP and beta-glucosidase activities were not controlled by climatic conditions over the course of two rainy seasons and one dry season but were temporally related to microbial biomass C and total C and N. Due to the steadiness of the alP activity over time the enzyme is considered a suitable indicator with which to monitor long-term changes of soil quality. Single sampling during the course of a year is adequate. Both microbial biomass and beta-glucosidase activity fluctuated highly. They were sensitive indicators to monitor short-term variations of soil quality with. Sampling for microbial biomass ought to be limited to the rainy seasons, whereas the measurement of beta-glucosidase activity need not be restricted seasonally. Due to the short-term variability found, sampling should be repeated. AcP and protease activity fluctuated highly during the course of a year and exhibited pronounced inter-seasonal differences. The marked seasonal changes could not be ascribed to soil moisture conditions and only poorly to major ecological C soil processes. This was more pronounced for acP than for protease. Hence, neither parameter was considered a sensitive and meaningful indicator of soil quality changes over time."],["dc.identifier.doi","10.1007/s00374-002-0455-7"],["dc.identifier.isi","000176060500002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43776"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0178-2762"],["dc.title","Temporal variability of selected soil microbiological and biochemical indicators under different soil quality conditions in south-western Nigeria"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]