Konietschke, Frank

[["dc.bibliographiccitation.firstpage","63"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The International Journal of Biostatistics"],["dc.bibliographiccitation.lastpage","73"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Boesiger, Sandra"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Hothorn, Ludwig A."],["dc.date.accessioned","2018-11-07T09:24:47Z"],["dc.date.available","2018-11-07T09:24:47Z"],["dc.date.issued","2013"],["dc.description.abstract","Multiple contrast tests can be used to test arbitrary linear hypotheses by providing local and global test decisions as well as simultaneous confidence intervals. The ANOVA-F-test on the contrary can be used to test the global null hypothesis of no treatment effect. Thus, multiple contrast tests provide more information than the analysis of variance (ANOVA) by offering which levels cause the significance. We compare the exact powers of the ANOVA-F-test and multiple contrast tests to reject the global null hypothesis. Hereby, we compute their least favorable configurations (LFCs). It turns out that both procedures have the same LFCs under certain conditions. Exact power investigations show that their powers are equal to detect their LFCs."],["dc.description.sponsorship","German Research Foundation [DFG-Br 655/16-1, Ho 1687/9-1]"],["dc.identifier.doi","10.1515/ijb-2012-0020"],["dc.identifier.isi","000329433300005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29910"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Walter De Gruyter Gmbh"],["dc.relation.issn","1557-4679"],["dc.relation.issn","2194-573X"],["dc.title","Are Multiple Contrast Tests Superior to the ANOVA?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","490"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The Breast Journal"],["dc.bibliographiccitation.lastpage","497"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Angic, Besim"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Obenauer, Silvia"],["dc.date.accessioned","2018-11-07T08:39:34Z"],["dc.date.available","2018-11-07T08:39:34Z"],["dc.date.issued","2010"],["dc.description.abstract","The object of this study was to assess the clinical usefulness of computer-assisted diagnosis (CAD) in the interpretation of early-research, benign and malignant mammograms in dependence on readers' experience with CAD. CAD was applied on digital mammograms of 303 patients who were divided into three groups: early-research (n = 103), benign (n = 102) and malignant group (n = 98). Mammograms were analyzed by three readers with different experience in evaluating mammograms (medical student, an assistant and an attending physician specifically trained in mammography). All images were presented accidentally with and without the influence of CAD and from different patient groups. The mammograms were classified according to BI-RADS classification. To evaluate readers' sensitivity and specificity with and without the application of the CAD system, ROC analysis and the corresponding area under the curve (AUC) were evaluated for each reader. Afterwards significant differences of the accuracy according to readers experience and according to the assistance of the CAD system were calculated. All readers have an account of accuracy by using CAD in both patient groups. The highest benefit has the student (10% increase of the AUC) followed by the resident (4%) and at least followed by the mammography fellow (3%). There are significant varieties of the accuracy in addiction to the readers' experience and to the examination method with and without CAD system. Patient group has not a significant influence to the elevation of accuracy by using the CAD. All three readers have nearly the same increase of AUC in the examinations of malignant and early-research group summarized and of the malignant group only. Finally, the increase of accuracy depends on the readers' experience. For all patient groups CAD-application causes a steeply increase of the ROC curve and consequently a gain of sensitivity."],["dc.identifier.doi","10.1111/j.1524-4741.2010.00963.x"],["dc.identifier.isi","000281667100006"],["dc.identifier.pmid","20642459"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19028"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1524-4741"],["dc.relation.issn","1075-122X"],["dc.title","Computer-assisted Diagnosis in Full-field Digital Mammography-Results in Dependence of Readers Experiences"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1753"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","1759"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Roedig, Tina"],["dc.contributor.author","Endres, Sarah"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Zimmermann, Ortrud"],["dc.contributor.author","Sydow, Hans Georg"],["dc.contributor.author","Wiegand, Annette"],["dc.date.accessioned","2018-11-07T10:23:17Z"],["dc.date.available","2018-11-07T10:23:17Z"],["dc.date.issued","2017"],["dc.description.abstract","This in vitro study evaluated the effect of fiber insertion depth on antimicrobial efficacy of antimicrobial photodynamic therapy (aPDT) using a photosensitizer (PS; toluidine blue) and a red light-emitting diode (LED) in root canals infected with Enterococcus faecalis. Single-rooted extracted teeth were prepared with nickel-titanium-instruments, sterilized, contaminated with E. faecalis, and incubated for 72 h. Roots were randomly divided into four experimental groups: PS only, LED only, aPDT with LED in the apical third, aPDT with LED in the coronal third, as well as into infection and sterile controls (each n = 10). Samples were taken by collecting standardized dentine shavings from the root canal walls. After serial dilution and culturing on blood agar, colony-forming units (CFU) were counted. Both aPDT groups showed a CFU reduction of 1-2 log(10) steps compared with the infection control, whereas the effect of fiber insertion depth was negligible (< 0.5 log(10) steps). CFU reduction of approximately 0.5 log(10) steps for PS alone was detected compared with the infection control, but PS alone was less effective than both aPDT groups. No antibacterial effect was detected for LED alone. aPDT reduced E. faecalis within the root canal, whereas fiber insertion depth had a negligible influence on antimicrobial effectiveness of aPDT. The insertion depth of the light-emitting diode may not influence the antibacterial efficacy of photodynamic therapy against E. faecalis in straight root canals."],["dc.identifier.doi","10.1007/s00784-016-1948-3"],["dc.identifier.isi","000402011500036"],["dc.identifier.pmid","27591860"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42428"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1436-3771"],["dc.relation.issn","1432-6981"],["dc.title","Effect of fiber insertion depth on antibacterial efficacy of photodynamic therapy against Enterococcus faecalis in rootcanals"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1410"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Endodontics"],["dc.bibliographiccitation.lastpage","1413"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Roedig, Tina"],["dc.contributor.author","Bozkurt, Meral"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Hülsmann, Michael"],["dc.date.accessioned","2018-11-07T08:40:53Z"],["dc.date.available","2018-11-07T08:40:53Z"],["dc.date.issued","2010"],["dc.description.abstract","Introduction: The aim of this study was to compare the efficiency of a sonic device (Vibringe), syringe irrigation, and passive ultrasonic irrigation in the removal of debris from simulated root canal irregularities. Methods: Root canals with 2 standardized grooves in the apical and coronal parts were filled with dentin debris. Three different irrigation procedures were performed with NaOCl (1%) and (1) syringe irrigation, (2) Vibringe, and (3) passive ultrasonic irrigation. The amount of remaining debris was evaluated by using a 4-grade scoring system. Results: Ultrasonic irrigation removed debris significantly better from the artificial canal irregularities than the Vibringe System and syringe irrigation (P < .0001). The Vibringe System demonstrated significantly better results than syringe irrigation in the apical part of the root canal (P = .011). Conclusions: Passive ultrasonic irrigation is more effective than the Vibringe System or syringe irrigation in removing debris. The sonic device demonstrated significantly better results than syringe irrigation in the apical root canal third. (J Endod 2010;36:1410-1413)"],["dc.identifier.doi","10.1016/j.joen.2010.04.023"],["dc.identifier.isi","000280691900027"],["dc.identifier.pmid","20647107"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19341"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0099-2399"],["dc.title","Comparison of the Vibringe System with Syringe and Passive Ultrasonic Irrigation in Removing Debris from Simulated Root Canal Irregularities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","92"],["dc.bibliographiccitation.journal","Clinical Imaging"],["dc.bibliographiccitation.lastpage","95"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Wienbeck, Susanne"],["dc.contributor.author","Bauer, Lukas"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Derlin, Thorsten"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Sohns, Jan Martin"],["dc.date.accessioned","2020-12-10T14:23:07Z"],["dc.date.available","2020-12-10T14:23:07Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.clinimag.2017.06.005"],["dc.identifier.issn","0899-7071"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71842"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Prevalence and clinical significance of incidental extra-mammary findings in breast magnetic resonance imaging: A retrospective study of 1070 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","197"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","JOURNAL OF ADHESIVE DENTISTRY"],["dc.bibliographiccitation.lastpage","205"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Roedig, Tina"],["dc.contributor.author","Nusime, Anne Kathrin"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Attin, Thomas"],["dc.date.accessioned","2018-11-07T08:47:53Z"],["dc.date.available","2018-11-07T08:47:53Z"],["dc.date.issued","2010"],["dc.description.abstract","Purpose: To evaluate the bond strength between two fiber posts (FRC Postec and DT Light Post) and different composite resins following different surface treatments of the posts. Materials and Methods: One hundred sixty extracted teeth were divided into sixteen groups (n = 10). After pretreatment of the post surface with (1) no treatment, (2) silanization, (3) sandblasting + silanization or (4) tribochemical coating, the posts were either luted with the resin cements provided by the manufacturers of the post system or with a core buildup material. Push-out tests were performed in a universal testing machine until the post segment was dislodged from the root section. Data were analyzed using ANOVA. Multiple comparisons were performed using Tukey's test. Results: FRC Postec achieved significantly higher bond strengths than DT Light Post (p < 0.0001). Cementation with the core buildup material showed significantly higher bond strengths than the resin cement provided by the post manufacturers (p < 0.0001). Conclusion: Post type, type of surface treatment and type of resin cement were significant factors for bond strength. Luting with a core buildup material significantly increased the bond strengths."],["dc.description.sponsorship","VDW; Ivoclar Vivadent"],["dc.identifier.doi","10.3290/j.jad.a18441"],["dc.identifier.isi","000278999100006"],["dc.identifier.pmid","20589257"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21070"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Quintessence Publishing Co Inc"],["dc.relation.issn","1461-5185"],["dc.title","Effects of Different Luting Agents on Bond Strengths of Fiber-reinforced Composite Posts to Root Canal Dentin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","461"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY"],["dc.bibliographiccitation.lastpage","473"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Pauly, Markus"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Konietschke, Frank"],["dc.date.accessioned","2018-11-07T10:00:44Z"],["dc.date.available","2018-11-07T10:00:44Z"],["dc.date.issued","2015"],["dc.description.abstract","In general factorial designs where no homoscedasticity or a particular error distribution is assumed, the well-known Wald-type statistic is a simple asymptotically valid procedure. However, it is well known that it suffers from a poor finite sample approximation since the convergence to its (2) limit distribution is quite slow. This becomes even worse with an increasing number of factor levels. The aim of the paper is to improve the small sample behaviour of the Wald-type statistic, maintaining its applicability to general settings as crossed or hierarchically nested designs by applying a modified permutation approach. In particular, it is shown that this approach approximates the null distribution of the Wald-type statistic not only under the null hypothesis but also under the alternative yielding an asymptotically valid permutation test which is even finitely exact under exchangeability. Finally, its small sample behaviour is compared with competing procedures in an extensive simulation study."],["dc.description.sponsorship","German Research Foundation [DFG-Br 655/16-1, Ho 1687/9-1]"],["dc.identifier.doi","10.1111/rssb.12073"],["dc.identifier.isi","000349206900007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37872"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1467-9868"],["dc.relation.issn","1369-7412"],["dc.title","Asymptotic permutation tests in general factorial designs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1581"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","The International Journal of Cardiovascular Imaging"],["dc.bibliographiccitation.lastpage","1587"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Sohns, Jan M."],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Schwarz, Alexander"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Placzek, Marius"],["dc.contributor.author","Weiberg, Desiree"],["dc.contributor.author","Nordlohne, Stefan"],["dc.contributor.author","Schmuck, Sebastian"],["dc.contributor.author","Schulz, Sebastian"],["dc.contributor.author","Derlin, Thorsten"],["dc.contributor.author","Staab, Wieland"],["dc.date.accessioned","2020-12-10T14:11:26Z"],["dc.date.available","2020-12-10T14:11:26Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s10554-017-1145-8"],["dc.identifier.eissn","1573-0743"],["dc.identifier.issn","1569-5794"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71072"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Incidental findings in cardiac magnetic resonance imaging: superiority of bSSFP over T1w-HASTE for extra-cardiac findings assessment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","883"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Statistics in Medicine"],["dc.bibliographiccitation.lastpage","898"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Mütze, Tobias"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Munk, Axel"],["dc.contributor.author","Friede, Tim"],["dc.date.accessioned","2017-09-07T11:53:20Z"],["dc.date.available","2017-09-07T11:53:20Z"],["dc.date.issued","2016"],["dc.description.abstract","The ‘gold standard’ design for three-arm trials refers to trials with an active control and a placebo control in addition to the experimental treatment group. This trial design is recommended when being ethically justifiable and it allows the simultaneous comparison of experimental treatment, active control, and placebo. Parametric testing methods have been studied plentifully over the past years. However, these methods often tend to be liberal or conservative when distributional assumptions are not met particularly with small sample sizes. In this article, we introduce a studentized permutation test for testing non-inferiority and superiority of the experimental treatment compared with the active control in three-arm trials in the ‘gold standard’ design. The performance of the studentized permutation test for finite sample sizes is assessed in a Monte Carlo simulation study under various parameter constellations. Emphasis is put on whether the studentized permutation test meets the target significance level. For comparison purposes, commonly used Wald-type tests, which do not make any distributional assumptions, are included in the simulation study. The simulation study shows that the presented studentized permutation test for assessing non-inferiority in three-arm trials in the ‘gold standard’ design outperforms its competitors, for instance the test based on a quasi-Poisson model, for count data. The methods discussed in this paper are implemented in the R package ThreeArmedTrials which is available on the comprehensive R archive network (CRAN)."],["dc.identifier.doi","10.1002/sim.7176"],["dc.identifier.gro","3145059"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2753"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","0277-6715"],["dc.title","A studentized permutation test for three-arm trials in the ‘gold standard’ design"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","418"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Imaging"],["dc.bibliographiccitation.lastpage","424"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Angic, Besim Cetin"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Obenauer, Silvia"],["dc.date.accessioned","2018-11-07T08:37:23Z"],["dc.date.available","2018-11-07T08:37:23Z"],["dc.date.issued","2010"],["dc.description.abstract","Aim To assess time expenditure using the influence of computer assisted detection (CAD) system in the interpretation of the dependence of early research and benign and malignant mammograms on readers experience Materials and Methods CAD (Image Checker V2 3 R2 Technology Los Altos CA USA) was prospectively applied on digital mammograms of 303 patients [early research (n=103) benign (n=102), and malignant group (n=98)] Mammograms were analyzed by three readers with varying experience in evaluating mammograms (medical student, resident and attending) according to the BI-RADS classification Time was stopped and recorded All images were presented randomly with and without the influence of CAD and from the different patient groups To evaluate the statistical significance, the corresponding P value for time to read the mammograms in addition to different patient groups, application of CAD, readers experience and interaction of reader was calculated Results The attending needs, independent of CAD application, the least time, followed by the medical assistant and the student In all three patient groups, CAD adoption elongates reading time of the student and the resident The medical specialist needs with and without CAD median the same time In the early research group, no significant differences were registered (P= 1343) Concerning readers experience, there is an explicit significant difference (P< 0001) The application of CAD correlates with the corresponding readers experience and also provides a not significant result In comparison, the P value for the malignant and benign groups shows significant interactions between the readers experiences as well as CAD application Conclusion The future role of CAD application depends on whether sensitivity can be increased and time expenditure caused by false-positive marks can be decreased In the future, second reading could be substituted by a CAD system if the reader has a wide professional experience (C) 2010 Elsevier Inc All rights reserved"],["dc.identifier.doi","10.1016/j.clinimag.2009.10.039"],["dc.identifier.isi","000285034600004"],["dc.identifier.pmid","21092870"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18517"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1873-4499"],["dc.relation.issn","0899-7071"],["dc.title","CAD in full-field digital mammography-influence of reader experience and application of CAD on interpretation of time"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]