Schulze, Thomas Gerd

[["dc.bibliographiccitation.journal","Frontiers in Psychiatry"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Reinbold, Céline S."],["dc.contributor.author","Forstner, Andreas J."],["dc.contributor.author","Hecker, Julian"],["dc.contributor.author","Fullerton, Janice M."],["dc.contributor.author","Hoffmann, Per"],["dc.contributor.author","Hou, Liping"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Adli, Mazda"],["dc.contributor.author","Akiyama, Kazufumi"],["dc.contributor.author","Cichon, Sven"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Schulze, Thomas G."],["dc.date.accessioned","2020-12-10T18:46:52Z"],["dc.date.available","2020-12-10T18:46:52Z"],["dc.date.issued","2018"],["dc.description.abstract","Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Consortium on Lithium Genetics (ConLiGen). Recently, we performed the first genome-wide analysis of the involvement of miRNAs in BD and identified nine BD-associated miRNAs. However, it is unknown whether these miRNAs are also associated with lithium response in BD. In the present study, we therefore tested whether common variants at these nine candidate miRNAs contribute to the variance in lithium response in BD. Furthermore, we systematically analyzed whether any other miRNA in the genome is implicated in the response to lithium. For this purpose, we performed gene-based tests for all known miRNA coding genes in the ConLiGen GWAS dataset (n = 2,563 patients) using a set-based testing approach adapted from the versatile gene-based test for GWAS (VEGAS2). In the candidate approach, miR-499a showed a nominally significant association with lithium response, providing some evidence for involvement in both development and treatment of BD. In the genome-wide miRNA analysis, 71 miRNAs showed nominally significant associations with the dichotomous phenotype and 106 with the continuous trait for treatment response. A total of 15 miRNAs revealed nominal significance in both phenotypes with miR-633 showing the strongest association with the continuous trait (p = 9.80E-04) and miR-607 with the dichotomous phenotype (p = 5.79E-04). No association between miRNAs and treatment response to lithium in BD in either of the tested conditions withstood multiple testing correction. Given the limited power of our study, the investigation of miRNAs in larger GWAS samples of BD and lithium response is warranted."],["dc.identifier.doi","10.3389/fpsyt.2018.00207"],["dc.identifier.eissn","1664-0640"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78571"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-0640"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S395"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","S396"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Andlauer, Till F.M."],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Nöthen, Markus"],["dc.contributor.author","Strohmaier, Jana"],["dc.contributor.author","Frank, Josef"],["dc.contributor.author","Witt, Stephanie"],["dc.contributor.author","Müller-Myhsok, Bertram"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Schulze, Thomas G."],["dc.date.accessioned","2020-12-10T14:23:51Z"],["dc.date.available","2020-12-10T14:23:51Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.euroneuro.2016.09.433"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72065"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Using Polygenic Scores Based on Schneiderian First Rank Symptoms To Characterize Disease Trajectories In Severe Mental Illnesses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","456"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","457"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Jain, Gaurav"],["dc.contributor.author","Kaurani, Lalit"],["dc.contributor.author","Kondofersky, Ivan"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Aldinger, Fanny"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Mueller, Nikola"],["dc.contributor.author","Theis, Fabian J."],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Fischer, André"],["dc.contributor.author","Schulze, Thomas G."],["dc.date.accessioned","2018-01-09T14:32:55Z"],["dc.date.available","2018-01-09T14:32:55Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.euroneuro.2016.09.527"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11601"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","The Role Of Micrornas In The Course Of Severe Mental Disorders"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","660"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Genes, Brain and Behavior"],["dc.bibliographiccitation.lastpage","668"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Geoffroy, Pierrette"],["dc.contributor.author","Etain, Bruno"],["dc.contributor.author","Lajnef, M."],["dc.contributor.author","Zerdazi, E-H."],["dc.contributor.author","Brichant-Petitjean, C."],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Hou, L."],["dc.contributor.author","Degenhardt, Franziska A."],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","McMahon, Francis J."],["dc.contributor.author","Schulze, Thomas G."],["dc.contributor.author","Jamain, Stephane"],["dc.contributor.author","Marie-Claire, C."],["dc.contributor.author","Bellivier, Frank"],["dc.date.accessioned","2018-11-07T10:09:29Z"],["dc.date.available","2018-11-07T10:09:29Z"],["dc.date.issued","2016"],["dc.description.abstract","Preliminary studies suggest that lithium (Li) response might be associated with some circadian gene polymorphisms, we therefore performed a pharmacogenetic study on the core clock genes in two independent samples suffering from bipolar disorder (BD) and thoroughly characterized for their Li response. Two independent Caucasian samples (165 and 58 bipolar patients) treated with Li were selected from samples recruited in a French multicenter study and assessed for their Li response using the Alda scale. The two samples were genotyped using the Human660 (H660) and OmniExpress (OE) BeadChips and gene-based association analyses of 22 core clock genes were conducted. In the first sample (H660 chip), the RAR-related orphan receptor-a gene (RORA) and the Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha gene (PPARGC1A or PGC-1) were significantly associated with the Li response (empirical P-value = 0.0015 and 0.04, respectively), and remained significant only for RORA after Bonferroni correction. In the second sample (OE chip), PPARGC1A was significantly associated with the Li response (empirical P-value = 0.04), and did not remain significant after Bonferroni correction. PPARGC1A is a master regulator of mitochondrial function and a key component of the endogenous clock that stimulates the expression of Bmal1 and Rev-erb-alpha through coactivation of RORA. Although the observed associations deserve further replication and investigation, our results suggest genetic associations between Li response and these two close biological partners: PPARGC1A and RORA involved in circadian rhythms and bioenergetics processes in Li response."],["dc.identifier.doi","10.1111/gbb.12306"],["dc.identifier.isi","000383775000005"],["dc.identifier.pmid","27324142"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39660"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1601-183X"],["dc.relation.issn","1601-1848"],["dc.title","Circadian genes and lithium response in bipolar disorders: associations with PPARGC1A (PGC-1) and RORA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1085"],["dc.bibliographiccitation.issue","10023"],["dc.bibliographiccitation.journal","The Lancet"],["dc.bibliographiccitation.lastpage","1093"],["dc.bibliographiccitation.volume","387"],["dc.contributor.author","Hou, Liping"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Adli, Mazda"],["dc.contributor.author","Akiyama, Kazufumi"],["dc.contributor.author","Akula, Nirmala"],["dc.contributor.author","Ardau, Raffaella"],["dc.contributor.author","Arias, Bárbara"],["dc.contributor.author","Backlund, Lena"],["dc.contributor.author","Banzato, Claudio E M"],["dc.contributor.author","Schulze, Thomas G"],["dc.date.accessioned","2020-12-10T15:21:52Z"],["dc.date.available","2020-12-10T15:21:52Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1016/S0140-6736(16)00143-4"],["dc.identifier.issn","0140-6736"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73198"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","89"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","180"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Anderson‐Schmidt, Heike"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Reich‐Erkelenz, Daniela"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Kalman, Janos L."],["dc.contributor.author","Senner, Fanny"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Andlauer, Till F. M."],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Comes, Ashley L."],["dc.contributor.author","Schulte, Eva C."],["dc.contributor.author","Klöhn‐Saghatolislam, Farah"],["dc.contributor.author","Gryaznova, Anna"],["dc.contributor.author","Hake, Maria"],["dc.contributor.author","Bartholdi, Kim"],["dc.contributor.author","Flatau, Laura"],["dc.contributor.author","Reitt, Markus"],["dc.contributor.author","Stegmaier, Sophia"],["dc.contributor.author","Meyers, Milena"],["dc.contributor.author","Emons, Barbara"],["dc.contributor.author","Haußleiter, Ida Sybille"],["dc.contributor.author","Juckel, Georg"],["dc.contributor.author","Nieratschker, Vanessa"],["dc.contributor.author","Dannlowski, Udo"],["dc.contributor.author","Schaupp, Sabrina K."],["dc.contributor.author","Schmauß, Max"],["dc.contributor.author","Zimmermann, Jörg"],["dc.contributor.author","Reimer, Jens"],["dc.contributor.author","Schulz, Sybille"],["dc.contributor.author","Reininghaus, Eva"],["dc.contributor.author","Anghelescu, Ion‐George"],["dc.contributor.author","Arolt, Volker"],["dc.contributor.author","Baune, Bernhard T."],["dc.contributor.author","Konrad, Carsten"],["dc.contributor.author","Thiel, Andreas"],["dc.contributor.author","Fallgatter, Andreas J."],["dc.contributor.author","Figge, Christian"],["dc.contributor.author","von Hagen, Martin"],["dc.contributor.author","Koller, Manfred"],["dc.contributor.author","Lang, Fabian U."],["dc.contributor.author","Becker, Thomas"],["dc.contributor.author","Jäger, Markus"],["dc.contributor.author","Dietrich, Detlef E."],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Folkerts, Here"],["dc.contributor.author","Witt, Stephanie H."],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Forstner, Andreas J."],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Nöthen, Markus M."],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Schulze, Thomas G."],["dc.date.accessioned","2021-06-01T10:49:14Z"],["dc.date.available","2021-06-01T10:49:14Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1002/ajmg.b.32639"],["dc.identifier.eissn","1552-485X"],["dc.identifier.issn","1552-4841"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86216"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1552-485X"],["dc.relation.issn","1552-4841"],["dc.title","A longitudinal approach to biological psychiatric research: The PsyCourse study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S995"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","S996"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Schulte, Eva"],["dc.contributor.author","Kondofersky, Ivan"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Aldinger, Fanny"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Andlauer, Till F.M."],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Theis, Fabian J."],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Müller, Nikola"],["dc.contributor.author","Schulze, Thomas G."],["dc.date.accessioned","2020-12-10T14:23:55Z"],["dc.date.available","2020-12-10T14:23:55Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2017.08.382"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72076"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","POLYGENIC BURDEN ANALYSIS OF LONGITUDINAL CLUSTERS OF PSYCHOPATHOLOGICAL FEATURES IN A CROSS-DIAGNOSTIC GROUP OF INDIVIDUALS WITH SEVERE MENTAL ILLNESS"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S1236"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Senner, Fanny"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Schulte, Eva C."],["dc.contributor.author","Comes, Ashley L."],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Andlauer, Till F.M."],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Nöthen, Markus M."],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Schulze, Thomas G."],["dc.contributor.author","Heilbronner, Urs"],["dc.date.accessioned","2020-12-10T14:23:56Z"],["dc.date.available","2020-12-10T14:23:56Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2018.08.310"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72080"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","SA88PSYCOURSE: A TRANSDIAGNOSTIC STUDY ON THE COURSE OF SEVERE MENTAL DISORDERS"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S993"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","S994"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Just, David"],["dc.contributor.author","Kannaiyan, Nirmal"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Rossner, Moritz"],["dc.contributor.author","Nilsson, Peter"],["dc.contributor.author","Schulze, Thomas"],["dc.date.accessioned","2019-08-12T12:07:58Z"],["dc.date.available","2019-08-12T12:07:58Z"],["dc.date.issued","2019"],["dc.description.abstract","Background The identification of biological markers in the peripheral blood for the prediction of the individual clinical outcome has an enormous potential in the frame of personalized medicine. Previous studies have already tried to create predictive models for major psychiatric disorders based on serum protein profiles though with inconclusive results. This study leverages the rich repertoire of biosamples available in the KFO241/PsyCourse cohort to perform a high-throughput antibody-based serum protein profiling. The aim of this pilot study is to establish the feasibility of such an analysis in the serum of these patients. This study also capitalizes on the availability of genomic data to carry out an integrative (genomics/proteomics) profiling. Methods Serum samples of 113 Schizophrenia (SCZ) and 125 Bipolar Disorder (BD) patients belonging to the German KFO241/PsyCourse cohort (www.kfo241.de; www.PsyCourse.de) were included in this study. All biomaterials in this cohort (blood, serum, plasma, DNA, RNA), available at different time points given its longitudinal design, are part of a high-end biobank. The expression of a selected panel of ~100 serum proteins was determined using a set of 155 antibodies in a high-throughput antibody-based assay. This suspension bead array technology enables a multiplexed protein profiling and it leverages the information generated by the Human Protein Atlas (www.proteinatlas.org). Median fluorescent intensities were log-transformed / standardized for downstream analyses. DNA samples were genotyped (Infinium PsychArray) and underwent genotype imputation (1000 Genomes Phase 3 ref. panel). Polygenic Risk Scores (PRS) were calculated by summing up the weighted effect of each SNP contributing to the PRS to obtain an individual estimate of SCZ genetic risk burden. Age, sex and ancestry principal components were used as covariates. Results Multivariate profiles based on the whole panel of quantified proteins did not significantly discriminate between both diagnoses (SCZ and BD). Single-protein ANCOVA analyses revealed, after Bonferroni correction, significant differences in C4B, CFB, VWF, NRG1, BACE1 and other proteins between SCZ and BD samples. High-risk versus Low-risk patients (according to PRS thresholds 5E-8, 5E-2 and 1) did not show a differential level of expression of these proteins. Likewise, polygenic risk did not correlate with the serum level of any of the proteins. Suggestive serum pQTL loci were identified. Discussion Our results confirm the feasibility and potential of this approach using serum samples of psychiatric patients. The observed differences in protein levels between diagnoses warrant replication in independent samples controlling the effect of medication. These results lay the groundwork for large-scale analyses for the discovery of predictive biomarkers of course, outcome and treatment response in SCZ and BD. Such an approach, joining the longitudinal phenotyping and biosample availability at four different time points in the KFO241/PsyCourse cohort with state-of-the-art biomarker quantification methodologies, holds promise for the generation of clinically-relevant predictive models in complex psychiatric disorders."],["dc.identifier.doi","10.1016/j.euroneuro.2017.08.378"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62359"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0924-977X"],["dc.title","High-Throutghtput Antibody-Based Profiling of Serum in Shiziphrenia and Bipolar Disorder Patients: An Integrative Genomics-Proteomics Pilot Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","EMBO Molecular Medicine"],["dc.bibliographiccitation.volume","13"],["dc.contributor.affiliation","Islam, Md Rezaul; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Kaurani, Lalit; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Berulava, Tea; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Heilbronner, Urs; 3Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital Ludwig‐Maximilians‐University Munich Munich Germany"],["dc.contributor.affiliation","Budde, Monika; 3Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital Ludwig‐Maximilians‐University Munich Munich Germany"],["dc.contributor.affiliation","Centeno, Tonatiuh Pena; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Elerdashvili, Vakthang; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Zafieriou, Maria‐Patapia; 4Institute of Pharmacology and Toxicology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Benito, Eva; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Sertel, Sinem M; 5Department of Neuro‐ and Sensory Physiology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Goldberg, Maria; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Senner, Fanny; 3Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital Ludwig‐Maximilians‐University Munich Munich Germany"],["dc.contributor.affiliation","Kalman, Janos L; 3Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital Ludwig‐Maximilians‐University Munich Munich Germany"],["dc.contributor.affiliation","Burkhardt, Susanne; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Oepen, Anne Sophie; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Sakib, Mohammad Sadman; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Kerimoglu, Cemil; 1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany"],["dc.contributor.affiliation","Wirths, Oliver; 2Department for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Bickeböller, Heike; 7Department of Genetic Epidemiology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Bartels, Claudia; 2Department for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Brosseron, Frederic; 8German Center for Neurodegenerative Diseases Bonn Germany"],["dc.contributor.affiliation","Buerger, Katharina; 10German Center for Neurodegenerative Diseases (DZNE, Munich) Munich Germany"],["dc.contributor.affiliation","Cosma, Nicoleta‐Carmen; 12Department of Psychiatry and Psychotherapy Charité – Universitätsmedizin Berlin Berlin Germany"],["dc.contributor.affiliation","Fliessbach, Klaus; 8German Center for Neurodegenerative Diseases Bonn Germany"],["dc.contributor.affiliation","Heneka, Michael T.; 8German Center for Neurodegenerative Diseases Bonn Germany"],["dc.contributor.affiliation","Janowitz, Daniel; 11Institute for Stroke and Dementia Research (ISD) University Hospital LMU Munich Munich Germany"],["dc.contributor.affiliation","Kilimann, Ingo; 13German Center for Neurodegenerative Diseases (DZNE) Rostock Germany"],["dc.contributor.affiliation","Kleinedam, Luca; 8German Center for Neurodegenerative Diseases Bonn Germany"],["dc.contributor.affiliation","Laske, Christoph; 14Department of Psychosomatic Medicine Rostock University Medical Center Rostock Germany"],["dc.contributor.affiliation","Metzger, Coraline D; 16German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany"],["dc.contributor.affiliation","Munk, Matthias H; 15Section for Dementia Research Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy University of Tübingen Tübingen Germany"],["dc.contributor.affiliation","Perneczky, Robert; 6Department of Psychiatry and Psychotherapy Ludwig‐Maximilians‐University Munich München Germany"],["dc.contributor.affiliation","Peters, Oliver; 12Department of Psychiatry and Psychotherapy Charité – Universitätsmedizin Berlin Berlin Germany"],["dc.contributor.affiliation","Priller, Josef; 22German Center for Neurodegenerative Diseases (DZNE) Berlin Germany"],["dc.contributor.affiliation","Rauchmann, Boris S.; 6Department of Psychiatry and Psychotherapy Ludwig‐Maximilians‐University Munich München Germany"],["dc.contributor.affiliation","Roy, Nina; 8German Center for Neurodegenerative Diseases Bonn Germany"],["dc.contributor.affiliation","Schneider, Anja; 8German Center for Neurodegenerative Diseases Bonn Germany"],["dc.contributor.affiliation","Spottke, Annika; 8German Center for Neurodegenerative Diseases Bonn Germany"],["dc.contributor.affiliation","Spruth, Eike J; 22German Center for Neurodegenerative Diseases (DZNE) Berlin Germany"],["dc.contributor.affiliation","Teipel, Stefan; 13German Center for Neurodegenerative Diseases (DZNE) Rostock Germany"],["dc.contributor.affiliation","Tscheuschler, Maike; 25Department of Psychiatry Medical Faculty University of Cologne Cologne Germany"],["dc.contributor.affiliation","Wagner, Michael; 8German Center for Neurodegenerative Diseases Bonn Germany"],["dc.contributor.affiliation","Wiltfang, Jens; 2Department for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Düzel, Emrah; 16German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany"],["dc.contributor.affiliation","Jessen, Frank; 8German Center for Neurodegenerative Diseases Bonn Germany"],["dc.contributor.affiliation","Rizzoli, Silvio O; 5Department of Neuro‐ and Sensory Physiology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Zimmermann, Wolfram‐Hubertus; 4Institute of Pharmacology and Toxicology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.author","Islam, Md Rezaul"],["dc.contributor.author","Kaurani, Lalit"],["dc.contributor.author","Berulava, Tea"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Centeno, Tonatiuh Pena"],["dc.contributor.author","Elerdashvili, Vakthang"],["dc.contributor.author","Zafieriou, Maria‐Patapia"],["dc.contributor.author","Benito, Eva"],["dc.contributor.author","Sertel, Sinem M."],["dc.contributor.author","Fischer, André"],["dc.contributor.author","Burkhardt, Susanne"],["dc.contributor.author","Kerimoglu, Cemil"],["dc.contributor.author","Wirths, Oliver"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Rizzoli, Silvio O."],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.contributor.author","Schulze, Thomas G."],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Sananbenesi, Farahnaz"],["dc.contributor.authorgroup","Delcode Study Group"],["dc.date.accessioned","2021-12-01T09:24:01Z"],["dc.date.available","2021-12-01T09:24:01Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T13:34:49Z"],["dc.description.abstract","Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3‐microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics."],["dc.description.abstract","SYNOPSIS image Alzheimer\\’s disease (AD) is usually diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. This study aimed to identify a minimally invasive biomarker that can help to identify individuals at risk for cognitive decline before clinical manifestation. Circulating microRNAs are linked to cognitive function in young and healthy humans. A circulating 3‐microRNA signature is identified using a longitudinal mouse model of age‐associated memory decline. The expression of the 3‐microRNA signature is increased in patients with mild cognitive impairment (MCI) and is associated with future conversion from MCI to AD. Targeting all 3‐ microRNAs using anti‐miRs ameliorates cognitive decline in AD mice."],["dc.description.abstract","Alzheimer\\’s disease (AD) is usually diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. This study aimed to identify a minimally invasive biomarker that can help to identify individuals at risk for cognitive decline before clinical manifestation. image"],["dc.description.sponsorship","EC|H2020|H2020 Priority Excellent Science|H2020 European Research Council (ERC) http://dx.doi.org/10.13039/100010663"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft (DFG) http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship","Bundesministerium für Bildung und Forschung (BMBF) http://dx.doi.org/10.13039/501100002347"],["dc.description.sponsorship","HHS|NIH|OSC|Common Fund (NIH Common Fund) http://dx.doi.org/10.13039/100015326"],["dc.identifier.doi","10.15252/emmm.202013659"],["dc.identifier.pmid","34633146"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94824"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/411"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/150"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | B06: Die Rolle von RNA in Synapsenphysiologie und Neurodegeneration"],["dc.relation.eissn","1757-4684"],["dc.relation.issn","1757-4676"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.relation.workinggroup","RG Zafeiriou (3D Electrically Excitable Cell Networks – Brain and Heart)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","A microRNA signature that correlates with cognition and is a target against cognitive decline"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]