Ilse, Benjamin

[["dc.bibliographiccitation.firstpage","871"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Social Indicators Research"],["dc.bibliographiccitation.lastpage","882"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Ilse, Benjamin"],["dc.contributor.author","Prell, Tino"],["dc.contributor.author","Walther, Mario"],["dc.contributor.author","Hartung, Viktor"],["dc.contributor.author","Penzlin, Susanne"],["dc.contributor.author","Tietz, Florian"],["dc.contributor.author","Witte, Otto-Wilhelm"],["dc.contributor.author","Strauss, Bernhard"],["dc.contributor.author","Grosskreutz, Julian"],["dc.date.accessioned","2018-11-07T10:01:50Z"],["dc.date.available","2018-11-07T10:01:50Z"],["dc.date.issued","2015"],["dc.description.abstract","Quality of life (QOL) is an important issue in patients with amyotrophic lateral sclerosis (ALS). QOL measurements can help the support care team understand how to maintain or improve QOL in ALS patients. The purpose of this study was to describe the relationship between health-related QOL, disease severity and social support in ALS patients. In the current study, 49 German ALS patients were evaluated using the European quality of life score (EQ-5D), ALS Functional Rating Scale in its revised form (ALSFRS-R), Social Support Questionnaire (F-SozU K-14) and the Beck depression inventory. Data concerning patient history and socioeconomic background were collected using a semi-structured interview. Age, gender, number of children, habitation, socioeconomic status and disease duration were not significantly related to health-related QOL (EQ-5D). Positive correlations were found between the ALSFRS-R, social support and health-related QOL, whereas depression was negatively correlated with the ALSFRS-R score. A multiple linear regression model indicated a significant influence of the ALSFRS-R score on health-related QOL in ALS patients, with an additional trend for social support as a predictor. These results suggest that because of the logarithmic association between measures, compensatory therapy for loss of health-related QOL should be optimised during the course of the disease in ALS patients."],["dc.identifier.doi","10.1007/s11205-014-0621-y"],["dc.identifier.isi","000347954300013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38110"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1573-0921"],["dc.relation.issn","0303-8300"],["dc.title","Relationships Between Disease Severity, Social Support and Health-Related Quality of Life in Patients with Amyotrophic Lateral Sclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0131114"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Prell, Tino"],["dc.contributor.author","Hartung, Viktor"],["dc.contributor.author","Tietz, Florian"],["dc.contributor.author","Penzlin, Susanne"],["dc.contributor.author","Ilse, Benjamin"],["dc.contributor.author","Schweser, Ferdinand"],["dc.contributor.author","Deistung, Andreas"],["dc.contributor.author","Bokemeyer, Martin"],["dc.contributor.author","Reichenbach, Juergen R."],["dc.contributor.author","Witte, Otto-Wilhelm"],["dc.contributor.author","Grosskreutz, Julian"],["dc.date.accessioned","2018-11-07T09:55:41Z"],["dc.date.available","2018-11-07T09:55:41Z"],["dc.date.issued","2015"],["dc.description.abstract","Background Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disorder, characterised by widespread white matter damage. There is growing evidence that disturbances in iron metabolism contribute to white matter alterations. Materials & Methods We analysed the data of susceptibility-weighted imaging (SWI) of white matter in a cohort of 27 patients with ALS and 30 healthy age-matched controls. Results Signal alterations were found on SWI in the corpus callosum; along the corticospinal tract (subcortical motor cortex, posterior limb of the internal capsule and brainstem levels) and in the subgyral regions of frontal, parietal, temporal, occipital and limbic lobes. Alterations of white matter in the corpus callosum correlated with disease severity as assessed by the revised ALS functional rating scale. Conclusion SWI is capable of indicating iron and myelin disturbances in white matter of ALS patients. The SWI patterns observed in this study suggest that widespread alterations due to iron disturbances occur in patients with ALS and correlate with disease severity."],["dc.identifier.doi","10.1371/journal.pone.0131114"],["dc.identifier.isi","000356933800118"],["dc.identifier.pmid","26110427"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11952"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36806"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Susceptibility-Weighted Imaging Provides Insight into White Matter Damage in Amyotrophic Lateral Sclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e104894"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Hartung, Viktor"],["dc.contributor.author","Prell, Tino"],["dc.contributor.author","Gaser, Christian"],["dc.contributor.author","Turner, Martin R."],["dc.contributor.author","Tietz, Florian"],["dc.contributor.author","Ilse, Benjamin"],["dc.contributor.author","Bokemeyer, Martin"],["dc.contributor.author","Witte, Otto-Wilhelm"],["dc.contributor.author","Grosskreutz, Julian"],["dc.date.accessioned","2018-11-07T09:36:31Z"],["dc.date.available","2018-11-07T09:36:31Z"],["dc.date.issued","2014"],["dc.description.abstract","Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of upper and lower motor neurons. Advanced MRI techniques such as diffusion tensor imaging have shown great potential in capturing a common white matter pathology. However the sensitivity is variable and diffusion tensor imaging is not yet applicable to the routine clinical environment. Voxel-based morphometry (VBM) has revealed grey matter changes in ALS, but the bias-reducing algorithms inherent to traditional VBM are not optimized for the assessment of the white matter changes. We have developed a novel approach to white matter analysis, namely voxel-based intensitometry (VBI). High resolution T1-weighted MRI was acquired at 1.5 Tesla in 30 ALS patients and 37 age-matched healthy controls. VBI analysis at the group level revealed widespread white matter intensity increases in the corticospinal tracts, corpus callosum, sub-central, frontal and occipital white matter tracts and cerebellum. VBI results correlated with disease severity (ALSFRS-R) and patterns of cerebral involvement differed between bulbar- and limb-onset. VBI would be easily translatable to the routine clinical environment, and once optimized for individual analysis offers significant biomarker potential in ALS."],["dc.identifier.doi","10.1371/journal.pone.0104894"],["dc.identifier.isi","000341302700048"],["dc.identifier.pmid","25133577"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11611"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32636"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Voxel-Based MRI Intensitometry Reveals Extent of Cerebral White Matter Pathology in Amyotrophic Lateral Sclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]