Viebahn, Christoph

[["dc.bibliographiccitation.artnumber","4"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","EvoDevo"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Kremnyov, Stanislav"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","Henningfeld, Kristine A."],["dc.date.accessioned","2018-04-18T14:43:20Z"],["dc.date.accessioned","2021-10-27T13:21:04Z"],["dc.date.available","2018-04-18T14:43:20Z"],["dc.date.available","2021-10-27T13:21:04Z"],["dc.date.issued","2018-01-31"],["dc.date.updated","2018-04-18T14:43:20Z"],["dc.description.abstract","Abstract Background The notochord has organizer properties and is required for floor plate induction and dorsoventral patterning of the neural tube. This activity has been attributed to sonic hedgehog (shh) signaling, which originates in the notochord, forms a gradient, and autoinduces shh expression in the floor plate. However, reported data are inconsistent and the spatiotemporal development of the relevant shh expression domains has not been studied in detail. We therefore studied the expression dynamics of shh in rabbit, chicken and Xenopus laevis embryos (as well as indian hedgehog and desert hedgehog as possible alternative functional candidates in the chicken). Results Our analysis reveals a markedly divergent pattern within these vertebrates: whereas in the rabbit shh is first expressed in the notochord and its floor plate domain is then induced during subsequent somitogenesis stages, in the chick embryo shh is expressed in the prospective neuroectoderm prior to the notochord formation and, interestingly, prior to mesoderm immigration. Neither indian hedgehog nor desert hedgehog are expressed in these midline structures although mRNA of both genes was detected in other structures of the early chick embryo. In X. laevis, shh is expressed at the beginning of gastrulation in a distinct area dorsal to the dorsal blastopore lip and adjacent to the prospective neuroectoderm, whereas the floor plate expresses shh at the end of gastrulation. Conclusions While shh expression patterns in rabbit and X. laevis embryos are roughly compatible with the classical view of “ventral to dorsal induction” of the floor plate, the early shh expression in the chick floor plate challenges this model. Intriguingly, this alternative sequence of domain induction is related to the asymmetrical morphogenesis of the primitive node and other axial organs in the chick. Our results indicate that the floor plate in X. laevis and chick embryos may be initially induced by planar interaction within the ectoderm or epiblast. Furthermore, we propose that the mode of the floor plate induction adapts to the variant topography of interacting tissues during gastrulation and notochord formation and thereby reveals evolutionary plasticity of early embryonic induction."],["dc.identifier.doi","10.1186/s13227-017-0090-x"],["dc.identifier.pmid","29423139"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15170"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91992"],["dc.language.iso","en"],["dc.language.rfc3066","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2041-9139"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","92"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Development (Cambridge)"],["dc.bibliographiccitation.lastpage","98"],["dc.bibliographiccitation.volume","142"],["dc.contributor.author","Stankova, Viktoria"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2021-06-01T10:48:14Z"],["dc.date.available","2021-06-01T10:48:14Z"],["dc.date.issued","2015"],["dc.description.abstract","During animal gastrulation, the specification of the embryonic axes is accompanied by epithelio-mesenchymal transition (EMT), the first major change in cell shape after fertilization. EMT takes place in disparate topographical arrangements, such as the circular blastopore of amphibians, the straight primitive streak of birds and mammals or in intermediate gastrulation forms of other amniotes such as reptiles. Planar cell movements are prime candidates to arrange specific modes of gastrulation but there is no consensus view on their role in different vertebrate classes. Here, we test the impact of interfering with Rho kinase-mediated cell movements on gastrulation topography in blastocysts of the rabbit, which has a flat embryonic disc typical for most mammals. Time-lapse video microscopy, electron microscopy, gene expression and morphometric analyses of the effect of inhibiting ROCK activity showed – besides normal specification of the organizer region – a dose-dependent disruption of primitive streak formation; this disruption resulted in circular, arc-shaped or intermediate forms, reminiscent of those found in amphibians, fishes and reptiles. Our results reveal a crucial role of ROCK-controlled directional cell movements during rabbit primitive streak formation and highlight the possibility that temporal and spatial modulation of cell movements were instrumental for the evolution of gastrulation forms."],["dc.identifier.doi","10.1242/dev.111583"],["dc.identifier.isi","000348240500014"],["dc.identifier.pmid","25516971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85863"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.eissn","1477-9129"],["dc.relation.issn","0950-1991"],["dc.title","Rho kinase activity controls directional cell movements during primitive streak formation in the rabbit embryo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","614"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Genesis"],["dc.bibliographiccitation.lastpage","625"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Otto, Annalena"],["dc.contributor.author","Pieper, Tobias"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.date.accessioned","2018-11-07T09:39:17Z"],["dc.date.available","2018-11-07T09:39:17Z"],["dc.date.issued","2014"],["dc.description.abstract","The primitive node is the \"hub\" of early left-right patterning in the chick embryo: (1) it undergoes asymmetrical morphogenesis immediately after its appearance at Stage 4; (2) it is closely linked to the emerging asymmetrical expression of nodal and shh at Stage 5; and (3) its asymmetry is spatiotemporally related to the emerging notochord, the midline barrier maintaining molecular left-right patterning from Stage 6 onward. Here, we study the correlation of node asymmetry to notochord marker expression using high-resolution histology, and we test pharmacological inhibition of shh signaling using cyclopamine at Stages 4 and 5. Just as noggin expression mirrors an intriguing structural continuity between the right node shoulder and the notochord, shh expression in the left node shoulder confirms a similar continuity with the future floor plate. Shh inhibition at Stage 4 or 5 suppressed nodal in both its paraxial or lateral plate mesoderm domains, respectively, and resulted in randomized heart looping. Thus, the \"primordial\" paraxial nodal asymmetry at Stage 4/5 (1) appears to be dependent on, but not instructed by, shh signaling and (2) may be fixed by asymmetrical roots of the notochord and the floor plate, thereby adding further twists to the node's pivotal role during left-right patterning. (C) 2014 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/dvg.22773"],["dc.identifier.isi","000338011500016"],["dc.identifier.pmid","24648137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33245"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1526-968X"],["dc.relation.issn","1526-954X"],["dc.title","Early Left-Right Asymmetries During Axial Morphogenesis in the Chick Embryo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","309"],["dc.bibliographiccitation.lastpage","317"],["dc.bibliographiccitation.seriesnr","1650"],["dc.contributor.author","Sydow, Hans-Georg"],["dc.contributor.author","Pieper, Tobias Karl"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.editor","Sheng, G."],["dc.date.accessioned","2019-11-11T12:47:47Z"],["dc.date.available","2019-11-11T12:47:47Z"],["dc.date.issued","2017"],["dc.description.abstract","Appropriate mechanical tension of the vitelline membrane as the culture substrate for the early chick embryo is frequently reported to be required for successful in vitro development. Here we describe a modified device, made of anodized aluminum, for in vitro culture which we used for studies of left-right symmetry breaking with emphasis on morphology and gene expression as readouts. The technique allows for easy, high-throughput tissue handling and provides a suitable tension in a stable and easily reproducible manner proven to be suitable for correct molecular left-right patterning and heart looping after long-term culture."],["dc.identifier.doi","10.1007/978-1-4939-7216-6_21"],["dc.identifier.pmid","28809031"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62594"],["dc.language.iso","en"],["dc.relation.crisseries","Methods in Molecular Biology"],["dc.relation.doi","10.1007/978-1-4939-7216-6"],["dc.relation.eissn","1940-6029"],["dc.relation.isbn","978-1-4939-7215-9"],["dc.relation.isbn","978-1-4939-7216-6"],["dc.relation.ispartof","Avian and Reptilian Developmental Biology"],["dc.relation.ispartofseries","Methods in molecular biology;1650"],["dc.relation.issn","1064-3745"],["dc.relation.issn","1940-6029"],["dc.title","An Early Chick Embryo Culture Device for Extended Continuous Observation"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1010"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Anatomy"],["dc.bibliographiccitation.lastpage","1022"],["dc.bibliographiccitation.volume","238"],["dc.contributor.author","Schäfer, Tobias"],["dc.contributor.author","Stankova, Viktoria"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Bakker, Bernadette"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.date.accessioned","2021-04-14T08:31:28Z"],["dc.date.available","2021-04-14T08:31:28Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract Bilaterally symmetrical primordia of visceral organs undergo asymmetrical morphogenesis leading to typical arrangement of visceral organs in the adult. Asymmetrical morphogenesis within the upper abdomen leads, among others, to the formation of the omental bursa dorsally to the rotated stomach. A widespread view of this process assumes kinking of thin mesenteries as a main mechanism. This view is based on a theory proposed already by Johannes Müller in 1830 and was repeatedly criticized, but some of the most plausible alternative views (initially proposed by Swaen in 1897 and Broman in 1904) still remain to be proven. Here, we analyzed serial histological sections of human embryos between stages 12 and 15 at high light microscopical resolution to reveal the succession of events giving rise to the development of the omental bursa and its relation to the emerging stomach asymmetry. Our analysis indicates that morphological symmetry breaking in the upper abdomen occurs within a wide mesenchymal plate called here mesenteric septum and is based on differential behavior of the coelomic epithelium which causes asymmetric paragastric recess formation and, importantly, precedes initial rotation of stomach. Our results thus provide the first histological evidence of breaking the symmetry of the early foregut anlage in the human embryo and pave the way for experimental studies of left‐right symmetry breaking in the upper abdomen in experimental model organisms."],["dc.description.sponsorship","De Snoo – van ’t Hoogerhuijs Foundation"],["dc.identifier.doi","10.1111/joa.13344"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83606"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1469-7580"],["dc.relation.issn","0021-8782"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.title","Initial morphological symmetry breaking in the foregut and development of the omental bursa in human embryos"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Mechanisms of Development"],["dc.bibliographiccitation.volume","145"],["dc.contributor.author","Pieper, Tobias Karl"],["dc.contributor.author","Carpaij, Meriam"],["dc.contributor.author","Sang, Helen"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.date.accessioned","2018-11-07T10:22:23Z"],["dc.date.available","2018-11-07T10:22:23Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.mod.2017.04.190"],["dc.identifier.isi","000402994800264"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42262"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","18th International Congress of Developmental Biology"],["dc.relation.eventlocation","Natil Univ Singapore, Singapore, SINGAPORE"],["dc.title","Asymmetrical morphogenesis and microcavities in the axial mesoderm of the chick"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Mechanisms of Development"],["dc.bibliographiccitation.volume","145"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","Rulle, Alexander"],["dc.contributor.author","Behr, Rüdiger"],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2018-11-07T10:22:24Z"],["dc.date.available","2018-11-07T10:22:24Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.mod.2017.04.297"],["dc.identifier.isi","000402994800370"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42263"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","18th International Congress of Developmental Biology"],["dc.relation.eventlocation","Natil Univ Singapore, Singapore, SINGAPORE"],["dc.title","Early left-sided nodal expression near the neurenteric canal of Callithrix jacchus supports flow-independent symmetry breaking in amniotes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","256"],["dc.bibliographiccitation.issue","5-6"],["dc.bibliographiccitation.journal","Cells Tissues Organs"],["dc.bibliographiccitation.lastpage","278"],["dc.bibliographiccitation.volume","205"],["dc.contributor.author","Rulle, Alexander"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","de Bakker, Bernadette"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Behr, Rüdiger"],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2019-11-11T12:49:20Z"],["dc.date.available","2019-11-11T12:49:20Z"],["dc.date.issued","2018"],["dc.description.abstract","Existence and biomedical relevance of the neurenteric canal, a transient midline structure during early neurulation in the human embryo, have been controversially discussed for more than a century by embryologists and clinicians alike. In this study, the authors address the long-standing enigma by high-resolution histology and three-dimensional reconstruction using new and historic histological sections of 5 human 17- to 21-day-old embryos and of 2 marmoset monkey embryos of the species Callithrix jacchus at corresponding stages. The neurenteric canal presents itself as the classical vertical connection between the amniotic cavity and the yolk sac cavity and is lined (a) craniolaterally by a horseshoe-shaped \"hinge of involuting notochordal cells\" within Hensen's node and (b) caudally by the receding primitive streak epiblast dorsally and by notochordal plate epithelium ventrally, the latter of which covered the (longitudinal) notochordal canal on its ventral side at the preceding stage. Furthermore, asymmetric parachordal nodal expression in Callithrix and morphological asymmetries within the nodes of the other specimens suggest an early non-cilium-dependent left-right symmetry breaking mode previously postulated for other mammals. We conclude that structure and position of the mammalian neurenteric canal support the notion of its homology with the reptilian blastopore as a whole and with a dorsal segment of the blastopore in amphibia. These new features of the neurenteric canal may further clarify the aetiology of foetal malformations such as junctional neurulation defects, neuroendodermal cysts, and the split notochord syndrome."],["dc.identifier.doi","10.1159/000493276"],["dc.identifier.pmid","30481762"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62595"],["dc.language.iso","en"],["dc.relation.eissn","1422-6421"],["dc.relation.issn","1422-6405"],["dc.relation.issn","1422-6421"],["dc.title","On the Enigma of the Human Neurenteric Canal"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1339"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Morphology"],["dc.bibliographiccitation.lastpage","1361"],["dc.bibliographiccitation.volume","282"],["dc.contributor.author","Harmoush, Braah"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2021-08-12T07:45:15Z"],["dc.date.available","2021-08-12T07:45:15Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract The epiblast of the amniote embryo is of paramount importance during early development as it gives rise to all tissues of the embryo proper. In mammals, it emerges through segregation of the hypoblast from the inner cell mass and subsequently undergoes transformation into an epithelial sheet to create the embryonic disc. In rodents and man, the epiblast cell layer is covered by the polar trophoblast which forms the placenta. In mammalian model organisms (rabbit, pig, several non‐human primates), however, the placenta is formed by mural trophoblast whereas the polar trophoblast disintegrates prior to gastrulation and thus exposes the epiblast to the microenvironment of the uterine cavity. Both, polar trophoblast disintegration and epiblast epithelialization, thus pose special cell‐biological requirements but these are still rather ill‐understood when compared to those of gastrulation morphogenesis. This study therefore applied high‐resolution light and transmission electron microscopy and three‐dimensional (3D) reconstruction to 8‐ to 10‐days‐old pig embryos and defines the following steps of epiblast transformation: (1) rosette formation in the center of the ball‐shaped epiblast, (2) extracellular cavity formation in the rosette center, (3) epiblast segregation into two subpopulations ‐ addressed here as dorsal and ventral epiblast ‐ separated by a “pro‐amniotic” cavity. Ventral epiblast cells form between them a special type of desmosomes with a characteristic dense felt of microfilaments and are destined to generate the definitive epiblast. The dorsal epiblast remains a mass of non‐polarized cells and closely associates with the disintegrating polar trophoblast, which shows morphological features of both apoptosis and autophagocytosis. Morphogenesis of the definitive epiblast in the pig may thus exclude a large portion of bona fide epiblast cells from contributing to the embryo proper and establishes contact de novo with the mural trophoblast at the junction between the two newly defined epiblast cell populations."],["dc.description.abstract","Correlative light and electron microscopy revealed novel subcellular features as signs of unexpected morphogenetic processes in newly defined sub‐stages and sub‐regions during epiblast epithelialization and trophoblast re‐organization of the late pre‐gastrulation pig embryo (between 8 and 10 days post coitum). The results re‐emphasize the value of the pig as a well‐defined and accessible model organism for early mammalian development not least in the context of embryonic and extra‐embryonic stem cells, lineages and molecular programs. image"],["dc.identifier.doi","10.1002/jmor.21389"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88406"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.publisher","John Wiley \\u0026 Sons, Inc."],["dc.relation.eissn","1097-4687"],["dc.relation.issn","0362-2525"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.title","Epiblast and trophoblast morphogenesis in the pre‐gastrulation blastocyst of the pig. A light‐ and electron‐microscopical study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","77"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cells Tissues Organs"],["dc.bibliographiccitation.lastpage","87"],["dc.bibliographiccitation.volume","201"],["dc.contributor.author","Schroeder, Silke S."],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","Weizbauer, Annette"],["dc.contributor.author","Hue, Isabelle"],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2018-11-07T10:02:29Z"],["dc.date.available","2018-11-07T10:02:29Z"],["dc.date.issued","2015"],["dc.description.abstract","Nodal activity in the left lateral plate mesoderm is a conserved sign of irreversible left-right asymmetry at early somite stages of the vertebrate embryo. An earlier, paraxial nodal domain accompanies the emergence and initial extension of the notochord and is either left-sided, as in the chick and pig, or symmetrical, as in the mouse and rabbit; intriguingly, this interspecific dichotomy is mirrored by divergent morphological features of the posterior notochord (also known as the left-right organizer), which is ventrally exposed to the yolk sac cavity and carries motile cilia in the latter 2 species only. By introducing the cattle embryo as a new model organism for early left-right patterning, we present data to establish 2 groups of mammals characterized by both the morphology of the left-right organizer and the dynamics of paraxial nodal expression: presence and absence of a ventrally open surface of the early (plate-like) posterior notochord correlates with a symmetrical (in mice and rab-bits) versus an asymmetrical (in pigs and cattle) paraxial nodal expression domain next to the notochordal plate. High-resolution histological analysis reveals that the latter domain defines in all 4 mammals a novel 'parachordal' axial mesoderm compartment, the topography of which changes according to the specific regression of the similarly novel subchordal mesoderm during the initial phases of notochord development. In conclusion, the mammalian axial mesoderm compartment (1) shares critical conserved features despite the marked differences in early notochord morphology and early left-right patterning and (2) provides a dynamic topographical framework for nodal activity as part of the mammalian left-right organizer. (C) 2016 The Author(s) Published by S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000440951"],["dc.identifier.isi","000372595000001"],["dc.identifier.pmid","26741372"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13230"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38232"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1422-6421"],["dc.relation.issn","1422-6405"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Paraxial Nodal Expression Reveals a Novel Conserved Structure of the Left-Right Organizer in Four Mammalian Species"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]