Viebahn, Christoph

[["dc.bibliographiccitation.firstpage","607"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Seminars in Cell and Developmental Biology"],["dc.bibliographiccitation.lastpage","617"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Idkowiak, J."],["dc.contributor.author","Weisheit, G."],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2018-11-07T10:45:26Z"],["dc.date.available","2018-11-07T10:45:26Z"],["dc.date.issued","2004"],["dc.description.abstract","The main aim of the gastrulation process is commonly regarded to be the generation of the definitive germ layers known as mesoderm, endoderm and ectoderm. Here we discuss how the topography of gene expression, cellular migration and proliferative activity in the preliminary germ layers (hypoblast and epiblast) of the rabbit embryo reveal the sequence of events that establishes the three major body axes. We present a testable model in which a combination of cellular movement in the hypoblast with a morphogen gradient created by the (extraembryonic) trophoblast creates morphological polarity in the embryo and, hence, the co-ordinates for germ layer formation. (C) 2004 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.semcdb.2004.04.007"],["dc.identifier.isi","000224051400017"],["dc.identifier.pmid","15271306"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47503"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Ltd Elsevier Science Ltd"],["dc.relation.issn","1084-9521"],["dc.title","Polarity in the rabbit embryo"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","591"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","605"],["dc.bibliographiccitation.volume","214"],["dc.contributor.author","Idkowiak, J."],["dc.contributor.author","Weisheit, G."],["dc.contributor.author","Plitzner, J."],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2018-11-07T10:43:21Z"],["dc.date.available","2018-11-07T10:43:21Z"],["dc.date.issued","2004"],["dc.description.abstract","Gastrulation in higher vertebrate species classically commences with the generation of mesoderm cells in the primitive streak by epithelio-mesenchymal transformation of epiblast cells. However, the primitive streak also marks, with its longitudinal orientation in the posterior part of the conceptus, the anterior-posterior (or head-tall) axis of the embryo. Results obtained in chick and mouse suggest that signals secreted by the hypoblast (or visceral endoderm), the extraembryonic tissue covering the epiblast ventrally, antagonise the mesoderm induction cascade in the anterior part of the epiblast and thereby restrict streak development to the posterior pole (and possibly initiate head development anteriorly). In this paper we took advantage of the disc-shape morphology of the rabbit gastrula for defining the expression compartments of the signalling molecules Cerberus and Dickkopf at pregastrulation and early gastrulation stages in a mammal other than the mouse. The two molecules are expressed in novel expression compartments in a complementary fashion both in the hypoblast and in the emerging primitive streak. In loss-of-function experiments, carried out in a New-type culturing system, hypoblast was removed prior to culture at defined stages before and at the beginning of gastrulation. The epiblast shows a stage-dependent and topographically restricted susceptibility to express Brachyury, a T-box gene pivotal for mesoderm formation, and to transform into (histologically proven) mesoderm. These results confirm for the mammalian embryo that the anterior-posterior axis of the conceptus is formed first as a molecular prepattern in the hypoblast and then irrevocably fixed, under the control of signals secreted from the hypoblast, by epithelio-mesenchymal transformation (primitive streak formation) in the epiblast."],["dc.identifier.doi","10.1007/s00427-004-0436-y"],["dc.identifier.isi","000226093300003"],["dc.identifier.pmid","15480760"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47033"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0949-944X"],["dc.title","Hypoblast controls mesoderm generation and axial patterning in the gastrulating rabbit embryo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","149"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Seminars in Cell and Developmental Biology"],["dc.bibliographiccitation.lastpage","150"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Idkowiak, J."],["dc.contributor.author","Weisheit, G."],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2018-11-07T08:30:51Z"],["dc.date.available","2018-11-07T08:30:51Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1016/j.semcdb.2004.12.001"],["dc.identifier.isi","000226906100017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16991"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Ltd Elsevier Science Ltd"],["dc.relation.issn","1084-9521"],["dc.title","Polarity in the rabbit embryo (vol 15, pg 607, 2004)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Cell Biology"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Idkowiak, J."],["dc.contributor.author","Weisheit, G."],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2018-11-07T10:40:19Z"],["dc.date.available","2018-11-07T10:40:19Z"],["dc.date.issued","2003"],["dc.format.extent","125"],["dc.identifier.isi","000182016200301"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46276"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","Annual Meeting of the Deutschen-Gesellschaft-fur-Zellbiologie/Gesellschaft-fur-Entwicklungsbio logie"],["dc.relation.eventlocation","BONN, GERMANY"],["dc.relation.issn","0171-9335"],["dc.title","The hypoblast inhibits mesoderm formation in the anterior part of the embryonic disk in the gastrulating rabbit embryo"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]