Lüthje, Lars

[["dc.bibliographiccitation.firstpage","1460"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","EP Europace"],["dc.bibliographiccitation.lastpage","1466"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Vollmann, Dirk"],["dc.date.accessioned","2018-11-07T08:38:23Z"],["dc.date.available","2018-11-07T08:38:23Z"],["dc.date.issued","2010"],["dc.description.abstract","Ventricular oversensing remains a significant problem in modern implantable cardioverter-defibrillator (ICD) systems. The role of manufacturer-related differences in device-based signal processing on the one hand and sensing lead properties on the other is largely unknown. This retrospective study aimed to evaluate and compare the incidence and mechanisms of ventricular oversensing in single- or dual-chamber ICD systems from Biotronik (BTK), Guidant (GDT), and Medtronic (MDT). In 245 consecutive patients, device function, stored episodes, and lead parameters were evaluated at implant and during 243 +/- 18 days of follow-up. Oversensing occurred in 3.3% of the patients [four T-wave oversensing (TWO), three R-wave double-sensing, and one diaphragmatic myopotentials]. The incidence of ventricular oversensing was generally low if an ICD device and an ICD lead were from one identical manufacturer (BTK: 2/68, GDT: 1/80, and MDT: 1/69; P = 0.67). In the subgroup of ICDs connected to leads from other manufacturers, however, ventricular oversensing was observed in none of 19 GDT and MDT ICDs but in 4 of 9 BTK devices (44.4%, P = 0.012). These four cases of oversensing (three R-wave double-sensing and one TWO) all occurred in BTK ICDs connected to integrated bipolar ICD leads from other manufacturers. Significant manufacturer-related differences exist in the incidence of ventricular oversensing in single- and dual-chamber ICD systems. Biotronik devices connected to integrated bipolar ICD leads from other manufacturers have an increased risk for R-wave double-sensing."],["dc.description.sponsorship","Medtronic; Biotronik"],["dc.identifier.doi","10.1093/europace/euq269"],["dc.identifier.isi","000282429700012"],["dc.identifier.pmid","20663783"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18757"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1099-5129"],["dc.title","Ventricular oversensing due to manufacturer-related differences in implantable cardioverter-defibrillator signal processing and sensing lead properties"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Hnatkova, Katerina"],["dc.contributor.author","Exposito, P. Munoz"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Malik, Marek"],["dc.contributor.author","Zabel, M."],["dc.date.accessioned","2018-11-07T09:35:35Z"],["dc.date.available","2018-11-07T09:35:35Z"],["dc.date.issued","2014"],["dc.format.extent","770"],["dc.identifier.isi","000343001304445"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32419"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","T-wave morphology markers from the 12-lead surface ECG for prediction of appropriate implantable cardioverter-defibrillator discharges and all-cause mortality"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Exposito, P. Munoz"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Zabel, M."],["dc.date.accessioned","2018-11-07T09:35:36Z"],["dc.date.available","2018-11-07T09:35:36Z"],["dc.date.issued","2014"],["dc.format.extent","939"],["dc.identifier.isi","000343001305332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32422"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Usefulness of approximate body-surface-potential-mapping (a-bspm) for risk stratification"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1076"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Pacing and Clinical Electrophysiology"],["dc.bibliographiccitation.lastpage","1079"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Vollmann, Dirk"],["dc.date.accessioned","2018-11-07T09:36:51Z"],["dc.date.available","2018-11-07T09:36:51Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1111/pace.12316"],["dc.identifier.isi","000342831900023"],["dc.identifier.pmid","24460891"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32709"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1540-8159"],["dc.relation.issn","0147-8389"],["dc.title","Ventricular Oversensing after ICD Lead Replacement: What Is the Mechanism?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cardiovascular Therapeutics"],["dc.bibliographiccitation.lastpage","12"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","von Gruben, Valerie"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Zabel, Markus"],["dc.date.accessioned","2018-11-07T09:44:27Z"],["dc.date.available","2018-11-07T09:44:27Z"],["dc.date.issued","2014"],["dc.description.abstract","AimsThe optimal pharmacological treatment for patients early after ablation of atrial fibrillation (AF) is still not clear. We analyzed if concomitant antiarrhythmic drug (AAD) therapy significantly alters early recurrence of AF/atrial tachycardia (AT) following pulmonary vein ablation (PVA). MethodsFor the first 2months after PVA, 274 patients (age 6210years; 66% male) were individually scheduled for concomitant treatment with beta-adrenergic blocking agents (BB) or AAD therapy. Primary endpoint of this study was a composite of (1) AF/AT lasting more than 30seconds; (2) symptomatic AF/AT recurrence requiring intervention; or (3) intolerance to the antiarrhythmic agent given. Univariate and multivariate analysis was performed to evaluate predictors for successful AAD therapy. ResultsEarly after PVA, patients were treated with BB (n=89), flecainide (n=99), sotalol (n=37), dronedarone (n=29), or amiodarone (n=115). Ninety-five patients received a combination of AAD therapy and BB. A total of 369 observation periods were analyzed. Over the first 2months following PVA, AF/AT recurrences were found in 42% of patients. No significant difference regarding freedom from AF/AT recurrence with regard to different drug therapies was observed (P=0.769). In multivariate analysis, none of the parameters were significant to predict success of AAD therapy. In nine observations, AAD therapy was terminated due to side effects presumably related to the respective agent. ConclusionsFollowing PVA, AAD therapy is not superior to BB treatment for the prevention of early atrial arrhythmias. Furthermore and confirmed by multivariate analysis, no drug was superior to another regarding the maintenance of sinus rhythm."],["dc.identifier.doi","10.1111/1755-5922.12052"],["dc.identifier.isi","000330853700002"],["dc.identifier.pmid","24138075"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34396"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1755-5922"],["dc.relation.issn","1755-5914"],["dc.title","Antiarrhythmic Drug Therapy for Maintaining Sinus Rhythm Early after Pulmonary Vein Ablation in Patients with Symptomatic Atrial Fibrillation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","263"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.lastpage","264"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Exposito, P. Munoz"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Dorenkamp, Marc"],["dc.contributor.author","Meinel, T."],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Zabel, M."],["dc.date.accessioned","2018-11-07T09:21:33Z"],["dc.date.available","2018-11-07T09:21:33Z"],["dc.date.issued","2013"],["dc.identifier.isi","000327744601412"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29136"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Amsterdam, NETHERLANDS"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Incidence of appropriate ICD shock after generator replacement without preceding shock: how necessary is the continued ICD therapy?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","303"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cardiovascular Therapeutics"],["dc.bibliographiccitation.lastpage","306"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Sossalla, Samuel"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Lüthje, Lars"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Zabel, Markus"],["dc.date.accessioned","2018-11-07T09:19:19Z"],["dc.date.available","2018-11-07T09:19:19Z"],["dc.date.issued","2013"],["dc.description.abstract","We report on a patient who was treated with several antiarrhythmic drugs as well as different ablation strategies. Nevertheless, symptomatic atrial fibrillation always recurred until an off-label use with ranolazine was started. We could demonstrate potent effects of ranolazine on atrial fibrillation in a \"wash-in wash-out\" situation. Although promising controlled studies are needed to investigate a potential role of ranolazine for the treatment of atrial fibrillation."],["dc.description.sponsorship","DFG [SFB 1002]"],["dc.identifier.doi","10.1111/1755-5922.12017"],["dc.identifier.isi","000324302900012"],["dc.identifier.pmid","23205928"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28604"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/58"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A03: Bedeutung CaMKII-abhängiger Mechanismen für die Arrhythmogenese bei Herzinsuffizienz"],["dc.relation.issn","1755-5922"],["dc.relation.issn","1755-5914"],["dc.relation.workinggroup","RG Sossalla (Kardiovaskuläre experimentelle Elektrophysiologie und Bildgebung)"],["dc.title","Ranolazine Maintained Sinus Rhythm in a Patient with Refractory Symptomatic Atrial Fibrillation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","65"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Interventional Cardiac Electrophysiology"],["dc.bibliographiccitation.lastpage","73"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Sossalla, Samuel"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Roever, Christian"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Zabel, Markus"],["dc.date.accessioned","2017-09-07T11:45:30Z"],["dc.date.available","2017-09-07T11:45:30Z"],["dc.date.issued","2014"],["dc.description.abstract","Remote magnetic navigation (RMN) is utilized for catheter guidance during pulmonary vein ablation (PVA). We aimed to determine whether the additional use of a circular mapping catheter (CMC) influences efficacy and outcome of RMN-guided PVA. A total of 80 consecutive subjects (65 % male, age 62 +/- 9 years) underwent circumferential PVA with a 3D mapping system and an RMN-guided irrigated catheter. Procedural endpoint was complete PV isolation (PVI), total radiofrequency (RF) time > 60 min, or procedure duration > 5 h. PVI was defined as an entrance and/or exit block, diagnosed with a CMC within the PV ostium or by pacing via the roving RMN-guided catheter (single-catheter technique). Prolonged Holter monitoring after 3 and 6 months was used to detect atrial tachyarrhythmia (AT/AF) recurrences. Complete PVI was achieved in 56 % (45/80) of all subjects (isolated PVs per patient, 3.1 +/- 1.2; RF time, 56.3 +/- 17.2 min; procedure duration, 3.8 +/- 0.8 h). Prospective validation of the single-catheter technique for diagnosing PVI demonstrated high concordance (94 %) with blinded CMC results. CMC use in first-time PVA was associated with similar total RF and procedure times but higher PV isolation rate. Upon multivariate analysis, CMC use, female gender, left PV, smaller PV ostium and repeat PVA predicted PVI during RMN-guided ablation. Persistent AF and mitral regurgitation at baseline and the number of non-isolated PVs predicted AT/AF recurrence during follow-up. Concomitant CMC use for first-time, RMN-guided PVA is associated with similar procedure duration but higher PV isolation rates as compared to a single-catheter approach. Since the number of isolated PVs predicts freedom from AT/AF, CMC utilization appears advisable for first-time, RMN-guided PVA."],["dc.identifier.doi","10.1007/s10840-014-9912-0"],["dc.identifier.gro","3142045"],["dc.identifier.isi","000342153000008"],["dc.identifier.pmid","24893795"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3934"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Stereotaxis; Biosense Webster"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.eissn","1572-8595"],["dc.relation.issn","1383-875X"],["dc.title","Remote magnetic navigation for circumferential pulmonary vein ablation: single-catheter technique or additional use of a circular mapping catheter?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","304"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.lastpage","305"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Flevari, P."],["dc.contributor.author","Willems, Rik"],["dc.contributor.author","Tuinenburg, A. E."],["dc.contributor.author","Vos, Marc A."],["dc.contributor.author","Munoz-Exposito, Pascal"],["dc.contributor.author","Fischer, Thomas H."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Roever, Christian"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Zabel, M."],["dc.date.accessioned","2018-11-07T10:10:26Z"],["dc.date.available","2018-11-07T10:10:26Z"],["dc.date.issued","2016"],["dc.identifier.isi","000383869501357"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39856"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Rome, ITALY"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Value of microvolt T-wave alternans assessed by ergometer and pacing as predictor for shock and mortality in a large ICD cohort"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","603"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Circulation: Arrhythmia and Electrophysiology"],["dc.bibliographiccitation.lastpage","610"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Zabel, Markus"],["dc.date.accessioned","2017-09-07T11:46:44Z"],["dc.date.available","2017-09-07T11:46:44Z"],["dc.date.issued","2009"],["dc.description.abstract","Background-Conventional catheter ablation of cavotricuspid isthmus (CTI)-dependent atrial flutter is a widely applied standard therapy. Remote magnetic catheter navigation (RMN) may provide benefits for different ablation procedures, but its efficacy for CTI ablation has not been evaluated in a randomized, controlled trial. Methods and Results-Ninety patients undergoing de novo ablation of atrial flutter were randomly assigned to conventional manual (n = 45) or RMN-guided (n = 45) CTI ablation with an 8-mm-tip catheter. Complete bidirectional isthmus block was achieved in 84% (RMN) and 91% (conventional catheter ablation) of the cases (P = 0.52). RMN was associated with shorter fluoroscopy time (median, 10.6 minutes; interquartile range [IQR], 7.6 to 19.9, versus 15.0 minutes; IQR, 11.5 to 23.1; P = 0.043) but longer total radiofrequency application (17.1 minutes; IQR, 8.6 to 25, versus 7.5 minutes; IQR, 3.6 to 10.9; P < 0.0001), ablation time (55 minutes; IQR, 28 to 76, versus 17 minutes; IQR, 7 to 31; P < 0.0001), and procedure duration (114 +/- 35 versus 77 +/- 24 minutes, P < 0.0001). Procedure duration in the RMN group did not decrease significantly with case experience. Long-term procedure success, defined as achievement of complete CTI block and freedom from atrial flutter recurrence during 6 months of follow-up, was lower in the RMN group (73% versus 89%, P = 0.063). Right atrial angiography after ablation revealed no significant differences between groups in terms of right atrial diameter or CTI length, morphology, and angulation. Furthermore, none of these parameters was predictive for difficult (ablation time > 20 minutes) or unsuccessful ablation. Conclusions-RMN-guided CTI ablation is associated with reduced radiation exposure but prolonged ablation and procedure times as compared with conventional catheter navigation. Our findings suggest that ablation lesions produced with an RMN-guided 8-mm catheter are less effective irrespective of CTI anatomy."],["dc.identifier.doi","10.1161/CIRCEP.109.884411"],["dc.identifier.gro","3143011"],["dc.identifier.isi","000272794300002"],["dc.identifier.pmid","20009074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/478"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Stereotaxis, Inc."],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1941-3149"],["dc.title","Remote Magnetic Catheter Navigation for Cavotricuspid Isthmus Ablation in Patients With Common-Type Atrial Flutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]