Kling, Alexander

[["dc.bibliographiccitation.artnumber","14677"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Kling, Alexander"],["dc.contributor.author","Schulz, Xenia"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Hemmerlein, Bernhard"],["dc.date.accessioned","2018-06-25T07:26:32Z"],["dc.date.available","2018-06-25T07:26:32Z"],["dc.date.issued","2017"],["dc.description.abstract","This study evaluates the effects of tumour-associated mast cells on the prognosis of patients suffering from oral squamous cell carcinoma (OSCC). Tryptase-positive (MCT+) and CD117-positive (CD117+) mast cells were immunohistochemically evaluated in tissue samples of 118 OSCC patients. Besides, various clinicopathological parameters, the influence of the MCT+ and CD117+ mast cell density on overall survival and the incidence of first local recurrence was analysed by Cox regression and competing risk regression. Among all investigated parameters, multiple Cox regression revealed a significant influence of the MCT+ (cut-off at 14.87 mast cells/mm2 stroma; p = 0.0027) and CD117+ mast cell density (cut-off at 33.19 mast cells/mm2 stroma; p = 0.004), the age at primary diagnosis, and the T and N stage (all p-values < 0.05) on overall survival. Patients with a low mast cell density showed a significantly poorer overall survival rate compared to those with a high mast cell density in the tumour-associated stroma. Competing risk regression revealed a significant influence of the resection status (R) on the incidence of first local recurrence (p = 0.0023). A high mast cell density in the tumour-associated stroma of oral squamous cell carcinoma indicates a longer patient survival."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1038/s41598-017-15406-5"],["dc.identifier.pmid","29116177"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14831"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15131"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","High mast cell density indicates a longer overall survival in oral squamous cell carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]