Reuter-Jessen, Kirsten

[["dc.bibliographiccitation.firstpage","C162"],["dc.bibliographiccitation.issue","a1"],["dc.bibliographiccitation.journal","Acta Crystallographica Section A Foundations of Crystallography"],["dc.bibliographiccitation.lastpage","C163"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Romier, C."],["dc.contributor.author","Reuter, K."],["dc.contributor.author","Suck, D."],["dc.contributor.author","Ficner, Ralf"],["dc.date.accessioned","2022-03-01T11:47:05Z"],["dc.date.available","2022-03-01T11:47:05Z"],["dc.date.issued","1996"],["dc.identifier.doi","10.1107/S0108767396092744"],["dc.identifier.pii","S0108767396092744"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103906"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0108-7673"],["dc.rights.uri","http://journals.iucr.org/services/copyrightpolicy.html"],["dc.title","RNA modification by base exchange: structure of tRNA-guanine transglycosylase"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2850"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","The EMBO Journal"],["dc.bibliographiccitation.lastpage","2857"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Romier, C."],["dc.contributor.author","Reuter, K."],["dc.contributor.author","Suck, D."],["dc.contributor.author","Ficner, Ralf"],["dc.date.accessioned","2022-03-01T11:46:04Z"],["dc.date.available","2022-03-01T11:46:04Z"],["dc.date.issued","1996"],["dc.identifier.doi","10.1002/j.1460-2075.1996.tb00646.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103550"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0261-4189"],["dc.title","Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange."],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","704"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Histopathology"],["dc.bibliographiccitation.lastpage","710"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Buerger, Tobias"],["dc.contributor.author","Schaefer, Inga-Marie"],["dc.contributor.author","Kueffer, Stefan"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.contributor.author","Reuter-Jessen, Kirsten"],["dc.contributor.author","Chan, John Kwok-Cheung"],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Hinterthaner, Marc"],["dc.contributor.author","Marx, Alexander"],["dc.contributor.author","Stroebel, Philipp"],["dc.date.accessioned","2018-11-07T10:25:44Z"],["dc.date.available","2018-11-07T10:25:44Z"],["dc.date.issued","2017"],["dc.description.abstract","AimsThe vast majority of type A thymomas are diagnosed in tumour stages 1 or 2, and metastatic cases are exceedingly rare. The histological and genetic features of such metastatic type A thymomas have not been described in detail. Methods and resultsFive metastatic type A thymomas in tumour stage Masaoka IVb that had been reviewed by a panel of expert pathologists were analysed using comparative genomic hybridization (CGH). Cases 1, 2 and 3 showed the prototypical morphology of type A thymomas with mainly solid growth patterns. These cases displayed only very subtle nuclear irregularities and slight nuclear crowding, but no other atypical features. Mitoses were absent. Cases 3 and 4, in contrast, had a distinctly atypical morphology. CGH revealed partially recurrent alterations in four cases (with and without atypical morphology), including gains on chromosome 1q (one case), 17q (two cases), chromosome 19 (three cases) and 22q (one case) and losses on chromosome 17p (two cases) and 22q (one case). ConclusionRare metastatic type A thymomas, both with typical and atypical' histological features, show partially recurrent genomic alterations that differ from the much more frequent localized and indolent tumours. The fact that these alterations were recurring points to a link between clinical behaviour and molecular features. Our findings may have implications for the management and treatment of such tumours."],["dc.identifier.doi","10.1111/his.13138"],["dc.identifier.isi","000397588600003"],["dc.identifier.pmid","27926794"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42916"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1365-2559"],["dc.relation.issn","0309-0167"],["dc.title","Metastatic type A thymoma: morphological and genetic correlation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","125"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","Medical Microbiology and Immunology"],["dc.bibliographiccitation.lastpage","134"],["dc.bibliographiccitation.volume","186"],["dc.contributor.author","Bereswill, S."],["dc.contributor.author","Faßbinder, F."],["dc.contributor.author","Völzing, C."],["dc.contributor.author","Haas, R."],["dc.contributor.author","Reuter, K."],["dc.contributor.author","Ficner, Ralf"],["dc.contributor.author","Kist, M."],["dc.date.accessioned","2022-03-01T11:44:35Z"],["dc.date.available","2022-03-01T11:44:35Z"],["dc.date.issued","1997"],["dc.identifier.doi","10.1007/s004300050054"],["dc.identifier.pii","71860125.430"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103060"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1432-1831"],["dc.relation.issn","0300-8584"],["dc.rights.uri","http://www.springer.com/tdm"],["dc.title","Cloning and functional characterization of the genes encoding 3-dehydroquinate synthase (aroB) and tRNA-guanine transglycosylase (tgt) from Helicobacter pylori"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","603"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Translational Lung Cancer Research"],["dc.bibliographiccitation.lastpage","616"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Overbeck, Tobias Raphael"],["dc.contributor.author","Cron, Dana Alina"],["dc.contributor.author","Schmitz, Katja"],["dc.contributor.author","Rittmeyer, Achim"],["dc.contributor.author","Körber, Wolfgang"],["dc.contributor.author","Hugo, Sara"],["dc.contributor.author","Schnalke, Juliane"],["dc.contributor.author","Lukat, Laura"],["dc.contributor.author","Hugo, Tabea"],["dc.contributor.author","Hinterthaner, Marc"],["dc.contributor.author","Reuter-Jessen, Kirsten"],["dc.contributor.author","Rosenthal, Tessa"],["dc.contributor.author","Moecks, Joachim"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Schildhaus, Hans-Ulrich"],["dc.date.accessioned","2021-04-14T08:25:11Z"],["dc.date.available","2021-04-14T08:25:11Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.21037/tlcr-19-339"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81546"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2226-4477"],["dc.relation.issn","2218-6751"],["dc.title","Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Der Onkologe"],["dc.bibliographiccitation.lastpage","99"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Reuter-Jessen, Kirsten"],["dc.contributor.author","Ströbel, Philipp"],["dc.date.accessioned","2022-02-01T10:31:55Z"],["dc.date.available","2022-02-01T10:31:55Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1007/s00761-021-01070-y"],["dc.identifier.pii","1070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98978"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1433-0415"],["dc.relation.issn","0947-8965"],["dc.rights.uri","https://www.springer.com/tdm"],["dc.title","Molekulare Diagnostik in der Pathologie: etablierte Marker und Innovationen"],["dc.title.translated","Molecular diagnostics in pathology: established markers and innovations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1507"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Gastroenterology"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","152"],["dc.contributor.author","Chen, Nai-Ming"],["dc.contributor.author","Neeße, Albrecht"],["dc.contributor.author","Dyck, Moritz Lino"],["dc.contributor.author","Steuber, Benjamin"],["dc.contributor.author","König, Alexander Otto"],["dc.contributor.author","Lubeseder-Martellato, Clara"],["dc.contributor.author","Winter, Thore"],["dc.contributor.author","Forster, Teresa"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.contributor.author","Kitz, Julia"],["dc.contributor.author","Reuter-Jessen, Kirsten"],["dc.contributor.author","Griesmann, Heidi"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Grade, Marian"],["dc.contributor.author","Zhang, J."],["dc.contributor.author","Tsai, Wan-Chi"],["dc.contributor.author","Siveke, Jens T."],["dc.contributor.author","Schildhaus, Hans-Ulrich"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Johnsen, Steven Arthur"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Heßmann, Elisabeth"],["dc.date.accessioned","2018-11-07T10:24:16Z"],["dc.date.available","2018-11-07T10:24:16Z"],["dc.date.issued","2017"],["dc.description.abstract","BACKGROUND & AIMS: The ability of exocrine pancreatic cells to change the cellular phenotype is required for tissue regeneration upon injury, but also contributes to their malignant transformation and tumor progression. We investigated context-dependent signaling and transcription mechanisms that determine pancreatic cell fate decisions toward regeneration and malignancy. In particular, we studied the function and regulation of the inflammatory transcription factor nuclear factor of activated T cells 1 (NFATC1) in pancreatic cell plasticity and tissue adaptation. METHODS: We analyzed cell plasticity during pancreatic regeneration and transformation in mice with pancreas-specific expression of a constitutively active form of NFATC1, or depletion of enhancer of zeste 2 homologue 2 (EZH2), in the context of wild-type or constitutively activate Kras, respectively. Acute and chronic pancreatitis were induced by intraperitoneal injection of caerulein. EZH2-dependent regulation of NFATC1 expression was studied in mouse in human pancreatic tissue and cells by immunohistochemistry, immunoblotting, and quantitative reverse transcription polymerase chain reaction. We used genetic and pharmacologic approaches of EZH2 and NFATC1 inhibition to study the consequences of pathway disruption on pancreatic morphology and function. Epigenetic modifications on the NFATC1 gene were investigated by chromatin immunoprecipitation assays. RESULTS: NFATC1 was rapidly and transiently induced in early adaptation to acinar cell injury in human samples and in mice, where it promoted acinar cell trans-differentiation and blocked proliferation of metaplastic pancreatic cells. However, in late stages of regeneration, Nfatc1 was epigenetically silenced by EZH2-dependent histone methylation, to enable acinar cell redifferentiation and prevent organ atrophy and exocrine insufficiency. In contrast, oncogenic activation of KRAS signaling in pancreatic ductal adenocarcinoma cells reversed the EZH2-dependent effects on the NFATC1 gene and was required for EZH2-mediated transcriptional activation of NFATC1. CONCLUSIONS: In studies of human and mouse pancreatic cells and tissue, we identified context-specific epigenetic regulation of NFATc1 activity as an important mechanism of pancreatic cell plasticity. Inhibitors of EZH2 might therefore interfere with oncogenic activity of NFATC1 and be used in treatment of pancreatic ductal adenocarcinoma."],["dc.identifier.doi","10.1053/j.gastro.2017.01.043"],["dc.identifier.isi","000401811300041"],["dc.identifier.pmid","28188746"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42625"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","1528-0012"],["dc.relation.issn","0016-5085"],["dc.title","Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","JCO Precision Oncology"],["dc.bibliographiccitation.lastpage","7"],["dc.contributor.author","Hamacher, Rainer"],["dc.contributor.author","Kämpfe, Dietrich"],["dc.contributor.author","Reuter-Jessen, Kirsten"],["dc.contributor.author","Pöttgen, Christoph"],["dc.contributor.author","Podleska, Lars E."],["dc.contributor.author","Farzaliyev, Farhad"],["dc.contributor.author","Steinau, Hans-Ulrich"],["dc.contributor.author","Schuler, Martin"],["dc.contributor.author","Schildhaus, Hans-Ulrich"],["dc.contributor.author","Bauer, Sebastian"],["dc.date.accessioned","2020-12-10T18:41:38Z"],["dc.date.available","2020-12-10T18:41:38Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1200/PO.17.00107"],["dc.identifier.eissn","2473-4284"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77634"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Dramatic Response of a PD-L1–Positive Advanced Angiosarcoma of the Scalp to Pembrolizumab"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","124"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","127"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Kromer, Christian"],["dc.contributor.author","Vlahova, Lyubomira D."],["dc.contributor.author","Julius, Katharina"],["dc.contributor.author","Schnabel, Viktor"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Reuter-Jessen, Kirsten"],["dc.contributor.author","Seif Amir Hosseini, Ali"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2022-04-01T10:00:30Z"],["dc.date.available","2022-04-01T10:00:30Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1097/CMR.0000000000000773"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105447"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.issn","0960-8931"],["dc.title","Response of metastatic melanoma with a rare BRAF V600K mutation to dabrafenib and trametinib"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5284"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Journal of Bacteriology"],["dc.bibliographiccitation.lastpage","5288"],["dc.bibliographiccitation.volume","177"],["dc.contributor.author","Reuter, K."],["dc.contributor.author","Ficner, Ralf"],["dc.date.accessioned","2022-03-01T11:47:20Z"],["dc.date.available","2022-03-01T11:47:20Z"],["dc.date.issued","1995"],["dc.description.abstract","tRNA-guanine transglycosylase (Tgt) is involved in the biosynthesis of the hypermodified tRNA nucleoside queuosine (Q). It catalyzes the posttranscriptional base exchange of the Q precursor 7-aminomethyl-7-deazaguanine (preQ1) with the genetically encoded guanine in the anticodon of tRNA(Asp), tRNA(Asn), tRNA(His), and tRNA(Tyr). A partially sequenced gene upstream of the DNA ligase (lig) gene of the Zymomonas mobilis chromosome shows strong homology to the tgt gene of Escherichia coli (K.B. Shark and T. Conway, FEMS Microbiol. Lett. 96:19-26, 1992). We showed that this gene is able to complement the tgt mutation in E. coli SJ1505, and we determined its complete sequence. Four start codons were possible for this gene, resulting in proteins of 386 to 399 amino acids (M(r), 42,800 to 44,300) showing 60.4% sequence identity with Tgt from E. coli. The smallest of the four possible reading frames, which was still extended at its 5' end compared with the E. coli tgt gene, was overexpressed in E. coli. The gene product was purified to homogeneity and was biochemically characterized. The kinetical parameters were virtually identical to those published for the E. coli enzyme. In contrast to E. coli Tgt, which is reported to be a homotrimer, Z. mobilis Tgt was found to be a monomer according to gel filtration. In this study, it was shown that the formation of homotrimers by the E. coli enzyme is readily reversible and is dependent on protein concentration."],["dc.description.abstract","tRNA-guanine transglycosylase (Tgt) is involved in the biosynthesis of the hypermodified tRNA nucleoside queuosine (Q). It catalyzes the posttranscriptional base exchange of the Q precursor 7-aminomethyl-7-deazaguanine (preQ1) with the genetically encoded guanine in the anticodon of tRNA(Asp), tRNA(Asn), tRNA(His), and tRNA(Tyr). A partially sequenced gene upstream of the DNA ligase (lig) gene of the Zymomonas mobilis chromosome shows strong homology to the tgt gene of Escherichia coli (K.B. Shark and T. Conway, FEMS Microbiol. Lett. 96:19-26, 1992). We showed that this gene is able to complement the tgt mutation in E. coli SJ1505, and we determined its complete sequence. Four start codons were possible for this gene, resulting in proteins of 386 to 399 amino acids (M(r), 42,800 to 44,300) showing 60.4% sequence identity with Tgt from E. coli. The smallest of the four possible reading frames, which was still extended at its 5' end compared with the E. coli tgt gene, was overexpressed in E. coli. The gene product was purified to homogeneity and was biochemically characterized. The kinetical parameters were virtually identical to those published for the E. coli enzyme. In contrast to E. coli Tgt, which is reported to be a homotrimer, Z. mobilis Tgt was found to be a monomer according to gel filtration. In this study, it was shown that the formation of homotrimers by the E. coli enzyme is readily reversible and is dependent on protein concentration."],["dc.identifier.doi","10.1128/jb.177.18.5284-5288.1995"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103994"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1098-5530"],["dc.relation.issn","0021-9193"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]