Busch, Albert

[["dc.bibliographiccitation.firstpage","633"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","644"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Eken, Suzanne M."],["dc.contributor.author","Jin, Hong"],["dc.contributor.author","Chernogubova, Ekaterina"],["dc.contributor.author","Li, Yuhuang"],["dc.contributor.author","Simon, Nancy"],["dc.contributor.author","Sun, Changyan"],["dc.contributor.author","Korzunowicz, Greg"],["dc.contributor.author","Busch, Albert"],["dc.contributor.author","Bäcklund, Alexandra"],["dc.contributor.author","Österholm, Cecilia"],["dc.contributor.author","Razuvaev, Anton"],["dc.contributor.author","Renné, Thomas"],["dc.contributor.author","Eckstein, Hans Henning"],["dc.contributor.author","Pelisek, Jaroslav"],["dc.contributor.author","Eriksson, Per"],["dc.contributor.author","González Díez, María"],["dc.contributor.author","Perisic Matic, Ljubica"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Leeper, Nicholas J."],["dc.contributor.author","Hansson, Göran K."],["dc.contributor.author","Paulsson-Berne, Gabrielle"],["dc.contributor.author","Hedin, Ulf"],["dc.contributor.author","Maegdefessel, Lars"],["dc.date.accessioned","2020-12-10T18:37:59Z"],["dc.date.available","2020-12-10T18:37:59Z"],["dc.date.issued","2017"],["dc.description.abstract","Rationale: In the search for markers and modulators of vascular disease, microRNAs (miRNAs) have emerged as potent therapeutic targets. Objective: To investigate miRNAs of clinical interest in patients with unstable carotid stenosis at risk of stroke. Methods and Results: Using patient material from the BiKE (Biobank of Karolinska Endarterectomies), we profiled miRNA expression in patients with stable versus unstable carotid plaque. A polymerase chain reactionbased miRNA array of plasma, sampled at the carotid lesion site, identified 8 deregulated miRNAs (miR-15b, miR29c, miR-30c/d, miR-150, miR-191, miR-210, and miR-500). miR-210 was the most significantly downregulated miRNA in local plasma material. Laser capture microdissection and in situ hybridization revealed a distinct localization of miR-210 in fibrous caps. We confirmed that miR-210 directly targets the tumor suppressor gene APC (adenomatous polyposis coli), thereby affecting Wnt (Wingless-related integration site) signaling and regulating smooth muscle cell survival, as well as differentiation in advanced atherosclerotic lesions. Substantial changes in arterial miR-210 were detectable in 2 rodent models of vascular remodeling and plaque rupture. Modulating miR210 in vitro and in vivo improved fibrous cap stability with implications for vascular disease. Conclusions: An unstable carotid plaque at risk of stroke is characterized by low expression of miR-210. miR-210 contributes to stabilizing carotid plaques through inhibition of APC, ensuring smooth muscle cell survival. We present local delivery of miR-210 as a therapeutic approach for prevention of atherothrombotic vascular events."],["dc.identifier.doi","10.1161/CIRCRESAHA.116.309318"],["dc.identifier.eissn","1524-4571"],["dc.identifier.isi","000394446200016"],["dc.identifier.issn","0009-7330"],["dc.identifier.pmid","27895035"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77157"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1524-4571"],["dc.relation.issn","0009-7330"],["dc.title","MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]