Kron, Miriam

[["dc.bibliographiccitation.firstpage","315"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","327"],["dc.bibliographiccitation.volume","583"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Moerschel, Michael"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Dutschmann, Mathias"],["dc.date.accessioned","2018-11-07T10:59:36Z"],["dc.date.available","2018-11-07T10:59:36Z"],["dc.date.issued","2007"],["dc.description.abstract","The Kolliker-Fuse nucleus (KF), part of the respiratory network, is involved in the modulation of respiratory phase durations in response to peripheral and central afferent inputs. The KF is immature at birth. Developmental changes in its physiological and anatomical properties have yet to be investigated. Since brain-derived neurotrophic factor (BDNF) is of major importance for the maturation of neuronal networks, we investigated its effects on developmental changes in the KF on different postnatal days (neonatal, P1-5; intermediate, P6-13;juvenile, P14-21) by analysing single neurones in the in vitro slice preparation and network activities in the perfased brainstem preparation in situ. The BDNF had only weak effects on the frequency of mixed excitatory and inhibitory spontaneous postsynaptic currents (sPSCs) in neonatal slice preparations. Postnatally, in the intermediate and juvenile age groups, a significant augmentation of the sPSC frequency was observed in the presence of 100 pm BDNF (+23.5 +/- 12.6 and +76.7 +/- 28.4%, respectively). Subsequent analyses of BDNF effects on evoked excitatory postsynaptic currents (eEPSCs) revealed significant enhancement of eEPSC amplitude of +20.8 +/- 7.0% only in juvenile stages (intermediates, -13.2 +/- 4.8%). On the network level, significant modulation of phrenic nerve activity following BDNF microinjection into the KF was also observed only in juveniles. The data suggest that KF neurones are subject to BDNF-mediated fast synaptic modulation after completion of postnatal maturation. After maturation, BDNF contributes to modulation of fast excitatory neurotransmission in respiratory-related KF neurones. This may be important for network plasticity associated with the processing of afferent information."],["dc.identifier.doi","10.1113/jphysiol.2007.134726"],["dc.identifier.isi","000249178600024"],["dc.identifier.pmid","17569735"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50744"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0022-3751"],["dc.title","Developmental changes in brain-derived neurotrophic factor-mediated modulations of synaptic activities in the pontine Kolliker-Fuse nucleus of the rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Respiratory Physiology & Neurobiology"],["dc.bibliographiccitation.lastpage","79"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Moerschel, Michael"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Gestreau, Christian"],["dc.contributor.author","Stettner, Georg M."],["dc.contributor.author","Kron, Miriam"],["dc.date.accessioned","2018-11-07T11:08:02Z"],["dc.date.available","2018-11-07T11:08:02Z"],["dc.date.issued","2008"],["dc.description.abstract","The shape of the three-phase respiratory motor pattern (inspiration, postinspiration, late expiration) is controlled by a central pattern generator (CPG) located in the ponto-medullary brainstem. Synaptic interactions between and within specific sub-compartments of the CPG are subject of intensive research. This review addresses the neural control of postinspiratory activity as the essential determinant of inspiratory/expiratory phase duration. The generation of the postinspiratory phase depends on synaptic interaction between neurones of the nucleus tractus solitarii (NTS), which relay afferent inputs from pulmonary stretch receptors, and the pontine Kolliker-Fuse nucleus (KF) as integral parts of the CPG. Both regions undergo significant changes during the first three postnatal weeks in rodents. Developmental changes in glutamatergic synaptic functions and its modulation by brain-derived neurotrophic factor may have implications in synaptic plasticity within the NTS/KF axis. We propose that dependent on these developmental changes, the CPG becomes permissive for short- and long-term plasticity associated with environmental, metabolic and behavioural adaptation of the breathing pattern. (C) 2008 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.resp.2008.06.013"],["dc.identifier.isi","000261248700010"],["dc.identifier.pmid","18620081"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52701"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1569-9048"],["dc.title","Postnatal emergence of synaptic plasticity associated with dynamic adaptation of the respiratory motor pattern"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2331"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","2343"],["dc.bibliographiccitation.volume","586"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Gerhardt, Ellen"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Dutschmann, Mathias"],["dc.date.accessioned","2018-11-07T11:15:39Z"],["dc.date.available","2018-11-07T11:15:39Z"],["dc.date.issued","2008"],["dc.description.abstract","The Kolliker-Fuse nucleus (KF) contributes essentially to respiratory pattern formation and adaptation of breathing to afferent information. Systems physiology suggests that these KF functions depend on NMDA receptors (NMDA-R). Recent investigations revealed postnatal changes in the modulation of glutamatergic neurotransmission by brain-derived neurotrophic factor (BDNF) in the KF. Therefore, we investigated postnatal changes in NMDA-R subunit composition and postsynaptic modulation of NMDA-R-mediated currents by BDNF in KF slice preparations derived from three age groups (neonatal: postnatal day (P) 1-5; intermediate: P6-13; juvenile: P14-21). Immunohistochemistry showed a developmental up-regulation of the NR2D subunit. This correlated with a developmental increase in decay time of NMDA currents and a decline of desensitization in response to repetitive exogenous NMDA applications. Thus, developmental up-regulation of the NR2D subunit, which reduces the Mg2+ block of NMDA-R, causes these specific changes in NMDA current characteristics. This may determine the NMDA-R-dependent function of the mature KF in the control of respiratory phase transition. Subsequent experiments revealed that bath-application of BDNF progressively potentiated these repetitively evoked NMDA currents only in intermediate and juvenile age groups. Pharmacological inhibition of protein kinase C (PKC), as a downstream component of the BDNF-tyrosine kinase B receptor (trkB) signalling, prevented BDNF-induced potentiation of NMDA currents. BDNF-induced potentiation of NMDA currents in later developmental stages might be essential for synaptic plasticity during the adaptation of the breathing pattern in response to peripheral/central commands. The lack of plasticity in neonatal neurones strengthens the hypothesis that the respiratory network becomes permissive for activity-dependent plasticity with ongoing postnatal development."],["dc.identifier.doi","10.1113/jphysiol.2007.148916"],["dc.identifier.isi","000255497900011"],["dc.identifier.pmid","18339694"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54416"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0022-3751"],["dc.title","Emergence of brain-derived neurotrophic factor-induced postsynaptic potentiation of NMDA currents during the postnatal maturation of the Kolliker-Fuse nucleus of rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","37"],["dc.bibliographiccitation.lastpage","41"],["dc.bibliographiccitation.seriesnr","669"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.editor","Homma, Ikuo"],["dc.date.accessioned","2018-11-07T08:48:16Z"],["dc.date.available","2018-11-07T08:48:16Z"],["dc.date.issued","2010"],["dc.description.abstract","The Kolliker-Fuse nucleus (KF) is an integral part of the central pattern generator for breathing and shows postnatal development of synaptic functions and cyto-architectural structure. Here, we analyzed the postnatal changes in cell morphology of biocytin-labelled KF neurones. Developmental analyses revealed an increasing size of somas and dendritic length. These changes were accompanied by changes in the orientation of the main dendritic branches from a diffuse orientation in neonates to a predominant medio-lateral orientation in juveniles. These developmental changes may allow for synaptic contacts with multiple ascending fibre tracts required for the processing of multi-modal respiratory inputs in the KF."],["dc.description.sponsorship","BMBF (BCCN) [01GQ0432]"],["dc.identifier.doi","10.1007/978-1-4419-5692-7_8"],["dc.identifier.isi","000277995200008"],["dc.identifier.pmid","20217317"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21162"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Berlin"],["dc.relation.conference","11th Oxford Conference on Modeling and Control of Breathing"],["dc.relation.crisseries","Advances in Experimental Medicine and Biology"],["dc.relation.doi","10.1007/978-1-4419-5692-7"],["dc.relation.eventend","2009-07-26"],["dc.relation.eventlocation","Nara, JAPAN"],["dc.relation.eventstart","2009-07-23"],["dc.relation.isbn","978-1-4419-5691-0"],["dc.relation.ispartof","New Frontiers in Respiratory Control"],["dc.relation.ispartofseries","Advances in Experimental Medicine and Biology; 669"],["dc.relation.issn","0065-2598"],["dc.title","Postnatal Changes in Morphology and Dendritic Organization of Neurones Located in the Area of the Kolliker-Fuse Nucleus of Rat"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]