Seehase, Matthias

[["dc.bibliographiccitation.artnumber","e0165397"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Herberg, Ulrike"],["dc.contributor.author","Linden, Katharina"],["dc.contributor.author","Dewald, Oliver"],["dc.contributor.author","Gatzweiler, Eva"],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Duerr, Georg Daniel"],["dc.contributor.author","Dörner, Jonas"],["dc.contributor.author","Kleppe, Stephanie"],["dc.contributor.author","Ladage, Dennis"],["dc.contributor.author","Breuer, Johannes"],["dc.date.accessioned","2019-07-09T11:42:58Z"],["dc.date.available","2019-07-09T11:42:58Z"],["dc.date.issued","2016"],["dc.description.abstract","Background Pressure-volume loops (PVL) provide vital information regarding ventricular performance and pathophysiology in cardiac disease. Unfortunately, acquisition of PVL by conductance technology is not feasible in neonates and small children due to the available human catheter size and resulting invasiveness. The aim of the study was to validate the accuracy of PVL in small hearts using volume data obtained by real-time three-dimensional echocardiography (3DE) and simultaneously acquired pressure data. Methods In 17 piglets (weight range: 3.6–8.0 kg) left ventricular PVL were generated by 3DE and simultaneous recordings of ventricular pressure using a mini pressure wire (PVL3D). PVL3D were compared to conductance catheter measurements (PVLCond) under various hemodynamic conditions (baseline, alpha-adrenergic stimulation with phenylephrine, beta-adrenoreceptor-blockage using esmolol). In order to validate the accuracy of 3D volumetric data, cardiac magnetic resonance imaging (CMR) was performed in another 8 piglets. Results Correlation between CMR- and 3DE-derived volumes was good (enddiastolic volume: mean bias -0.03ml ±1.34ml). Computation of PVL3D in small hearts was feasible and comparable to results obtained by conductance technology. Bland-Altman analysis showed a low bias between PVL3D and PVLCond. Systolic and diastolic parameters were closely associated (Intraclass-Correlation Coefficient for: systolic myocardial elastance 0.95, arterial elastance 0.93, diastolic relaxation constant tau 0.90, indexed end-diastolic volume 0.98). Hemodynamic changes under different conditions were well detected by both methods (ICC 0.82 to 0.98). Inter- and intra-observer coefficients of variation were below 5% for all parameters. Conclusions PVL3D generated from 3DE combined with mini pressure wire represent a novel, feasible and reliable method to assess different hemodynamic conditions of cardiac function in hearts comparable to neonate and infant size. This methodology may be integrated into clinical practice and cardiac catheterization programs and has the capability to contribute to clinical decision making even in small hearts."],["dc.identifier.doi","10.1371/journal.pone.0165397"],["dc.identifier.pmid","27776179"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14061"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58799"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","3D Real-Time Echocardiography Combined with Mini Pressure Wire Generate Reliable Pressure-Volume Loops in Small Hearts"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","353"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Clinical Monitoring and Computing"],["dc.bibliographiccitation.lastpage","360"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Linden, Katharina"],["dc.contributor.author","Ladage, Dennis"],["dc.contributor.author","Dewald, Oliver"],["dc.contributor.author","Gatzweiler, Eva"],["dc.contributor.author","Pieper, Andrea"],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Duerr, Georg Daniel"],["dc.contributor.author","Breuer, Johannes"],["dc.contributor.author","Herberg, Ulrike"],["dc.date.accessioned","2018-10-11T05:57:39Z"],["dc.date.available","2018-10-11T05:57:39Z"],["dc.date.issued","2017-04"],["dc.description.abstract","To compare stroke volumes (SV) in small hearts assessed by real-time three-dimensional echocardiography (3DE) with SV measured by transpulmonary thermodilution (TPTD) and continuous pulse contour analysis (PC) under various hemodynamic conditions. In thirteen anesthetized piglets (range 3.6-7.1 kg) SV were measured by 3DE, TPTD and PC at baseline and during phenylephrine and esmolol administration. 3DE and TPTD measurements were done successively while SV calculated by PC was documented at the time of 3DE. 3DE and TPTD showed a good correlation (r2 = 0.74) and a bias of -1.3 ml (limits of agreement -4.1 to 1.5 ml). While TPTD measured higher SV than 3DE, both methods tracked SV changes with a concordance rate of 91 %. PC and 3DE showed a lower correlation coefficient of r2 = 0.57 and a bias of -2.1 ml (limits of agreement -5.9 to 1.8 ml). Inter- and intra-observer variability of SV measured by 3DE was good with a mean bias <5 %. SV3DE showed a small variance and tracked acute small changes in SV in acceptable concordance with TPTD. PC measured SV with a higher variance and mean difference compared to 3DE. In an experimental setting 3DE has the possibility to offer non-invasive assessments of ventricular volumes volume changes. To determine whether 3DE could be used for SV assessment in a clinical routine our results need confirmation in a clinical setting."],["dc.identifier.doi","10.1007/s10877-016-9843-7"],["dc.identifier.pmid","26886899"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15965"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1573-2614"],["dc.title","Comparison of stroke volumes assessed by three-dimensional echocardiography and transpulmonary thermodilution in a pediatric animal model"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]