Kurth, Christoph

[["dc.bibliographiccitation.firstpage","19"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Metabolic Brain Disease"],["dc.bibliographiccitation.lastpage","28"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Bahn, Erik"],["dc.contributor.author","Nolte, Wilhelm"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Ramadori, G."],["dc.contributor.author","Rüther, Eckart"],["dc.contributor.author","Wiltfang, Jens"],["dc.date.accessioned","2017-11-21T09:21:38Z"],["dc.date.available","2017-11-21T09:21:38Z"],["dc.date.issued","2002"],["dc.description.abstract","The aim of the study was the quantification of metabolically caused electroencephalo- graphic changes of portal-systemic encephalopathy, a prototype of hepatic encephalopathy. We examined 12 patients with liver cirrhosis before and after implantation of a transjugular intrahepatic portosystemic stent shunt (TIPSS) by means of quantitative digital electroen- cephalography (EEG). One month after TIPSS implantation, all patients showed an increase in the power of the theta frequency band as well as a decrease in the power of the alpha fre- quency band. To reduce the error variance, we formed the quotient of the relative power of the theta and alpha frequency band. Theta/alpha quotient values over 0.7 indicate a general change of the EEG with a sensitivity of 93% and a specificity of 87%. The results we have to hand indicate a correlation between the albumin concentration and the theta/alpha quotient 1 and 3 months after TIPSS. No significant correlation was revealed with regard to the Child- Pugh score or the liver function parameters cholinesterase, bilirubin, and prothrombin time. Neither the arterial ammonia concentration nor the performance in the psychometric test showed significance in relation to the theta/alpha quotient. Substances with a high albumin bond and potential neurotoxicity may—in the case of lower albumin levels—be absorbed with increased frequency in the CNS and may be responsible for the observed EEG change."],["dc.identifier.doi","10.1023/A:1014048229754"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/10123"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0885-7490"],["dc.relation.issn","1573-7365"],["dc.title","Quantification of the electroencephalographic theta/alpha ratio for the assessment of portal-systemic encephalopathy following implantation of transjugular intrahepatic portosystemic stent shunt (TIPSS)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Metabolic Brain Disease"],["dc.bibliographiccitation.lastpage","6"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Bahn, Erik"],["dc.contributor.author","Wiltfang, J."],["dc.contributor.author","Nolte, W."],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Steinhoff, B."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Kurth, C."],["dc.date.accessioned","2018-11-07T11:20:57Z"],["dc.date.available","2018-11-07T11:20:57Z"],["dc.date.issued","2005"],["dc.description.abstract","We examined a 41-year-old female with a subacute Budd-Chiari Syndrome (BCS) before and after implantation of a transjugular intrahepatic portosystemic stent shunt (TIPSS) by means of digital electroencephalography (EEG). After TIPSS implantation hepatic decompression had been achieved and the liver function as well as the clinical status improved daily. Simultaneously, the digital EEG showed a decrease in the power of the theta band and an increase in the physiological alpha frequency band. The theta/alpha ratio decreased after TIPSS, despite an elevated arterial ammonia level. The patient had a well-preserved liver parenchyma before the occurrence of the BCS. After portal decompression by TIPSS, the liver function normalized and the liver resumed efficient synthesis and parts of its detoxification task. This regeneration capacity was documented by a rise in cholinesterase after TIPSS. After temporary substitution of albumin the serum albumin concentration returned to normal. Thus, some neurotoxic substances with high albumin-binding capacity may not be absorbed by the central nervous system (CNS). Furthermore, it appears likely that the length of time the brain is exposed to neurotoxic substances plays a role in the clinical and electroencephalographic changes. Compared to the conventional EEG the theta/alpha ratio reflected better metabolically conditioned electroencephalographic changes after TIPSS."],["dc.identifier.doi","10.1007/s11011-005-2471-4"],["dc.identifier.isi","000228973300001"],["dc.identifier.pmid","15918545"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55660"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0885-7490"],["dc.title","Quantification of changes in electroencephalographic power spectra in a patient with Budd-Chiari-syndrome after implantation of a transjugular intrahepatic portosystemic stent shunt (TIPSS)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]