Kurth, Christoph

[["dc.bibliographiccitation.firstpage","947"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Epilepsia"],["dc.bibliographiccitation.lastpage","949"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Bittermann, H. J."],["dc.contributor.author","Wegerer, V."],["dc.contributor.author","Bleich, Stefan"],["dc.contributor.author","Steinhoff, B. J."],["dc.date.accessioned","2018-11-07T08:54:41Z"],["dc.date.available","2018-11-07T08:54:41Z"],["dc.date.issued","2001"],["dc.description.abstract","An adult patient had EEG occipital spike fixation off sensitivity and spontaneous occipital seizures due to perinatal asphyxia with bioccipital hemorrhage. EEG abnormalities consisted of repetitive posterior spikes that occurred when the eyes were closed and other conditions of fixation-off. Magnetic resonance imaging (MRI) documented severe posterior lesions with wallerian degeneration of the optic radiation. Electron capture detector single-photon emission computed tomography (ECD-SPECT) during the state of fixation-off showed regional hyperperfusion in the right posterior regions. We suggest that partial denervation of the primary visual cortex in this patient resulted in an increased cortical excitability and that the inhibitory effect of central vision and fixation leads to a suppression of spontaneous epileptic activity. This unusual symptomatic case may serve as a-model for the pathophysiology in the more often reported cases of idiopathic benign epilepsy syndrome of childhood."],["dc.identifier.doi","10.1046/j.1528-1157.2001.042007947.x"],["dc.identifier.isi","000170661000021"],["dc.identifier.pmid","11488898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22725"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0013-9580"],["dc.title","Fixation-off sensitivity in an adult with symptomatic occipital epilepsy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1235"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuroreport"],["dc.bibliographiccitation.lastpage","1238"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Wegerer, V."],["dc.contributor.author","Degner, Detlef"],["dc.contributor.author","Sperling, W."],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Bleich, Stefan"],["dc.date.accessioned","2018-11-07T09:04:14Z"],["dc.date.available","2018-11-07T09:04:14Z"],["dc.date.issued","2001"],["dc.description.abstract","Recently, it has been suggested that alcohol-induced hyperhomocysteinaemia in patients suffering from chronic alcoholism might be a risk factor for alcohol withdrawal seizures. In the present follow-up study 12 patients with chronic alcoholism who suffered from withdrawal seizures had significantly higher revers of homocysteine (Hcy) on admission (71.43 +/- 25.84 mol/l) than patients (n=37) who did not develop seizures (32.60+/-24.87 mol/l; U=37.50, p=0.0003). Using a logistic regression analysis, withdrawal seizures were best predicted by a high Hcy level on admission (p<0.01; odds ratio 2.07). Based on these findings we developed an artificial neural network system (Kohonen feature map, KFM) for an improved prediction of the risk of alcohol withdrawal seizures. Forty-nine patients with chronic alcoholism (12 with alcohol withdrawal seizures and 37 without seizures) were randomized into a training set and a test set. Best results for sensitivity of the KFM was 83.3% (five of six seizure patients were predicted correctly) with a specificity of 94.4% (one false positive prediction of 19 patients). We conclude that in patients with alcohol-induced hyperhomocysteinaemia the KFM is a useful tool to predict alcohol withdrawal seizures. NeuroReport 12:1235-1238 (C) 2001 Lippincott Williams & Wilkins."],["dc.identifier.doi","10.1097/00001756-200105080-00036"],["dc.identifier.isi","000168260200037"],["dc.identifier.pmid","11338198"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25071"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0959-4965"],["dc.title","Risk assessment of alcohol withdrawal seizures with a Kohonen feature map"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","367"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neuroreport"],["dc.bibliographiccitation.lastpage","371"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Wegerer, V."],["dc.contributor.author","Reulbach, Udo"],["dc.contributor.author","Lewczuk, Piotr"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Steinhoff, B. J."],["dc.contributor.author","Bleich, Stefan"],["dc.date.accessioned","2018-11-07T10:51:11Z"],["dc.date.available","2018-11-07T10:51:11Z"],["dc.date.issued","2004"],["dc.description.abstract","We investigated the correlation of hippocampal volume with homocysteine, folate, vitamin B12 and 136 in alcoholic patients and healthy controls applying a Kohonen feature map (KFM) and conventional statistics. Representation of subjects on the KFM suggested an inverse correlation of hippocampal volume with blood levels of homocysteine and correlation with folate and vitamin B6. In conventional statistical analyses (t-test) reduced folate and increased homocysteine was found in alcoholics compared to healthy controls (p<0.01). In female alcoholics vitamin 136 was reduced significantly (p=0.03). Multiple linear regression analyses showed a significant correlation between average hippocampal volume and homocysteine (p<0.001). KFM proved to be a sensitive tool for visualisation of statistical correlations in data sets even if no further statistical information is available."],["dc.identifier.doi","10.1097/00001756-200402090-00031"],["dc.identifier.isi","000225139900031"],["dc.identifier.pmid","15076770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48833"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0959-4965"],["dc.title","Analysis of hippocampal atrophy in alcoholic patients by a Kohonen feature map"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]