Schaumburg, Frieder

[["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Schaumburg, Frieder"],["dc.contributor.author","Mugisha, Lawrence"],["dc.contributor.author","Kappeler, Peter"],["dc.contributor.author","Fichtel, Claudia"],["dc.contributor.author","Köck, Robin"],["dc.contributor.author","Kondgen, S."],["dc.contributor.author","Becker, Karsten"],["dc.contributor.author","Boesch, Christophe"],["dc.contributor.author","Peters, Georg"],["dc.contributor.author","Leendertz, Fabian H."],["dc.date.accessioned","2018-03-20T14:05:31Z"],["dc.date.available","2018-03-20T14:05:31Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1371/annotation/c2148f4d-866d-479a-b0e6-97aa6ab931f6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13103"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Correction: Evaluation of Non-Invasive Biological Samples to Monitor Staphylococcus aureus Colonization in Great Apes and Lemurs"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","312"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","FEMS Microbiology Letters"],["dc.bibliographiccitation.lastpage","319"],["dc.bibliographiccitation.volume","258"],["dc.contributor.author","Keller, Peter"],["dc.contributor.author","Schaumburg, F."],["dc.contributor.author","Fischer, S. F."],["dc.contributor.author","Hacker, G."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Lüder, C. G. K."],["dc.date.accessioned","2018-11-07T09:52:22Z"],["dc.date.available","2018-11-07T09:52:22Z"],["dc.date.issued","2006"],["dc.description.abstract","The intracellular parasite Toxoplasma gondii is known to inhibit apoptosis of its host cell. The molecular mechanisms of this interference are, however, not yet completely understood. We show here that viable parasites prominently inhibited the activation of caspase 3/7 induced by cytochrome c, dATP and dithiothreitol in cytosolic extracts of human-derived Jurkat leukemic T cells. In contrast, granzyme B-induced caspase activity was only slightly diminished. De novo protein biosynthesis by T. gondii was dispensable for the inhibition of cytochrome c-induced caspase activation. Furthermore, a complete parasite lysate or, more importantly, molecules released by extracellular parasites mediated the interaction with the caspase cascade. The cell-free system applied here is thus a valuable tool to study the interaction of T. gondii and possibly other intracellular pathogens with host cell apoptosis."],["dc.identifier.doi","10.1111/j.1574-6968.2006.00241.x"],["dc.identifier.isi","000237096000023"],["dc.identifier.pmid","16640590"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36112"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0378-1097"],["dc.title","Direct inhibition of cytochrome c-induced caspase activation in vitro by Toxoplasma gondii reveals novel mechanisms of interference with host cell apoptosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S69"],["dc.bibliographiccitation.journal","Parasitology"],["dc.bibliographiccitation.lastpage","S85"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Schaumburg, F."],["dc.contributor.author","Hippe, Diana"],["dc.contributor.author","Vutova, Polya"],["dc.contributor.author","Lueder, Carsten Guenter Kurt"],["dc.date.accessioned","2018-11-07T10:40:35Z"],["dc.date.available","2018-11-07T10:40:35Z"],["dc.date.issued","2006"],["dc.description.abstract","During infection, programmed cell death, i.e. apoptosis, is an important effector mechanism of innate and adaptive host responses to parasites. In addition, it fulfils essential functions in regulating host immunity and tissue homeostasis. Not surprisingly, however, adaptation of parasitic protozoa to their hosts also involves modulation or even exploitation of cell death in order to facilitate parasite survival in a hostile environment. During recent years, considerable progress has been made in our understanding of apoptosis during parasitic infections and there is now convincing evidence that apoptosis and its modulation by protozoan parasites has a major impact on the parasite-host interaction and on the pathogenesis of disease. This review updates our current knowledge on the diverse functions apoptosis may fulfil during infections with diverse protozoan parasites including apicomplexans, kinetoplastids and amoebae. Furthermore, we also summarize common mechanistic themes of the pro- and anti-apoptotic activities of protozoan parasites. The diverse and complex effects which parasitic protozoa exert on apoptotic cell death within the host highlight fascinating interactions of parasites and their hosts. Importantly, they also stress the importance of further investigations before the modulation of host cell apoptosis can be exploited to combat parasitic infections."],["dc.identifier.doi","10.1017/S0031182006000874"],["dc.identifier.isi","000242346400008"],["dc.identifier.pmid","17018167"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46335"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0031-1820"],["dc.title","Pro- and anti-apoptotic activities of protozoan parasites"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.volume","298"],["dc.contributor.author","Graumann, K."],["dc.contributor.author","Schaumburg, F."],["dc.contributor.author","Englert, N."],["dc.contributor.author","Hintz, M."],["dc.contributor.author","Dihazi, H."],["dc.contributor.author","Jomaa, H."],["dc.contributor.author","Lüder, C. G. K."],["dc.date.accessioned","2018-11-07T11:11:32Z"],["dc.date.available","2018-11-07T11:11:32Z"],["dc.date.issued","2008"],["dc.identifier.isi","000259589400077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53458"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","60th Annual Meeting of the Deutschen-Gesellschaft-fur-Hygiene-und-Mikrobiologie"],["dc.relation.eventlocation","Dresden, GERMANY"],["dc.title","Blockade of cytochrome c-induced host cell apoptosis by Toxoplasma gondii: Molecular mechanisms and putative parasite effector molecules"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]