Krawczak, Michael

[["dc.bibliographiccitation.firstpage","278"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Medizinische Genetik"],["dc.bibliographiccitation.lastpage","283"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Mathieu, N."],["dc.contributor.author","Loehnhardt, B."],["dc.contributor.author","Gruetz, R."],["dc.contributor.author","Weil, P."],["dc.contributor.author","Drepper, J."],["dc.contributor.author","Krawczak, Michael"],["dc.date.accessioned","2018-11-07T09:23:52Z"],["dc.date.available","2018-11-07T09:23:52Z"],["dc.date.issued","2013"],["dc.description.abstract","The development of DNA sequencing technologies challenges human genome research considerably regarding its legal and ethical consequences. The deep insights into the genetic endowment of an individual that are already possible today are of potentially great importance for the current and future health status of the individual. Furthermore, genomic data also allow conclusions about the identity and genetic properties of close blood relatives to be drawn. Owing to their inherently personal nature, genomic data require particularly careful treatment. Alongside appropriate informed consent from all participants, central elements of responsible genomic data management within the framework of a research project include anonymization/pseudonymization of the data and separation of data management responsibilities. Additionally and in keeping with good scientific practice, time constraints and regulations pertaining to the retention of data must be adhered to. These aspects will be highlighted in the present article and discussed in terms of their implementation into scientific practice."],["dc.identifier.doi","10.1007/s11825-013-0380-1"],["dc.identifier.isi","000321323000011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29687"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1863-5490"],["dc.title","Ethical and legal implications of storing human genomic data"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","388"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Medizinische Genetik"],["dc.bibliographiccitation.lastpage","394"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Gruetz, R."],["dc.contributor.author","Mathieu, N."],["dc.contributor.author","Loehnhardt, B."],["dc.contributor.author","Weil, P."],["dc.contributor.author","Krawczak, Michael"],["dc.date.accessioned","2018-11-07T09:20:09Z"],["dc.date.available","2018-11-07T09:20:09Z"],["dc.date.issued","2013"],["dc.description.abstract","In view of the increasing amount of data arising from genome research, efficient research data management is becoming increasingly important in this domain. The third, and last, article of the series on \"Research data management for genome data\" describes the general lifecycle of research data-from their planning via the selection and inclusion into storage facilities to preservation measures and final user access. Archives play an important role in nearly all phases of this life cycle, which renders them an important component of genome data processing. Three exemplary public archives for genome data are introduced: the European Molecular Biology Laboratory (EMBL) databank, the Sequence Read Archive, and the Trace Archive. Owing to the high level of specialization of these institutions, however, additional archives are required that allow more generic data storage or, alternatively, easy extension to other genome data types. A generic concept for such archives will be described and recommendations given for their practical implementation."],["dc.identifier.doi","10.1007/s11825-013-0403-y"],["dc.identifier.isi","000328077600009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28816"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/21"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | INF: Unterstützung der SFB 1002 Forschungsdatenintegration, -visualisierung und -nachnutzung"],["dc.relation.issn","1863-5490"],["dc.relation.workinggroup","RG Nußbeck"],["dc.title","Archivierung von Genomdaten"],["dc.title.alternative","Archiving genome data"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","15"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Medizinische Genetik"],["dc.bibliographiccitation.lastpage","21"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Dickmann, Frank"],["dc.contributor.author","Mathieu, N."],["dc.contributor.author","Gruetz, R."],["dc.contributor.author","Krawczak, Michael"],["dc.date.accessioned","2018-11-07T09:27:11Z"],["dc.date.available","2018-11-07T09:27:11Z"],["dc.date.issued","2013"],["dc.description.abstract","The ever increasing amount and complexity of newly generated molecular data requires the issue of reliable data management and digital preservation to be addressed in the context of genomic research as well. The named processes are highly relevant for ensuring good scientific practice. The present article introduces general aspects of research data management and digital preservation, and links them to genomic data as an example. In addition, the ensuing scientific, ethical and organizational challenges to genome research will be exposed. In conclusion, transparent governance rules turn out to be most vital for any management and preservation of genomic research to be both practical and sensible."],["dc.identifier.doi","10.1007/s11825-013-0373-0"],["dc.identifier.isi","000320382600002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30477"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1863-5490"],["dc.title","Management and preservation of genome research data"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]