Ströbel, Philipp

[["dc.bibliographiccitation.firstpage","738"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Genes Chromosomes and Cancer"],["dc.bibliographiccitation.lastpage","749"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Stroebel, Philipp"],["dc.contributor.author","Zettl, Andreas"],["dc.contributor.author","Shilo, Konstantin"],["dc.contributor.author","Chuang, Wen-Yu"],["dc.contributor.author","Nicholson, Andrew G."],["dc.contributor.author","Matsuno, Yoshihiro"],["dc.contributor.author","Gal, Anthony"],["dc.contributor.author","Laeng, Rolf Hubert"],["dc.contributor.author","Engel, Peter"],["dc.contributor.author","Capella, Carlo"],["dc.contributor.author","Marino, Mirella"],["dc.contributor.author","Chan, John Kwok-Cheung"],["dc.contributor.author","Rosenwald, Andreas"],["dc.contributor.author","Travis, William D."],["dc.contributor.author","Franks, Teri J."],["dc.contributor.author","Ellenberger, David"],["dc.contributor.author","Schaefer, Inga-Marie"],["dc.contributor.author","Marx, Alexander"],["dc.date.accessioned","2018-11-07T09:36:21Z"],["dc.date.available","2018-11-07T09:36:21Z"],["dc.date.issued","2014"],["dc.description.abstract","Thymic neuroendocrine tumors (TNET) are rare primary epithelial neoplasms of the thymus. This study aimed to determine clinically relevant parameters for their classification and for therapeutic decisions. We performed a comprehensive histological, clinical, and genetic study of 73 TNET cases (13 thymic typical carcinoids [TTC], 40 thymic atypical carcinoids [TAC], and 20 high-grade neuroendocrine carcinomas [HGNEC] of the thymus), contributed by multiple institutions. The mean number of chromosomal imbalances per tumor was 0.8 in TTC (31% aberrant cases) versus 1.1 in TAC (44% aberrant cases) versus 4.7 in HGNEC (75% aberrant cases). Gains of 8q24 (MYC gene locus) were the most frequent alteration and one of the overlapping features between carcinoids and HGNEC. The 5-year survival rates for TTC, TAC, and HGNEC were 100, 60, and 30%. The 10-year survival rates for TTC and TAC were 50 and 30% (P=0.002). Predictive mitotic cut-off values for TTC versus TAC were 2.5 per 10 high-power fields (HPF; indicating a higher death rate, P=0.062) and 15 per 10 HPF (indicating higher risk of recurrence, P=0.036) for separating HGNEC from TAC. We conclude that the current histopathologic classifications of TNET reflect tumor biology and provide important information for therapeutic management. (C) 2014 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/gcc.22183"],["dc.identifier.isi","000339670200003"],["dc.identifier.pmid","24764238"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32598"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1098-2264"],["dc.relation.issn","1045-2257"],["dc.title","Tumor Genetics and Survival of Thymic Neuroendocrine Neoplasms: A Multi-Institutional Clinicopathologic Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","894"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY"],["dc.bibliographiccitation.lastpage","905"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Belharazem, Djeda"],["dc.contributor.author","Schalke, Berthold"],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Nix, Wilfred"],["dc.contributor.author","Vitacolonna, Mario"],["dc.contributor.author","Hohenberger, Peter"],["dc.contributor.author","Roessner, Eric"],["dc.contributor.author","Schulze, Torsten J."],["dc.contributor.author","Saruhan-Direskeneli, Gueher"],["dc.contributor.author","Yilmaz, Vuslat"],["dc.contributor.author","Ott, German"],["dc.contributor.author","Stroebel, Philipp"],["dc.contributor.author","Marx, Alexander"],["dc.date.accessioned","2018-11-07T09:51:57Z"],["dc.date.available","2018-11-07T09:51:57Z"],["dc.date.issued","2015"],["dc.description.abstract","Objective: The capacity of thymomas to generate mature CD4+ effector T cells from immature precursors inside the tumor and export them to the blood is associated with thymoma-associated myasthenia gravis (TAMG). Why TAMG (+) thymomas generate and export more mature CD4+ T cells than MG(-) thymomas is unknown. Methods: Unfixed thymoma tissue, thymocytes derived thereof, peripheral blood mononuclear cells (PBMCs), T-cell subsets and B cells were analysed using qRT-PCR and western blotting. Survival of PBMCs was measured by MTT assay. FAS-mediated apoptosis in PBMCs was quantified by flow cytometry. NF-kappa B in PBMCs was inhibited by the NF-kappa B-Inhibitor, EF24 prior to FAS-Ligand (FASLG) treatment for apoptosis induction. Results: Expression levels of the apoptosis inhibitor cellular FLICE-like inhibitory protein (c-FLIP) in blood T cells and intratumorous thymocytes were higher in TAMG(+) than in MG(-) thymomas and non-neoplastic thymic remnants. Thymocytes and PBMCs of TAMG patients showed nuclear NF-kappa B accumulation and apoptosis resistance to FASLG stimulation that was sensitive to NF-kappa B blockade. Thymoma removal reduced cFLIP expression in PBMCs. Interpretation: We conclude that thymomas induce cFLIP overexpression in thymocytes and their progeny, blood T cells. We suggest that the stronger cFLIP overexpression in TAMG(+) compared to MG(-) thymomas allows for the more efficient generation of mature CD4+ T cells in TAMG(+) thymomas. cFLIP overexpression in thymocytes and exported CD4+ T cells of patients with TAMG might contribute to the pathogenesis of TAMG by impairing central and peripheral T-cell tolerance."],["dc.identifier.doi","10.1002/acn3.210"],["dc.identifier.isi","000367238200003"],["dc.identifier.pmid","26401511"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36014"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","2328-9503"],["dc.title","cFLIP overexpression in T cells in thymoma-associated myasthenia gravis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Tumori Journal"],["dc.bibliographiccitation.lastpage","368"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Ronellenfitsch, Ulrich"],["dc.contributor.author","Ernst, Kristina"],["dc.contributor.author","Mertens, Christina"],["dc.contributor.author","Trunk, Marcus J."],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Marx, Alexander"],["dc.contributor.author","Kienle, Peter"],["dc.contributor.author","Post, Stefan"],["dc.contributor.author","Nowak, Kai"],["dc.date.accessioned","2020-12-10T18:38:25Z"],["dc.date.available","2020-12-10T18:38:25Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1177/0300891618792485"],["dc.identifier.eissn","2038-2529"],["dc.identifier.issn","0300-8916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77310"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Extensive intraperitoneal lavage to eliminate intraperitoneal tumor cells in gastrectomy with D2 lymphadenectomy for gastric cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0197435"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Weis, Cleo-Aron"],["dc.contributor.author","Aban, Inmaculada B."],["dc.contributor.author","Cutter, Garry"],["dc.contributor.author","Kaminski, Henry J."],["dc.contributor.author","Scharff, Christoph"],["dc.contributor.author","Grießmann, Benedict W."],["dc.contributor.author","Deligianni, Maria"],["dc.contributor.author","Kayser, Klaus"],["dc.contributor.author","Wolfe, Gil I."],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Marx, Alexander"],["dc.contributor.editor","Phillips, William D."],["dc.date.accessioned","2020-12-10T18:42:07Z"],["dc.date.available","2020-12-10T18:42:07Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1371/journal.pone.0197435"],["dc.identifier.eissn","1932-6203"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77812"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Histopathology of thymectomy specimens from the MGTX-trial: Entropy analysis as strategy to quantify spatial heterogeneity of lymphoid follicle and fat distribution"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","89580"],["dc.bibliographiccitation.issue","52"],["dc.bibliographiccitation.journal","Oncotarget"],["dc.bibliographiccitation.lastpage","89594"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Belharazem, Djeda"],["dc.contributor.author","Grass, Albert"],["dc.contributor.author","Paul, Cornelia"],["dc.contributor.author","Vitacolonna, Mario"],["dc.contributor.author","Schalke, Berthold"],["dc.contributor.author","Rieker, Ralf J."],["dc.contributor.author","Körner, Daniel"],["dc.contributor.author","Jungebluth, Philipp"],["dc.contributor.author","Simon-Keller, Katja"],["dc.contributor.author","Hohenberger, Peter"],["dc.contributor.author","Roessner, Eric M."],["dc.contributor.author","Wiebe, Karsten"],["dc.contributor.author","Gräter, Thomas"],["dc.contributor.author","Kyriss, Thomas"],["dc.contributor.author","Ott, German"],["dc.contributor.author","Geserick, Peter"],["dc.contributor.author","Leverkus, Martin"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Marx, Alexander"],["dc.date.accessioned","2019-12-17T11:02:35Z"],["dc.date.accessioned","2021-10-27T13:21:59Z"],["dc.date.available","2019-12-17T11:02:35Z"],["dc.date.available","2021-10-27T13:21:59Z"],["dc.date.issued","2017"],["dc.description.abstract","The anti-apoptotic cellular FLICE-like inhibitory protein cFLIP plays a pivotal role in normal tissues homoeostasis and the development of many tumors, but its role in normal thymus (NT), thymomas and thymic carcinomas (TC) is largely unknown. Expression, regulation and function of cFLIP were analyzed in biopsies of NT, thymomas, thymic squamous cell carcinomas (TSCC), thymic epithelial cells (TECs) derived thereof and in the TC line 1889c by qRT-PCR, western blot, shRNA techniques, and functional assays addressing survival, senescence and autophagy. More than 90% of thymomas and TSCCs showed increased cFLIP expression compared to NT. cFLIP expression declined with age in NTs but not in thymomas. During short term culture cFLIP expression levels declined significantly slower in neoplastic than non-neoplastic primary TECs. Down-regulation of cFLIP by shRNA or NF-κB inhibition accelerated senescence and induced autophagy and cell death in neoplastic TECs. The results suggest a role of cFLIP in the involution of normal thymus and the development of thymomas and TSCC. Since increased expression of cFLIP is a known tumor escape mechanism, it may serve as tissue-based biomarker in future clinical trials, including immune checkpoint inhibitor trials in the commonly PD-L1high thymomas and TCs."],["dc.identifier.doi","10.18632/oncotarget.15929"],["dc.identifier.eissn","1949-2553"],["dc.identifier.pmid","29163772"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92059"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.eissn","1949-2553"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.subject.ddc","610"],["dc.title","Increased cFLIP expression in thymic epithelial tumors blocks autophagy via NF-κB signalling"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","704"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Histopathology"],["dc.bibliographiccitation.lastpage","710"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Buerger, Tobias"],["dc.contributor.author","Schaefer, Inga-Marie"],["dc.contributor.author","Kueffer, Stefan"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.contributor.author","Reuter-Jessen, Kirsten"],["dc.contributor.author","Chan, John Kwok-Cheung"],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Hinterthaner, Marc"],["dc.contributor.author","Marx, Alexander"],["dc.contributor.author","Stroebel, Philipp"],["dc.date.accessioned","2018-11-07T10:25:44Z"],["dc.date.available","2018-11-07T10:25:44Z"],["dc.date.issued","2017"],["dc.description.abstract","AimsThe vast majority of type A thymomas are diagnosed in tumour stages 1 or 2, and metastatic cases are exceedingly rare. The histological and genetic features of such metastatic type A thymomas have not been described in detail. Methods and resultsFive metastatic type A thymomas in tumour stage Masaoka IVb that had been reviewed by a panel of expert pathologists were analysed using comparative genomic hybridization (CGH). Cases 1, 2 and 3 showed the prototypical morphology of type A thymomas with mainly solid growth patterns. These cases displayed only very subtle nuclear irregularities and slight nuclear crowding, but no other atypical features. Mitoses were absent. Cases 3 and 4, in contrast, had a distinctly atypical morphology. CGH revealed partially recurrent alterations in four cases (with and without atypical morphology), including gains on chromosome 1q (one case), 17q (two cases), chromosome 19 (three cases) and 22q (one case) and losses on chromosome 17p (two cases) and 22q (one case). ConclusionRare metastatic type A thymomas, both with typical and atypical' histological features, show partially recurrent genomic alterations that differ from the much more frequent localized and indolent tumours. The fact that these alterations were recurring points to a link between clinical behaviour and molecular features. Our findings may have implications for the management and treatment of such tumours."],["dc.identifier.doi","10.1111/his.13138"],["dc.identifier.isi","000397588600003"],["dc.identifier.pmid","27926794"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42916"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1365-2559"],["dc.relation.issn","0309-0167"],["dc.title","Metastatic type A thymoma: morphological and genetic correlation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","ENDOCRINE CONNECTIONS"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Belharazem, Djeda"],["dc.contributor.author","Kirchner, Matthias"],["dc.contributor.author","Geissler, Franziska"],["dc.contributor.author","Bugert, Peter"],["dc.contributor.author","Spahn, Martin"],["dc.contributor.author","Kneitz, Burkhard"],["dc.contributor.author","Riedmiller, Hubertus"],["dc.contributor.author","Sauer, Christian"],["dc.contributor.author","Kueffer, Stefan"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Bolenz, Christian"],["dc.contributor.author","Michel, Maurice Stephan"],["dc.contributor.author","Marx, Alexander"],["dc.contributor.author","Stroebel, Philipp"],["dc.date.accessioned","2018-11-07T09:04:21Z"],["dc.date.available","2018-11-07T09:04:21Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: Insulin-like growth factor 2 (IGF2) is the predominant IGF in adults and regulates cell growth. In contrast to normal tissues, where IGF2 is imprinted and only expressed from the paternal allele, loss of imprinting (LOI) and biallelic IGF2 expression are observed in many cancers including prostate cancer (PCa). We here studied whether LOI of IGF2 in normal circulating peripheral blood lymphocytes can predict increased PCa risk. Samples and methods: We analyzed IGF2 protein levels, IGF2 820G/A genotype and imprinting status, as well as methylation status of the IGF2 imprinting control region (ICR) in 113 blood samples of patients with a history of radical prostatectomy (RPE) for PCa by ELISA, restriction-fragment length polymorphism, and bisulfite-DNA sequencing. Results were compared to 249 male blood donors with unknown prostate specific antigen (PSA) status. Results: The 820G/A genotype was enriched in the RPE group and was associated with younger age at cancer diagnosis. LOI in patients was only slightly more frequent than in controls, but IGF2 levels were significantly higher and uncoupled from the imprinting status. Analysis of the IGF2/H19 ICR revealed marked hypermethylation. Conclusions: The IGF 820G/A genotype is associated with PCa diagnosis at younger age. Increased IGF2 in patients with PCa appears to be the result of impaired imprinting in non-neoplastic cells rather than a paracrine tumor product. Uncoupling of IGF2 protein levels from imprinting status (not LOI alone) and hypermethylation of the ICR characterized PCa patients and could have the potential to indicate persons at risk in screening programs."],["dc.identifier.doi","10.1530/EC-12-0054"],["dc.identifier.isi","000209773300005"],["dc.identifier.pmid","23781309"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25099"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bioscientifica Ltd"],["dc.relation.issn","2049-3614"],["dc.title","Relaxed imprinting of IGF2 in peripheral blood cells of patients with a history of prostate cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Pathology & Oncology Research"],["dc.bibliographiccitation.volume","27"],["dc.contributor.affiliation","Jain, Deepali; \r\n\r\n1\r\nDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India"],["dc.contributor.affiliation","Guleria, Prerna; \r\n\r\n1\r\nDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India"],["dc.contributor.affiliation","Singh, Varsha; \r\n\r\n1\r\nDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India"],["dc.contributor.affiliation","Parshad, Rajinder; \r\n\r\n2\r\nDepartment of Surgery, All India Institute of Medical Sciences, New Delhi, India"],["dc.contributor.affiliation","Kumar, Sunil; \r\n\r\n3\r\nSurgical Oncology, All India Institute of Medical Sciences, New Delhi, India"],["dc.contributor.affiliation","Gaiser, Timo; \r\n\r\n4\r\nInstitute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany"],["dc.contributor.affiliation","Kurz, Katrin S.; \r\n\r\n5\r\nDr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, Germany"],["dc.contributor.affiliation","Ott, German; \r\n\r\n5\r\nDr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, Germany"],["dc.contributor.affiliation","Porubsky, Stefan; \r\n\r\n4\r\nInstitute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany"],["dc.contributor.affiliation","Preissler, Gerhard; \r\n\r\n8\r\nDepartment of Thoracic Surgery, Schillerhöhe Clinics, Robert-Bosch-Krankenhaus, Gerlingen, Germany"],["dc.contributor.affiliation","Sauer, Christian G.; \r\n\r\n4\r\nInstitute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany"],["dc.contributor.affiliation","Schölch, Sebastian; \r\n\r\n9\r\nDepartment of Surgery, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany"],["dc.contributor.affiliation","Ströbel, Philipp; \r\n\r\n11\r\nInstitute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Hielscher, Thomas; \r\n\r\n12\r\nDepartment of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany"],["dc.contributor.affiliation","Marx, Alexander; \r\n\r\n4\r\nInstitute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany"],["dc.contributor.affiliation","Popovic, Zoran V.; \r\n\r\n4\r\nInstitute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany"],["dc.contributor.author","Jain, Deepali"],["dc.contributor.author","Guleria, Prerna"],["dc.contributor.author","Singh, Varsha"],["dc.contributor.author","Parshad, Rajinder"],["dc.contributor.author","Kumar, Sunil"],["dc.contributor.author","Gaiser, Timo"],["dc.contributor.author","Kurz, Katrin S."],["dc.contributor.author","Ott, German"],["dc.contributor.author","Porubsky, Stefan"],["dc.contributor.author","Preissler, Gerhard"],["dc.contributor.author","Popovic, Zoran V."],["dc.contributor.author","Sauer, Christian G."],["dc.contributor.author","Schölch, Sebastian"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Hielscher, Thomas"],["dc.contributor.author","Marx, Alexander"],["dc.date.accessioned","2021-10-01T09:58:20Z"],["dc.date.available","2021-10-01T09:58:20Z"],["dc.date.issued","2021"],["dc.date.updated","2022-09-04T10:01:51Z"],["dc.description.abstract","Thymomas are the most frequent adult mediastinal cancers. Their etiology is unknown and their pathogenesis poorly understood. Racial, ethnic and environmental factors influence tumorigenesis in many cancers, but their role in thymomas remains unclear to date. In this study that included pretreatment thymoma cases from India and Germany ( n = 37 and n = 77, respectively) we compared i) the prevalence of the thymoma-specific chromosome 7 c.74146970T > A mutation of the GTF2I gene in type A and AB thymomas; ii) epidemiological features; and iii) the frequency of myasthenia gravis (MG). Due to a known predominance of GTF2I mutation in A and AB histotypes, we included only a marginal number of type B thymomas as a control group in both cohorts. While the distribution of histological types between the cohorts was similar ( p = 0.1622), Indian patients were strikingly younger ( p < 0.0001; median age 50 vs. 65 years) and showed significantly lower tumour stage (Masaoka-Koga stage I) at primary diagnosis ( p = 0.0005) than the German patients. In patients with known MG status ( n = 17 in Indian and n = 25 in German cohort), a clear trend towards more frequent MG was observed in the Indian group ( p = 0.0504; 48 vs. 82%). The prevalence of the GTF2I mutation (analysed in n = 34 Indian and n = 77 German patients) was identical in the two cohorts. We conclude that racial-ethnic and environmental factors do not significantly influence the most common molecular feature of thymomas but may have an impact on the timing of clinical presentation."],["dc.identifier.doi","10.3389/pore.2021.1609858"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90044"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1532-2807"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","GTF2I Mutation in Thymomas: Independence From Racial-Ethnic Backgrounds. An Indian/German Comparative Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","323"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Virchows Archiv"],["dc.bibliographiccitation.lastpage","327"],["dc.bibliographiccitation.volume","476"],["dc.contributor.author","Porubsky, Stefan"],["dc.contributor.author","Jessup, Peter"],["dc.contributor.author","Kee, Damien"],["dc.contributor.author","Sharma, Rajiv"],["dc.contributor.author","Ochi, Ayame"],["dc.contributor.author","Xu, Huiling"],["dc.contributor.author","Froelich, Jens J."],["dc.contributor.author","Nott, Louise"],["dc.contributor.author","Scott, Clare"],["dc.contributor.author","Awad, Raef"],["dc.contributor.author","Moldovan, Cristina"],["dc.contributor.author","Hardikar, Ashutosh A."],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.contributor.author","Küffer, Stefan"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Marx, Alexander"],["dc.date.accessioned","2020-12-10T14:10:36Z"],["dc.date.available","2020-12-10T14:10:36Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00428-019-02644-3"],["dc.identifier.eissn","1432-2307"],["dc.identifier.issn","0945-6317"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70816"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","381"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Histopathology"],["dc.bibliographiccitation.lastpage","396"],["dc.bibliographiccitation.volume","80"],["dc.contributor.affiliation","Richter, Annika; 1Institute of Pathology University Medical Centre Göttingen Göttingen Germany"],["dc.contributor.affiliation","Filmar, Simon; 1Institute of Pathology University Medical Centre Göttingen Göttingen Germany"],["dc.contributor.affiliation","Kircher, Stefan; 2Institute of Pathology University of Würzburg Würzburg Germany"],["dc.contributor.affiliation","Rosenwald, Andreas; 2Institute of Pathology University of Würzburg Würzburg Germany"],["dc.contributor.affiliation","Küffer, Stefan; 1Institute of Pathology University Medical Centre Göttingen Göttingen Germany"],["dc.contributor.affiliation","Nettersheim, Daniel; 3Department of Urology Urological Research Laboratory Translational UroOncology Medical Faculty and University Hospital Düsseldorf Heinrich‐Heine‐University Düsseldorf Germany"],["dc.contributor.affiliation","Oing, Christoph; 4Division of Pneumology Department of Oncology, Haematology and Bone Marrow Transplantation University Medical Centre Hamburg‐Eppendorf Hamburg Germany"],["dc.contributor.affiliation","Marx, Alexander; 6Institute of Pathology University Medical Centre Mannheim Mannheim Germany"],["dc.contributor.affiliation","Ströbel, Philipp; 1Institute of Pathology University Medical Centre Göttingen Göttingen Germany"],["dc.contributor.affiliation","Bremmer, Felix; 1Institute of Pathology University Medical Centre Göttingen Göttingen Germany"],["dc.contributor.author","Fichtner, Alexander"],["dc.contributor.author","Richter, Annika"],["dc.contributor.author","Filmar, Simon"],["dc.contributor.author","Kircher, Stefan"],["dc.contributor.author","Rosenwald, Andreas"],["dc.contributor.author","Küffer, Stefan"],["dc.contributor.author","Nettersheim, Daniel"],["dc.contributor.author","Oing, Christoph"],["dc.contributor.author","Marx, Alexander"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Bremmer, Felix"],["dc.date.accessioned","2021-12-01T09:21:14Z"],["dc.date.available","2021-12-01T09:21:14Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T09:57:31Z"],["dc.description.abstract","Aims Primary mediastinal germ cell tumours (PMGCTs) are rare mediastinal neoplasms, and their diagnosis can be challenging, owing to small biopsy samples. The aim of this study was to develop a diagnostic algorithm using immunohistochemical staining, with a focus on novel markers, and molecular analysis of isochromosome 12p [i(12p)]. Methods and results Paraffin‐embedded tissues of 32 mediastinal tumours were analysed with immunohistochemical staining for sal‐like transcription factor 4 (SALL4), Lin‐28 homologue A (LIN28), octamer‐binding transcription factor 3/4 (OCT3/4), D2‐40, cluster of differentiation 117 (CD117), sex‐determining region Y‐box 17, sex‐determining region Y‐box 2 (SOX2), cluster of differentiation 30, the β‐subunit of human chorionic gonadotropin (β‐hCG), GATA‐binding protein 3 (GATA3), forkhead box protein A2 (FOXA2), glypican‐3 (GPC3), α‐fetoprotein (AFP), terminal deoxynucleotidyl transferase (TdT), nuclear protein of the testis (NUT), and pan‐cytokeratin. Quantitative real‐time polymerase chain reaction was performed to investigate the i(12p) status. Fifteen seminomas, seven teratomas, one yolk sac tumour, one choriocarcinoma and seven mixed PMGCTs were diagnosed. Each entity had different immunohistochemical staining patterns, which helped to distinguish them: OCT3/4, D2‐40, CD117 and TdT for seminoma; OCT3/4 and SOX2 for embryonal carcinoma; FOXA2, GPC3 and AFP for yolk sac tumour; and β‐hCG and GATA3 for choriocarcinoma. Mature teratomas stained positively for pan‐cytokeratin in epithelial components and focally for SALL4, SOX2, GATA3, D2‐40, and FOXA2. Furthermore, a NUT carcinoma mimicking a PMGCT was diagnosed, showing strong nuclear SOX2 staining and speckled nuclear NUT staining. i(12p) was detected in 24 of 27 PMGCTs (89%). Conclusion A diagnostic algorithm is of great importance for a reliable diagnosis of PMGCT in, usually small, tissue biopsy samples. Therefore, a combination of three to four antibodies to identify the correct histological subtype is usually necessary, in addition to morphological features. The i(12p) status serves as an additional option to indicate a germ cell origin in selected cases."],["dc.description.abstract","image"],["dc.description.sponsorship","Wilhelm Sander‐Stiftung http://dx.doi.org/10.13039/100008672"],["dc.identifier.doi","10.1111/his.14560"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94381"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","1365-2559"],["dc.relation.issn","0309-0167"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Primary mediastinal germ cell tumours: an immunohistochemical and molecular diagnostic approach"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]