Tavosanis, Gaia

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Prisco, Luigi"],["dc.contributor.author","Deimel, Stephan Hubertus"],["dc.contributor.author","Yeliseyeva, Hanna"],["dc.contributor.author","Fiala, André"],["dc.contributor.author","Tavosanis, Gaia"],["dc.date.accessioned","2022-02-01T10:31:53Z"],["dc.date.available","2022-02-01T10:31:53Z"],["dc.date.issued","2021"],["dc.description.abstract","To identify and memorize discrete but similar environmental inputs, the brain needs to distinguish between subtle differences of activity patterns in defined neuronal populations. The Kenyon cells (KCs) of the Drosophila adult mushroom body (MB) respond sparsely to complex olfactory input, a property that is thought to support stimuli discrimination in the MB. To understand how this property emerges, we investigated the role of the inhibitory anterior paired lateral (APL) neuron in the input circuit of the MB, the calyx. Within the calyx, presynaptic boutons of projection neurons (PNs) form large synaptic microglomeruli (MGs) with dendrites of postsynaptic KCs. Combining electron microscopy (EM) data analysis and in vivo calcium imaging, we show that APL, via inhibitory and reciprocal synapses targeting both PN boutons and KC dendrites, normalizes odour-evoked representations in MGs of the calyx. APL response scales with the PN input strength and is regionalized around PN input distribution. Our data indicate that the formation of a sparse code by the KCs requires APL-driven normalization of their MG postsynaptic responses. This work provides experimental insights on how inhibition shapes sensory information representation in a higher brain centre, thereby supporting stimuli discrimination and allowing for efficient associative memory formation."],["dc.identifier.doi","10.7554/eLife.74172"],["dc.identifier.pmid","34964714"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98969"],["dc.identifier.url","https://for2705.de/literature/publications/50"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 6: The role of gap junctions during mushroom body development and remodeling"],["dc.relation.eissn","2050-084X"],["dc.relation.workinggroup","RG Fiala"],["dc.relation.workinggroup","RG Tavosanis (Developmental Neurobiology)"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1008491"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Marchetti, Giovanni"],["dc.contributor.author","Tavosanis, Gaia"],["dc.date.accessioned","2022-08-19T10:08:46Z"],["dc.date.available","2022-08-19T10:08:46Z"],["dc.date.issued","2019"],["dc.description.abstract","Neuronal diversity is at the core of the complex processing operated by the nervous system supporting fundamental functions such as sensory perception, motor control or memory formation. A small number of progenitors guarantee the production of this neuronal diversity, with each progenitor giving origin to different neuronal types over time. How a progenitor sequentially produces neurons of different fates and the impact of extrinsic signals conveying information about developmental progress or environmental conditions on this process represent key, but elusive questions. Each of the four progenitors of the Drosophila mushroom body (MB) sequentially gives rise to the MB neuron subtypes. The temporal fate determination pattern of MB neurons can be influenced by extrinsic cues, conveyed by the steroid hormone ecdysone. Here, we show that the activation of Transforming Growth Factor-β (TGF-β) signalling via glial-derived Myoglianin regulates the fate transition between the early-born α'β' and the pioneer αβ MB neurons by promoting the expression of the ecdysone receptor B1 isoform (EcR-B1). While TGF-β signalling is required in MB neuronal progenitors to promote the expression of EcR-B1, ecdysone signalling acts postmitotically to consolidate theα'β' MB fate. Indeed, we propose that if these signalling cascades are impaired α'β' neurons lose their fate and convert to pioneer αβ. Conversely, an intrinsic signal conducted by the zinc finger transcription factor Krüppel-homolog 1 (Kr-h1) antagonises TGF-β signalling and acts as negative regulator of the response mediated by ecdysone in promoting α'β' MB neuron fate consolidation. Taken together, the consolidation of α'β' MB neuron fate requires the response of progenitors to local signalling to enable postmitotic neurons to sense a systemic signal."],["dc.identifier.doi","10.1371/journal.pgen.1008491"],["dc.identifier.pmid","31809495"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113045"],["dc.identifier.url","https://for2705.de/literature/publications/15"],["dc.language.iso","en"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 6: The role of gap junctions during mushroom body development and remodeling"],["dc.relation.eissn","1553-7404"],["dc.relation.workinggroup","RG Tavosanis (Developmental Neurobiology)"],["dc.rights","CC BY 4.0"],["dc.title","Modulators of hormonal response regulate temporal fate specification in the Drosophila brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Prisco, Luigi"],["dc.contributor.author","Deimel, Stephan Hubertus"],["dc.contributor.author","Yeliseyeva, Hanna"],["dc.contributor.author","Fiala, André"],["dc.contributor.author","Tavosanis, Gaia"],["dc.date.accessioned","2022-08-19T12:49:22Z"],["dc.date.available","2022-08-19T12:49:22Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1101/2021.09.20.461071"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113080"],["dc.identifier.url","https://for2705.de/literature/publications/49"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 6: The role of gap junctions during mushroom body development and remodeling"],["dc.relation.workinggroup","RG Fiala"],["dc.relation.workinggroup","RG Tavosanis (Developmental Neurobiology)"],["dc.title","The anterior paired lateral neuron normalizes odour-evoked activity at the mushroom body calyx"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","222"],["dc.bibliographiccitation.journal","Current Opinion in Neurobiology"],["dc.bibliographiccitation.lastpage","230"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Tavosanis, Gaia"],["dc.date.accessioned","2022-08-19T12:23:04Z"],["dc.date.available","2022-08-19T12:23:04Z"],["dc.date.issued","2021"],["dc.description.abstract","Neuronal dendrites acquire complex morphologies during development. These are not just the product of cell-intrinsic developmental programs; rather they are defined in close interaction with the cellular environment. Thus, to understand the molecular cascades that yield appropriate morphologies, it is essential to investigate them in vivo, in the actual complex tissue environment encountered by the differentiating neuron in the developing animal. Particularly, genetic approaches have pointed to factors controlling dendrite differentiation in vivo. These suggest that localized and transient molecular cascades might underlie the formation and stabilization of dendrite branches with neuron type-specific characteristics. Here, I highlight the need for studies of neuronal dendrite differentiation in the animal, the challenges provided by such an approach, and the promising pathways that have recently opened."],["dc.identifier.doi","10.1016/j.conb.2021.05.001"],["dc.identifier.pmid","34134010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113068"],["dc.identifier.url","https://for2705.de/literature/publications/44"],["dc.language.iso","en"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 6: The role of gap junctions during mushroom body development and remodeling"],["dc.relation.eissn","1873-6882"],["dc.relation.issn","0959-4388"],["dc.relation.workinggroup","RG Tavosanis (Developmental Neurobiology)"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","Dendrite enlightenment"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","overview_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","108871"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Baltruschat, Lothar"],["dc.contributor.author","Prisco, Luigi"],["dc.contributor.author","Ranft, Philipp"],["dc.contributor.author","Lauritzen, J. Scott"],["dc.contributor.author","Fiala, André"],["dc.contributor.author","Bock, Davi D."],["dc.contributor.author","Tavosanis, Gaia"],["dc.date.accessioned","2021-04-14T08:29:02Z"],["dc.date.available","2021-04-14T08:29:02Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.celrep.2021.108871"],["dc.identifier.pmid","33730583"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82778"],["dc.identifier.url","https://for2705.de/literature/publications/39"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 6: The role of gap junctions during mushroom body development and remodeling"],["dc.relation.issn","2211-1247"],["dc.relation.workinggroup","RG Fiala"],["dc.relation.workinggroup","RG Tavosanis (Developmental Neurobiology)"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]