Zhang, Weiqi

[["dc.bibliographiccitation.artnumber","5"],["dc.bibliographiccitation.journal","Frontiers in Microbiology"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Gong, Chaowen"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Zhou, X."],["dc.contributor.author","Wang, H."],["dc.contributor.author","Sun, Guowei"],["dc.contributor.author","Xiao, Jinzhou"],["dc.contributor.author","Pan, Yingjie"],["dc.contributor.author","Yan, Shuling"],["dc.contributor.author","Wang, Y."],["dc.date.accessioned","2018-11-07T10:19:15Z"],["dc.date.available","2018-11-07T10:19:15Z"],["dc.date.issued","2016"],["dc.description.abstract","Virophages are small double-stranded DNA viruses that are parasites of giant DNA viruses that infect unicellular eukaryotes. Here we identify a novel group of virophages, named Dishui Lake virophages (DSLVs) that were discovered in Dishui Lake (DSL): an artificial freshwater lake in Shanghai, China. Based on PCR and metagenomic analysis, the complete genome of DSLV1 was found to be circular and 28,788 base pairs in length, with a G+C content 43.2%, and 28 predicted open reading frames (ORFs). Fifteen of the DSLV1 ORFs have sequence similarity to known virophages. Two DSLV1 ORFs exhibited sequence similarity to that of prasinoviruses (Phycodnaviridae) and chloroviruses (Phycodnaviridae), respectively, suggesting horizontal gene transfer occurred between these large algal DNA viruses and DSLV1. 46 other virophages-related contigs were also obtained, including six homologous major capsid protein (MCP) gene. Phylogenetic analysis of these MCPs showed that DSLVs are closely related to OLV (Organic Lake virophage) and YSLVs (Yellowstone Lake virophages), especially to YSLV3, except for YSLV7. These results indicate that freshwater ecotopes are the hotbed for discovering novel virophages as well as understanding their diversity and properties."],["dc.identifier.doi","10.3389/fmicb.2016.00005"],["dc.identifier.isi","000368498800002"],["dc.identifier.pmid","26834726"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12862"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41627"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media Sa"],["dc.relation.issn","1664-302X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Novel Virophages Discovered in a Freshwater Lake in China"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","15131"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Zhou, J."],["dc.contributor.author","Liu, Taigang"],["dc.contributor.author","Yu, Yongxin"],["dc.contributor.author","Pan, Yingjie"],["dc.contributor.author","Yan, Shuling"],["dc.contributor.author","Wang, Y."],["dc.date.accessioned","2018-11-07T09:50:16Z"],["dc.date.available","2018-11-07T09:50:16Z"],["dc.date.issued","2015"],["dc.description.abstract","Phycodnaviruses are algae-infecting large dsDNA viruses that are widely distributed in aquatic environments. Here, partial genomic sequences of four novel algal viruses were assembled from a Yellowstone Lake metagenomic data set. Genomic analyses revealed that three Yellowstone Lake phycodnaviruses (YSLPVs) had genome lengths of 178,262 bp, 171,045 bp, and 171,454 bp, respectively, and were phylogenetically closely related to prasinoviruses (Phycodnaviridae). The fourth (YSLGV), with a genome length of 73,689 bp, was related to group III in the extended family Mimiviridae comprising Organic Lake phycodnaviruses and Phaeocystis globosa virus 16 T (OLPG). A pair of inverted terminal repeats was detected in YSLPV1, suggesting that its genome is nearly complete. Interestingly, these four putative YSL giant viruses also bear some genetic similarities to Yellowstone Lake virophages (YSLVs). For example, they share nine non-redundant homologous genes, including ribonucleotide reductase small subunit (a gene conserved in nucleo-cytoplasmic large DNA viruses) and Organic Lake virophage OLV2 (conserved in the majority of YSLVs). Additionally, putative multidrug resistance genes (emrE) were found in YSLPV1 and YSLPV2 but not in other viruses. Phylogenetic trees of emrE grouped YSLPVs with algae, suggesting that horizontal gene transfer occurred between giant viruses and their potential algal hosts."],["dc.identifier.doi","10.1038/srep15131"],["dc.identifier.isi","000362633600001"],["dc.identifier.pmid","26459929"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12279"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35677"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Four novel algal virus genomes discovered from Yellowstone Lake metagenomes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","10599"],["dc.bibliographiccitation.issue","41"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","10613"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Dudanova, Irina"],["dc.contributor.author","Sedej, Simon"],["dc.contributor.author","Ahmad, Mohiuddin"],["dc.contributor.author","Masius, Henriette"],["dc.contributor.author","Sargsyan, Vardanush"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Angenstein, Frank"],["dc.contributor.author","Schild, Detlev"],["dc.contributor.author","Rupnik, Marjan"],["dc.contributor.author","Missler, Markus"],["dc.date.accessioned","2018-11-07T09:06:58Z"],["dc.date.available","2018-11-07T09:06:58Z"],["dc.date.issued","2006"],["dc.description.abstract","alpha-Neurexins constitute a family of neuronal cell surface molecules that are essential for efficient neurotransmission, because mice lacking two or all three alpha-neurexin genes show a severe reduction of synaptic release. Although analyses of alpha-neurexin knock-outs and transgenic rescue animals suggested an involvement of voltage-dependent Ca2+ channels, it remained unclear whether alpha-neurexins have a general role in Ca2+-dependent exocytosis and how they may affect Ca2+ channels. Here we show by membrane capacitance measurements from melanotrophs in acute pituitary gland slices that release from endocrine cells is diminished by > 50% in adult alpha-neurexin double knock-out and newborn triple knock-out mice. There is a reduction of the cell volume in mutant melanotrophs; however, no ultrastructural changes in size or intracellular distribution of the secretory granules were observed. Recordings of Ca2+ currents from melanotrophs, transfected human embryonic kidney cells, and brainstem neurons reveal that alpha-neurexins do not affect the activation or inactivation properties of Ca2+ channels directly but may be responsible for coupling them to release-ready vesicles and metabotropic receptors. Our data support a general and essential role for alpha-neurexins in Ca2+-triggered exocytosis that is similarly important for secretion from neurons and endocrine cells."],["dc.identifier.doi","10.1523/JNEUROSCI.1913-06.2006"],["dc.identifier.isi","000241192800034"],["dc.identifier.pmid","17035546"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25679"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1807"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Genome Biology and Evolution"],["dc.bibliographiccitation.lastpage","1816"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Bletz, Stefan"],["dc.contributor.author","Bielaszewska, Martina"],["dc.contributor.author","Leopold, Shana R."],["dc.contributor.author","Koeck, Robin"],["dc.contributor.author","Witten, Anika"],["dc.contributor.author","Schuldes, Joerg"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Karch, Helge"],["dc.contributor.author","Mellmann, Alexander"],["dc.date.accessioned","2018-11-07T09:29:29Z"],["dc.date.available","2018-11-07T09:29:29Z"],["dc.date.issued","2013"],["dc.description.abstract","Enterohemorrhagic Escherichia coli (EHEC) O26:H11/H- is the predominant non-O157 EHEC serotype among patients with diarrhea, bloody diarrhea, and hemolytic uremic syndrome (HUS) worldwide. To elucidate their phylogeny and association between their phylogenetic background and clinical outcome of the infection, we investigated 120 EHEC O26:H11/H- strains isolated between 1965 and 2012 from asymptomatic carriers and patients with diarrhea or HUS. Whole-genome shotgun sequencing (WGS) was applied to ten representative EHEC O26 isolates to determine single nucleotide polymorphism (SNP) localizations within a predefined set of core genes. A multiplex SNP assay, comprising a randomly distributed subset of 48 SNPs, was established to detect SNPs in 110 additional EHEC O26 strains. Within approximately 1 Mb of core genes, WGS resulted in 476 high-quality bi-allelic SNP localizations. Forty-eight of these were subsequently investigated in 110 EHEC O26 and four different SNP clonal complexes (SNP-CC) were identified. SNP-CC2 was significantly associated with the development of HUS. Within the subsequently established evolutionary model of EHEC O26, we dated the emergence of human EHEC O26 to approximately 19,700 years ago and demonstrated a recent evolution within humans into the 4 SNP-CCs over the past 1,650 years. WGS and subsequent SNP typing enabled us to gain new insights into the evolution of EHEC O26 suggesting a common theme in this EHEC group with analogies to EHEC O157. In addition, the SNP-CC analysis may help to assess a risk in infected individuals for the progression to HUS and to implement more specific infection control measures."],["dc.identifier.doi","10.1093/gbe/evt136"],["dc.identifier.isi","000327438000005"],["dc.identifier.pmid","24105689"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10611"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31044"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1759-6653"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Evolution of Enterohemorrhagic Escherichia coli O26 Based on Single-Nucleotide Polymorphisms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e18605"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Deng, Ying"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Farhat, Katja"],["dc.contributor.author","Oberland, Sonja"],["dc.contributor.author","Gisselmann, Guenter"],["dc.contributor.author","Neuhaus, Eva M."],["dc.date.accessioned","2018-11-07T08:57:06Z"],["dc.date.available","2018-11-07T08:57:06Z"],["dc.date.issued","2011"],["dc.description.abstract","Seven-transmembrane receptors typically mediate olfactory signal transduction by coupling to G-proteins. Although insect odorant receptors have seven transmembrane domains like G-protein coupled receptors, they have an inverted membrane topology, constituting a key difference between the olfactory systems of insects and other animals. While heteromeric insect ORs form ligand-activated non-selective cation channels in recombinant expression systems, the evidence for an involvement of cyclic nucleotides and G-proteins in odor reception is inconsistent. We addressed this question in vivo by analyzing the role of G-proteins in olfactory signaling using electrophysiological recordings. We found that G alpha(s) plays a crucial role for odorant induced signal transduction in OR83b expressing olfactory sensory neurons, but not in neurons expressing CO2 responsive proteins GR21a/GR63a. Moreover, signaling of Drosophila ORs involved G alpha(s) also in a heterologous expression system. In agreement with these observations was the finding that elevated levels of cAMP result in increased firing rates, demonstrating the existence of a cAMP dependent excitatory signaling pathway in the sensory neurons. Together, we provide evidence that G alpha(s) plays a role in the OR mediated signaling cascade in Drosophila."],["dc.description.sponsorship","NE [755/3-1]; Max-Planck-Research School for Chemical Biology (IMPRS-CB)"],["dc.identifier.doi","10.1371/journal.pone.0018605"],["dc.identifier.isi","000289238700028"],["dc.identifier.pmid","21490930"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8314"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23308"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","The Stimulatory G alpha(s) Protein Is Involved in Olfactory Signal Transduction in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","25"],["dc.bibliographiccitation.journal","Neural Development"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Heupel, Katharina"],["dc.contributor.author","Sargsyan, Vardanush"],["dc.contributor.author","Plomp, Jaap J."],["dc.contributor.author","Rickmann, Michael"],["dc.contributor.author","Varoqueaux, Frederique"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Krieglstein, Kerstin"],["dc.date.accessioned","2018-11-07T11:10:04Z"],["dc.date.available","2018-11-07T11:10:04Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: The formation of functional synapses is a crucial event in neuronal network formation, and with regard to regulation of breathing it is essential for life. Members of the transforming growth factor-beta (TGF-beta) superfamily act as intercellular signaling molecules during synaptogenesis of the neuromuscular junction of Drosophila and are involved in synaptic function of sensory neurons of Aplysia. Results: Here we show that while TGF-beta 2 is not crucial for the morphology and function of the neuromuscular junction of the diaphragm muscle of mice, it is essential for proper synaptic function in the pre-Botzinger complex, a central rhythm organizer located in the brainstem. Genetic deletion of TGF-beta 2 in mice strongly impaired both GABA/glycinergic and glutamatergic synaptic transmission in the pre-Botzinger complex area, while numbers and morphology of central synapses of knock-out animals were indistinguishable from their wild-type littermates at embryonic day 18.5. Conclusion: The results demonstrate that TGF-beta 2 influences synaptic function, rather than synaptogenesis, specifically at central synapses. The functional alterations in the respiratory center of the brain are probably the underlying cause of the perinatal death of the TGF-beta 2 knock-out mice."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft through GRK [632]; SFB [406, 780]"],["dc.identifier.doi","10.1186/1749-8104-3-25"],["dc.identifier.isi","000260872000001"],["dc.identifier.pmid","18854036"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4952"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53134"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8104"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Loss of transforming growth factor-beta 2 leads to impairment of central synapse function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","827"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Cellular and Molecular Neurobiology"],["dc.bibliographiccitation.lastpage","839"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Ribic, Adema"],["dc.contributor.author","Zhang, M."],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Maetz-Rensing, Kerstin"],["dc.contributor.author","Uchanska-Ziegler, Barbara"],["dc.contributor.author","Fluegge, Gabriele"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2018-11-07T08:40:40Z"],["dc.date.available","2018-11-07T08:40:40Z"],["dc.date.issued","2010"],["dc.description.abstract","Several recent studies suggested a role for neuronal major histocompatibility complex class I (MHCI) molecules in certain forms of synaptic plasticity in the hippocampus of rodents. Here, we report for the first time on the expression pattern and functional properties of MHCI molecules in the hippocampus of a nonhuman primate, the common marmoset monkey (Callithrix jacchus). We detected a presynaptic, mossy fiber-specific localization of MHCI proteins within the marmoset hippocampus. MHCI molecules were present in the large, VGlut1-positive, mossy fiber terminals, which provide input to CA3 pyramidal neurons. Furthermore, whole-cell recordings of CA3 pyramidal neurons in acute hippocampal slices of the common marmoset demonstrated that application of antibodies which specifically block MHCI proteins caused a significant decrease in the frequency, and a transient increase in the amplitude, of spontaneous excitatory postsynaptic currents (sEPSCs) in CA3 pyramidal neurons. These findings add to previous studies on neuronal MHCI molecules by describing their expression and localization in the primate hippocampus and by implicating them in plasticity-related processes at the mossy fiber-CA3 synapses. In addition, our results suggest significant interspecies differences in the localization of neuronal MHCI molecules in the hippocampus of mice and marmosets, as well as in their potential function in these species."],["dc.description.sponsorship","EC [NEST-28594]; [SFB 449]; [TP B6]"],["dc.identifier.doi","10.1007/s10571-010-9510-3"],["dc.identifier.isi","000280564700002"],["dc.identifier.pmid","20232136"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5014"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19285"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0272-4340"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Neuronal MHC Class I Molecules are Involved in Excitatory Synaptic Transmission at the Hippocampal Mossy Fiber Synapses of Marmoset Monkeys"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","103011"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Kunnus, Kristjan"],["dc.contributor.author","Josefsson, Ida"],["dc.contributor.author","Rajkovic, Ivan"],["dc.contributor.author","Schreck, Simon"],["dc.contributor.author","Quevedo, Wilson"],["dc.contributor.author","Beye, Martin"],["dc.contributor.author","Greubel, Sebastian"],["dc.contributor.author","Scholz, Mirko"],["dc.contributor.author","Nordlund, Dennis"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Hartsock, Robert W."],["dc.contributor.author","Gaffney, Kelly J."],["dc.contributor.author","Schlotter, William F."],["dc.contributor.author","Turner, Joshua J."],["dc.contributor.author","Kennedy, Brian"],["dc.contributor.author","Hennies, Franz"],["dc.contributor.author","Techert, Simone"],["dc.contributor.author","Wernet, Philippe"],["dc.contributor.author","Odelius, Michael"],["dc.contributor.author","Foehlisch, Alexander"],["dc.date.accessioned","2018-11-07T10:07:45Z"],["dc.date.available","2018-11-07T10:07:45Z"],["dc.date.issued","2016"],["dc.description.abstract","Ultrafast electronic and structural dynamics of matter govern rate and selectivity of chemical reactions, as well as phase transitions and efficient switching in functional materials. Since x-rays determine electronic and structural properties with elemental, chemical, orbital and magnetic selectivity, short pulse x-ray sources have become central enablers of ultrafast science. Despite of these strengths, ultrafast x-rays have been poor at picking up excited state moieties from the unexcited ones. With time-resolved anti-Stokes resonant x-ray Raman scattering (AS-RXRS) performed at the LCLS, and ab initio theory we establish background free excited state selectivity in addition to the elemental, chemical, orbital and magnetic selectivity of x-rays. This unparalleled selectivity extracts low concentration excited state species along the pathway of photo induced ligand exchange of Fe(CO)(5) in ethanol. Conceptually a full theoretical treatment of all accessible insights to excited state dynamics with AS-RXRS with transform-limited x-ray pulses is given-which will be covered experimentally by upcoming transform-limited x-ray sources."],["dc.identifier.doi","10.1088/1367-2630/18/10/103011"],["dc.identifier.isi","000386047000005"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39338"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/669531/EU/Beating Complexity through Selectivity:Excited state Dynamics from Anti-Stokes and non-linear resonant inelastic X-ray scattering/EDAX"],["dc.relation.issn","1367-2630"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Techert (Structural Dynamics in Chemical Systems)"],["dc.rights","CC BY 3.0"],["dc.title","Anti-Stokes resonant x-ray Raman scattering for atom specific and excited state selective dynamics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","37"],["dc.bibliographiccitation.journal","BMC Biology"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Adamcio, Bartosz"],["dc.contributor.author","Sargin, Derya"],["dc.contributor.author","Stradomska, Alicja"],["dc.contributor.author","Medrihan, Lucian"],["dc.contributor.author","Gertler, Christoph"],["dc.contributor.author","Theis, Fabian"],["dc.contributor.author","Zhang, Mingyue"],["dc.contributor.author","Müller, Michael"],["dc.contributor.author","Hassouna, Imam"],["dc.contributor.author","Hannke, Kathrin"],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Radyushkin, Konstantin"],["dc.contributor.author","El-Kordi, Ahmed"],["dc.contributor.author","Schulze, Lizzy"],["dc.contributor.author","Ronnenberg, Anja"],["dc.contributor.author","Wolf, Fred"],["dc.contributor.author","Brose, Nils"],["dc.contributor.author","Rhee, Jeong-Seop"],["dc.contributor.author","Zhang, Weiqi"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:48:12Z"],["dc.date.available","2017-09-07T11:48:12Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Erythropoietin (EPO) improves cognition of human subjects in the clinical setting by as yet unknown mechanisms. We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of how EPO influences cognition, and how it may act on hippocampal neurons to modulate plasticity. Results: We show here that a 3-week treatment of young mice with EPO enhances long-term potentiation (LTP), a cellular correlate of learning processes in the CAI region of the hippocampus. This treatment concomitantly alters short-term synaptic plasticity and synaptic transmission, shifting the balance of excitatory and inhibitory activity. These effects are accompanied by an improvement of hippocampus dependent memory, persisting for 3 weeks after termination of EPO injections, and are independent of changes in hematocrit. Networks of EPO-treated primary hippocampal neurons develop lower overall spiking activity but enhanced bursting in discrete neuronal assemblies. At the level of developing single neurons, EPO treatment reduces the typical increase in excitatory synaptic transmission without changing the number of synaptic boutons, consistent with prolonged functional silencing of synapses. Conclusion: We conclude that EPO improves hippocampus dependent memory by modulating plasticity, synaptic connectivity and activity of memory-related neuronal networks. These mechanisms of action of EPO have to be further exploited for treating neuropsychiatric diseases."],["dc.identifier.doi","10.1186/1741-7007-6-37"],["dc.identifier.gro","3143237"],["dc.identifier.isi","000260109300001"],["dc.identifier.pmid","18782446"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8430"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/729"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1741-7007"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Erythropoietin enhances hippocampal long-term potentiation and memory"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","043204"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Structural Dynamics"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Kunnus, Kristjan"],["dc.contributor.author","Josefsson, Ida"],["dc.contributor.author","Rajkovic, Ivan"],["dc.contributor.author","Schreck, Simon"],["dc.contributor.author","Quevedo, Wilson"],["dc.contributor.author","Beye, Martin"],["dc.contributor.author","Weniger, C."],["dc.contributor.author","Gruebel, S."],["dc.contributor.author","Scholz, M."],["dc.contributor.author","Nordlund, D."],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Hartsock, Robert W."],["dc.contributor.author","Gaffney, Kelly J."],["dc.contributor.author","Schlotter, William F."],["dc.contributor.author","Turner, Joshua J."],["dc.contributor.author","Kennedy, Brian"],["dc.contributor.author","Hennies, F."],["dc.contributor.author","de Groot, F. M. F."],["dc.contributor.author","Techert, Simone"],["dc.contributor.author","Odelius, Michael"],["dc.contributor.author","Wernet, Ph."],["dc.contributor.author","Foehlisch, Alexander"],["dc.date.accessioned","2018-11-07T10:11:53Z"],["dc.date.available","2018-11-07T10:11:53Z"],["dc.date.issued","2016"],["dc.description.abstract","We utilized femtosecond time-resolved resonant inelastic X-ray scattering and ab initio theory to study the transient electronic structure and the photoinduced molecular dynamics of a model metal carbonyl photocatalyst Fe(CO)(5) in ethanol solution. We propose mechanistic explanation for the parallel ultrafast intra-molecular spin crossover and ligation of the Fe(CO)(4) which are observed following a charge transfer photoexcitation of Fe(CO)(5) as reported in our previous study [ Wernet et al., Nature 520, 78 (2015)]. We find that branching of the reaction pathway likely happens in the (1)A(1) state of Fe(CO)(4). A sub-picosecond time constant of the spin crossover from B-1(2) to B-3(2) is rationalized by the proposed B-1(2) -> (1)A(1) -> B-3(2) mechanism. Ultrafast ligation of the B-1(2) Fe(CO)(4) state is significantly faster than the spin-forbidden and diffusion limited ligation process occurring from the B-3(2) Fe(CO)(4) ground state that has been observed in the previous studies. We propose that the ultrafast ligation occurs via B-1(2) -> (1)A(1) -> (1)A'Fe(CO)(4)EtOH pathway and the time scale of the (1)A(1) Fe(CO)(4) state ligation is governed by the solute-solvent collision frequency. Our study emphasizes the importance of understanding the interaction of molecular excited states with the surrounding environment to explain the relaxation pathways of photoexcited metal carbonyls in solution. (C) 2016 Author(s)."],["dc.identifier.doi","10.1063/1.4941602"],["dc.identifier.isi","000383880700006"],["dc.identifier.pmid","26958587"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13794"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40130"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Inst Physics"],["dc.publisher.place","Melville"],["dc.relation","SFB 1073: Kontrolle von Energiewandlung auf atomaren Skalen"],["dc.relation","SFB 1073 | Topical Area C | C02 In situ hochauflösende Untersuchung des aktiven Zustands bei der photo- und elektrochemischen Wasserspaltung"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","2329-7778"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Techert (Structural Dynamics in Chemical Systems)"],["dc.rights","CC BY 3.0"],["dc.title","Identification of the dominant photochemical pathways and mechanistic insights to the ultrafast ligand exchange of Fe(CO)(5) to Fe(CO)(4)EtOH"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]