Nietert, Manuel Manfred

[["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Ruehlmann, Felix"],["dc.contributor.author","Nietert, Manuel M."],["dc.contributor.author","Sprenger, Thilo"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Homayounfar, Kia"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Liersch, Torsten"],["dc.contributor.author","Conradi, Lena-Christin"],["dc.date.accessioned","2018-11-07T09:34:12Z"],["dc.date.available","2018-11-07T09:34:12Z"],["dc.date.issued","2014"],["dc.identifier.isi","000343816900255"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32127"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.title","SRC expression in locally advanced rectal cancer-before and after neoadjuvant chemoradiotherapy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Conradi, Lena-Christin"],["dc.contributor.author","Quack, H."],["dc.contributor.author","Sprenger, Thilo"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Binder, L."],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Homayounfar, Kia"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Lorenzen, Stephan"],["dc.contributor.author","Nietert, Manuel M."],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Liersch, Torsten"],["dc.date.accessioned","2018-11-07T09:19:02Z"],["dc.date.available","2018-11-07T09:19:02Z"],["dc.date.issued","2013"],["dc.format.extent","73"],["dc.identifier.isi","000326360900167"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28546"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","1423-0240"],["dc.relation.issn","0378-584X"],["dc.title","5-FU dose monitoring under neoadjuvant radiochemotherapy and adjuvant chemotherapy for locally advanced rectal cancer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Islam, Shariful"],["dc.contributor.author","Nietert, Manuel Manfred"],["dc.contributor.author","Haberl, Michael"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Beißbarth, Tim"],["dc.date.accessioned","2020-03-27T12:32:56Z"],["dc.date.available","2020-03-27T12:32:56Z"],["dc.date.issued","2015"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63385"],["dc.notes.preprint","yes"],["dc.relation.conference","Computational Models in Biology and Medicine"],["dc.relation.eventlocation","Leipzig"],["dc.relation.eventstart","2015-09"],["dc.relation.iserratumof","yes"],["dc.title","Automated characterization of cell tracks and classification by using their position coordinates and velocity components"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Cancer"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Kirchner, Benjamin"],["dc.contributor.author","Nietert, Manuel"],["dc.contributor.author","Peeck, Micha"],["dc.contributor.author","Balkenhol, Marko"],["dc.contributor.author","Egert, Daniela"],["dc.contributor.author","Rohde, T. Veit"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Pukrop, Tobias"],["dc.date.accessioned","2021-04-14T08:31:20Z"],["dc.date.available","2021-04-14T08:31:20Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1186/s12885-020-07459-z"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83564"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1471-2407"],["dc.title","Impact of pre-OP independence in patients with limited brain metastases on long-term survival"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","522"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","American Journal of Surgical Pathology"],["dc.bibliographiccitation.lastpage","531"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Conradi, Lena-Christin"],["dc.contributor.author","Styczen, Hanna"],["dc.contributor.author","Sprenger, Thilo"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Roedel, Claus"],["dc.contributor.author","Nietert, Manuel M."],["dc.contributor.author","Homayounfar, Kia"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Kitz, Julia"],["dc.contributor.author","Talaulicar, Recca"],["dc.contributor.author","Becker, Heinz"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Middel, Peter"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Rüschoff, Josef R."],["dc.contributor.author","Liersch, Torsten"],["dc.date.accessioned","2018-11-07T09:26:46Z"],["dc.date.available","2018-11-07T09:26:46Z"],["dc.date.issued","2013"],["dc.description.abstract","In patients with advanced rectal cancer (cUICC II and III) multimodality therapy resulted in better long-term local tumor control. Ongoing clinical trials are focusing on therapy intensification to improve disease-free (DFS) and cancer-specific survival (CSS), the integration of biomarkers for prediction of individual recurrence risk, and the identification of new targets. In this context, we investigated HER-2, a member of the epidermal growth factor receptor family, whose expression pattern and role was unclear in rectal cancer. A total of 264 patients (192 male, 72 female; median age 64 y) received standardized multidisciplinary treatment according to protocols of phase II/III trials of the German Rectal Cancer Study Group. HER-2 status was determined in pretherapeutic biopsies and resection specimens using immunohistochemistry scoring and detection of silver in situ hybridization amplification. Tumors with an immunohistochemistry score of 3(+) or silver in situ hybridization ratios of >= 2.0 were classified HER-2 positive; these results were correlated with clinicopathologic parameters [eg, resection (R) status, nodal status ((y)pN)], DFS, and CSS. Positive HER-2 status was found in 12.4% of biopsies and in 26.7% of resected specimens. With a median follow-up of 46.5 months, patients with HER-2 positivity showed in trend a better DFS (P = 0.1) and a benefit in CSS (P = 0.03). The 5-year survival rate was 96.0% (HER-2 positive) versus 80.0% (HER-2 negative). In univariate and multivariate analyses, HER-2 was an independent predictor for CSS (0.02) along with the (y)pN status (P < 0.00001) and R status (P = 0.011). HER-2 amplification is detectable in a relevant proportion (26.7%) of rectal cancer patients. For the development of innovative new therapies, HER-2 may represent a promising target and should be further assessed within prospective clinical trials."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [KFO 179-2]"],["dc.identifier.doi","10.1097/PAS.0b013e318272ff4d"],["dc.identifier.isi","000316184000006"],["dc.identifier.pmid","23282976"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1532-0979"],["dc.relation.issn","0147-5185"],["dc.title","Frequency of HER-2 Positivity in Rectal Cancer and Prognosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Quack, H."],["dc.contributor.author","Stanek, K."],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Dröge, Leif Hendrik"],["dc.contributor.author","Binder, L."],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Nietert, Manuel M."],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Lorenzen, Stephan"],["dc.contributor.author","Liersch, Torsten"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Conradi, Lena-Christin"],["dc.date.accessioned","2018-11-07T09:34:11Z"],["dc.date.available","2018-11-07T09:34:11Z"],["dc.date.issued","2014"],["dc.format.extent","83"],["dc.identifier.isi","000343816900196"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32125"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Effects of 5-FU dose monitoring under neoadjuvant radiochemotherapy for locally advanced rectal cancer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","13"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Oncogene"],["dc.bibliographiccitation.lastpage","23"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Linke, F."],["dc.contributor.author","Zaunig, S."],["dc.contributor.author","Nietert, M. M."],["dc.contributor.author","Bonin, F. von"],["dc.contributor.author","Lutz, S."],["dc.contributor.author","Dullin, C."],["dc.contributor.author","Janovská, P."],["dc.contributor.author","Beissbarth, T."],["dc.contributor.author","Alves, F."],["dc.contributor.author","Klapper, W."],["dc.contributor.author","Bryja, V."],["dc.contributor.author","Pukrop, T."],["dc.contributor.author","Trümper, L."],["dc.contributor.author","Wilting, J."],["dc.contributor.author","Kube, D."],["dc.date.accessioned","2018-10-19T06:32:50Z"],["dc.date.available","2018-10-19T06:32:50Z"],["dc.date.issued","2017"],["dc.description.abstract","Classical Hodgkin lymphoma (cHL) has a typical clinical manifestation, with dissemination involving functionally neighboring lymph nodes. The factors involved in the spread of lymphoma cells are poorly understood. Here we show that cHL cell lines migrate with higher rates compared with non-Hodgkin lymphoma cell lines. cHL cell migration, invasion and adhesion depend on autocrine WNT signaling as revealed by the inhibition of WNT secretion with the porcupine inhibitors Wnt-C59/IWP-2, but did not affect cell proliferation. While application of recombinant WNT5A or WNT5A overexpression stimulates HL cell migration, neither WNT10A, WNT10B nor WNT16 did so. Time-lapse studies revealed an amoeboid type of cell migration modulated by WNT5A. Reduced migration distances and velocity of cHL cells, as well as altered movement patterns, were observed using porcupine inhibitor or WNT5A antagonist. Knockdown of Frizzled5 and Dishevelled3 disrupted the WNT5A-mediated RHOA activation and cell migration. Overexpression of DVL3-K435M or inhibition of ROCK (Rho-associated protein kinase) by Y-27632/H1152P disrupted cHL cell migration. In addition to these mechanistic insights into the role of WNT5A in vitro, global gene expression data revealed an increased WNT5A expression in primary HL cells in comparison with normal B-cell subsets and other lymphomas. Furthermore, the activity of both porcupine and WNT5A in cHL cells had an impact on lymphoma development in the chick chorionallantoic membrane assay. Massive bleeding of these lymphomas was significantly reduced after inhibition of WNT secretion by Wnt-C59. Therefore, a model is proposed where WNT signaling has an important role in regulating tumor-promoting processes."],["dc.fs.pkfprnr","66887"],["dc.identifier.doi","10.1038/onc.2016.183"],["dc.identifier.fs","626468"],["dc.identifier.pmid","27270428"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16088"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1476-5594"],["dc.title","WNT5A: a motility-promoting factor in Hodgkin lymphoma"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Knopp, Cornelius"],["dc.contributor.author","Bauer, Christian R. K. D."],["dc.contributor.author","Baum, Benjamin"],["dc.contributor.author","Löhnhardt, Benjamin"],["dc.contributor.author","Nietert, Manuel Manfred"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Sax, Ulrich"],["dc.date.accessioned","2020-03-27T11:22:14Z"],["dc.date.available","2020-03-27T11:22:14Z"],["dc.date.issued","2016"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63384"],["dc.notes.preprint","yes"],["dc.relation.conference","Conference: HEC 2016 - Health-Exploring Complexity: An Interdisciplinairy Systems Approach"],["dc.relation.eventlocation","München"],["dc.relation.eventstart","2016-08"],["dc.relation.iserratumof","yes"],["dc.title","A validatable data management solution for multi-center research consortia: research data management with openBIS"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","04"],["dc.bibliographiccitation.journal","Zentralblatt für Chirurgie"],["dc.bibliographiccitation.lastpage","366"],["dc.bibliographiccitation.volume","143"],["dc.contributor.author","Jo, Peter"],["dc.contributor.author","Kesruek, Hatice"],["dc.contributor.author","Nietert, Manuel"],["dc.contributor.author","Sahlmann, Carsten"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Sperling, Jens"],["dc.date.accessioned","2020-12-10T18:12:02Z"],["dc.date.available","2020-12-10T18:12:02Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1055/a-0651-0878"],["dc.identifier.eissn","1438-9592"],["dc.identifier.issn","0044-409X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74230"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Inzidenz und prädiktive Faktoren des bilateralen papillären Schilddrüsenkarzinoms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1932"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","ChemBioChem"],["dc.bibliographiccitation.lastpage","1936"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Tanrikulu, Yusuf"],["dc.contributor.author","Nietert, Manuel"],["dc.contributor.author","Scheffer, Ute"],["dc.contributor.author","Proschak, Ewgenij"],["dc.contributor.author","Grabowski, Kristina"],["dc.contributor.author","Schneider, Petra"],["dc.contributor.author","Weidlich, Markus"],["dc.contributor.author","Karas, Michael"],["dc.contributor.author","Göbel, Michael"],["dc.contributor.author","Schneider, Gisbert"],["dc.date.accessioned","2022-06-08T07:59:56Z"],["dc.date.available","2022-06-08T07:59:56Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1002/cbic.200700195"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110912"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1439-7633"],["dc.relation.issn","1439-4227"],["dc.title","Scaffold Hopping by “Fuzzy” Pharmacophores and its Application to RNA Targets"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]