Dressel, Ralf

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[["dc.bibliographiccitation.firstpage","253"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Tissue Antigens"],["dc.bibliographiccitation.lastpage","254"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Figueiredo, Constanca"],["dc.contributor.author","Lukis, S."],["dc.contributor.author","Seltsam, Axel"],["dc.contributor.author","Wittmann, M."],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Blasczyk, Rainer"],["dc.contributor.author","Eiz-Vesper, Britta"],["dc.date.accessioned","2018-11-07T11:11:56Z"],["dc.date.available","2018-11-07T11:11:56Z"],["dc.date.issued","2008"],["dc.identifier.isi","000258444500065"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53546"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.conference","15th International Histocompatibility and Immunogenetics Workshop and Conference"],["dc.relation.eventlocation","Rio de Janeiro, BRAZIL"],["dc.relation.issn","0001-2815"],["dc.title","Heat shock protein 70 (HSP70) induces cytotoxicity and KIR expression in T helper cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","120"],["dc.bibliographiccitation.journal","Wiener klinische Wochenschrift"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Wang, D."],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Blasczyk, Rainer"],["dc.contributor.author","Werfel, T."],["dc.contributor.author","Eiz-Vesoeer, B."],["dc.contributor.author","Wittmann, M."],["dc.date.accessioned","2018-11-07T11:12:50Z"],["dc.date.available","2018-11-07T11:12:50Z"],["dc.date.issued","2008"],["dc.identifier.isi","000259367100393"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53753"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0043-5325"],["dc.title","Eukaryotically expressed, endotoxin-free recombinant human HSP70 enhances uptake of antigenic peptides in macrophages and primary human epithelial cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Tissue Antigens"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Eiz-Vesper, Britta"],["dc.contributor.author","DeLuca, D."],["dc.contributor.author","Wittmann, M."],["dc.contributor.author","Bade-Doeding, C."],["dc.contributor.author","Paine, A."],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Blasczyk, Rainer"],["dc.date.accessioned","2018-11-07T11:03:04Z"],["dc.date.available","2018-11-07T11:03:04Z"],["dc.date.issued","2007"],["dc.format.extent","381"],["dc.identifier.isi","000245985000023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51534"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","21st European Immunogenetics and Histocompatibility Conference"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","0001-2815"],["dc.title","Definition of the peptide binding repertoire of solubly expressed HSP70"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Human Immunology"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Figueiredo, Constanca"],["dc.contributor.author","Wittmann, Miriam"],["dc.contributor.author","Ralf, Dressel"],["dc.contributor.author","Blasczyk, Rainer"],["dc.contributor.author","Britta, Eiz-Vesper"],["dc.date.accessioned","2018-11-07T11:20:03Z"],["dc.date.available","2018-11-07T11:20:03Z"],["dc.date.issued","2008"],["dc.format.extent","S113"],["dc.identifier.doi","10.1016/j.humimm.2008.08.236"],["dc.identifier.isi","000260373800218"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55439"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","34th Annual Meeting of the American-Society-for-Histocompatibility-and-Immunogenetics"],["dc.relation.eventlocation","Toronto, CANADA"],["dc.relation.issn","0198-8859"],["dc.title","HEAT SHOCK PROTEIN 70 (HSP70) INDUCES CYTOTOXICITY OF T-HELPER CELLS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3008"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.lastpage","3016"],["dc.bibliographiccitation.volume","113"],["dc.contributor.author","Figueiredo, Constanca"],["dc.contributor.author","Wittmann, Miriam"],["dc.contributor.author","Wang, D."],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Seltsam, Axel"],["dc.contributor.author","Blasczyk, Rainer"],["dc.contributor.author","Eiz-Vesper, Britta"],["dc.date.accessioned","2018-11-07T08:31:35Z"],["dc.date.available","2018-11-07T08:31:35Z"],["dc.date.issued","2009"],["dc.description.abstract","Heat shock protein 70 (HSP70) has gained plenty of attention because of its adjuvant capability to induce CD8(+) cytotoxic T lymphocyte and CD4(+) T-helper cell responses. We investigated the behavior of T-cell subsets stimulated with endotoxin-free HSP70 with respect to proliferation, cytokine expression, cytotoxicity against allogeneic B-lymphoblastoid cell line and K562 cells, as well as target-independent cytotoxicity. CD4(+) cells exhibited a strong increase in proliferation after stimulation with HSP70 (29%). In the presence of targets, a 35-fold up-regulation of granzyme B was observed after stimulation of CD4(+) T cells with HSP70 in combination with interleukin-7 (IL-7)/IL-12/IL-15. The target cell-independent secretion of granzyme B by CD4(+) cells was greatly augmented after stimulation with HSP70 plus IL-2 or IL-7/IL-12/IL-15. In this study, we showed that HSP70 is capable of inducing a cytotoxic response of T-helper cells in the absence of lipopolysaccharide. The granzyme B secretion and cytolytic activity of T-helper cells are induced in a target-independent way, whereas the cytotoxic activity of CD3(+) and CD8(+) T cells can be further enhanced in the presence of target cells. Our data provide novel insights into the role of extracellular HSP70 on T-cell immune response concerning the induction of target-independent T-helper cell cytotoxicity. (Blood. 2009; 113: 3008-3016)"],["dc.identifier.doi","10.1182/blood-2008-06-162727"],["dc.identifier.isi","000264559000019"],["dc.identifier.pmid","19018093"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17153"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Hematology"],["dc.relation.issn","0006-4971"],["dc.title","Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Experimental Hematology"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Eiz-Vesper, Britta"],["dc.contributor.author","Lukis, S."],["dc.contributor.author","Figueiredo, Constanca"],["dc.contributor.author","Paine, A."],["dc.contributor.author","Wittmann, M."],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Horn, P. A."],["dc.contributor.author","Blasczyk, Rainer"],["dc.date.accessioned","2018-11-07T10:58:58Z"],["dc.date.available","2018-11-07T10:58:58Z"],["dc.date.issued","2007"],["dc.format.extent","86"],["dc.identifier.isi","000249535200238"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50590"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","36th Annual Meeting of the International-Society-for-Experimental-Hematology"],["dc.relation.eventlocation","Hamburg, GERMANY"],["dc.relation.issn","0301-472X"],["dc.title","Soluble expression of recombinant signal-peptide fused HSP70 for generating tumorantigen-specific CD8+T cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Molecular Medicine"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Eiz-Vesper, Britta"],["dc.contributor.author","Figueiredo, Constanca"],["dc.contributor.author","Wachstein, Julian"],["dc.contributor.author","Bajor, Anna"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Wittmann, Miriam"],["dc.contributor.author","Blasczyk, Rainer"],["dc.date.accessioned","2018-11-07T08:34:41Z"],["dc.date.available","2018-11-07T08:34:41Z"],["dc.date.issued","2009"],["dc.format.extent","S47"],["dc.identifier.isi","000270497500172"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17875"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Spandidos Publ Ltd"],["dc.publisher.place","Athens"],["dc.relation.issn","1107-3756"],["dc.title","Heat Shock Protein 70 induces cytotoxicity of T-helper cells and augmented the immunosuppressive capacity of FoxP3(+) T regulatory cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]