Herrmann‐Lingen, Christoph

[["dc.bibliographiccitation.artnumber","14"],["dc.bibliographiccitation.journal","BMC Family Practice"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Koschack, Janka"],["dc.contributor.author","Scherer, Martin"],["dc.contributor.author","Luers, Claus"],["dc.contributor.author","Kochen, Michael M."],["dc.contributor.author","Wetzel, Dirk"],["dc.contributor.author","Kleta, Sibylle"],["dc.contributor.author","Pouwels, Claudia"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Pieske, Burkert M."],["dc.contributor.author","Binder, Lutz"],["dc.date.accessioned","2018-11-07T11:18:13Z"],["dc.date.available","2018-11-07T11:18:13Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Screening of primary care patients at risk for left ventricular systolic dysfunction by a simple blood-test might reduce referral rates for echocardiography. Whether or not natriuretic peptide testing is a useful and cost-effective diagnostic instrument in primary care settings, however, is still a matter of debate. Methods: N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, clinical information, and echocardiographic data of left ventricular systolic function were collected in 542 family practice patients with at least one cardiovascular risk factor. We determined the diagnostic power of the NT-proBNP assessment in ruling out left ventricular systolic dysfunction and compared it to a risk score derived from a logistic regression model of easily acquired clinical information. Results: 23 of 542 patients showed left ventricular systolic dysfunction. Both NT-proBNP and the clinical risk score consisting of dyspnea at exertion and ankle swelling, coronary artery disease and diuretic treatment showed excellent diagnostic power for ruling out left ventricular systolic dysfunction. AUC of NT-proBNP was 0.83 (95% CI, 0.75 to 0.92) with a sensitivity of 0.91 (95% CI, 0.71 to 0.98) and a specificity of 0.46 (95% CI, 0.41 to 0.50). AUC of the clinical risk score was 0.85 (95% CI, 0.79 to 0.91) with a sensitivity of 0.91 (95% CI, 0.71 to 0.98) and a specificity of 0.64 (95% CI, 0.59 to 0.67). 148 misclassifications using NT-proBNP and 55 using the clinical risk score revealed a significant difference (McNemar test; p < 0.001) that was based on the higher specificity of the clinical risk score. Conclusion: The evaluation of clinical information is at least as effective as NT-proBNP testing in ruling out left ventricular systolic dysfunction in family practice patients at risk. If these results are confirmed in larger cohorts and in different samples, family physicians should be encouraged to rely on the diagnostic power of the clinical information from their patients."],["dc.identifier.doi","10.1186/1471-2296-9-14"],["dc.identifier.isi","000254051900001"],["dc.identifier.pmid","18298821"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8928"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54989"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1471-2296"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Natriuretic peptide vs. clinical information for diagnosis of left ventricular systolic dysfunction in primary care"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","13"],["dc.bibliographiccitation.journal","BMC Musculoskeletal Disorders"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Blozik, Eva"],["dc.contributor.author","Laptinskaya, Daria"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Schaefer, Helene"],["dc.contributor.author","Kochen, Michael M."],["dc.contributor.author","Himmel, Wolfgang"],["dc.contributor.author","Scherer, Martin"],["dc.date.accessioned","2018-11-07T08:33:26Z"],["dc.date.available","2018-11-07T08:33:26Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Although psychosocial factors are known to be highly linked with neck pain, current therapies focus on somatically based interventions such as medicinal or manipulatory therapies. This study examines how socio-demographic, psychosocial and medical history and health-promoting lifestyle factors interact with neck pain in general practice patients. Methods: This is a cross-sectional survey including 448 patients from a general practice setting in Germany. Participants completed a comprehensive questionnaire including the Neck Pain and Disability Scale German version (NPAD-d) and the Hospital Anxiety and Depression Scale. Crude and adjusted regression analyses were done to assess the relationship between neck pain and socio-demographic, psychosocial and medical history and health-promoting lifestyle factors. Results: Both in crude and adjusted regression analyses, depression and anxiety were highly significantly linked with increasing levels of neck pain. Educational level, deficits in social support and physical exercise were associated with neck pain in bivariate analyses, but these associations did not persist with adjustment for depression and anxiety. When investigating levels of depression and anxiety by NPAD-d quartile subgroups, those who were identified to have depressive mood or to be anxious were very likely to be in the group with the highest levels of neck pain. Conclusion: The higher the neck pain level, the more attention should be paid to psychosocial distress as a related burden. Further research is needed to elucidate the causality and the direction of the association between psychosocial distress and neck pain and to determine the benefit of psychosocial interventions."],["dc.description.sponsorship","German Ministry of Education and Research (BMBF) [01 GK 0516]; BMBF"],["dc.identifier.doi","10.1186/1471-2474-10-13"],["dc.identifier.isi","000263230600001"],["dc.identifier.pmid","19171034"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17577"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1471-2474"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY 2.0"],["dc.title","Depression and anxiety as major determinants of neck pain: a cross-sectional study in general practice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","Doc09"],["dc.bibliographiccitation.journal","German medical science : GMS e-journal"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Ladwig, Karl-Heinz"],["dc.contributor.author","Lederbogen, Florian"],["dc.contributor.author","Albus, Christian"],["dc.contributor.author","Angermann, Christiane"],["dc.contributor.author","Borggrefe, Martin"],["dc.contributor.author","Fischer, Denise"],["dc.contributor.author","Fritzsche, Kurt"],["dc.contributor.author","Haass, Markus"],["dc.contributor.author","Jordan, Jochen"],["dc.contributor.author","Jünger, Jana"],["dc.contributor.author","Kindermann, Ingrid"],["dc.contributor.author","Köllner, Volker"],["dc.contributor.author","Kuhn, Bernhard"],["dc.contributor.author","Scherer, Martin"],["dc.contributor.author","Seyfarth, Melchior"],["dc.contributor.author","Völler, Heinz"],["dc.contributor.author","Waller, Christiane"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.date.accessioned","2019-07-09T11:41:21Z"],["dc.date.available","2019-07-09T11:41:21Z"],["dc.date.issued","2014"],["dc.description.abstract","BACKGROUND: The rapid progress of psychosomatic research in cardiology and also the increasing impact of psychosocial issues in the clinical daily routine have prompted the Clinical Commission of the German Heart Society (DGK) to agree to an update of the first state of the art paper on this issue which was originally released in 2008. METHODS: The circle of experts was increased, general aspects were implemented and the state of the art was updated. Particular emphasis was dedicated to coronary heart diseases (CHD), heart rhythm diseases and heart failure because to date the evidence-based clinical knowledge is most advanced in these particular areas. Differences between men and women and over the life span were considered in the recommendations as were influences of cognitive capability and the interactive and synergistic impact of classical somatic risk factors on the affective comorbidity in heart disease patients. RESULTS: A IA recommendation (recommendation grade I and evidence grade A) was given for the need to consider psychosocial risk factors in the estimation of coronary risks as etiological and prognostic risk factors. Furthermore, for the recommendation to routinely integrate psychosocial patient management into the care of heart surgery patients because in these patients, comorbid affective disorders (e.g. depression, anxiety and post-traumatic stress disorder) are highly prevalent and often have a malignant prognosis. A IB recommendation was given for the treatment of psychosocial risk factors aiming to prevent the onset of CHD, particularly if the psychosocial risk factor is harmful in itself (e.g. depression) or constrains the treatment of the somatic risk factors. Patients with acute and chronic CHD should be offered anti-depressive medication if these patients suffer from medium to severe states of depression and in this case medication with selective reuptake inhibitors should be given. In the long-term course of treatment with implanted cardioverter defibrillators (ICDs) a subjective health technology assessment is warranted. In particular, the likelihood of affective comorbidities and the onset of psychological crises should be carefully considered. CONCLUSIONS: The present state of the art paper presents an update of current empirical evidence in psychocardiology. The paper provides evidence-based recommendations for the integration of psychosocial factors into cardiological practice and highlights areas of high priority. The evidence for estimating the efficiency for psychotherapeutic and psychopharmacological interventions has increased substantially since the first release of the policy document but is, however, still weak. There remains an urgent need to establish curricula for physician competence in psychodiagnosis, communication and referral to ensure that current psychocardiac knowledge is translated into the daily routine."],["dc.description.abstract","Hintergrund: Die rasche Weiterentwicklung der psychokardiologischen Forschung, aber auch die wachsende Verankerung psychosozialer Fragestellungen im klinischen Alltag haben die Klinische Kommission der DGK bewogen, einer Aktualisierung und Weiterentwicklung des 2008 erstmals publizierten Positionspapiers zur Bedeutung psychosozialer Faktoren in der Kardiologie zuzustimmen. Methoden: Der Kreis der Autoren wurde vergrößert, allgemeine Aspekte eingefügt und das Wissen in allen Abschnitten auf den heutigen Stand gebracht. Schwerpunkte der Empfehlungen sind die koronare Herzerkrankung, Herzrhythmusstörungen und die Herzinsuffizienz, da hier der Stand der empirischen Evidenz und des klinisches Wissens zu psychosozialen Fragestellungen am weitesten entwickelt ist. Berücksichtigt wurden bei den Empfehlungen Besonderheiten von Frauen und Männern, Unterschiede bzgl. der Lebensspanne, Einflüsse auf die kognitive Leistungsfähigkeit und die interaktive synergistische Bedeutung klassischer Risikofaktoren bei affektiver Komorbidität. Ergebnisse: Eine I-A-Empfehlung (Empfehlungsgrad I, Evidenzgrad A) wurde vergeben für die Aufforderung, psychosoziale Risikofaktoren bei der Einschätzung des KHK-Risikos zu berücksichtigen, die als unabhängige ätiologische und prognostische Risikofaktoren für das Auftreten der koronaren Herzerkrankung (KHK) und für Komplikationen im Behandlungsverlauf der KHK bedeutsam sind. Ferner für die Empfehlung, Patienten mit Herzoperationen von einem interdisziplinären Team zu betreuten, in dem die Möglichkeit besteht, auf psychosoziale Aspekte einzugehen, da bei diesen Patienten komorbide psychische Störungen wie Depressivität, Angst und posttraumatische Belastungsstörung häufig und prognostisch ungünstig sind. Eine I-B-Empfehlung wurde vergeben für die Behandlung psychosozialer Risikofaktoren mit dem Ziel einer Primärprävention der KHK, wenn das Risikomerkmal an sich Krankheitswert hat (z. B. Depression) oder die Behandlung klassischer Risikofaktoren erschwert ist. Eine antidepressive Pharmakotherapie soll Patienten nach akutem Koronarsyndrom sowie in der Phase der chronischen KHK angeboten werden, die an einer mindestens mittelschweren rezidivierenden depressiven Störung leiden. Dabei sollen vorzugsweise Substanzen aus der Gruppe der selektiven Serotoninwiederaufnahmehemmer (SSRI) zum Einsatz kommen. Bei der langfristigen ärztlichen Begleitung von ICD-Patienten sollen die psychosozialen Folgen der ICD-Technologie beachtet und insbesondere relevante Affektstörungen sowie Krisen bei ICD-Patienten erkannt und fachgerecht behandelt werden. Schlussfolgerungen: Das Positionspapier formuliert konkrete Anwendungsfelder mit hoher Priorität für die Einbeziehung psychosozialer Faktoren in die kardiologische Praxis, die eine leitlinienkonforme Evidenz aufweisen. Trotz deutlicher Fortschritte seit der Erstveröffentlichung des Positionspapiers existieren weiterhin Forschungsdefizite für die Bewertung der Wirksamkeit psychotherapeutischer und psychopharmakologischer Konzepte bei kardialen Patienten. Curricula für die Vermittlung von (psycho-)diagnostischer, kommunikativer und differenzialdiagnostischer Kompetenz müssen rasch entwickelt werden, um eine Transmission des aktuellen Wissensstands in die Alltagspraxis zu ermöglichen."],["dc.identifier.doi","10.3205/000194"],["dc.identifier.fs","610882"],["dc.identifier.pmid","24808816"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11990"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58411"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1612-3174"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.subject.mesh","Cardiology"],["dc.subject.mesh","Cardiovascular Diseases"],["dc.subject.mesh","Germany"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Mental Disorders"],["dc.subject.mesh","Practice Guidelines as Topic"],["dc.subject.mesh","Psychology"],["dc.subject.mesh","Psychotherapy"],["dc.title","Position paper on the importance of psychosocial factors in cardiology: Update 2013."],["dc.title.translated","Positionspapier zur Bedeutung psychosozialer Faktoren in der Kardiologie: Update 2013"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","922"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","European Spine Journal"],["dc.bibliographiccitation.lastpage","929"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Scherer, Martin"],["dc.contributor.author","Blozik, Eva"],["dc.contributor.author","Himmel, Wolfgang"],["dc.contributor.author","Laptinskaya, Daria"],["dc.contributor.author","Kochen, Michael M."],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.date.accessioned","2018-11-07T11:13:24Z"],["dc.date.available","2018-11-07T11:13:24Z"],["dc.date.issued","2008"],["dc.description.abstract","The aim of this study is to evaluate the validity and the psychometric properties of a German version of the 20-item neck pain and disability scale (NPAD) for use in primary care settings. Four hundred and forty-eight participants from 15 general practices in the area of Gottingen Germany completed a multidimensional questionnaire including a newly developed German version of the NPAD (NPAD-d) and self-reported demographic and clinical information. Reliability was tested using Cronbach's alpha. Item-to-total score correlations were analysed. Factor structure was explored by using unrestricted principal factor analysis. Construct validity of the NPAD-d was evaluated by simple correlation analyses (Pearson's rho) with social and clinical characteristics. The discriminative abilities of the NPAD-d were examined by comparing differences between subgroups stratified on non-NPAD-d pain related characteristics using t tests for mean scores. Cronbach's alpha of NPAD-d was 0.94. Item-to-total scale correlations ranged between 0.414 and 0.829. Exploratory principal factor analysis indicated that the NPAD-d covers one factor with an explained variance of 48%. Correlation analysis showed high correlations with criterion variables. The NAPD-d scores of subgroups of patients were significantly different showing good discriminative validity of the scale. The NPAD-d demonstrated good validity and reliability in this general practice setting. The NPAD-d may be useful in the clinical assessment process and the management of neck pain."],["dc.identifier.doi","10.1007/s00586-008-0677-y"],["dc.identifier.isi","000257392100003"],["dc.identifier.pmid","18437433"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3096"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53886"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0940-6719"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Psychometric properties of a German version of the neck pain and disability scale"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","71"],["dc.bibliographiccitation.journal","BMC Family Practice"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Eisele, Marion"],["dc.contributor.author","Rakebrandt, Anja"],["dc.contributor.author","Boczor, Sigrid"],["dc.contributor.author","Kazek, Agata"],["dc.contributor.author","Pohontsch, Nadine"],["dc.contributor.author","Okolo-Kulak, Magdalena"],["dc.contributor.author","Blozik, Eva"],["dc.contributor.author","Traeder, Jens-Martin"],["dc.contributor.author","Stoerk, Stefan"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Scherer, Martin"],["dc.date.accessioned","2018-11-07T10:22:44Z"],["dc.date.available","2018-11-07T10:22:44Z"],["dc.date.issued","2017"],["dc.description.abstract","Background: Depression is more prevalent in patients with heart failure (HF) than in those without, but its detection is complicated by the symptom overlap between the two diseases. General practitioners (GPs) are the first point of contact for patients with HF. Therefore, this study aims to investigate GPs' awareness of depression in their HF patients and factors associated with this awareness. Methods: In this cross-sectional, observational study 3224 primary care patients with HF were screened for depressive symptomatology using an algorithm based on the Hospital Anxiety and Depression Scale, the 9-item subscale on Depression of the Patient Health Questionnaire, and selected items from the PROMIS Depression and Anxiety scales. The 272 GPs of all patients involved in the study were interviewed by telephone regarding their patients' somatic and psychological comorbidities. The awareness rates of depressive symptomatology by the patients' GPs are analyzed using descriptive statistics. Logistic regression analyses are applied to investigate the patient-and GP-based factors associated with the GPs' awareness of depressive symptomatology. Results: GPs were aware of their patients' depressive symptomatology in 35% of all cases. Factors associated with the awareness of depressive symptomatology were: higher patient education levels, a history of depression known to the GP, GP-consultations due to emotional distress within the last 6 months, a higher frequency of GP-contacts within the last 6 months, a higher New York Heart Association (NYHA) classification and more severe depressive symptomatology. The GPs' characteristics, including further education in psychology/psychiatry, were not associated with GP awareness. Conclusions: Many aspects, including the definition of awareness and the practical issues in primary care, may contribute to the unexpectedly low awareness rates of depressive symptomatology in HF patients in primary care. Awareness rates might increase, if GPs encouraged their patients to talk about emotional distress, held detailed medical interviews including a patient's history of depression and payed special attention to HF patients with low education levels. However, it remains to be investigated whether GPs' judgement of depressive symptomatology is a better or worse indicator for the future prognosis and quality of life of HF patients than psychiatry based diagnostic criteria."],["dc.description.sponsorship","German Federal Ministry of Education and Research [01GY1150, 01EO1004]"],["dc.identifier.doi","10.1186/s12875-017-0641-1"],["dc.identifier.isi","000403401700001"],["dc.identifier.pmid","28599626"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14505"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42330"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2296"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Factors associated with general practitioners' awareness of depression in primary care patients with heart failure: baseline-results from the observational RECODE-HF study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","248"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychosomatics"],["dc.bibliographiccitation.lastpage","256"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Meyer, Thomas"],["dc.contributor.author","Stanske, Beate"],["dc.contributor.author","Kochen, Michael M."],["dc.contributor.author","Cordes, Andreas"],["dc.contributor.author","Yüksel, Iraz"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Lüers, Claus"],["dc.contributor.author","Scherer, Martin"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Pieske, Burkert"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.date.accessioned","2019-07-09T11:52:56Z"],["dc.date.available","2019-07-09T11:52:56Z"],["dc.date.issued","2010"],["dc.description.abstract","BACKGROUND: Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines. OBJECTIVE: The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors. METHOD: The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N=178) who were assigned to the highest and lowest quartiles of the MQ, respectively. RESULTS: We found that elevated serum concentrations of IL-6, TNFα, and IL-10, but not IL-1β or natriuretic peptides were associated with high MQ scores indicative of vital exhaustion. Using logistic regression analyses controlling for clinical variables and Type D personality, both TNFα (multivariate odds ratio [OR] =1.86; 95%-confidence interval [CI] =1.30-2.68; p=0.001) and IL-10(OR=1.62; 95%-CI=1.15-2.28; p=0.006), but not other cytokines significantly predicted vital exhaustion independently of other clinical and laboratory parameters examined [corrected]. CONCLUSION: The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and anti-inflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion."],["dc.identifier.doi","10.1176/appi.psy.51.3.248"],["dc.identifier.fs","573439"],["dc.identifier.pmid","20484723"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60303"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1545-7206"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Austria"],["dc.subject.mesh","Cardiovascular Diseases"],["dc.subject.mesh","Cohort Studies"],["dc.subject.mesh","Coronary Disease"],["dc.subject.mesh","Fatigue"],["dc.subject.mesh","Female"],["dc.subject.mesh","Heart Failure"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Interleukin-10"],["dc.subject.mesh","Interleukin-6"],["dc.subject.mesh","Irritable Mood"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Morale"],["dc.subject.mesh","Personality Inventory"],["dc.subject.mesh","Primary Health Care"],["dc.subject.mesh","Psychometrics"],["dc.subject.mesh","Risk Factors"],["dc.subject.mesh","Tumor Necrosis Factor-alpha"],["dc.title","Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","180"],["dc.bibliographiccitation.journal","BMC Family Practice"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Eisele, Marion"],["dc.contributor.author","Blozik, Eva"],["dc.contributor.author","Stoerk, Stefan"],["dc.contributor.author","Traeder, Jens-Martin"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Scherer, Martin"],["dc.date.accessioned","2018-11-07T09:17:26Z"],["dc.date.available","2018-11-07T09:17:26Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: International disease management guidelines recommend the regular assessment of depression and anxiety in heart failure patients. Currently there is little data on the effect of screening for depression and anxiety on the quality of life and the prognosis of heart failure (HF). We will investigate the association between the recognition of current depression/anxiety by the general practitioner (GP) and the quality of life and the patients' prognosis. Methods/Design: In this multicenter, prospective, observational study 3,950 patients with HF are recruited by general practices in Germany. The patients fill out questionnaires at baseline and 12-month follow-up. At baseline the GPs are interviewed regarding the somatic and psychological comorbidities of their patients. During the follow-up assessment, data on hospitalization and mortality are provided by the general practice. Based on baseline data, the patients are allocated into three observation groups: HF patients with depression and/or anxiety recognized by their GP (P+/+), those with depression and/or anxiety not recognized (P+/-) and patients without depression and/or anxiety (P-/-). We will perform multivariate regression models to investigate the influence of the recognition of depression and/or anxiety on quality of life at 12 month follow-up, as well as its influences on the prognosis (hospital admission, mortality). Discussion: We will display the frequency of GP-acknowledged depression and anxiety and the frequency of installed therapeutic strategies. We will also describe the frequency of depression and anxiety missed by the GP and the resulting treatment gap. Effects of correctly acknowledged and missed depression/anxiety on outcome, also in comparison to the outcome of subjects without depression/anxiety will be addressed. In case results suggest a treatment gap of depression/anxiety in patients with HF, the results of this study will provide methodological advice for the efficient planning of further interventional research."],["dc.description.sponsorship","German Federal Ministry of Education and Research [01GY1150]"],["dc.identifier.doi","10.1186/1471-2296-14-180"],["dc.identifier.isi","000328470200001"],["dc.identifier.pmid","24279590"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9554"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28170"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2296"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Recognition of depression and anxiety and their association with quality of life, hospitalization and mortality in primary care patients with heart failure - study protocol of a longitudinal observation study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","202"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Family Practice"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Boczor, Sigrid"],["dc.contributor.author","Eisele, Marion"],["dc.contributor.author","Rakebrandt, Anja"],["dc.contributor.author","Menzel, Agata"],["dc.contributor.author","Blozik, Eva"],["dc.contributor.author","Träder, Jens-Martin"],["dc.contributor.author","Störk, Stefan"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Scherer, Martin"],["dc.date.accessioned","2021-11-23T12:55:15Z"],["dc.date.accessioned","2022-08-18T12:33:40Z"],["dc.date.available","2021-11-23T12:55:15Z"],["dc.date.available","2022-08-18T12:33:40Z"],["dc.date.issued","2021-10-13"],["dc.date.updated","2022-07-29T12:00:21Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n The implementation of care concepts fitting the needs of patients with chronic heart failure (HF) remains challenging. In this context, psycho-emotional well-being is not routinely assessed, and under-researched despite indications that it is of great relevance for, e.g., acceptance, adherence, and prognosis. The aim of this study was to observe clinical characteristics for their prognostic utility in HF patients, and to compare the patients’ health-related quality of life (QoL) with German population norm values.\r\n \r\n \r\n Methods\r\n The current post-hoc analysis was performed on data collected amongst participants of the RECODE-HF study who had fully answered the EQ-5D-5L™ items at both baseline and 12 months (n = 2354). The status in the patients’ self-assessment items, EQ-5D visual analog scale (VAS) and EQ-5D index was categorized into worse/unchanged/improved. General linear mixed models (GLMM) with logit link were applied. Subgroups included 630 patients (26.8%) screened positive and 1724 patients (73.2%) screened negative for psychosocial distress (PSD).\r\n \r\n \r\n Results\r\n The 12-months change in EQ-5D index, generally resulting from change in individual EQ-5D items, additionally associated not only with high NYHA class but sociodemographics (employment/living alone/GP practice years) (96.2% correctly classified in GLMM). The 12- months change in individual QoL aspects showed associations with age*NYHA, gender, body-mass index, and comorbidities dyslipidemia, myocardial infarction, asthma/chronic pulmonary disease. Important social roles were reflected in particular when HF patients lived alone or the doctor mentioned to the patient that the patient had HF. Patients with/without PSD differed in some sociodemographic and clinical parameters. However, no influence of PSD could be demonstrated in the 12-month follow-up of the EQ-5D-5L™. Nonetheless, comparison of the 12-months QoL with general German population norm values by age groups < 75 years and 75+ showed markedly health restrictions in HF patients in all EQ-5D-5L™ aspects.\r\n \r\n \r\n Conclusion\r\n Our analysis revealed different prognostic factors primarily associated with change of burden in different QoL aspects in HF patients. In GP practice it is important to consider in addition to the overall day-related VAS all the individual health-related QoL aspects to take a holistic view of the patient, as well as to pay particular attention to the interrelation of individual characteristics."],["dc.identifier.citation","BMC Family Practice. 2021 Oct 13;22(1):202"],["dc.identifier.doi","10.1186/s12875-021-01554-1"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93453"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112921"],["dc.language.iso","en"],["dc.publisher","BioMed Central"],["dc.rights.holder","The Author(s)"],["dc.subject","Primary care"],["dc.subject","Heart failure"],["dc.subject","Quality of life"],["dc.subject","EQ-5D-5L"],["dc.title","Prognostic factors associated with quality of life in heart failure patients considering the use of the generic EQ-5D-5L™ in primary care: new follow-up results of the observational RECODE-HF study"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Behavioral Medicine"],["dc.bibliographiccitation.lastpage","80"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Pedersen, Susanne S."],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","de Jonge, Peter"],["dc.contributor.author","Scherer, Martin"],["dc.date.accessioned","2018-11-07T08:46:18Z"],["dc.date.available","2018-11-07T08:46:18Z"],["dc.date.issued","2010"],["dc.description.abstract","Quality of life is an important patient-centered outcome and predictor of mortality in heart failure, but little is known about the role of personality as a determinant of quality of life in this patient group. We examined the influence of Type D personality (i.e., increased negative emotions paired with emotional non-expression) on quality of life in primary care heart failure patients, using a prospective study design. Heart failure patients (n = 251) recruited from 44 primary care practices in Germany completed standardized questionnaires at baseline and 9 months. The prevalence of Type D was 31.9%. Type D patients experienced poorer emotional (P < .001) and physical quality of life (P = .01) at baseline and 9 months compared to non-Type D patients. There was no significant change in emotional (P = .78) nor physical quality of life (P = .74) over time; neither the interaction for time by Type D for emotional (P = .31) nor physical quality of life (P = .91) was significant, indicating that Type D exerted a stable effect on quality of life over time. Adjusting for demographics, New York Heart Association functional class, and depressive symptoms, Type D remained an independent determinant of emotional (P = .03) but not physical quality of life (P = .29). Primary care heart failure patients with a Type D personality experienced poorer emotional but not physical quality of life compared to non-Type D patients. Patients with this personality profile should be identified in primary care to see if their treatment is optimal, as both Type D and poor quality of life have been associated with increased morbidity and mortality."],["dc.identifier.doi","10.1007/s10865-009-9236-1"],["dc.identifier.isi","000274088100007"],["dc.identifier.pmid","19937107"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7628"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20659"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0160-7715"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Type D personality is a predictor of poor emotional quality of life in primary care heart failure patients independent of depressive symptoms and New York Heart Association functional class"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","100"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Family Practice"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Eisele, Marion"],["dc.contributor.author","Boczor, Sigrid"],["dc.contributor.author","Rakebrandt, Anja"],["dc.contributor.author","Blozik, Eva"],["dc.contributor.author","Träder, Jens-Martin"],["dc.contributor.author","Störk, Stefan"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Scherer, Martin"],["dc.date.accessioned","2018-04-18T14:42:50Z"],["dc.date.accessioned","2021-10-27T13:21:02Z"],["dc.date.available","2018-04-18T14:42:50Z"],["dc.date.available","2021-10-27T13:21:02Z"],["dc.date.issued","2017-12-08"],["dc.date.updated","2018-04-18T14:42:50Z"],["dc.description.abstract","Background Depression is a common comorbidity in patients with chronic heart failure (HF) and linked to a wider range of symptoms which, in turn, are linked to a decreased health-related quality of life (HRQOL). Treatment of depression might improve HRQOL but detecting depression is difficult due to the symptom overlap between HF and depression. Therefore, clinical guidelines recommend to routinely screen for depression in HF patients. No studies have so far investigated the treatment after getting aware of a depressive symptomatology and its correlation with HRQOL in primary care HF patients. Therefore, we examined the factors linked to depression treatment and those linked to HRQOL in HF patients. We hypothesized that GPs’ awareness of depressive symptomatology was associated with depression treatment and HRQOL in HF patients. Methods For this observational study, HF patients were recruited in primary care practices and filled out a questionnaire including PHQ-9 and HADS. A total of 574 patients screened positive for depressive symptomatology. Their GPs were interviewed by phone regarding the patients’ comorbidities and potential depression treatment. Descriptive and regression analysis were performed. Results GPs reported various types of depression treatments (including dialogue/counselling by the GP him/herself in 31.8% of the patients). The reported rates differed considerably between GP-reported initiated treatment and patient-reported utilised treatment regarding psychotherapy (16.4% vs. 9.5%) and pharmacotherapy (61.2% vs. 30.3%). The GPs' awareness of depressive symptomatology was significantly associated with the likelihood of receiving pharmacotherapy (OR 2.8; p < 0.001) but not psychotherapy. The patient’s HRQOL was not significantly associated with the GPs' awareness of depression. Conclusion GPs should be aware of the gap between GP-initiated and patient-utilised depression treatments in patients with chronic HF, which might lead to an undersupply of depression treatment. It remains to be investigated why GPs’ awareness of depressive symptomatology is not linked to patients’ HRQOL. We hypothesize that GPs are aware of cases with reduced HRQOL (which improves under depression treatment) and unaware of cases whose depression do not significantly impair HRQOL, resulting in comparable levels of HRQOL in both groups. This hypothesis needs to be further investigated."],["dc.identifier.doi","10.1186/s12875-017-0670-9"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15118"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16980"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91989"],["dc.language.rfc3066","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY 4.0"],["dc.rights.access","openAccess"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","General practitioners’ awareness of depressive symptomatology is not associated with quality of life in heart failure patients – cross-sectional results of the observational RECODE-HF Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]