Herrmann‐Lingen, Christoph

[["dc.bibliographiccitation.firstpage","374"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","11"],["dc.contributor.affiliation","Weber, Cora; 1Department of Psychosomatic Medicine and Psychotherapy, Clinic Hennigsdorf, Oberhavel Clinic, 16761 Hennigsdorf, Germany"],["dc.contributor.affiliation","Fangauf, Stella V.; 3Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center, 37075 Göttingen, Germany; sfangauf@outlook.com (S.V.F.); cherrma@gwdg.de (C.H.-L.)"],["dc.contributor.affiliation","Michal, Matthias; 4Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, 55131 Mainz, Germany; matthias.michal@unimedizin-mainz.de (M.M.); manfred.beutel@unimedizin-mainz.de (M.B.)"],["dc.contributor.affiliation","Ronel, Joram; 5Department of Psychosomatic Medicine, Klinik Barmelweid, 5017 Barmelweid, Switzerland; Joram.Ronel@barmelweid.ch"],["dc.contributor.affiliation","Herrmann-Lingen, Christoph; 3Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center, 37075 Göttingen, Germany; sfangauf@outlook.com (S.V.F.); cherrma@gwdg.de (C.H.-L.)"],["dc.contributor.affiliation","Ladwig, Karl-Heinz; 6Department of Psychosomatic Medicine and Psychotherapy, University Hospital Rechts der Isar, Technical University of Munich, 81675 Munich, Germany; karl-heinz.ladwig@tum.de"],["dc.contributor.affiliation","Beutel, Manfred; 4Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, 55131 Mainz, Germany; matthias.michal@unimedizin-mainz.de (M.M.); manfred.beutel@unimedizin-mainz.de (M.B.)"],["dc.contributor.affiliation","Albus, Christian; 7Department of Psychosomatics and Psychotherapy, University of Cologne, 50937 Cologne, Germany; christian.albus@uk-koeln.de"],["dc.contributor.affiliation","Söllner, Wolfgang; 8Department of Psychosomatic Medicine and Psychotherapy, Paracelsus Medical University, Nuremberg Medical Hospital, 90419 Nuremberg, Germany; Wolfgang.Soellner@klinikum-nuernberg.de"],["dc.contributor.affiliation","Perschel, Frank Holger; 9Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany; frank.perschel@charite.de"],["dc.contributor.affiliation","de Zwaan, Martina; 11Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, 30625 Hannover, Germany; deZwaan.Martina@mh-hannover.de"],["dc.contributor.affiliation","Fritzsche, Kurt; 12Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Freiburg, 79104 Freiburg, Germany; kurt.fritzsche@uniklinik-freiburg.de"],["dc.contributor.affiliation","Deter, Hans-Christian; 2Department of Psychosomatics and Psychotherapy, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, 12203 Berlin, Germany; deter@charite.de"],["dc.contributor.author","Weber, Cora"],["dc.contributor.author","Fangauf, Stella V."],["dc.contributor.author","Michal, Matthias"],["dc.contributor.author","Ronel, Joram"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Ladwig, Karl-Heinz"],["dc.contributor.author","Beutel, Manfred"],["dc.contributor.author","Albus, Christian"],["dc.contributor.author","Söllner, Wolfgang"],["dc.contributor.author","Perschel, Frank Holger"],["dc.contributor.author","Deter, Hans-Christian"],["dc.contributor.author","de Zwaan, Martina"],["dc.contributor.author","Fritzsche, Kurt"],["dc.contributor.editor","Waller, Christiane"],["dc.contributor.editor","Radermacher, Peter"],["dc.contributor.editor","Henein, Michael"],["dc.date.accessioned","2022-02-01T10:31:50Z"],["dc.date.available","2022-02-01T10:31:50Z"],["dc.date.issued","2022"],["dc.date.updated","2022-02-09T13:17:59Z"],["dc.description.abstract","Disturbances of HPA axis functioning as represented by cortisol awakening reaction (CAR) belong to the mediating pathways linking psychosocial distress and cardiovascular risk. Both depression and anxiety have been confirmed as independent risk factors for coronary artery disease (CAD). However, data on anxiety and cortisol output in CAD patients are scarce. Based on previous data, we hypothesized that anxiety would be associated with higher cortisol output and a more pronounced morning increase in moderately depressed CAD patients. 77 patients (60 y, 79% male) underwent saliva sampling (+0, +30, +45, +60 min after awakening, midday and late-night sample). Anxiety was measured using the Hospital Anxiety and Depression Scale (HADS) and patients were grouped into anxious versus non anxious subjects based upon the recommended score (≥11). A repeated measures ANOVA yielded a significant time and quadratic time effect referring to the typical CAR. Anxious patients showed a significantly steeper 30 min increase, higher AUCi, lower waking and late-night cortisol levels. The steeper cortisol increase in the anxious group is in line with previous data and may be interpreted as a biological substrate of affect regulation. The lower basal and late-night levels coupled with greater AUCi mirror a more dynamic reactivity pattern compared to depressed subjects without anxiety."],["dc.description.abstract","Disturbances of HPA axis functioning as represented by cortisol awakening reaction (CAR) belong to the mediating pathways linking psychosocial distress and cardiovascular risk. Both depression and anxiety have been confirmed as independent risk factors for coronary artery disease (CAD). However, data on anxiety and cortisol output in CAD patients are scarce. Based on previous data, we hypothesized that anxiety would be associated with higher cortisol output and a more pronounced morning increase in moderately depressed CAD patients. 77 patients (60 y, 79% male) underwent saliva sampling (+0, +30, +45, +60 min after awakening, midday and late-night sample). Anxiety was measured using the Hospital Anxiety and Depression Scale (HADS) and patients were grouped into anxious versus non anxious subjects based upon the recommended score (≥11). A repeated measures ANOVA yielded a significant time and quadratic time effect referring to the typical CAR. Anxious patients showed a significantly steeper 30 min increase, higher AUCi, lower waking and late-night cortisol levels. The steeper cortisol increase in the anxious group is in line with previous data and may be interpreted as a biological substrate of affect regulation. The lower basal and late-night levels coupled with greater AUCi mirror a more dynamic reactivity pattern compared to depressed subjects without anxiety."],["dc.identifier.doi","10.3390/jcm11020374"],["dc.identifier.eissn","2077-0383"],["dc.identifier.pii","jcm11020374"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98956"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.publisher","MDPI"],["dc.relation.eissn","2077-0383"],["dc.rights","Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."],["dc.title","Cortisol Awakening Reaction and Anxiety in Depressed Coronary Artery Disease Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]